利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

184 条记录 (耗时 0.032 秒)

    Attenuation of encephalitogenic alphavirus and uses thereof
    86.
    发明授权
    Attenuation of encephalitogenic alphavirus and uses thereof 有权
    脑炎病毒的减毒及其用途

    公开(公告)号：US08614082B2

    公开(公告)日：2013-12-24

    申请号：US13284098

    申请日：2011-10-28

    申请人： Ilya V. Frolov ,  Elena Frolova ,  Scott C. Weaver

    发明人： Ilya V. Frolov ,  Elena Frolova ,  Scott C. Weaver

    IPC分类号： C12N7/04 ,  A61K39/12

    CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5254 ,  C07K14/005 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2770/36161

    摘要： The present invention is drawn to generating attenuated and less cytopathic forms of New World alphaviruses that can be used in immunogenic compositions as vaccines against both Old and New World alphaviruses. In this regard, the present invention discloses that the N-terminal, ˜35-aa-long peptide of VEEV, EEEV and, most likely, of WEEV capsid proteins plays the most critical role in the downregulation of cellular transcription and development of cytopathic effect. The identified, VEEV-specific peptide, CVEE30-68, includes two domains with distinguished functions. The integrity of both domains determines not only the intracellular distribution of CVEE, but is also essential for direct capsid function in the inhibition of transcription. The replacement of the N-terminal fragment of CVEE by its SINV-specific counterpart in VEEV TC-83 genome does not affect virus replication in vitro, but makes it less cytopathic and more attenuated in vivo.

    摘要翻译： 本发明被用于产生减毒和较少细胞病变形式的新世界甲病毒，其可用于免疫原性组合物中作为针对旧世界和新世界甲病毒的疫苗。 在这方面，本发明公开了VEEV，EEEV和最有可能的WEEV衣壳蛋白的N末端〜35-aa长肽在细胞转录的下调和细胞病变效应的发展中起着最关键的作用 。 鉴定的VEEV特异性肽CVEE30-68包括具有显着功能的两个结构域。 两个结构域的完整性不仅决定了CVEE的细胞内分布，而且对抑制转录的直接衣壳功能也是至关重要的。 VEEV TC-83基因组中由其特定于SINV特异的对应物替代CVEE的N-末端片段不影响体外病毒复制，但使体内细胞致病性降低并减弱。

    Detecting a deposition condition
    87.
    发明授权
    Detecting a deposition condition 有权
    检测沉积条件

    公开(公告)号：US08546205B2

    公开(公告)日：2013-10-01

    申请号：US13186356

    申请日：2011-07-19

    申请人： Lam T. Luu ,  Heather L. Knoedler ,  Richard S. Bingle ,  Daniel C. Weaver

    发明人： Lam T. Luu ,  Heather L. Knoedler ,  Richard S. Bingle ,  Daniel C. Weaver

    IPC分类号： C23C16/00 ,  C23C8/00 ,  H05H1/24 ,  H01L21/84 ,  H01L21/8249

    CPC分类号： H01L21/68764 ,  C23C14/044 ,  C23C14/24 ,  C23C14/546 ,  H01L21/2855 ,  H01L21/28575 ,  H01L21/67253 ,  H01L21/68771

    摘要： Apparatus and methods for detecting evaporation conditions in an evaporator for evaporating metal onto semiconductor wafers, such as GaAs wafers, are disclosed. One such apparatus can include a crystal monitor sensor configured to detect metal vapor associated with a metal source prior to metal deposition onto a semiconductor wafer. This apparatus can also include a shutter configured to remain in a closed position when the crystal monitor sensor detects an undesired condition, so as to prevent metal deposition onto the semiconductor wafer. In some implementations, the undesired condition can be indicative of a composition of a metal source, a deposition rate of a metal source, impurities of a metal source, position of a metal source, position of an electron beam, and/or intensity of an electron beam.

