公开(公告)号：US20110312032A1

公开(公告)日：2011-12-22

申请号：US13207848

申请日：2011-08-11

Applicant: Byung-Kwon Choi ,  Piotr Bobrowicz ,  W. James Cook ,  Elena E. Brevnova

Inventor： Byung-Kwon Choi ,  Piotr Bobrowicz ,  W. James Cook ,  Elena E. Brevnova

IPC: C12P21/00 ,  C12N9/00 ,  C12N1/19

CPC classification number: C12N9/90 ,  C07K14/4725 ,  C12N9/1051 ,  C12N15/815 ,  C12N15/85 ,  C12N2800/102 ,  C12P21/005

Abstract: Lower eukaryote host cells in which the function of at least one endogenous gene encoding a chaperone protein, such as a Protein Disulphide Isomerase (PDI), has been reduced or eliminated and at least one mammalian homolog of the chaperone protein is expressed are described. In particular aspects, the host cells further include a deletion or disruption of one or more O-protein mannosyltransferase genes, and/or overexpression of an endogenous or exogenous Ca2+ATPase. These host cells are useful for producing recombinant glycoproteins in large amounts and for producing recombinant glycoproteins that have reduced O-glycosylation.

Abstract translation: 描述了其中至少一个编码分子伴侣蛋白（例如蛋白质二硫键异构酶（PDI））的内源基因的功能已经被还原或消除并且伴侣蛋白的至少一个哺乳动物同系物被表达的低等真核生物宿主细胞。 在特定方面，宿主细胞还包括一个或多个O-蛋白质甘露糖基转移酶基因的缺失或破坏，和/或内源或外源Ca2 + ATP酶的过度表达。 这些宿主细胞可用于大量生产重组糖蛋白和用于产生具有降低的O-糖基化的重组糖蛋白。

公开(公告)号：US20110117523A1

公开(公告)日：2011-05-19

申请号：US12991940

申请日：2009-05-21

Applicant: Richard James Cook ,  Timothy F. Watson ,  Ian D. Thompson

Inventor： Richard James Cook ,  Timothy F. Watson ,  Ian D. Thompson

IPC: A61K8/81 ,  A61Q11/00 ,  A61C17/00 ,  A61C19/04

CPC classification number: A61K6/0029 ,  C08L33/08

Abstract: The present invention relates to the use of a polyalkenoate acid, such as polyacrylic acid or polymaleic acid, in the manufacture of an air abrasive agent for use in conditioning dental tissue, methods of using such air abrasive agents, dental compositions comprising a polyalkenoate acid, air abrasive agents comprising a polyalkenoate acid and at least one of a bioactive glass, a glycine salt, baking soda and alumina, methods of treatment and/or prophylaxis using an air abrasive agent comprising a polyalkenoate acid.

Abstract translation: 本发明涉及聚烯酸酸如聚丙烯酸或聚马来酸在制备用于调节牙齿组织的空气研磨剂中的用途，使用这种空气磨料的方法，包含聚烯酸的酸， 包含聚烯丙酸和包含生物活性玻璃，甘氨酸盐，小苏打和氧化铝中的至少一种的空气研磨剂，使用包含聚烯丙酸的空气研磨剂进行处理和/或预防的方法。

公开(公告)号：US20090170159A1

公开(公告)日：2009-07-02

申请号：US12084591

申请日：2006-11-10

Applicant: Piotr Bobrowicz ,  W. James Cook ,  Warren Kett

Inventor： Piotr Bobrowicz ,  W. James Cook ,  Warren Kett

IPC: C12P21/00

CPC classification number: C07K16/32 ,  C07K2317/41 ,  C12P21/005

Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more α-1,2-mannosidases.

Abstract translation: 描述了一种用于生产具有减少量的O-连接糖基化的蛋白质组合物的方法。 该方法包括在存在Pmt介导的O-连接糖基化抑制剂和/或在一种或多种α-1,2-甘露糖苷酶存在下培养的细胞中产生蛋白质。

公开(公告)号：US20070292545A1

公开(公告)日：2007-12-20

申请号：US11697582

申请日：2007-04-06

Applicant: Aaron Monte ,  Mohd Kabir ,  James Cook ,  Marc Rott ,  William Schwan ,  Leah Defoe

Inventor： Aaron Monte ,  Mohd Kabir ,  James Cook ,  Marc Rott ,  William Schwan ,  Leah Defoe

IPC: A61K31/05 ,  A61K31/085 ,  A61K31/10 ,  A61K31/38 ,  A61K36/18 ,  A61P31/04

CPC classification number: A61K36/185 ,  C07D213/30 ,  C07D213/64 ,  C07D213/65 ,  C07D213/68 ,  C07D333/16

Abstract: The present invention provides compounds and methods of using of the compounds as anti-infective agents. In a preferred embodiment, the present invention provides wherein R1 is not H when R2 is H and R2 is not H when R1 is H, further wherein R1 is CH(2n+1)O, wherein n is 1-10; wherein R2 is OH or CH(2n+1)O, wherein n is 1-10; and wherein A, B and R1, R2, R5, R6, and R7 are independently selected from a group consisting of H, alkyl and aryl groups and R11 is an alkyl or an aryl group

