公开(公告)号：US20050181424A1

公开(公告)日：2005-08-18

申请号：US11085681

申请日：2005-03-21

申请人： Masumi Abe

发明人： Masumi Abe

IPC分类号： C12P19/34 ,  C12Q1/68

CPC分类号： C12Q1/6809 ,  C12Q1/6858 ,  C12Q2527/107 ,  C12Q2525/191 ,  C12Q2525/131 ,  C12Q2531/113 ,  C12Q2565/125

摘要： The present invention provides a method for preparing a gene expression profile with a high precision, by carrying out the annealing of primers to templates in the temperature range of TmMAX+6° C. to TmMAX+14° C. of the primer in a PCR step of a HiCEP method.

摘要翻译： 本发明提供了通过在引物的TmMAX + 6℃至TmMAX + 14℃的温度范围内对引物进行PCR的退火，从而提供了高精度制备基因表达谱的方法。 HiCEP方法的一步。

公开(公告)号：US06870069B2

公开(公告)日：2005-03-22

申请号：US10699743

申请日：2003-11-04

申请人： Kazutoshi Suzuki ,  Ming-Rong Zhang ,  Tetsuya Suhara ,  Atsuro Nakazato ,  Makoto Goto

发明人： Kazutoshi Suzuki ,  Ming-Rong Zhang ,  Tetsuya Suhara ,  Atsuro Nakazato ,  Makoto Goto

IPC分类号： C07C233/15 ,  C07C233/05 ,  A61K31/16

CPC分类号： C07C233/15

摘要： A phenyloxyaniline derivative useful as a ligand for peripheral benzodiazepine receptor having a strong affinity and a high selectivity, which is represented by formula (1): wherein X1 and X2 are same or different and each is hydrogen atom or halogen atom; R1 and R2 are same or different and each is hydrogen atom, an alkyl group having 1 to 10 carbon(s) or a halogen-substituted alkyl group having 1 to 10 carbon(s); and R3 is a halogen-substituted alkyl group having 1 to 5 carbon(s), or a radioisotope thereof.

摘要翻译： 用作具有强亲合力和高选择性的外部苯并二氮杂受体的配体的苯氧基苯胺衍生物，其由式（1）表示：其中X 1和X 2相同或不同，各自为氢原子或卤素 原子; R 1和R 2相同或不同，各自为氢原子，具有1〜10个碳原子的烷基或具有1〜10个碳原子的卤素取代的烷基; R 3是具有1〜5个碳原子的卤素取代的烷基或其放射性同位素。

公开(公告)号：US20040138310A1

公开(公告)日：2004-07-15

申请号：US10699743

申请日：2003-11-04

申请人： NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES ,  TAISHO PHARMACEUTICAL CO., LTD. ,  NIHON NOHYAKU CO., LTD.

发明人： Kazutoshi Suzuki ,  Ming-Rong Zhang ,  Tetsuya Suhara ,  Atsuro Nakazato ,  Makoto Goto

IPC分类号： A61K031/16

CPC分类号： C07C233/15

摘要： A phenyloxyaniline derivative useful as a ligand for peripheral benzodiazepine receptor having a strong affinity and a high selectivity, which is represented by formula (1): 1 wherein X1 and X2 are same or different and each is hydrogen atom or halogen atom; R1 and R2 are same or different and each is hydrogen atom, an alkyl group having 1 to 10 carbon(s) or a halogen-substituted alkyl group having 1 to 10 carbon(s); and R3 is a halogen-substituted alkyl group having 1 to 5 carbon(s), or a radioisotope thereof.

摘要翻译： 用作具有强亲合力和高选择性的外部苯并二氮杂受体的配体的苯氧基苯胺衍生物，其由式（1）表示：其中X 1和X 2相同或不同，各自为氢原子或卤素 原子; R 1和R 2相同或不同，各自为氢原子，具有1〜10个碳原子的烷基或具有1〜10个碳原子的卤素取代的烷基; R 3是具有1〜5个碳原子的卤素取代的烷基或其放射性同位素。

公开(公告)号：US20160253455A1

公开(公告)日：2016-09-01

申请号：US15027160

申请日：2014-01-29

申请人： NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES

发明人： Shin HASEGAWA ,  Yasuo OKUDA

IPC分类号： G06F19/00 ,  G06F3/0484 ,  G09G5/06 ,  H04B3/54 ,  G06T11/00

CPC分类号： G06F19/321 ,  A61B6/461 ,  G06F3/04845 ,  G06F3/04847 ,  G06T11/001 ,  G06T2210/41 ,  G09G5/026 ,  G09G5/06 ,  G09G5/14 ,  G09G2320/0271 ,  G09G2320/0693 ,  G09G2354/00 ,  G09G2380/08 ,  H04B3/54

