公开(公告)号：US20190247286A1

公开(公告)日：2019-08-15

申请号：US16342872

申请日：2017-09-25

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Kei WATANABE ,  Takashi MENO

IPC: A61K8/04 ,  A61Q19/10 ,  A61Q1/14 ,  A61K8/46 ,  A61K8/44 ,  A61K8/49 ,  A61K8/86 ,  A61K8/37 ,  A61K8/31 ,  A61K8/58 ,  A61K8/34 ,  A61K8/39 ,  A61K8/06

CPC classification number: A61K8/046 ,  A61K8/062 ,  A61K8/31 ,  A61K8/345 ,  A61K8/37 ,  A61K8/375 ,  A61K8/39 ,  A61K8/44 ,  A61K8/442 ,  A61K8/46 ,  A61K8/463 ,  A61K8/466 ,  A61K8/4946 ,  A61K8/585 ,  A61K8/86 ,  A61K8/89 ,  A61K2800/596 ,  A61Q1/14 ,  A61Q19/10 ,  C11D1/18 ,  C11D1/29 ,  C11D1/72 ,  C11D1/94

Abstract: Provided is a detergent composition that contains (A) 2-17.5 mass % of an anionic surfactant, (B) 1-17.5 mass % of an amphoteric surfactant, (C) 2.5-17 mass % of a hydrophilic non-ionic surfactant and (D) 0.2-5 mass % of an oily component. However, the detergent composition does not contain substantial amounts of fatty acid monoglycerol esters and fatty acid monoalkyl monoglyceryl ethers having alkyl groups or acyl groups having 9 or more carbon atoms. The detergent composition does not contain substantial amounts of fatty acid diglycerol esters or fatty acid monoalkyl diglyceryl ethers which have alkyl groups or acyl groups having 8 or more carbon atoms.

公开(公告)号：US20190218481A1

公开(公告)日：2019-07-18

申请号：US16319440

申请日：2017-08-03

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Ayano TOSHIDA ,  Akira MATSUO

IPC: C11D7/26 ,  C11D7/24

CPC classification number: C11D7/261 ,  C11D7/24 ,  C11D7/242 ,  C11D7/26 ,  C11D11/0017 ,  C11D17/04 ,  C11D17/041

Abstract: [Problem] To provide a cosmetic brush cleaner excellent in quick dryability and capable of removing stains such as deposited cosmetics with ease in the following manner: impregnating tissue paper, towel, or the like with the cleaner to wipe off the cosmetics, sebum, and the like deposited on a cosmetic brush; or directly spraying the cleaner on a cosmetic brush, and wiping the brush with dry tissue paper or the like.[Solution] A cosmetic brush cleaner including: (A) a lower alcohol in an amount of 30 to 99 mass %; (B) a volatile oil in an amount of 1 to 70 mass %; and (C) water in an amount of 7 mass % or less (including 0 mass %).

公开(公告)号：US10344266B2

公开(公告)日：2019-07-09

申请号：US14788925

申请日：2015-07-01

Applicant: Shiseido Company, Ltd.

Inventor： Shigeyoshi Fujiwara ,  Jiro Kishimoto ,  Tsutomu Soma

IPC: C12N5/00 ,  C12N5/071 ,  C12N5/0775

Abstract: The present invention provides a method of producing a cell mass capable of serving as a primitive organ-like structure comprised of a plurality of somatic cell types of somatic origin, comprising: preparing cultures containing the plurality of types of somatic cells; mixing the plurality of types of somatic cell cultures followed by adding a Wnt signal activator to the mixed cell culture; subjecting the culture containing the Wnt signal activator to non-plate contact culturing over a predetermined time period; and replacing the medium of the culture cultured by the non-plate contact culturing with medium not containing Wnt signal activator and further culturing for a predetermined time period; wherein, at least one type of the plurality of somatic cells is maintained in an undifferentiated state.

