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    PATCH AND METHOD FOR PRODUCING THE SAME
    82.
    发明申请
    PATCH AND METHOD FOR PRODUCING THE SAME 有权
    配对及其制造方法

    公开(公告)号：US20150164862A1

    公开(公告)日：2015-06-18

    申请号：US14417205

    申请日：2013-07-25

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Masayuki Suzuki ,  Hiroaki Okutsu ,  Takashi Yasukochi ,  Yasunori Takada

    IPC: A61K31/407 ,  A61K47/12 ,  A61K47/14 ,  A61K9/70

    CPC classification number: A61K47/12 ,  A61K9/7038 ,  A61K9/7046 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K31/407 ,  A61K31/55 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61M37/00

    Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer comprises: a mixture preparation step of mixing asenapine or a pharmaceutically acceptable salt thereof with sodium acetate whose particle diameter D50 at a cumulative volume of 50% in a particle diameter distribution is 40 to 1000 μm, in such a manner that the sodium acetate and sodium diacetate generated from the sodium acetate have a particle diameter D50 of 10 μm or smaller, thereby obtaining a mixture containing the sodium diacetate and the asenapine or pharmaceutically acceptable salt; and an adhesive-agent-layer formation step of forming the adhesive agent layer comprising the sodium diacetate, the asenapine or pharmaceutically acceptable salt, and a pressure-sensitive adhesive base agent, by using an adhesive agent layer composition obtained by mixing the mixture with the pressure-sensitive adhesive base agent.

    Abstract translation: 制备包含支持层和粘合剂层的贴剂的方法包括：混合制备步骤，其将粒径分布中累积体积为50％的粒径D50与甲酸钠的药学上可接受的盐混合， 40至1000μm，使得由乙酸钠生成的乙酸钠和二乙酸钠的粒径D50为10μm或更小，从而获得含有二乙酸钠和阿替平或其药学上可接受的盐的混合物; 以及通过使用通过将混合物与所述粘合剂层组合物混合而获得的粘合剂层组合物形成包含二乙酸钠，阿替平或其药学上可接受的盐的粘合剂层和粘合剂基剂的粘合剂层形成步骤 压敏胶基剂。

    METHOD FOR PRODUCING PATCH, PATCH AND PACKAGE
    84.
    发明申请
    METHOD FOR PRODUCING PATCH, PATCH AND PACKAGE 有权
    生产配件，配件和包装的方法

    公开(公告)号：US20150004215A1

    公开(公告)日：2015-01-01

    申请号：US14317976

    申请日：2014-06-27

    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

    Inventor： Takahito YOSHIZAKI ,  Kouji Tanaka ,  Kazunosuke Aida ,  Terumitsu Kaiho ,  Nobuo Tsutsumi

    IPC: A61K31/4045 ,  A61K9/70

    CPC classification number: A61K31/4045 ,  A61K9/7053

    Abstract: A method for producing a patch comprising a support layer and an adhesive agent layer arranged on at least one surface of the support layer, the method comprising: step A) obtaining an adhesive agent layer composition comprising free ropinirole in an amount which results in a content of 5 to 13.2% by mass in an obtained adhesive agent layer; step B) heating the adhesive agent layer composition at a temperature in a range from 50 to 76° C. for 5 minutes to 24 hours; and step C) cooling the heated adhesive agent layer composition to normal temperature at an average rate of temperature drop of 1 to 20° C./hour, thereby obtaining the adhesive agent layer comprising the free ropinirole at a supersaturated concentration in a dissolved form.

    Abstract translation: 一种贴剂的制造方法，其特征在于，在支承层的至少一个表面配置有支撑层和粘合剂层，其特征在于，包括：工序A）得到粘合剂层组合物，其含有游离罗哌尼罗， 在所得粘合剂层中为5〜13.2质量％ 步骤B）将粘合剂层组合物在50至76℃的温度下加热5分钟至24小时; 和步骤C）以1〜20℃/小时的平均降温速度将加热的粘合剂层组合物冷却至常温，由此以溶解形式的过饱和浓度得到包含游离罗哌尼罗的粘合剂层。

    ROPINIROLE-CONTAINING PATCH AND PACKAGE THEREOF
    86.
    发明申请
    ROPINIROLE-CONTAINING PATCH AND PACKAGE THEREOF 有权
    ROPINIROLE包含PATCH及其包装

    公开(公告)号：US20140170205A1

    公开(公告)日：2014-06-19

    申请号：US14123148

    申请日：2012-05-23

    Applicant: Hisamitsu Pharmaceutical Co., Inc.

    Inventor： Naoyuki Uchida ,  Yuka Takagi ,  Toshiro Yamaguchi

    IPC: A61K9/70 ,  A61K31/4045

    CPC classification number: A61K9/7053 ,  A61K31/4045

    Abstract: A ropinirole-containing patch comprises an adhesive agent layer and a support layer, the adhesive agent layer containing ropinirole and/or a pharmaceutically acceptable salt thereof, wherein a content of the ropinirole and/or the pharmaceutically acceptable salt thereof in terms of free ropinirole in the adhesive agent layer satisfies the following two conditions: 5 to 13.2% by mass relative to a total mass of the adhesive agent layer, and 0.12 to 2.7 mg/cm2 per unit area of the adhesive agent layer.