摘要： A viewer part 38b accesses an image viewer web server 14 by a user terminal 16, in which a medical image display program 38 is installed, to acquire at least medical image data 13a, input data accepted in a touch input part 21a is transmitted in an input transmission part 31 and is transferred to the image viewer web server 14, the medical image data 13a outputted from the image viewer web server 14 is acquired in a capture acquisition part 34, at least a medical image data 13a portion is subjected to image conversion in an image conversion part 35, and image data for display after conversion is outputted to a display part 23 by an output part 36. Accordingly, there is provided a medical image display device that can display a medical image in proper gradation without using color management by hardware, and without performing modification corresponding to gradation correction to an individual application having a display function of the medical image.

摘要翻译： 观看者部分38b通过其中安装有医学图像显示程序38的用户终端16访问图像查看器web服务器14以获取至少医学图像数据13a，在一个触摸输入部分21a中接收的输入数据被发送到 输入传送部分31并被传送到图像查看器web服务器14，在捕获获取部分34中获取从图像查看器web服务器14输出的医学图像数据13a，至少医学图像数据13a部分被进行图像转换 在图像转换部分35中，并且用于转换后显示的图像数据由输出部分36输出到显示部分23.因此，提供了一种能够以适当灰度显示医学图像而不使用颜色管理的医学图像显示装置 并且不对具有医学图像的显示功能的单个应用执行与灰度校正相对应的修改。

公开(公告)号：US20160029934A1

公开(公告)日：2016-02-04

申请号：US14425317

申请日：2012-09-03

申请人： Nobuya HASHIZUME ,  Keishi KITAMURA ,  Takahiro NISHIMOTO ,  Yuichi KIMURA ,  Hiroshi TOYAMA ,  Takashi YAMADA

发明人： Nobuya HASHIZUME ,  Keishi KITAMURA ,  Takahiro NISHIMOTO ,  Yuichi KIMURA ,  Hiroshi TOYAMA ,  Takashi YAMADA

IPC分类号： A61B5/155 ,  A61B5/153 ,  A61B5/15

CPC分类号： A61B5/155 ,  A61B5/15003 ,  A61B5/150221 ,  A61B5/150229 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/157 ,  A61B2503/40

摘要： A suction drain device of a disclosed liquid collecting apparatus actively pushes and pulls blood. This achieves liquid collection at high speed even under decreased pressure depending on a physiological state of an animal. Moreover, the liquid collecting apparatus includes a First flow path and a second flow path having a given length. Accordingly, the flow path with a given length set in advance and thus a known volume allows collection of a given amount volume of blood without measuring a length and an amount of blood using a volume measuring device. Accordingly, no need of the measuring device allows reduction in size of the liquid collecting apparatus. Consequently, the liquid collecting apparatus can be installed adjacent to the animal to achieve reduction in dead volume. Moreover, blood is flown to a fourth flow path branched with a connecting terminal, and is also flown to the second flow path branched with a connecting terminal. The blood flown in the second flow path is collected at the highest priority. This obtains collection of fresh blood from a collecting source as a blood supply source.

摘要翻译： 所公开的液体收集装置的吸入排水装置主动地推动和拉动血液。 即使在取决于动物的生理状态的压力降低的情况下也可以高速地进行液体收集。 此外，液体收集装置包括具有给定长度的第一流动路径和第二流动路径。 因此，具有给定长度的流路预先设定，因此已知体积允许收集给定量的血液，而不用使用体积测量装置测量血液的长度和量。 因此，不需要测量装置，能够减小液体收集装置的尺寸。 因此，液体收集装置可以安装在动物附近以实现死体积的减少。 此外，血液流向通过连接端子分支的第四流路，并且也流到通过连接端子分支的第二流路。 以最高优先级收集在第二流路中流动的血液。 从收集源获取新鲜血液作为血液供应源。

