公开(公告)号：US20210271062A1

公开(公告)日：2021-09-02

申请号：US17256362

申请日：2019-07-04

Applicant: NIPRO CORPORATION ,  SAPPORO MEDICAL UNIVERSITY

Inventor： Osamu HONMOU ,  Daiki TATEYAMA ,  Kosuke TAKAHASHI ,  Kosei TATEYAMA ,  Yoshihiro YOSHIKAWA

IPC: G02B21/08 ,  G02B21/14 ,  G02B21/36 ,  G02B21/26 ,  C12M1/34 ,  C12M1/00 ,  G06K9/00 ,  G06K9/20

Abstract: An observation device includes a microscope. The microscope includes an illumination light beam source, an illumination optical system, and an observation optical system forming an optical image of an observation target from reflected light beams obtained by reflection of illumination light beams by the observation target. The observation optical system includes a phase plate changing the phase of directly reflected light beams reflected on a reflection surface among the reflected light beams. Both the illumination optical system and the observation optical system are arranged under the observation target. The observation device includes an image pickup device photoelectrically converting the optical image obtained by the observation optical system to create image data of the observation target and a display device displaying the image data. The illumination light beam emitted from the illumination optical system is a collimated light beam.

公开(公告)号：US20210196906A1

公开(公告)日：2021-07-01

申请号：US17057329

申请日：2019-04-16

Applicant: NIPRO CORPORATION

Inventor： Yukihiro YABE ,  Kazuto ADACHI

IPC: A61M11/00

Abstract: A syringe-shaped spraying device includes: a barrel; a nozzle; a packing disposed therebetween; and a core disposed inside the nozzle. The nozzle is connected to a connecting portion provided at a front end of the barrel. The nozzle has a first facing surface facing a front end surface of the connecting portion and a second facing surface facing an outer circumferential surface of the connecting portion. The outer circumferential surface is provided with an annular recess portion, and the second facing surface is provided with a first annular protrusion portion and a second annular protrusion portion. By engaging the first annular protrusion portion with the annular recess portion, the packing is compressed in an axial direction by the front end surface and the first facing surface. The second annular protrusion portion is in pressure contact with the outer circumferential surface of the connecting portion entirely in a circumferential direction.

公开(公告)号：US11045611B2

公开(公告)日：2021-06-29

申请号：US15573695

申请日：2016-04-26

Applicant: NIPRO CORPORATION

Inventor： Teruhisa Hirobe

IPC: A61M5/34 ,  A61M5/28 ,  A61J1/20 ,  A61M5/32 ,  A61M5/20

Abstract: A drug delivering apparatus includes a drug container, a pre-filled syringe including a cylindrical container having a nozzle portion and an injection needle attachment portion, and a connecting tool configured to allow communication between the inside of the cylindrical container and the inside of the drug container. The connecting tool further includes a nozzle insertion portion. The pre-filled syringe further includes a cap member configured to be detachably fitted on the injection needle attachment portion, the cap member having an opening into which the nozzle insertion portion can be inserted. The injection needle attachment portion has a guiding groove in the inner periphery thereof. In the state where the cap member is fitted on the injection attachment portion, at least a part of the edge of the opening is located on the inner side relative to the bottom portion of the guiding groove.

公开(公告)号：USD919803S1

公开(公告)日：2021-05-18

申请号：US29768090

申请日：2021-01-27

Applicant: NIPRO CORPORATION

Designer： Yukihiro Yabe ,  Minoru Honda ,  Masanobu Iwasa

公开(公告)号：US20210138162A1

公开(公告)日：2021-05-13

申请号：US16611744

申请日：2018-05-08

Applicant: NIPRO CORPORATION

Inventor： Hiroyuki NAKAGAMI ,  Shingo SAKAMOTO

IPC: A61M5/32 ,  A61M5/34

Abstract: A valved needle assembly including a needle hub provided to a proximal end side of a hollow needle, and a valve member incorporated therein for blocking communication with the hollow needle. A protrusion protrudes from a distal end side toward a proximal end side inside the needle hub and the valve member blocks the proximal end side of the protrusion inside the needle hub. A central valve part of the valve member having a slit moves toward the protrusion such that the slit is opened and placed in communication by the protrusion. The central valve part includes a distal end tubular part and a proximal end tubular part extending from its outer circumferential portion toward the distal end side and the proximal end side respectively.

