公开(公告)号：US20060056156A1

公开(公告)日：2006-03-16

申请号：US10939230

申请日：2004-09-10

Applicant: David Long ,  Glenn Daves ,  David Edwards ,  Ronald Hering ,  Sushumna Iruvanti ,  Kenneth Marston ,  Jason Miller

Inventor： David Long ,  Glenn Daves ,  David Edwards ,  Ronald Hering ,  Sushumna Iruvanti ,  Kenneth Marston ,  Jason Miller

IPC: H05K7/20

CPC classification number: H01L23/4006 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A flexible plate for securing a microchip surface to the surface of a cooling device. The flexible plate allows for z-directional movement between the microchip subassembly having a circuit board and a semiconductor substrate, and the cooling device. The flexible plate is a compact, single piece design that provides constraints in alignment in the x-, y-, and theta-directions, while allowing for z-direction compliance and tilt compliance. The flexible plate has tabs for mounting the microchip subassembly and tabs for mounting the cooling device. The microchip tabs are opposite one another and the cooling device mounting tabs are opposite one another. The flexible plate is a one-piece construction made from sheet metal, plastic, or metal castings. The flexible plate has a band with all the tabs mounted on the inside of the band, or one set of tabs mounted on the outside of the band.

Abstract translation: 用于将微芯片表面固定到冷却装置的表面的柔性板。 柔性板允许具有电路板的微芯片组件和半导体衬底之间的z方向运动以及冷却装置。 柔性板是一种紧凑的单件设计，可在x轴，y轴和θ轴方向上对齐，同时允许z方向顺应性和倾斜顺应性。 柔性板具有用于安装用于安装冷却装置的微芯片组件和突出部的突片。 微芯片接头彼此相对，并且冷却装置安装接头彼此相对。 柔性板是由金属板，塑料或金属铸件制成的一体式结构。 柔性板具有带子，其中所有突片安装在带的内部，或者一组安装在带的外侧上的突片。

公开(公告)号：US20060018776A1

公开(公告)日：2006-01-26

申请号：US11166682

申请日：2005-10-11

Applicant: David Mioduszewski ,  David Edwards ,  Richard Jacobson

Inventor： David Mioduszewski ,  David Edwards ,  Richard Jacobson

IPC: F04B9/08 ,  F04B47/00

CPC classification number: F04B9/14 ,  F04B47/00

Abstract: A pneumatic groundwater retrieving piston pump comprising generally of a piston and a foot valve is disclosed. A pneumatic driver slides the piston assembly up and down inside the foot valve assembly, which is connected to the driver by means of a stationary length of pipe. The drive shaft of the pneumatic driver is connected to the piston assembly by means of a polypropylene coated epoxy resin based rod. On the upward stroke the foot valve opens and lets water enter the volume below the piston assembly and the piston assembly check valve is closed and lifts the column of water. On the down stroke the foot valve closes holding the column of water and the piston check valve open, and allows the water to pass through to recharge the cylinder for the next lift cycle.

Abstract translation: 公开了一种通常包括活塞和底阀的气动地下水回收活塞泵。 气动驱动器在底阀组件内上下滑动活塞组件，该阀组件通过固定长度的管连接到驱动器。 气动驱动器的驱动轴通过聚丙烯涂覆的环氧树脂基棒连接到活塞组件。 在向上行程中，脚阀打开，让水进入活塞组件下方的体积，活塞组件止回阀关闭并提升水柱。 在下降行程中，脚踏阀关闭，保持水柱，活塞止回阀打开，并允许水通过，为下一个提升循环的气缸充气。

公开(公告)号：US20060002996A1

公开(公告)日：2006-01-05

申请号：US11176841

申请日：2005-07-07

Applicant: David Edwards ,  Jeffrey Hrkach

Inventor： David Edwards ,  Jeffrey Hrkach

IPC: A61K38/28 ,  A61K9/127

CPC classification number: A61K9/0075 ,  A61K9/1617 ,  Y10S514/951 ,  Y10S514/97 ,  Y10S514/975

Abstract: Spray-dried particles having improved protein stability are produced by spray-drying a mixture including a protein, a phospholipid and an organic-aqueous co-solvent. Spray-dried particles which include at least 1 weight % phospholipid, having a tap density of less than 0.4 g/cm3 can be prepared. The particles can be delivered to the pulmonary system of a patient.