    摘要翻译： 公开了一种用于检测用于将金属蒸发到诸如GaAs晶片的半导体晶片上的蒸发器中的蒸发条件的装置和方法。 一种这样的设备可以包括晶体监视器传感器，其被配置为在金属沉积到半导体晶片之前检测与金属源相关联的金属蒸气。 该装置还可以包括配置为当晶体监视器传感器检测到不期望的状况时保持在关闭位置的快门，以防止金属沉积到半导体晶片上。 在一些实施方案中，不期望的条件可以指示金属源的组成，金属源的沉积速率，金属源的杂质，金属源的位置，电子束的位置和/或 电子束。

    Dropped ceiling fan housing
    89.
    发明授权
    Dropped ceiling fan housing 有权
    吊顶吊扇外壳

    公开(公告)号：US08147193B2

    公开(公告)日：2012-04-03

    申请号：US12244308

    申请日：2008-10-02

    申请人： William C. Weaver

    发明人： William C. Weaver

    IPC分类号： F03B11/02

    CPC分类号： F24F7/007 ,  F04D25/12 ,  F04D29/542 ,  F24F9/00

    摘要： A modular ceiling fan housing unit designed to create a focused column or columns of downwardly moving air such that there is little deflection when the column or columns of downwardly moving air arrives at the ground level. The modular ceiling fan housing includes an elongated body element having a fluid impelling device to create the downwardly moving air. At least one plate disposed within the elongated body element directs the downwardly moving air into columns. The modular ceiling fan housing unit may be coupled to another modular ceiling fan housing unit to provide additional columns of downwardly moving air. The modular ceiling fan housing units may be coupled in various configurations, depending on the type of application. Furthermore, the modular ceiling fan housing unit or multiple modular fan housing units may be coupled to an elevated structure located either above or below the housing units.

    摘要翻译： 模块化吊扇壳体单元设计用于产生聚焦的列或向下移动的空气列，使得当下列移动的空气的塔或塔抵达地面时几乎没有偏转。 模块化吊扇壳体包括具有流体推动装置的细长主体元件，以产生向下移动的空气。 设置在细长主体元件内的至少一个板将向下移动的空气引导到塔中。 模块化吊扇壳体单元可以联接到另一个模块化吊扇风扇壳体单元，以提供附加的向下移动的空气列。 根据应用的类型，模块化吊扇壳体单元可以以各种配置耦合。 此外，模块化吊扇壳体单元或多个模块化风扇壳体单元可以联接到位于壳体单元的上方或下方的升高的结构。

    Minimally invasive spinal stabilization system
    90.
    发明授权
    Minimally invasive spinal stabilization system 有权
    微创脊柱稳定系统

    公开(公告)号：US08123785B2

    公开(公告)日：2012-02-28

    申请号：US12117294

    申请日：2008-05-08

    申请人： Paul C. Weaver ,  Brian E. Dalton

    发明人： Paul C. Weaver ,  Brian E. Dalton

    IPC分类号： A61B17/80

    CPC分类号： A61B17/025 ,  A61B17/3421 ,  A61B17/7007 ,  A61B17/7011 ,  A61B17/7037 ,  A61B17/7058 ,  A61B17/7076 ,  A61B17/7083 ,  A61B17/808 ,  A61B17/864 ,  A61B17/8897 ,  A61B2017/00469 ,  A61B2017/0256

    摘要： A spinal stabilization system includes an implant and instrumentation for stabilizing the spine. In one embodiment, the system includes a plate having a side rail and a channel extending adjacent the side rail. A pedicle screw assembly is positioned in the channel in releasable engagement with the side rail. The pedicle screw assembly includes a polyaxial screw seated in a lower housing having a lower locking flange. An upper housing having an upper locking flange secures the plate to the lower housing. The side rail of the plate is releasably engaged between the upper locking flange and the lower locking flange. The upper and lower housings include on-board locking mechanisms for fixing components in the screw assembly. The screw assembly and plate are inserted and oriented by remote manipulation. Minimally invasive techniques for inserting the implant are performed with the instrumentation, and cause minimal disturbance to surrounding tissue.

    摘要翻译： 脊柱稳定系统包括用于稳定脊柱的植入物和仪器。 在一个实施例中，系统包括具有侧轨和邻近侧轨延伸的通道的板。 椎弓根螺钉组件定位在通道中以与侧轨可释放地接合。 椎弓根螺钉组件包括位于具有下锁定凸缘的下壳体中的多轴螺钉。 具有上锁定凸缘的上壳体将板固定到下壳体。 板的侧轨可释放地接合在上锁定凸缘和下锁定凸缘之间。 上壳体和下壳体包括用于固定螺钉组件中的部件的板上锁定机构。 螺丝组件和板通过远程操作进行插入和定向。 使用仪器进行插入植入物的微创技术，并对周围组织造成最小的干扰。