公开(公告)号：US10980582B2

公开(公告)日：2021-04-20

申请号：US15324331

申请日：2015-07-09

Applicant: National University Corporation Nagoya University ,  Nipro Corporation

Inventor： Hitoshi Hirata ,  Tatsuya Hara ,  Hidemasa Yoneda ,  Shunichi Bandoh

IPC: A61B17/80 ,  A61B17/68 ,  A61B17/86 ,  A61B17/00

Abstract: Provided is a locking plate system for treatment of a distal radius fracture including a locking plate (4) that is a flat laminate of intermediate molding materials that includes carbon fibers as a reinforcing material and thermoplastic resin as a matrix; a screw anchor (5) having a shaft portion (10) which has a principal thread (13) achieving a self-tapping action formed thereon and an outer circumference of a head portion of the screw anchor (5) which has an auxiliary thread (13) achieving a self-tapping action tapped thereon; and a through-hole (6) in the radius locking plate (4), which allows the radius main body (3) and the fractured bone piece (2) to be threadably fixed to the radius locking plate (4) and having a diameter that is oversized relative to the principal thread (11), and that is undersized relative to the auxiliary thread (13).

公开(公告)号：US10975345B2

公开(公告)日：2021-04-13

申请号：US15574516

申请日：2016-05-24

Applicant: Nipro Corporation

Inventor： Masakatsu Takeuchi ,  Atsushi Taguchi

IPC: C12M3/04 ,  C12M1/36 ,  C12M1/00 ,  C12M1/10 ,  B01L3/00 ,  C12M1/06 ,  C12M1/38 ,  C12M3/02 ,  C12M3/00

Abstract: A compact culture device capable of performing large-scale culture in an aseptic state. A culture device has a culture bag which has ports through which a liquid flows and enables cell culture, a bag holding portion having holding plates holding the culture bag and rotating shafts, a rotation mechanism supporting and rotating the rotating shaft, a liquid supply/discharge mechanism supplying and discharging a liquid to/from the culture bag, and a rotation control portion controlling the rotation of the rotation mechanism. The rotation control portion brings the bag holding portion into a first position in parallel with the approximately horizontal direction according to a first information, brings the bag holding portion into a second position when a culture medium in the culture bag is caused to flow out of the port according to a second information, and brings the bag holding portion into a third position in parallel with the approximately vertical direction at least when a cell suspension in the culture bag is caused to flow out of the port according to a third information.

公开(公告)号：USD914876S1

公开(公告)日：2021-03-30

申请号：US35507196

申请日：2019-01-28

Applicant: NIPRO CORPORATION

Designer： Yukihiro Yabe ,  Minoru Honda ,  Masanobu Iwasa

公开(公告)号：US10883078B2

公开(公告)日：2021-01-05

申请号：US15574546

申请日：2016-05-24

Applicant: Nipro Corporation

Inventor： Norihisa Sasayama ,  Masakatsu Takeuchi ,  Atsushi Taguchi

IPC: C12M1/34 ,  C12M3/04 ,  C12M1/00

Abstract: A culture device supplying an accurate amount of liquid into a culture bag has a culture bag having ports, a first bag holding portion having supporting surfaces supporting the culture bag, a rotation mechanism rotating the first bag holding portion, a liquid supplying mechanism supplying a liquid through a tube communicating with the ports a weight detector detecting the weight of the culture bag and the first bag holding portion, and a control portion, in which the control portion sets a first reference value according to a first detection information output from the weight detector in a first state and carries out a liquid supplying step of stopping the liquid supplying mechanism under the condition where a second detection information output from the weight detector when a liquid is supplied to the culturing bag reaches a first target value obtained by adding the weight of the liquid to be supplied to the first reference value.

公开(公告)号：US20200345781A1

公开(公告)日：2020-11-05

申请号：US16760630

申请日：2018-11-09

Applicant: Sapporo Medical University ,  Nipro Corporation

Inventor： Osamu HONMOU ,  Yoshihiro YOSHIKAWA ,  Ryo TOMII ,  Masafumi YAO ,  Yukari NISHII ,  Yusuke WAGATSUMA

IPC: A61K35/28 ,  C12N5/0775 ,  C12Q1/686 ,  G01N33/68 ,  A61P25/00 ,  A61P37/02

Abstract: The present invention relates to a cell-based medicine comprising mesenchymal stem cells, and a method for producing the same. More specifically, the present invention relates to: a cell-based medicine containing mesenchymal stem cells, wherein a) the mesenchymal stem cells express CX3CL1 under stimulation with an inflammatory cytokine, and/or b) 90% or more of the mesenchymal stem cells express EGFR and/or ITGA4; and a method for producing a cell-based medicine containing mesenchymal stem cells, the method comprising the steps of: a) adding an inflammatory cytokine to a culture containing mesenchymal stem cells, and confirming that the mesenchymal stem cells express CX3CL1; and/or b) confirming that 90% or more of the mesenchymal stem cells express EGFR and/or ITGA4.