Abstract translation: 本发明提供化合物和使用该化合物作为抗感染剂的方法。 在一个优选的实施方案中，本发明提供了当R 2为H且R 1不为H时R 1不为H，当R 1为H时，R 1为H， 其中R 1是CH（2n + 1）O，其中n是1-10; 其中R 2是OH或CH（2n + 1）O，其中n是1-10; 并且其中A，B和R 1，R 2，R 5，R 6和R SUB > 7 独立地选自H，烷基和芳基，R 11是烷基或芳基

公开(公告)号：US20070250808A1

公开(公告)日：2007-10-25

申请号：US11812945

申请日：2007-06-22

Applicant: James Zeanah ,  Charles Abbott ,  Nik Boyd ,  Albert Cohen ,  James Cook ,  Michael Grandcolas ,  Sikun Lan ,  Bonnie Lindsley ,  Grigor Markarian ,  Leslie Moss

Inventor： James Zeanah ,  Charles Abbott ,  Nik Boyd ,  Albert Cohen ,  James Cook ,  Michael Grandcolas ,  Sikun Lan ,  Bonnie Lindsley ,  Grigor Markarian ,  Leslie Moss

IPC: G06F9/44

CPC classification number: G06Q20/30 ,  G06Q20/32 ,  G06Q20/322 ,  G06Q20/3227 ,  G06Q20/3552 ,  G06Q40/00 ,  G07F19/206

Abstract: A financial institution can provide financial services to a plurality of remote devices, such as personal computers, personal data assistants, screen phones, automatic teller machines, external service providers, and internally to staff terminals and individual branches. By separating the components of the system into independent components, the system and method can be developed and tested on a component level rather than the entire system level, thereby reducing the development and maintenance cycle time. The system and method operate in sessions and can employ a dialog component for gathering information from a customer, a rule broker component for providing answers to the various legal and regulatory rules in a particular country, a language man component for selecting appropriate language, a transaction executor component for performing transactions, and a presentation manager component for formatting outputs to the customer.

Abstract translation: 金融机构可以向个人计算机，个人数据助理，屏幕电话，自动取款机，外部服务提供商等多个远程设备提供金融服务，并且向内部向员工终端和各个分支机构提供金融服务。 通过将系统的组件分离成独立的组件，可以在组件级别而不是整个系统级别上开发和测试系统和方法，从而减少开发和维护周期时间。 该系统和方法在会话中进行操作，并且可以使用用于从客户收集信息的对话组件，用于提供特定国家的各种法律和规则规则的答案的规则代理组件，用于选择适当语言的语言人组件，交易 执行交易的执行者组件，以及用于将输出格式化给客户的演示管理器组件。

公开(公告)号：US20070164859A1

公开(公告)日：2007-07-19

申请号：US11331722

申请日：2006-01-13

Applicant: Cornel Cobianu ,  Ion Georgescu ,  James Cook ,  Viorel Avramescu

Inventor： Cornel Cobianu ,  Ion Georgescu ,  James Cook ,  Viorel Avramescu

IPC: G08B1/08 ,  G08B13/14

CPC classification number: G06K19/0723 ,  G06K19/0716

Abstract: A multifunctional multichip system can operate in a passive mode by using at least one antenna to receive electromagnetic energy and using that energy to perform system functions. The system includes a sensor, an impedance matching circuit and an RFID module. The sensor produces a sensor signal containing a measurement. The RFID can produce an identification signal containing identification information. Alternatively, the RFID chip can be used in an addressing mode wherein the system only produces a signal in response to an addressing signal containing addressing information. The addressing signal is received from the electromagnetic field. In either mode, the sensor signal is coupled from the antenna into the electromagnetic field from which a receiver can obtain it. The signal can contain the identification information as well as the measurement. A matching network minimizes the effects of impedance mismatches between the system elements.

Abstract translation: 多功能多芯片系统可以通过使用至少一个天线来接收电磁能并使用该能量来执行系统功能，以无源模式操作。 该系统包括传感器，阻抗匹配电路和RFID模块。 传感器产生包含测量值的传感器信号。 RFID可以产生包含识别信息的识别信号。 或者，RFID芯片可以以寻址模式使用，其中系统仅响应于包含寻址信息的寻址信号产生信号。 从电磁场接收寻址信号。 在任一模式中，传感器信号从天线耦合到电磁场中，接收器可从该电磁场获得它。 该信号可以包含识别信息以及测量。 匹配网络可以最大限度地减少系统元件之间阻抗失配的影响。

公开(公告)号：US20070084737A1

公开(公告)日：2007-04-19

申请号：US11250967

申请日：2005-10-14

Applicant: James Cook ,  Richard Holschuh ,  Craig Kirouac ,  Benjamin Sarbo ,  Heather Sorebo

Inventor： James Cook ,  Richard Holschuh ,  Craig Kirouac ,  Benjamin Sarbo ,  Heather Sorebo

IPC: B65D71/00

CPC classification number: A47K10/3827 ,  A47K2010/3266

Abstract: A portable free-standing kit which can serve as a functional trial product, particularly for children, includes a combination of dry toilet paper and moist wipes. A roll of toilet paper is rotatably mounted on a functional spindle housed within the kit. The moist wipes are provided in a container which is supported by either a shelf or the bottom of the kit.