公开(公告)号：US08457379B2

公开(公告)日：2013-06-04

申请号：US11920254

申请日：2006-05-12

申请人： Mutsumi Tashiro ,  Shinichi Minohara

发明人： Mutsumi Tashiro ,  Shinichi Minohara

IPC分类号： G06K9/62

CPC分类号： A61N5/1049 ,  A61B6/466 ,  A61B6/541 ,  A61N5/1037 ,  A61N5/1064 ,  G06T7/33 ,  G06T7/35 ,  G06T2207/10076 ,  G06T2207/10081 ,  G06T2207/20164 ,  G06T2207/30004 ,  G06T2207/30061

摘要： A plurality of CT images of an organ (10) which has undergone a subtle variation or deformation are used as input data, blood vessels and trachea 12 distributed inside the organ are extracted and subjected to thinning, the thus thinned images 14 are used to extract the coordinates of bifurcations 16 and connections, the thus extracted coordinates are used as feature points to track the motion of individual points between a plurality of CT images in a three dimensional space, thereby measuring the movement of the organ (10). Thus, it is possible to realize a local motion tracking at an arbitrary point over an entire region inside an organ, which would be impossible by using a metal marker.

摘要翻译： 使用已经经历微小变化或变形的器官（10）的多个CT图像作为输入数据，提取分布在器官内部的血管和气管12，并进行变薄，由此变薄的图像14用于提取 分叉16和连接的坐标，由此提取的坐标被用作特征点以跟踪三维空间中的多个CT图像之间的各个点的运动，从而测量器官（10）的运动。 因此，可以在器官内部的整个区域上的任意点实现局部运动跟踪，这通过使用金属标记物是不可能的。

公开(公告)号：US20130056638A1

公开(公告)日：2013-03-07

申请号：US13636936

申请日：2010-03-29

申请人： Naoko Inadama ,  Hideo Murayama ,  Taiga Yamaya ,  Mitsuo Watanabe ,  Takahiro Moriya ,  Kenshi Fukumitsu ,  Tomohide Omura

发明人： Naoko Inadama ,  Hideo Murayama ,  Taiga Yamaya ,  Mitsuo Watanabe ,  Takahiro Moriya ,  Kenshi Fukumitsu ,  Tomohide Omura

IPC分类号： G01T1/164

CPC分类号： G01T1/1644

摘要： A three-dimensional position-sensitive radiation detector is provided which has a three-dimensional array of photodetectors disposed on the surface of a scintillator block and which is capable of three-dimensionally identifying the position of light emission at which radiation has been detected within the detector. The three-dimensional position-sensitive radiation detector includes: a scintillator block including a central portion which restricts the direction of diffusion of light so as to direct the light in three axial directions and which has an optically discontinuous region, and an outer portion which is disposed on the outside of the central portion and which does not restrict the direction of diffusion of light; and photodetectors disposed on at least two outer circumferential surfaces of the scintillator block. The detector identifies three-dimensionally the position of light emission, thereby preventing deterioration in position discrimination performance even when inner scintillator elements are smaller than the photodetectors.

摘要翻译： 提供了三维位置敏感的放射线检测器，其具有设置在闪烁体块的表面上的光电检测器的三维阵列，并且能够三维地识别已经在其内检测到辐射的发光的位置 探测器。 三维位置敏感型放射线检测器包括：闪烁体块，其包括限制光的扩散方向的中心部，以使光在三个轴向引导，并具有光学不连续区域;外部部分 设置在中心部分的外侧，并且不限制光的扩散方向; 以及设置在闪烁体块的至少两个外周表面上的光电检测器。 检测器三维地识别发光的位置，从而即使当内部闪烁体元件小于光电检测器时也防止位置判别性能的劣化。

公开(公告)号：US08358405B2

公开(公告)日：2013-01-22

申请号：US12863968

申请日：2008-01-22

申请人： Keishi Kitamura ,  Takahiro Nishimoto ,  Yuichi Kimura ,  Chie Seki ,  Iwao Kanno

发明人： Keishi Kitamura ,  Takahiro Nishimoto ,  Yuichi Kimura ,  Chie Seki ,  Iwao Kanno

IPC分类号： G01N33/48

CPC分类号： G01F3/38 ,  A61B5/14503 ,  A61B5/14546 ,  A61B5/15003 ,  A61B5/150229 ,  A61B5/150755 ,  A61B5/150946 ,  A61B5/150992 ,  A61B5/153 ,  A61B5/155 ,  A61B5/157 ,  A61B2503/40 ,  G01F13/00 ,  G01F13/006 ,  G01N21/07 ,  G01N21/6428 ,  G01N21/645

摘要： A blood collecting apparatus includes a main flow path and a pressure generator. The pressure generator is provided in an intermediate position of the main flow path to insert a gas as separators at designated predetermined intervals, thereby to take out blood to be measured, as separated in a time series. The blood can be taken out in minute volumes by inserting the separators consisting of the gas while feeding the blood continuously into the main flow path in this way. And consumption of the blood can be held down, and the amount of collected blood can be minimized. Since the operation to insert the separators is excellent in speed, repeated collection in a short time, i.e. frequency of blood collection, can be secured.