公开(公告)号：US20190145967A1

公开(公告)日：2019-05-16

申请号：US16096861

申请日：2017-04-19

Applicant: Shiseido Company. Ltd.

Inventor： Chika TANAKA ,  Chieko MIZUMOTO ,  Tomoko ONODERA ,  Setsuya AIBA ,  Katsuko KIKUCHI ,  Kenshi YAMASAKI ,  Maki OZAWA

IPC: G01N33/543 ,  G06F17/18 ,  G16H50/30

Abstract: Provided is an objective and convenient index for judging full recovery from atopic dermatitis and severity thereof. The present invention provides a diagnosis assisting method for determining a treatment policy for an atopic dermatitis subject under the treatment, said method comprising: measuring the expression value of SCCA-1 in skin horny cells of the subject; i) when the SCCA-1 expression value is not statistically significantly higher than the level of those who do not suffer from atopic dermatitis, then determining that the continuation of the treatment for the disease becomes unnecessary thanks to the treatment; and, in the case where the continuation of the treatment is determined as still necessary, ii) ranking the severity of atopic dermatitis of the subject using the SCCA-1 expression value as an index and determining an adequate treatment method for atopic dermatitis to be given to the subject depending on the rank.

公开(公告)号：US20190046421A1

公开(公告)日：2019-02-14

申请号：US15765012

申请日：2016-10-07

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Satoshi YAMAKI ,  Taichi HARADA ,  Takashi MATSUDA

IPC: A61K8/06 ,  A61K8/26 ,  A61K8/86 ,  A61K8/894 ,  A61K8/04 ,  A61K8/49 ,  A61K8/37 ,  A61Q17/04

CPC classification number: A61K8/064 ,  A61K8/025 ,  A61K8/0254 ,  A61K8/046 ,  A61K8/26 ,  A61K8/37 ,  A61K8/4966 ,  A61K8/585 ,  A61K8/60 ,  A61K8/86 ,  A61K8/891 ,  A61K8/894 ,  A61K2800/48 ,  A61K2800/592 ,  A61K2800/612 ,  A61Q17/04

Abstract: A sprayable sunscreen cosmetic contains substantially no ultraviolet ray scattering agents which cause whiteness, and which is transparent immediately after being applied/sprayed, and that has excellent ultraviolet ray protection effect and a good sensation in use. The ultraviolet ray protection effect is not reduced, and the effects improve when in contact with water. A water-in-oil emulsified sunscreen cosmetic comprises: (A) 6 to 40 mass % of an ultraviolet ray absorbing agent; (B) an organically modified clay mineral; (C) an oil phase thickener other than the aforementioned (B); (D) a silicone-based surfactant having an HLB of less than 8; (E) a spherical resin powder; and (F) a volatile silicone oil; wherein a ratio defined as [total amount of ingredient (B) and ingredient (C)]/[total amount of (G) non-volatile liquid oils other than silicone oils] is at least 0.04 and less than 0.68.

公开(公告)号：US10172332B2

公开(公告)日：2019-01-08

申请号：US15076836

申请日：2016-03-22

Applicant: Shiseido Company, Ltd.

Inventor： Yuzo Yoshida ,  Tsutomu Soma ,  Shigeyoshi Fujiwara

IPC: A01N63/00 ,  A01N65/00 ,  C12N5/071 ,  A01K67/027 ,  A61K35/36 ,  A61L27/38 ,  A61K8/98 ,  A61Q7/00 ,  C12N5/0775

Abstract: Provided is a method for regenerating hair follicles by transplanting a composition containing CD36-expressing dermal sheath cells (DSc) to a human. The composition may be prepared by sorting CD36-expressing dermal sheath cells from a hair follicle tissue by use of a cell-sorting technique along with an antibody to CD36. The composition may also contain dermal papilla cells (DPc).

