公开(公告)号：US20050233074A1

公开(公告)日：2005-10-20

申请号：US10521002

申请日：2003-08-14

申请人： Sean Dalziel ,  Prathibha Gai ,  Thomas Friedmann ,  Qian Zhao ,  George Schurr

发明人： Sean Dalziel ,  Prathibha Gai ,  Thomas Friedmann ,  Qian Zhao ,  George Schurr

IPC分类号： A61K9/14 ,  B01J2/00 ,  B05D7/00 ,  C08K20060101

CPC分类号： A61K9/143 ,  B01J2/006 ,  B82Y30/00

摘要： A process of manufacturing compositions comprised of carrier particles under 100 nm that have been loaded to a level of greater than 60% by weight with a liquid. The highly-liquid-loaded particles can be further coated or encapsulated with functional coating or encapsulating materials.

摘要翻译： 一种制备组合物的方法，该组合物由100nm以下的载体颗粒组成，其用液体装载至大于60重量％的水平。 高度液体负载的颗粒可以用功能性涂层或包封材料进一步涂覆或包封。

公开(公告)号：US09527865B2

公开(公告)日：2016-12-27

申请号：US13607016

申请日：2012-09-07

申请人： Eli Wallace ,  George Topalov ,  Joseph Lyssikatos ,  Alexandre Buckmelter ,  Qian Zhao

发明人： Eli Wallace ,  George Topalov ,  Joseph Lyssikatos ,  Alexandre Buckmelter ,  Qian Zhao

IPC分类号： C07D239/94 ,  C07D498/10 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04 ,  C04B35/632

摘要： This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

公开(公告)号：US09434719B2

公开(公告)日：2016-09-06

申请号：US14408418

申请日：2014-03-12

申请人： Thomas Raymond Caferro ,  Zhuoliang Chen ,  Young Shin Cho ,  Abran Q. Costales ,  Julian Roy Levell ,  Gang Liu ,  James R. Manning ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  James Sutton ,  Yaping Wang ,  Qian Zhao

发明人： Thomas Raymond Caferro ,  Zhuoliang Chen ,  Young Shin Cho ,  Abran Q. Costales ,  Julian Roy Levell ,  Gang Liu ,  James R. Manning ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  James Sutton ,  Yaping Wang ,  Qian Zhao

IPC分类号： C07D413/04 ,  A61K31/506 ,  C07D413/14 ,  C07D417/14 ,  A61K31/5377

CPC分类号： C07D413/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/04 ,  C07D417/14

摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.

公开(公告)号：US09377286B2

公开(公告)日：2016-06-28

申请号：US13985789

申请日：2011-11-17

申请人： Xinchun Lu ,  Dewen Zhao ,  Zilian Qu ,  Qian Zhao ,  Yongyong He ,  Yonggang Meng

发明人： Xinchun Lu ,  Dewen Zhao ,  Zilian Qu ,  Qian Zhao ,  Yongyong He ,  Yonggang Meng

IPC分类号： G01B7/06 ,  G01B1/00 ,  G01R1/00

CPC分类号： G01B7/10 ,  G01B1/00 ,  G01B7/105 ,  G01R1/00 ,  H01L2221/00

摘要： A device for globally measuring a thickness of a metal film (901), comprises: a base (10); a rotating unit (20) comprising a fixed member (21) fixed on the base (10) and a rotating member (22) having a rotating joint (23); a working table (50) fixed on the rotating member (22) and having a vacuum passage which is formed therein and connected with the rotating joint (23); a linear driving unit (30) including a guide rail (31) fixed on the base (10) and a sliding block (32) slidable along the guide rail (31); a cantilever beam (40) disposed horizontally and defining a first end fixed with the sliding block (32) and a second end; a measuring head (80) connected to the second end of the cantilever beam (40), facing a surface of the working table (50) and having an eddy current probe (82) disposed therein.

