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公开(公告)号：US20150173897A1
公开(公告)日：2015-06-25
申请号：US14402387
申请日：2013-05-20
Inventor： Ehud Raanani , Boris Orlov , Boaz Harari , Oded Meiri , Lichen Rozitsky
IPC: A61F2/24
CPC classification number: A61F2/2418 , A61F2/243 , A61F2/2436 , A61F2/2457 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2230/0013 , A61F2230/005 , A61F2230/0078 , A61F2250/006
Abstract: A prosthetic mitral valve with a frame comprises at least one arm shaped to deploy among a region of chordae tendineae of the native mitral valve to deflect these chords in order to pull the native valve leaflets around the frame to avoid paravalvular leaks. The frame may be made from two parts that are connected by sutures. The prosthetic valve may be deployed by a catherer comprising a deployment clamp attached to the valve frame where the deployment clamp is actuable to induce rotation of the frame.
Abstract translation: 具有框架的假体二尖瓣包括至少一个臂，其形状以在天然二尖瓣的腱索腱索区域之间展开，以偏转这些弦杆，以便将天然瓣膜瓣周围牵引到框架上，以避免瓣膜内泄漏。 框架可以由通过缝合线连接的两个部分制成。 人造瓣膜可以由包括附接到瓣膜框架的展开夹具的收集器展开，其中展开夹具可致动以引起框架的旋转。
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82.发明授权Peptides and compositions for prevention of cell adhesion and methods of using same 有权用于预防细胞粘附的肽和组合物及其使用方法公开(公告)号：US09045550B2
公开(公告)日：2015-06-02
申请号：US14016480
申请日：2013-09-03
Inventor： Amir Zlotkin
CPC classification number: C07K14/435 , C02F1/441 , C02F1/50 , C02F2303/04 , C02F2303/20 , C07K7/06 , C07K7/08 , C07K14/43595
Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence comprising FNFDWY (SEQ ID NO: 5), or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.
Abstract translation: 包含分离的肽的组合物，其可以例如任选地包含包含FNFDWY（SEQ ID NO：5）的序列或其任何环化形式，以及使用它们的方法，包括用于治疗或预防微生物生物膜的形成和抗粘附 的细胞到表面。
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公开(公告)号：US20150079065A1
公开(公告)日：2015-03-19
申请号：US14394465
申请日：2013-04-16
Inventor： Ido Wolf , Tamar Rubinek
IPC: C12N9/42
CPC classification number: C12N9/2434 , A61K38/00 , A61K48/005 , C07K14/71 , C12N9/24 , C12Y302/01031
Abstract: Disclosed are Klotho variant proteins in which residue Glu414 and/or residue Asp238 is substituted with an amino acid different than L-Glu or L-Asp, respectively, as well as polynucleotides encoding the variant proteins, and the use thereof in therapy, especially for the treatment of cancers, especially breast cancer and pancreatic cancer.
Abstract translation: 公开了其中残基Glu414和/或残基Asp238分别被不同于L-Glu或L-Asp的氨基酸取代的Klotho变体蛋白，以及编码变体蛋白的多核苷酸及其在治疗中的用途，特别是 治疗癌症，特别是乳腺癌和胰腺癌。
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公开(公告)号：US20140342939A1
公开(公告)日：2014-11-20
申请号：US14449124
申请日：2014-07-31
Applicant: YEDA RESEARCH & DEVELOPMENT CO. LTD. , TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
Inventor： Irun R. Cohen , Eytan Domany , Noam Shental , Ittai Fattal
IPC: G01N33/564
CPC classification number: G01N33/564 , G01N2800/104
Abstract: The present invention relates to methods and kits for diagnosing systemic lupus erythematosus (SLE) in a subject. Particularly, the present invention relates to a specific antibody profile useful in diagnosing SLE in a subject.
Abstract translation: 本发明涉及用于诊断受试者的系统性红斑狼疮（SLE）的方法和试剂盒。 特别地，本发明涉及可用于诊断受试者中的SLE的特异性抗体谱。
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公开(公告)号：US20130150261A1
公开(公告)日：2013-06-13
申请号：US13678126
申请日：2012-11-15
Applicant: Technion Research and Development Foundation Ltd. , Tel Hashomer Medical Research, Infrastructure and Services Ltd.