公开(公告)号：US20180352934A1

公开(公告)日：2018-12-13

申请号：US15771597

申请日：2016-11-02

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Mieko NASU ,  Akiko TAKAHASHI ,  Masahiko NAGOSHI ,  Motoki TAKATA

IPC: A45D34/04 ,  A61M35/00

CPC classification number: A45D34/04 ,  A45D2034/005 ,  A45D2200/155 ,  A61M35/00 ,  A61M35/003

Abstract: A health and beauty device includes: a cartridge that stores a fluid content which is applied to a body surface of a human body to impart at least one of a cosmetic effect and a health effect, equipped with an outlet from which the content flows out, and a feeding portion that causes the content to flow out from the outlet by an externally applied force; and a housing that removably accommodates the cartridge. A coating portion having a discharge outlet aligned with the outlet of the cartridge and a coating surface for applying the content that flows out of the outlet and the discharge outlet to the body surface of the human body; a temperature operation portion incorporated in the coating portion that heats or cools the coating surface by receiving electric power; and a battery housing portion that houses a battery are provided in the housing.

公开(公告)号：US20180340866A1

公开(公告)日：2018-11-29

申请号：US15771505

申请日：2015-11-05

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Motoki TAKATA ,  Mieko NASU ,  Akihito TORII ,  Masahiko NAGOSHI

IPC: G01N1/04

Abstract: A kit is constituted by: a stratum corneum collecting device formed by a rod shaped portion having a grip portion to be gripped by a user at one end, a columnar portion which is continuous with the other end of the rod shaped portion, and an adhesive layer formed on a circumferential surface of the columnar portion; and a solvent container, a solvent container, which is a bottomed cylindrical container having an opening in an upper portion thereof, containing a solvent for extracting a component from stratum corneum collected by the adhesive layer, the solvent container receiving the columnar portion of the stratum corneum device through the opening so as to enable the adhesive layer to be immersed in the solvent. A lid and a solvent outlet, which is opened to take the solvent out from the interior of the solvent container, are provided.

公开(公告)号：US20180289610A1

公开(公告)日：2018-10-11

申请号：US15764738

申请日：2016-09-30

Applicant: SHISEIDO COMPANY, LTD.

Inventor： SATOSHI YAMAKI ,  Kouichi NAGAI ,  Yuki SUGIYAMA

IPC: A61K8/86 ,  A61Q17/04 ,  A61K8/37 ,  A61K8/35 ,  A61K8/894 ,  A61K8/41 ,  A61K8/92

Abstract: A sunscreen cosmetic exerts stably an excellent ultraviolet shielding effect without undergoing photodegradation even in a system where 4-tert-butyl-4′-methoxydibenzoylmethane and ethylhexyl methoxycinnamate coexist. The sunscreen cosmetic comprises (a) 0.5-5.0 mass % of 4-tert-butyl-4′-methoxydibenzoylmethane, (b) 3.0-10 mass % of ethylhexyl methoxycinnamate, (c) 5.0 mass % or more of an amphipathic substance, and (d) a liquid oil component containing an ester oil having an IOB of 0.05-0.60, characterized in that the contents of components (a), (b) and (c) satisfy the requirement 0.5≤[(a)+(b)]/(c)≤3.5.

公开(公告)号：US20180252730A1

公开(公告)日：2018-09-06

申请号：US15580855

申请日：2016-06-10

Applicant: Kanazawa University ,  Shiseido Company. Ltd

Inventor： Takashi Wada ,  Kengo FURUICHI ,  Norihiro SAKAI ,  Yasunori IWATA ,  Akinori HARA ,  Yusuke NAKADE ,  Kenji HAMASE ,  Yurika MIYOSHI ,  Maiko NAKANE ,  Masashi MITA

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/6806 ,  G01N2800/347

Abstract: The present invention addresses the problem of developing an analytical method which makes it possible to diagnose early or mild renal disorders. The method is based on calculating a disease-state index value for renal disorders on the basis of the quantities of D-form and/or L-form amino acids, from feces or intestinal content. By comparing the disease-state index value with a threshold value determined from the disease-state index values of a renal failure patient group and a healthy subject group, it is possible to diagnose a mild renal disorder patient group.