摘要翻译： 用于全面测量金属膜（901）的厚度的装置包括：基座（10）; 旋转单元（20）包括固定在基座（10）上的固定构件（21）和具有旋转接头（23）的旋转构件（22）; 固定在旋转构件（22）上并具有形成在其中并与旋转接头（23）连接的真空通道的工作台（50）; 线性驱动单元（30），其包括固定在基座（10）上的导轨（31）和可沿导轨（31）滑动的滑块（32）; 悬臂梁（40）水平设置并且限定固定有滑块（32）的第一端和第二端; 连接到所述悬臂梁（40）的第二端的测量头（80），面向所述工作台（50）的表面并且具有布置在其中的涡流探针（82）。

公开(公告)号：US08933084B2

公开(公告)日：2015-01-13

申请号：US13698922

申请日：2011-05-13

申请人： Steven Wade Andrews ,  Kevin Ronald Condroski ,  Julia Haas ,  Yutong Jiang ,  Gabrielle R. Kolakowski ,  Jeongbeob Seo ,  HongWoon Yang ,  Qian Zhao

发明人： Steven Wade Andrews ,  Kevin Ronald Condroski ,  Julia Haas ,  Yutong Jiang ,  Gabrielle R. Kolakowski ,  Jeongbeob Seo ,  HongWoon Yang ,  Qian Zhao

IPC分类号： A61K31/519 ,  C07D487/02 ,  C07D519/00 ,  C07D498/22 ,  C07D487/04 ,  C07D471/22

CPC分类号： C07D498/22 ,  A61K31/519 ,  C07D471/22 ,  C07D487/04 ,  C07D487/22 ,  C07D519/00

摘要： Compounds of Formula I: and pharmaceutically acceptable salts thereof, wherein ring A, ring B, W, m, D, R2, R2a, R3, R3a, and Z are as defined herein, are inhibitors of Trk kinases and are useful in the treatment of pain, cancer, inflammation, neurodegenerative diseases and certain infectious diseases.

摘要翻译： 式I化合物及其药学上可接受的盐，其中环A，环B，W，m，D，R2，R2a，R3，R3a和Z如本文所定义，是Trk激酶的抑制剂，可用于治疗 疼痛，癌症，炎症，神经变性疾病和某些传染病。

公开(公告)号：US08765944B2

公开(公告)日：2014-07-01

申请号：US13210776

申请日：2011-08-16

申请人： Li-Qiang Sun ,  Eric Mull ,  Qian Zhao ,  Tao Wang ,  Zhongxing Zhang ,  Paul Michael Scola

发明人： Li-Qiang Sun ,  Eric Mull ,  Qian Zhao ,  Tao Wang ,  Zhongxing Zhang ,  Paul Michael Scola

IPC分类号： C07D251/52 ,  A61K31/53 ,  A61P31/12

CPC分类号： C07D251/52 ,  A61K31/53 ,  A61K45/06 ,  C07D401/04 ,  C07D401/12 ,  C07D403/12 ,  A61K2300/00

摘要： The disclosure provides compounds of formula I, including pharmaceutically acceptable salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

公开(公告)号：US20130274244A1

公开(公告)日：2013-10-17

申请号：US13994048

申请日：2011-12-13

申请人： Mark Laurence Boys ,  Robert Kirk Delisle ,  Erik James Hicken ,  April L. Kennedy ,  David A. Mareska ,  Fredrik P. Marmsater ,  Mark C. Munson ,  Brad Newhouse ,  Bryson Rast ,  James P. Rizzi ,  Martha E. Rodriguez ,  George T. Topalov ,  Qian Zhao

发明人： Mark Laurence Boys ,  Robert Kirk Delisle ,  Erik James Hicken ,  April L. Kennedy ,  David A. Mareska ,  Fredrik P. Marmsater ,  Mark C. Munson ,  Brad Newhouse ,  Bryson Rast ,  James P. Rizzi ,  Martha E. Rodriguez ,  George T. Topalov ,  Qian Zhao

IPC分类号： C07D471/04

CPC分类号： C07D471/04 ,  A61K31/496 ,  A61K45/06

摘要： Compounds of Formula I: and pharmaceutically acceptable salts thereof in which R1, R2, R3, R4, R5 and R6 have the meanings given in the specification, are inhibitors of cFMS and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.

