公开(公告)号：US20180256704A1

公开(公告)日：2018-09-13

申请号：US15800245

申请日：2017-11-01

Applicant: GlaxoSmithKline Biologicals, SA

Inventor： Alfredo NICOSIA ,  Ricardo CORTESE ,  Alessandra VITELLI

IPC: A61K39/155 ,  A61K39/275 ,  A61K39/235

Abstract: Administration regimens suitable for vaccine compositions comprising polynucleotides encoding immunogenic polypeptides. Such administration regimens involve the repeated administration of a vaccine composition.

公开(公告)号：US10040832B2

公开(公告)日：2018-08-07

申请号：US15119220

申请日：2015-02-20

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Normand Blais ,  Cindy Castado ,  Patrick Chomez ,  Marianne Dewerchin

IPC: A61K39/00 ,  C07K14/21 ,  C07K16/12 ,  A61K39/102 ,  A61K39/104

Abstract: The present invention relates to compositions comprising Moraxella catarrhalis (M. catarrhalis) Ubiquitous surface protein A2 (UspA2). More particularly, the present application relates to UspA2 protein constructs and immunogenic compositions comprising the constructs, vaccines comprising such immunogenic compositions and therapeutic uses of the same. The invention further relates to compositions comprising UspA2 in combination with at least one antigen from Haemophilus influenzae, immunogenic compositions comprising the antigens, vaccines comprising such immunogenic compositions and therapeutic uses of the same.

公开(公告)号：US20180169210A1

公开(公告)日：2018-06-21

申请号：US15802347

申请日：2017-11-02

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Mariagrazia PIZZA

IPC: A61K39/095 ,  A61K39/39

CPC classification number: A61K39/095 ,  A61K39/00 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/55505 ,  C07K14/22 ,  Y02A50/464 ,  Y02A50/466

Abstract: Two or more Neisserial proteins are joined such that they are translated as a single polypeptide chain. Hybrid proteins are represented by the formula NH2-A-[—X-L-]n—B—COOH where X is an amino acid sequence, L is an optional linker amino acid sequence, A is an optional N-terminal amino acid sequence, B is an optional C-terminal amino acid sequence, and n is an integer greater than 1. Proteins where each of the n —X— moieties shares sequence identity to each other —X— moiety, the protein is a ‘tandem protein’.

公开(公告)号：US09981031B2

公开(公告)日：2018-05-29

申请号：US15240385

申请日：2016-08-18

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Paolo Costantino

IPC: A61K39/095 ,  A61K39/385 ,  A61K39/00 ,  A61K39/116 ,  C07K14/22 ,  A61K9/00 ,  A61K39/08 ,  A61K39/102 ,  A61K39/09 ,  A61K39/05 ,  A61K39/29 ,  A61K39/02 ,  A61K39/12

CPC classification number: A61K39/095 ,  A61K9/0019 ,  A61K39/0017 ,  A61K39/0018 ,  A61K39/05 ,  A61K39/08 ,  A61K39/092 ,  A61K39/099 ,  A61K39/102 ,  A61K39/116 ,  A61K39/12 ,  A61K39/292 ,  A61K39/385 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/575 ,  A61K2039/6037 ,  A61K2039/62 ,  A61K2039/627 ,  A61K2039/70 ,  C07K14/22

Abstract: An injectable immunogenic composition comprising capsular saccharides from at least two of serogroups A, C, W135 and Y of Neisseria meningitidis, wherein said capsular saccharides are conjugated to carrier protein(s) and/or are oligosaccharides, and wherein (i) the composition comprises

公开(公告)号：US09932374B2

公开(公告)日：2018-04-03

申请号：US14425037

申请日：2013-09-19

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Cesira Galeotti ,  Rosanna Leuzzi ,  Mariagrazia Pizza ,  Maria Scarselli ,  Meera Unnikrishnan ,  Manuele Martinelli

IPC: A61K39/08 ,  C07K14/33 ,  C07K16/12 ,  A61K39/00

CPC classification number: C07K14/33 ,  A61K39/08 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/70 ,  C07K16/1282

Abstract: The invention provides methods, proteins, nucleic acids and antibodies for preventing or treating a C. difficile infection in a mammal.

公开(公告)号：US20180064801A1

公开(公告)日：2018-03-08

申请号：US15693663

申请日：2017-09-01

Applicant: GLAXOSMITHKLINE BIOLOGICALS SA

Inventor： Mariagrazia PIZZA

IPC: A61K39/095 ,  A61K47/64 ,  A61K39/39

CPC classification number: A61K39/095 ,  A61K39/39 ,  A61K47/646 ,  A61K2039/55505 ,  A61K2039/58 ,  C07K14/22 ,  C07K16/1217 ,  C07K2317/21 ,  C07K2317/33

Abstract: Methods and compositions for immunizing a human subject against Neisseria gonorrhoeae.