Abstract translation: 具有改善的蛋白质稳定性的喷雾干燥颗粒通过喷雾干燥包括蛋白质，磷脂和有机 - 水性共溶剂的混合物而产生。 包含至少1重量％磷脂的喷雾干燥颗粒，其振实密度小于0.4g / cm 3，可以制备。 颗粒可以输送到患者的肺部系统。

公开(公告)号：US20050265928A1

公开(公告)日：2005-12-01

申请号：US11125010

申请日：2005-05-09

Applicant: David Edwards ,  Jean Sung ,  Brian Pulliam ,  Eric Wehrenberg-Klee ,  Evan Schwartz ,  Philip Dreyfuss ,  Sandeep Kulkarni ,  Erez Lieberman

Inventor： David Edwards ,  Jean Sung ,  Brian Pulliam ,  Eric Wehrenberg-Klee ,  Evan Schwartz ,  Philip Dreyfuss ,  Sandeep Kulkarni ,  Erez Lieberman

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/14 ,  A61K9/16 ,  A61K9/51 ,  A61K39/00 ,  A61K39/015 ,  A61L9/04

CPC classification number: A61K9/0073 ,  A61K9/0075 ,  A61K39/00 ,  A61K39/015 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/544 ,  A61K2039/55555 ,  Y02A50/412

Abstract: Particulate compositions for delivery, preferably pulmonary, which provide sustained release of antigens, preferably DNA and/or peptide and/or protein antigens, have been developed. In the preferred embodiment, aggregate nanoparticles are in the aerodynamic range of 1-5 microns diameter and fly deep into the lungs. As the aggregate particles degrade in the body, MSP-1 and AMA-1 proteins are released into the blood stimulating a humoural immune response. The individual particles in the range of 0.1 micron are preferentially phagocytosed by APCs which express the proteins encoded by AMA-1 and MSP-1 plasmid DNA thereby initiating the cellular immune response that is necessary for a complete immunity.

Abstract translation: 已经开发了用于递送，优选肺部的颗粒组合物，其提供抗原的持续释放，优选DNA和/或肽和/或蛋白质抗原。 在优选实施方案中，聚集体纳米颗粒处于1-5微米直径的空气动力学范围内并深入肺部。 随着聚集体颗粒在体内降解，MSP-1和AMA-1蛋白被释放到刺激幽门免疫应答的血液中。 0.1微米范围内的单个颗粒优先被表达由AMA-1和MSP-1质粒DNA编码的蛋白质的APC吞噬，由此引发完全免疫所必需的细胞免疫应答。

公开(公告)号：US20050255152A1

公开(公告)日：2005-11-17

申请号：US10511413

申请日：2003-04-17

Applicant: David Edwards ,  Daniel Deaver ,  Thaddeus Fulford-Jones ,  Jane Kucera ,  Shang-You Tee

Inventor： David Edwards ,  Daniel Deaver ,  Thaddeus Fulford-Jones ,  Jane Kucera ,  Shang-You Tee

IPC: A61K9/127 ,  A61K9/14 ,  A61K9/51 ,  A61K38/09 ,  A61K38/22 ,  A61K47/48

CPC classification number: A61K31/704 ,  A61K9/127 ,  A61K9/1271 ,  A61K9/1278 ,  A61K47/62 ,  A61K47/6933 ,  B82Y5/00

Abstract: A method and compositions for targeted drug delivery have been developed. The compositions include a targeting molecules such as a hormone that specifically binds to a receptor on the surface of the targeted cells; a drug to be delivered, such as a toxin that will kill the targeted cells; and a nanoparticle, which contains on or within the nanoparticle, the drug to be delivered, as well as has attached thereto, the targeting molecule. Nanoparticles can consist of drug or drug associated with carrier, such as a controlled or sustained release materials like a poly(lactide-co-glycolide), a liposome or surfactant. The compositions are administered by injections in most cases, although compositions can be applied topically orally, nasally, vaginally, rectally, and ocularly. Compositions can also be administered to the pulmonary or respiratory system, most preferably in an aerosol.

