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公开(公告)号：US10689631B2
公开(公告)日：2020-06-23
申请号：US16535305
申请日：2019-08-08
IPC分类号： C12N9/16
摘要： Unnatural, mutated thioesterases having an amino acid sequence that is at least 80% identical to SEQ ID NO:1 and having substitutions at one or more of amino acid positions I107, R108, L109, S122, M141, E142, Y145, and L146, gene constructs encoding and configured to express the mutated thioesterases in a transformed host cell, and host cells transformed to contain the gene constructs.
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82.发明授权公开(公告)号：US10657651B2
公开(公告)日：2020-05-19
申请号：US16212942
申请日：2018-12-07
发明人： Jia Li , James Z. Wang
摘要： Systems, methods, and computer-readable media for electronically assessing a visual significance of pixels or regions in an electronic image are disclosed. A method includes receiving the electronic image, performing a composition analysis on the electronic image, the composition analysis includes partitioning the electronic image into a plurality of segments or a plurality of parts, constructing an attributed composition graph having a plurality of nodes, where each node corresponds to a segment or a part and where each node includes one or more attributes, modeling the visual significance of the electronic image based on the attributed composition graph using a statistical modeling process or a computational modeling process to obtain a plurality of values, and constructing a composition significance map having a significance score for each segment or each part according to the values obtained from the statistical modeling process or the computational modeling process.
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公开(公告)号：US10653405B2
公开(公告)日：2020-05-19
申请号：US15749981
申请日：2016-08-03
发明人： Rena Kass , Kristine Widders , Barry M. Fell , Randy Haluck , Peter Dillon
摘要： The device can include a first member connected to a second member via junctions. The members can be statically or pivotally connected at the junctions via arms extending from cross-beams of the members. The junctions can be configured to provide a biasing force. Methods of using the device may include collapsing the device and inserting it through an incision, allowing the biasing force to cause continuous traction and counter-traction adjacent to a leading dissection edge so that retraction of the skin from the tissue can be facilitated during a surgical procedure.
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公开(公告)号：US10597735B2
公开(公告)日：2020-03-24
申请号：US15384507
申请日：2016-12-20
摘要： Inhibitors of the tmRNA pathway have antibacterial activity with broad species specificity, including B. anthracis and other pathogens of military and civilian interest. Identified cyclic or linear peptides are further selected by in vivo selection methods, kill bacterial pathogens when added exogenously, and/or eliminate plasmids carrying antibiotic resistance or virulence genes. The molecular target of each cyclic peptide is in the tmRNA pathway and the tmRNA pathway is inhibited in vitro and in vive by the addition of the peptides.
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85.发明授权公开(公告)号：US10588941B2
公开(公告)日：2020-03-17
申请号：US16040592
申请日：2018-07-20
发明人： Na Xiong , Mingcan Xia
IPC分类号： A61K38/19 , C07K14/52 , C07K14/715 , C12N15/113 , A61K45/06
摘要： The invention provides compositions and methods for targeting CCR10 and/or the CCR10/ligand axis to modulate the immune response in a subject.
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公开(公告)号：US10586628B2
公开(公告)日：2020-03-10
申请号：US14853825
申请日：2015-09-14
发明人： Tobin J. Marks , Michael T. Lanagan , Mark A. Ratner , Massimiliano Delferro , Lisa A. Fredin , Zhong Li
IPC分类号： H01B3/30 , H01B3/10 , C08K9/02 , C08F110/06 , C08F10/00 , B82Y30/00 , C09C1/64 , H01G4/18 , H01G4/20 , C08F4/6592 , C08F4/659 , C08K3/22 , C08K3/08 , H01G4/10
摘要： A nanoparticle composition comprising a substrate comprising a metal oxide component and an aluminum oxide component; and a metallocene olefin polymerization catalyst component coupled to the substrate is disclosed. The metal oxide component is homogenously dispersed throughout the nanocomposite composition.
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87.发明申请公开(公告)号：US20200061710A1
公开(公告)日：2020-02-27
申请号：US16540243
申请日：2019-08-14
摘要： Embodiments of the systems can be configured to receive electromagnetic emissions of a substrate (e.g., a build material of a part being made via additive manufacturing) by a detector (e.g., a multi-spectral sensor) and generate a ratio of the electromagnetic emissions to perform spectral analysis with a reduced dependence on location and orientation of a surface of the substrate relative to the multi-spectral sensor. The additive manufacturing process can involve use of a laser to generate a laser beam for fusion of the build material into the part. The system can be configured to set the multi-spectral sensor off-axis with respect to the laser (e.g., an optical path of the multi-spectral sensor is at an angle that is different than the angle of incidence of the laser beam). This can allow the multi-spectral sensor to collect spectral data simultaneously as the laser is used to build the part.
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公开(公告)号：US20200056996A1
公开(公告)日：2020-02-20
申请号：US16543254
申请日：2019-08-16
摘要： The present invention generally relates to the generation of tunable coloration and/or interference from, for example, surfaces, emulsion droplets and particles. Embodiments described herein may be useful for generation of tunable electromagnetic radiation such as coloration (e.g., iridescence, structural color) and/or interference patterns from, for example, surfaces (e.g., comprising a plurality of microdomes and/or microwells), emulsion droplets and/or particles. In some embodiments, the surfaces, interfaces, droplets, and/or particles produce visible color (e.g., structural color) without the need for dyes.
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公开(公告)号：US20200056043A1
公开(公告)日：2020-02-20
申请号：US16610249
申请日：2018-05-04
IPC分类号： C08L83/04 , B33Y10/00 , B33Y70/00 , B29C64/124
摘要： Thermosetting formulations useful for forming bulk structures such as in additive manufacturing can include (a) a compound including reactive functional groups, (b) a curing agent having functional groups reactive with the reactive functional groups of the compound, and (c) a photothermally active material. Such formulations can be cured by applying actinic radiation to the formulation.
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90.发明申请公开(公告)号：US20200054711A1
公开(公告)日：2020-02-20
申请号：US16487345
申请日：2018-02-28
发明人： Gong Chen
摘要： Methods of treating the effects of disruption of normal blood flow in the CNS in an individual subject in need thereof are provided according to aspects of the present invention which include administering a therapeutically effective dose of exogenous NeuroD1 to an area where normal blood flow has been disrupted. Compositions are provided including 1) a recombinant adeno-associated adenovirus expression vector comprising a glial cell specific promoter operably linked to a nucleic acid encoding a site-specific recombinase and 2) a recombinant adeno-associated adenovirus expression vector comprising a ubiquitous promoter operably linked to a nucleic acid encoding NeuroD1, wherein the nucleic acid encoding NeuroD1 is inverted and flanked by two sets of site-specific recombinase recognition sites such that action of the recombinase irreversibly inverts the nucleic acid encoding NeuroD1 such that NeuroD1 is expressed in a mammalian cell.
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