摘要翻译： 式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5和R 6具有说明书中给出的含义，是cFMS的抑制剂，可用于治疗纤维化，骨相关疾病，癌症 ，自身免疫性疾病，炎性疾病，心血管疾病，哺乳动物的疼痛和灼伤。

公开(公告)号：US20130245256A1

公开(公告)日：2013-09-19

申请号：US13607016

申请日：2012-09-07

申请人： Eli Wallace ,  George Topalov ,  Joseph Lyssikatos ,  Alexandre Buckmelter ,  Qian Zhao

发明人： Eli Wallace ,  George Topalov ,  Joseph Lyssikatos ,  Alexandre Buckmelter ,  Qian Zhao

IPC分类号： C07D498/10 ,  C07D498/04 ,  C07D413/12 ,  C07D239/94 ,  C07D401/12

CPC分类号： C07D498/10 ,  C04B35/632 ,  C07D239/94 ,  C07D401/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D498/04

摘要： This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

公开(公告)号：US20130115190A1

公开(公告)日：2013-05-09

申请号：US13459403

申请日：2012-04-30

申请人： Sheldon Hiebert ,  Ramkumar Rajamani ,  Li-Qiang Sun ,  Eric Mull ,  Eric P. Gillis ,  Michael S. Bowsher ,  Qian Zhao ,  Nicholas A. Meanwell ,  Kishore V. Renduchintala ,  Kandhasamy Sarkunam ,  Pulicharla Nagalakshmi ,  P. V. K. Suresh Babu ,  Paul Michael Scola

发明人： Sheldon Hiebert ,  Ramkumar Rajamani ,  Li-Qiang Sun ,  Eric Mull ,  Eric P. Gillis ,  Michael S. Bowsher ,  Qian Zhao ,  Nicholas A. Meanwell ,  Kishore V. Renduchintala ,  Kandhasamy Sarkunam ,  Pulicharla Nagalakshmi ,  P. V. K. Suresh Babu ,  Paul Michael Scola

IPC分类号： A61K38/12 ,  C07K5/12

CPC分类号： C07K5/0823 ,  A61K31/13 ,  A61K31/4745 ,  A61K31/7056 ,  A61K38/00 ,  A61K38/06 ,  A61K38/2013 ,  A61K38/204 ,  A61K38/2053 ,  A61K38/21 ,  A61K38/212 ,  A61K45/06 ,  C07D487/04 ,  C07K5/0804 ,  C07K5/0827 ,  A61K2300/00

摘要： Hepatitis C virus inhibitors having the general formula (I) are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

公开(公告)号：US20130053073A1

公开(公告)日：2013-02-28

申请号：US13581324

申请日：2010-09-21

申请人： Qian Zhao ,  Zhenzhuo Zeng ,  Chenxi Li

发明人： Qian Zhao ,  Zhenzhuo Zeng ,  Chenxi Li

IPC分类号： H04W4/02

CPC分类号： H04W48/04 ,  H04M1/72572 ,  H04M1/72577

摘要： A method for controlling wireless communication terminals based on location areas is disclosed, including: a wireless communication terminal obtaining its own current location information (101); using a service and function control table to deactivate services and functions that need to be restricted according to the obtained location information, and storing the location information and the deactivated services and functions (102); the wireless communication terminal re-obtaining the location information, activating restriction-cancelled services and functions or deactivating restricted services and functions according to the re-obtained location information, the stored location information and/or the deactivated services and functions; a device for controlling wireless communication terminals based on location areas is also disclosed, and the method and device can be used to control all the services and functions of the wireless communication terminal at the terminal side, so that controlling the wireless communication terminal is more flexibly and more targeted.

摘要翻译： 公开了一种基于位置区域控制无线通信终端的方法，包括：无线通信终端获取其自己的当前位置信息（101）; 使用服务和功能控制表来根据所获得的位置信息去激活需要限制的服务和功能，并存储位置信息和停用的服务和功能（102）; 无线通信终端根据重新获得的位置信息，存储的位置信息和/或停用的服务和功能，重新获取位置信息，激活限制取消的服务和功能或停用受限服务和功能; 还公开了一种基于位置区域来控制无线通信终端的装置，并且该方法和装置可用于控制终端侧无线通信终端的所有业务和功能，从而更灵活地控制无线通信终端 更具针对性。