Abstract translation: 已经开发了用于靶向药物递送的方法和组合物。 组合物包括靶向分子，例如与靶细胞表面上的受体特异性结合的激素; 待传递的药物，例如将杀死靶细胞的毒素; 以及在纳米颗粒上或内部含有待递送药物以及与其连接的靶向分子的纳米颗粒。 纳米颗粒可以由与载体相关的药物或药物组成，例如受控或持续的释放材料如聚（丙交酯 - 共 - 乙交酯），脂质体或表面活性剂。 组合物在大多数情况下通过注射施用，尽管组合物可以局部地口服，经鼻，阴道，直肠和眼睛施用。 组合物也可以施用于肺或呼吸系统，最优选以气溶胶施用。

公开(公告)号：US20050244614A1

公开(公告)日：2005-11-03

申请号：US11176435

申请日：2005-07-07

Applicant: Rishikesh Bharadwaj ,  Hugo Cornelissen ,  Dennis Couzin ,  David Edwards ,  Reza Mehrabi

Inventor： Rishikesh Bharadwaj ,  Hugo Cornelissen ,  Dennis Couzin ,  David Edwards ,  Reza Mehrabi

IPC: B29C35/08 ,  B29C41/46 ,  B29C59/02 ,  B29C59/04 ,  B29D7/01 ,  B29D11/00 ,  B32B3/00 ,  B32B3/28 ,  B32B3/30 ,  G02B5/30 ,  H05B6/00

CPC classification number: B32B3/30 ,  B29C35/0272 ,  B29C35/0805 ,  B29C35/0888 ,  B29C59/02 ,  B29C59/04 ,  B29C2035/0811 ,  B29C2035/0822 ,  B29C2035/0838 ,  B29C2035/0855 ,  B29C2035/0861 ,  B29C2059/023 ,  B29L2011/00 ,  B32B7/12 ,  B32B27/08 ,  B32B27/308 ,  B32B27/36 ,  B32B38/06 ,  B32B2307/412 ,  B32B2307/42 ,  B32B2307/516 ,  B32B2307/704 ,  B32B2307/706 ,  B32B2398/20 ,  G02B5/3083 ,  Y10T428/24479 ,  Y10T428/2457

Abstract: A method of making an embossed optical sheet material includes: providing an optically anisotropic, uniaxially oriented polymer substrate having a first major surface and a second major surface; heating a patterned tool using radiant energy from a radiant energy source, wherein the pattern comprises a plurality of parallel raised microstructures having a longitudinal direction; pressing the tool against the first major surface of the polymer substrate such that the longitudinal direction of the raised microstructures is substantially parallel to the direction of orientation of the polymer substrate, to soften the first major surface of the polymer substrate and emboss groove-shaped microchannels into the polymer substrate; cooling the embossed polymer substrate; and separating the tool from the polymer substrate; wherein the orientation of the polymer substrate is unchanged throughout the polymer substrate and first major surface.

公开(公告)号：US20050179150A1

公开(公告)日：2005-08-18

申请号：US11086511

申请日：2005-03-22

Applicant: Rishikesh Bharadwaj ,  Hugo Cornelissen ,  Dennis Couzin ,  David Edwards ,  Reza Mehrabi

Inventor： Rishikesh Bharadwaj ,  Hugo Cornelissen ,  Dennis Couzin ,  David Edwards ,  Reza Mehrabi

IPC: B29C35/08 ,  B29C41/46 ,  B29C59/02 ,  B29C59/04 ,  B29D7/01 ,  B29D11/00 ,  B32B3/00 ,  B32B3/28 ,  B32B3/30 ,  G02B5/30 ,  H05B6/00

CPC classification number: B32B3/30 ,  B29C35/0272 ,  B29C35/0805 ,  B29C35/0888 ,  B29C59/02 ,  B29C59/04 ,  B29C2035/0811 ,  B29C2035/0822 ,  B29C2035/0838 ,  B29C2035/0855 ,  B29C2035/0861 ,  B29C2059/023 ,  B29L2011/00 ,  B32B7/12 ,  B32B27/08 ,  B32B27/308 ,  B32B27/36 ,  B32B38/06 ,  B32B2307/412 ,  B32B2307/42 ,  B32B2307/516 ,  B32B2307/704 ,  B32B2307/706 ,  B32B2398/20 ,  G02B5/3083 ,  Y10T428/24479 ,  Y10T428/2457

Abstract: A method of making an embossed optical sheet material includes: providing an optically anisotropic, uniaxially oriented polymer substrate having a first major surface and a second major surface; heating a patterned tool using radiant energy from a radiant energy source, wherein the pattern comprises a plurality of parallel raised microstructures having a longitudinal direction; pressing the tool against the first major surface of the polymer substrate such that the longitudinal direction of the raised microstructures is substantially parallel to the direction of orientation of the polymer substrate, to soften the first major surface of the polymer substrate and emboss groove-shaped microchannels into the polymer substrate; cooling the embossed polymer substrate; and separating the tool from the polymer substrate; wherein the orientation of the polymer substrate is unchanged throughout the polymer substrate and first major surface.