摘要翻译： 血液采集装置包括主流路和压力发生器。 压力发生器设置在主流路的中间位置，以指定的预定间隔插入作为分离器的气体，从而以时间序列分离取出待测血液。 通过插入由气体组成的分离器，以这种方式将血液连续地供给到主流路中，可以以微量的体积取出血液。 可以抑制血液的消耗，并且可以将收集的血液量减至最少。 由于插入分离器的操作速度极佳，所以可以确保在短时间内进行重复收集，即采集频率。

公开(公告)号：US20120165651A1

公开(公告)日：2012-06-28

申请号：US13257526

申请日：2009-03-23

申请人： Taiga Yamaya ,  Eiji Yoshida ,  Fumihiko Nishikido ,  Taku Inaniwa ,  Hideo Murayama

发明人： Taiga Yamaya ,  Eiji Yoshida ,  Fumihiko Nishikido ,  Taku Inaniwa ,  Hideo Murayama

IPC分类号： A61B6/00

CPC分类号： A61N5/1049 ,  A61B6/037 ,  A61N2005/1052 ,  A61N2005/1087 ,  G01T1/1603 ,  G01T1/2985

摘要： An imaging device, or a PET device, opposed gamma camera type PET device, or open PET device in particular, that is combined with a radiation therapy device, in which detectors are rotated to reduce incidence of nuclear fragments on the detectors. For example, in an opposed gamma camera type PET device, beam irradiation and detector rotation can be synchronized to prevent the detectors from interfering with the treatment beam and reduce the incidence of nuclear fragments on the detectors. This makes it possible to reduce the incidence of nuclear fragments on the detectors without interfering with a treatment beam, thereby enabling measurement of annihilation radiations and three-dimensional imaging of the irradiation field immediately after irradiation or during irradiation.

摘要翻译： 与成像装置或PET装置相对的γ相机型PET装置或特别是开放的PET装置，其与辐射治疗装置组合，其中检测器被旋转以减少检测器上的核碎片的发生率。 例如，在相对的γ照相机类型的PET装置中，可以同步束照射和检测器旋转，以防止检测器干扰处理束并减少检测器上核碎片的发生。 这使得可以在不干扰处理束的情况下降低检测器上核碎片的发生率，从而能够在照射后或照射期间立即测量湮灭辐射和照射场的三维成像。

公开(公告)号：US08188437B2

公开(公告)日：2012-05-29

申请号：US12450529

申请日：2007-08-30

申请人： Eiji Yoshida ,  Kengo Shibuya ,  Taiga Yamaya ,  Hideo Murayama ,  Keishi Kitamura

发明人： Eiji Yoshida ,  Kengo Shibuya ,  Taiga Yamaya ,  Hideo Murayama ,  Keishi Kitamura

IPC分类号： G01T1/166

CPC分类号： G01T1/2985 ,  A61B6/037 ,  G01T1/1647

摘要： Upon detection of radiation by using a (three-dimensional) detector capable of distinguishing a detection position in a depth direction and energy, an energy window for distinguishing between a signal and noise is changed depending on the detection position in the depth direction, thus making it possible to obtain scattering components inside the detector. Alternatively, a weight is given to a detection event depending on the detection position in the depth direction and energy information to obtain scattering components inside the detector. Thereby, scattering components inside the detector can be obtained to increase the sensitivity of the detector. In this case, different detecting elements can be used depending on the detection position in the depth direction.

摘要翻译： 通过使用能够区分深度方向的检测位置和能量的（三维）检测器来检测辐射，根据深度方向的检测位置来改变用于区分信号和噪声的能量窗，从而使 可能在检测器内部获得散射成分。 或者，根据深度方向上的检测位置和能量信息给予检测事件的权重，以获得检测器内部的散射成分。 因此，可以获得检测器内部的散射分量，以提高检测器的灵敏度。 在这种情况下，根据深度方向的检测位置，可以使用不同的检测元件。