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    Treatment for bone diseases
    82.
    发明授权
    Treatment for bone diseases 有权

    公开(公告)号：US09925260B2

    公开(公告)日：2018-03-27

    申请号：US13934433

    申请日：2013-07-03

    Applicant: UCB PHARMA S.A.

    Inventor： Martyn Kim Robinson

    IPC: A61K39/395 ,  C07K16/18 ,  C07K16/22 ,  A61K45/06 ,  A61K33/42 ,  A61K39/00

    CPC classification number: A61K39/3955 ,  A61K33/42 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/22 ,  C07K2317/94

    Abstract: The invention relates to the treatment of bone disorders. In particular, the invention is directed to the use of a dosing holiday to help overcome the resistance to anti-sclerostin antibodies which develops over time when a plurality of doses of antibody are given to a subject. By giving the subject to be treated such a dosing holiday, the subject may subsequently display an increased response to a subsequent dose of the anti-sclerostin antibody. The subject may be given multiple cycles of a batch of at least two doses of anti-sclerostin antibody and a dosing holiday. In some instances, the subject may be monitored to help determine when to give the dosing holiday. Further, the subject may be given a different treatment for the bone disorder during the dosing holiday from the anti-sclerostin antibody.

    BACTERIAL HOST STRAIN
    84.
    发明申请
    BACTERIAL HOST STRAIN 有权

    公开(公告)号：US20160200810A1

    公开(公告)日：2016-07-14

    申请号：US15083446

    申请日：2016-03-29

    Applicant: UCB PHARMA, S.A.

    Inventor： MARK ELLIS ,  DAVID PAUL HUMPHREYS

    IPC: C07K16/24

    CPC classification number: C12N1/20 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/14 ,  C07K2317/20 ,  C07K2317/55 ,  C12N9/52 ,  C12N15/70 ,  C12P21/02 ,  C12R1/19 ,  Y02P20/52

    Abstract: A recombinant gram-negative bacterial cell comprising one or more of the following mutated protease genes: a) a mutated Tsp gene, wherein the mutated Tsp gene encodes a Tsp protein having reduced protease activity or is a knockout mutated Tsp gene; b) a mutated ptr gene, wherein the mutated ptr gene encodes a Protease III protein having reduced protease activity or is a knockout mutated ptr gene; and c) a mutated DegP gene encoding a DegP protein having chaperone activity and reduced protease activity; wherein the cell is isogenic to a wild-type bacterial cell except for the mutated Tsp gene and/or mutated ptr gene and/or mutated DegP gene and optionally a polynucleotide sequence encoding a protein of interest.

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