公开(公告)号：US20050173677A1

公开(公告)日：2005-08-11

申请号：US10773176

申请日：2004-02-09

Applicant: Shaun Mesher ,  David Edwards

Inventor： Shaun Mesher ,  David Edwards

IPC: B01F1/00 ,  C09K3/32 ,  C09K8/52 ,  C09K8/72 ,  C09K8/74 ,  E21B37/06 ,  E21B43/27

CPC classification number: C09K8/52 ,  C09K8/72 ,  C09K8/74

Abstract: A solvent system for use in acidizing and cleanup in oil wells and gas wells. The solvent system comprises a substantially water-soluble alcohol, such as methanol, or ethanol or any mixture thereof, a substantially water/oil-soluble ester, such as one or more C.sub.2-esters through C.sub.10-esters and a substantially water/oil-soluble ketone, such as one or more C.sub.2-ketones through C.sub.10-ketones.

Abstract translation: 用于油井和气井酸化和清理的溶剂系统。 溶剂系统包括基本上水溶性的醇，例如甲醇或乙醇或其任何混合物，基本上水/油溶性的酯，例如一种或多种C.-通过C.- 酯和基本上水/油溶性的酮，例如一种或多种C.2-酮通过十五酮。

公开(公告)号：US20050062640A1

公开(公告)日：2005-03-24

申请号：US10898705

申请日：2004-07-23

Applicant: David Edwards ,  Dominic Pearce ,  Jan Grothusen

Inventor： David Edwards ,  Dominic Pearce ,  Jan Grothusen

IPC: G01S3/32 ,  G01S7/02 ,  G01S13/34 ,  G01S13/75 ,  G01S13/87 ,  G01S13/93

CPC classification number: G01S13/876 ,  G01S3/32 ,  G01S7/025 ,  G01S13/343 ,  G01S13/751

Abstract: The present invention provides a rotating antenna that can be used in combination with a coded modulated transponder as part of a vehicle positioning and tracking radar system. The antenna transmits a pair of frequency-modulated continuous-wave (FMCW) electromagnetic signals that have a vertical polarisation, for example. The transmit signals are incident on the transponder which returns or transmits an electromagnetic signal back to the antenna having a horizontal polarisation, for example. The transponder can alter the polarisation of the incident transmit signals using a known technique. The transmit and receive feeds at the antenna are cross-polarised and are therefore isolated from each other.

Abstract translation: 本发明提供一种旋转天线，其可以与作为车辆定位和跟踪雷达系统的一部分的编码调制转发器组合使用。 例如，天线发射一对具有垂直偏振的调频连续波（FMCW）电磁信号。 发送信号入射到应答器，该应答器例如将电磁信号返回或发送到具有水平极化的天线。 应答器可以使用已知技术改变入射发射信号的极化。 天线处的发射和接收馈送是交叉极化的，因此彼此隔离。

公开(公告)号：US06732732B2

公开(公告)日：2004-05-11

申请号：US10268059

申请日：2002-10-10

Applicant: David Edwards ,  Colleen Conlon ,  Sarah Dreesen ,  Mark DeLong

Inventor： David Edwards ,  Colleen Conlon ,  Sarah Dreesen ,  Mark DeLong

IPC: A61M1500

CPC classification number: A61M15/0028 ,  A61M11/003 ,  A61M15/0033 ,  A61M15/0035 ,  A61M15/0041 ,  A61M2202/064

Abstract: Inhalation device and associated method for facilitating inhalation by a patient of powder medicaments contained in a receptacle. The inhalation device has a chamber for receiving the receptacle. A ring is circumferentially coupled to an inner surface of the chamber to achieve a higher reproducible emitted dose of medicament from the receptacle. The inhalation device also includes an improved implement for puncturing the receptacle, requiring less force and experiencing fewer failures. The inhalation device also includes a means for indicating readiness.