公开(公告)号：US20180002679A1

公开(公告)日：2018-01-04

申请号：US15540690

申请日：2015-12-24

Applicant: GLAXOSMITHKLINE BIOLOGICALS, SA

Inventor： Jurgen HAAS ,  Julian IHSSEN ,  Michael Thomas KOWARIK ,  Torsten Franz SCHWEDE ,  Linda Christiane THÖNY-MEYER

IPC: C12N9/10 ,  C12P21/00

CPC classification number: C12N9/1081 ,  C12P21/005

Abstract: Described herein are oligosaccharyl transferases for use in N-glycosylating proteins of interest in vitro and in host cells. Methods for using such oligosaccharyl transferases, nucleic acids encoding such oligosaccharyl transferases, and host cells comprising such oligosaccharyl transferases are also provided herein. Glycoconjugates generated by using such oligosaccharyl transferases are also provided herein.

公开(公告)号：US09855325B2

公开(公告)日：2018-01-02

申请号：US14424370

申请日：2013-10-03

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Guido Grandi ,  Immaculada Margarit Y Ros ,  Domenico Maione

IPC: A61K39/09 ,  A61K39/00 ,  A61K39/05 ,  A61K39/08 ,  A61K39/02 ,  A61K39/13 ,  A61K39/12 ,  C12N7/00 ,  A61K9/00 ,  A61K47/64

CPC classification number: A61K39/092 ,  A61K9/0019 ,  A61K39/0018 ,  A61K39/05 ,  A61K39/08 ,  A61K39/099 ,  A61K39/12 ,  A61K39/13 ,  A61K47/646 ,  A61K2039/55 ,  A61K2039/55505 ,  A61K2039/6037 ,  A61K2039/70 ,  C12N7/00 ,  C12N2770/32334 ,  C12N2770/32634 ,  Y02A50/466

Abstract: The invention provides an immunogenic composition comprising: a) a conjugate that is a capsular saccharide from GBS serotype Ia conjugated to a carrier protein; b) a conjugate that is a capsular saccharide from GBS serotype Ib conjugated to a carrier protein; c) a conjugate that is a capsular saccharide from GBS serotype III conjugated to a carrier protein; d) a conjugate that is a capsular saccharide from GBS serotype II conjugated to a carrier protein; and e) a conjugate that is a capsular saccharide from GBS serotype V conjugated to a carrier protein.

公开(公告)号：US20170369854A1

公开(公告)日：2017-12-28

申请号：US15534903

申请日：2015-12-14

Applicant: GlaxoSmithKline Biologicals SA ,  The Chemo-Sero-Therapeutic Research Institute

Inventor： Pascal Charles Louis GERKENS ,  Jean-Francois Jose Alain Marie Ghislain LERUSE

IPC: C12N7/02

CPC classification number: C12N7/02 ,  C12N7/00 ,  C12N2760/16051

Abstract: Methods of producing and purifying viruses using density gradient ultracentrifugation. The methods are suitable for large scale production, and for viruses produced in eggs or in cell culture.

公开(公告)号：US09839686B2

公开(公告)日：2017-12-12

申请号：US14612111

申请日：2015-02-02

Applicant: GlaxoSmithKline Biologicals SA

Inventor： Francesco Berti ,  Paolo Costantino ,  Maria Rosaria Romano

IPC: A61K39/385 ,  A61K39/085 ,  A61K31/70 ,  A61K47/48 ,  A61K47/64 ,  A61K39/00

CPC classification number: A61K39/385 ,  A61K39/085 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/6037 ,  A61K2039/627 ,  Y10S424/831 ,  Y10S530/807

Abstract: The invention provides a process for preparing a conjugate of a S. aureus type 8 capsular polysaccharide and a carrier molecule, comprising the steps of: (a) depolymerising the capsular polysaccharide, to give a polysaccharide fragment; (b) oxidising the fragment in order to introduce an aldehyde group into at least one saccharide residue in the fragment, to give an oxidised saccharide residue; and (c) coupling the oxidised saccharide residue to a carrier molecule via the aldehyde group, thereby giving the conjugate. The coupling in step (c) may be direct, or may be via a linker molecule. The invention also provides a conjugate obtained or obtainable by this process.