Inventor： Hossam Haick , Nir Peled
IPC: G01N33/497
CPC classification number: G01N33/497 , G01N33/0034 , G01N2800/7028
Abstract: The present invention provides a unique profile of volatile organic compounds as breath biomarkers for lung cancer. The present invention further provides the diagnosis, prognosis and monitoring of lung cancer or predicting the response to an anti-cancer treatment through the detection of the unique profile of volatile organic compounds indicative of lung cancer at its various stages.
Abstract translation: 本发明提供挥发性有机化合物作为肺癌呼吸生物标志物的独特特征。 本发明还通过检测其各种阶段的指示肺癌的挥发性有机化合物的独特特征，进一步提供对肺癌的诊断，预后和监测或预测对抗癌治疗的反应。
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Patent Agency Ranking
公开(公告)号：US12251417B2
公开(公告)日：2025-03-18
申请号：US17548662
申请日：2021-12-13
Applicant: Ministry of Health, State of Israel , Sami Shamoon College of Engineering (R.A) , Tel HaShomer Medical Research Infrastructure and Services Ltd.
Inventor： Israel Nissan , Noa Lea Tejman-Yarden , Chaim Rubinovitz , Yakov Davidov , Galia Rahav , Ari Robinson , Yoram Shotland
Abstract: Cultures of Delftia bacteria are disclosed. Antimicrobial agents derived therefrom are also disclosed.
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公开(公告)号：US20240268693A1
公开(公告)日：2024-08-15
申请号：US18583445
申请日：2024-02-21
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Genady Kostenich , Arie Orenstein , Michael Belkin
CPC classification number: A61B5/0261 , A61B1/041 , A61B3/12 , A61B3/1241 , A61B5/0075 , A61B5/489 , A61B5/0077 , A61B5/0084 , F04C2270/041
Abstract: Disclosed are methods and devices useful for imaging blood-containing tissue, for example for angiography, especially retinal angiography, whereby an image is generated by dividing pixels of an image acquired at some wavelength range by corresponding pixels of an image acquired at a different wavelength range. In some embodiments, a first wavelength range includes predominantly light having wavelengths between about 400 nm and about 620 nm and a second wavelength range includes predominantly light having wavelengths between about 620 nm and about 800 nm.
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公开(公告)号：US20240170147A1
公开(公告)日：2024-05-23
申请号：US18280254
申请日：2022-03-03
Inventor： Abraham TSUR , Raanan MEYER , Roni EILENBERG
CPC classification number: G16H50/20 , A61B5/435 , A61B8/0866 , G16H50/30
Abstract: There is provided a computer implemented method of training a machine learning model for prediction of unplanned Cesarean Delivery (uCD), comprising: creating or receiving a multi-record training dataset, wherein a record comprises: at least one fetal biometric parameter of a sample fetus obtained by an ultrasonography device, at least one personal parameter of a sample mother of the sample fetus, and a ground truth indicating whether a birth of the sample fetus by the sample mother was a uCD, and training the machine learning model on the multi-record training dataset for generating an outcome indicating likelihood of uCD for a target mother in response to an input of at least one fetal biometric parameter of a target fetus of the target mother and at least one personal parameter of the target mother.
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公开(公告)号：US11974947B2
公开(公告)日：2024-05-07
申请号：US18098291
申请日：2023-01-18
Inventor： Gilad Lavi , Yoseph Glovinsky , Vadim Shmukler , Nir Israeli
IPC: A61F9/007
CPC classification number: A61F9/00763
Abstract: Medical devices and methods for removing a predetermined portion of soft tissue from a target tissue layer, thereby creating a channel between two side walls of the target tissue layer, are described. The medical device is a cutting tool comprising: an elongated round body extending along a longitudinal axis and having a uniform outer cross-section at a proximal side thereof; a cutting portion at a distal side of the elongated body, comprising at a distal end thereof a cutting edge of a first cross-section being smaller than said outer cross-section, and a distally and continuously decreasing outer cross-section; and a chamber extending along the longitudinal axis inside the cutting tool from said cutting portion, the chamber having dimensions enabling storing of the removed soft tissue portion inside the chamber thereby providing a validation to the channel creation.
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公开(公告)号：US11931569B2
公开(公告)日：2024-03-19
申请号：US16980104
申请日：2019-03-12
Inventor： Yael Mardor , Shirley Sharabi , Itzik Cooper , David Last , David Guez , Dianne Daniels Elmakias , Yael Bresler
Abstract: A system and a method for increasing permeability of a brain barrier selected from a blood-brain barrier or a blood-cerebrospinal fluid barrier by controlled application of pulsed electric fields.
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