    Abstract translation: 含罗匹尼罗的贴剂包含粘合剂层和支持层，所述粘合剂层含有罗匹尼罗和/或其药学上可接受的盐，其中根据游离罗哌卡罗的罗匹尼罗和/或其药学上可接受的盐的含量 粘合剂层满足以下两个条件：相对于粘合剂层的总质量为5〜13.2质量％，粘合剂层的每单位面积为0.12〜2.7mg / cm 2。

    Functional chimeric molecules capable of sliding
    88.
    发明申请
    Functional chimeric molecules capable of sliding 审中-公开
    能够滑动的功能性嵌合分子

    公开(公告)号：US20030199471A1

    公开(公告)日：2003-10-23

    申请号：US10361028

    申请日：2003-02-10

    Applicant: Secretary of Agency of Industrial Science & Technology ,  Hisamitsu Pharmaceutical Co., Inc.

    Inventor： Kazunari Taira ,  Masaki Warashina ,  Tomoko Kuwabara ,  Hiroaki Kawasaki

    IPC: A61K048/00 ,  C07H021/02 ,  C12P019/34 ,  C12Q001/68

    CPC classification number: C12N15/113 ,  A61K38/00 ,  C07K2319/00 ,  C12N9/90 ,  C12N2310/121 ,  C12N2310/3513

    Abstract: This invention relates to a chimeric molecule comprising a region with binding affinity for a molecule capable of sliding and any functional region; a chimeric molecule comprising a molecule capable of sliding and any functional region; a chimeric molecule comprising a region with binding affinity for a molecule forming a complex with a molecule capable of sliding, and any functional region; a chimeric molecule comprising a protein capable of sliding and any functional nucleic acid; a chimeric molecule comprising a nucleic acid with binding affinity for a protein capable of sliding or a nucleic acid with binding affinity for a molecule forming a complex with said protein, and any functional nucleic acid; a vector comprising DNA encoding the chimeric molecule; and use thereof in medicaments, etc.

    Abstract translation: 本发明涉及包含对能够滑动的分子具有结合亲和力的区域和任何功能区域的嵌合分子; 包含能够滑动的分子和任何功能区的嵌合分子; 嵌合分子，其包含与能够滑动的分子形成复合物的分子具有结合亲和性的区域和任何功能区域; 包含能够滑动的蛋白质和任何功能性核酸的嵌合分子; 嵌合分子，其包含对能够滑动的蛋白质具有结合亲和性的核酸或对与所述蛋白质形成复合物的分子具有结合亲和力的核酸和任何功能性核酸; 包含编码嵌合分子的DNA的载体; 并在药物等中使用

    Transdermal or transmucosal drug delivery device
    89.
    发明申请
    Transdermal or transmucosal drug delivery device 有权

    公开(公告)号：US20030167073A1

    公开(公告)日：2003-09-04

    申请号：US10396428

    申请日：2003-03-26

    Applicant: Hisamitsu Pharmaceutical Co., Inc.

    Inventor： Katsuhiro Nakamura ,  Kazuya Katagai ,  Kazutaka Inoue ,  Naruhito Higo

    IPC: A61N001/30 ,  A61N001/00

    CPC classification number: A61N1/0432 ,  A61N1/0436 ,  A61N1/325

    Abstract: A transdermal or transmucosal drug delivery device excellent in terms of drug permeability and skin irritability and capable of reducing power consumption, is disclosed. An output control circuit (4) of an energization pattern controller (1) supplies a combined energization of pulse depolarized type energization and at least one of direct current type energization and pulse energization between an anode-side device (5) and a cathode-side device (6) of iontophoresis. The details of combination of energization in the output control circuit (4) is determined based on external setting of the energization pattern controller (1) or internal storage information.

    Nucleic acid carriers and pharmaceutical compositions for gene therapy
    90.
    发明申请
    Nucleic acid carriers and pharmaceutical compositions for gene therapy 审中-公开
    用于基因治疗的核酸载体和药物组合物

    公开(公告)号：US20030148929A1

    公开(公告)日：2003-08-07

    申请号：US10317060

    申请日：2002-12-12

    Applicant: Hisamitsu Pharmaceutical Co., Inc.

    Inventor： Takeshi Goto ,  Keishi Yonemura ,  Tetsuji Kuwahara ,  Masanao Oya ,  Katsuhiko Akiyama

    IPC: A61K048/00 ,  C07K014/00

    CPC classification number: A61K48/00 ,  C12N15/87

    Abstract: A novel nucleic acid carrier and a pharmaceutical composition for gene therapy are disclosed. The nucleic acid carrier of this invention is characterized by containing a polypeptide comprising diaminobutyric acid with a suitable number of residues and/or a pharmaceutically acceptable salt thereof. The nucleic acid carrier of this invention can form a complex with a variety of therapeutic genes that is safe and has extremely low immunogenicity (the pharmaceutical composition of this invention); and it can allow the therapeutic gene to be introduced into cells efficiently and safely whereby high expression of the gene in the cells can be realized.

    Abstract translation: 公开了一种新型的核酸载体和用于基因治疗的药物组合物。 本发明的核酸载体的特征在于含有含有适当数目残基的二氨基丁酸和/或其药学上可接受的盐的多肽。 本发明的核酸载体可以形成与各种安全且具有极低免疫原性的治疗基因的复合物（本发明的药物组合物）; 并且能够使治疗性基因高效安全地导入细胞，从而可以实现细胞中基因的高表达。

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