Abstract translation: 可以作为功能性试用产品，特别是儿童的便携式独立套件包括干厕纸和湿巾的组合。 一卷卫生纸可旋转地安装在容纳在套件内的功能主轴上。 湿纸巾设置在容器中，该容器由试剂盒的搁板或底部支撑。

公开(公告)号：US20060228232A1

公开(公告)日：2006-10-12

申请号：US10907430

申请日：2005-03-31

Applicant: James Cook

Inventor： James Cook

IPC: F04B17/00

CPC classification number: F04B9/04 ,  F04B17/03

Abstract: A fluid pumping system that includes a motor and a pump, wherein an output shaft of the motor is directly coupled to an input shaft of the pump. This coupling between the output shaft of the motor and the input shaft of the pump may be the primary mechanism for coupling the motor to the pump. Such a configuration may be called a “floating pump mount”, because the pump is primarily coupled to the motor via the shaft connection. As a result of this connection, the output shaft of the motor may be naturally “aligned” with the input shaft of the pump. To help prevent the pump from freely rotating with the output shaft of the motor during operation, a rotational stop mechanism may be provided. The rotational stop mechanism may include at least one resilient member for absorbing or substantially absorbing at least some of any relative movement between the pump and the motor.

Abstract translation: 一种包括马达和泵的流体泵送系统，其中马达的输出轴直接联接到泵的输入轴。 马达的输出轴与泵的输入轴之间的这种耦合可以是用于将马达耦合到泵的主要机构。 这种配置可以被称为“浮动泵安装座”，因为泵通过轴连接主要耦合到电动机。 作为这种连接的结果，马达的输出轴可以与泵的输入轴自然地“对准”。 为了在操作期间防止泵与电动机的输出轴自由旋转，可以设置旋转停止机构。 旋转停止机构可以包括至少一个弹性构件，用于吸收或基本上吸收泵和马达之间的任何相对运动中的至少一些。

公开(公告)号：US07098015B2

公开(公告)日：2006-08-29

申请号：US10386414

申请日：2003-03-11

Applicant: Kyle J. MacBeth ,  Joseph M. Carroll ,  William James Cook ,  Rachel E. Meyers ,  Miyoung Chun ,  Mark J. Williamson

Inventor： Kyle J. MacBeth ,  Joseph M. Carroll ,  William James Cook ,  Rachel E. Meyers ,  Miyoung Chun ,  Mark J. Williamson

IPC: C12N9/16 ,  C12N15/54 ,  C12N15/62 ,  C12N15/79

CPC classification number: G01N33/5008 ,  A61K38/00 ,  C12N9/1007 ,  C12N9/16 ,  C12N9/6489 ,  C12Q1/37 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/56983 ,  G01N33/56994 ,  G01N33/57426 ,  G01N33/5761 ,  G01N33/5767 ,  G01N33/68 ,  G01N2333/916 ,  G01N2333/96486 ,  G01N2500/04

Abstract: The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.

Abstract translation: 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。

公开(公告)号：US20060130585A1

公开(公告)日：2006-06-22

申请号：US11017171

申请日：2004-12-18

Applicant: Steven Magee ,  James Cook ,  James Liu

Inventor： Steven Magee ,  James Cook ,  James Liu

IPC: G01N9/24

CPC classification number: G01L1/165 ,  G01L3/10 ,  G01L9/0025

Abstract: Sensor systems and methods are disclosed herein, including a sensor chip, upon which at least two surface acoustic wave (SAW) sensing elements are centrally located on a first side (e.g., front side) of the sensor chip. The SAW sensing elements occupy a common area on the first side of the sensor chip. An etched diaphragm is located centrally on the second side (i.e., back side) of the sensor chip opposite the first side in association with the two SAW sensing elements in order to concentrate the mechanical strain of the sensor system or sensor device in the etched diagram, thereby providing high strength, high sensitivity and ease of manufacturing thereof.

Abstract translation: 传感器系统和方法在本文中公开，包括传感器芯片，至少两个表面声波（SAW）感测元件位于传感器芯片的第一侧（例如，前侧）的中心。 SAW感测元件占据传感器芯片第一侧上的公共区域。 与两个SAW传感元件相关联，蚀刻的隔膜位于与第一侧相对的传感器芯片的第二侧（即后侧）的中央，以将传感器系统或传感器设备的机械应变集中在蚀刻图中 从而提供高强度，高灵敏度和易于制造。