公开(公告)号：US20130035472A1

公开(公告)日：2013-02-07

申请号：US13634279

申请日：2011-03-15

申请人： Robert Horlick ,  John Macomber ,  Andrew Cubitt ,  David King

发明人： Robert Horlick ,  John Macomber ,  Andrew Cubitt ,  David King

IPC分类号： C12N15/11 ,  C12P19/34 ,  C07K14/00 ,  C12N5/10 ,  C12N15/63 ,  C12N1/21 ,  C12N1/19 ,  C07H1/00 ,  C07K19/00

CPC分类号： C12P21/02 ,  C07K16/00 ,  C07K16/244 ,  C07K2317/34 ,  C12N15/111 ,  C12N15/63 ,  C12N2310/14 ,  C12N2330/00

摘要： The invention is directed to a method of preparing a nucleic acid sequence with a modified splice site usage profile, which employs the use of a nucleic acid sequence comprising a cryptic splice donor site. The invention also provides a method of producing an alternate form of an RNA molecule encoded by a nucleic acid sequence, which nucleic acid sequence comprises a cryptic splice donor site, a heterologous nucleic acid sequence, and a splice acceptor site.

摘要翻译： 本发明涉及一种制备具有经修饰的剪接位点使用谱的核酸序列的方法，其使用包含隐蔽剪接供体位点的核酸序列。 本发明还提供了产生由核酸序列编码的RNA分子的替代形式的方法，所述核酸序列包含隐蔽剪接供体位点，异源核酸序列和剪接受体位点。

公开(公告)号：US07939076B2

公开(公告)日：2011-05-10

申请号：US10831432

申请日：2004-04-23

申请人： Lesley B. Pickford ,  Christopher R. Bebbington ,  Geoffrey T. Yarranton ,  David King

发明人： Lesley B. Pickford ,  Christopher R. Bebbington ,  Geoffrey T. Yarranton ,  David King

IPC分类号： A61K39/395

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/30

摘要： Compositions and methods for the therapy of Inflammatory Bowel Disease (IBD), including Celiac Disease, Crohn's Disease, and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more anti-type 1 interferon antagonists, such as anti-type 1 interferon receptor antibody antagonists and fragments thereof, as well as polypeptides and small molecules that inhibit the interaction of type 1 interferon with its receptor (IFNAR).

摘要翻译： 公开了用于治疗炎性肠病（IBD）的组合物和方法，包括腹腔疾病，克罗恩病和溃疡性结肠炎。 示例性组合物包含一种或多种抗1型干扰素拮抗剂，例如抗1型干扰素受体抗体拮抗剂及其片段，以及抑制1型干扰素与其受体（IFNAR）相互作用的多肽和小分子。

公开(公告)号：US07935338B2

公开(公告)日：2011-05-03

申请号：US10317747

申请日：2002-12-11

申请人： Gary R. Fanger ,  Neil Fanger ,  David King ,  Marc W. Retter ,  Kenneth L. Rock

发明人： Gary R. Fanger ,  Neil Fanger ,  David King ,  Marc W. Retter ,  Kenneth L. Rock

IPC分类号： A61K39/395

CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/732

摘要： Compositions and methods for the treatment of cancer, particularly melanoma, myeloma, small cell lung cancer, thymic lymphoma, T-cell lymphoma, B-cell lymphoma, osteosarcoma, and acute T-cell leukemia, are disclosed. Illustrative compositions include one or more anti-ganglioside antibodies and polynucleotides that encode such anti-ganglioside antibodies. These antibodies may be for example, hamster antibodies, chimeric human/hamster antibodies, or humanized antibodies. The disclosed compositions are useful, for example, in the treatment of cancer and can be used to induce apoptosis in a cancer cell.

摘要翻译： 公开了用于治疗癌症，特别是黑素瘤，骨髓瘤，小细胞肺癌，胸腺淋巴瘤，T细胞淋巴瘤，B细胞淋巴瘤，骨肉瘤和急性T细胞白血病的组合物和方法。 说明性组合物包括一种或多种编码这种抗神经节苷脂抗体的抗神经节苷脂抗体和多核苷酸。 这些抗体可以是例如仓鼠抗体，嵌合人/仓鼠抗体或人源化抗体。 所公开的组合物可用于例如治疗癌症，并可用于诱导癌细胞中的细胞凋亡。

公开(公告)号：US20100263020A1

公开(公告)日：2010-10-14

申请号：US12686764

申请日：2010-01-13

申请人： Kyle Harrison ,  David King

发明人： Kyle Harrison ,  David King

IPC分类号： H04L29/06

CPC分类号： G06F17/30017 ,  G06Q30/02 ,  H04L67/02 ,  H04L67/20

摘要： An item of hosted content is received from a media host. A match metric representing an aspect of a match between the item of hosted content and an item of reference content, the item of reference content provided by a content owner having rights to the item of reference content. A policy associated with the item of reference content is identified responsive to the value to that represents the correspondence, the policy including terms of use for the hosted content. The policy is provided to the media host.

摘要翻译： 从媒体主机接收托管内容的项目。 表示托管内容的项目与参考内容项目之间的匹配方面的匹配度量，由具有参考内容项目的权限的内容所有者提供的参考内容项目。 与参考内容项相关联的策略是响应于表示对应关系的值来确定的，该策略包括托管内容的使用条款。 该政策提供给媒体主持人。

公开(公告)号：US20100262488A1

公开(公告)日：2010-10-14

申请号：US12755298

申请日：2010-04-06

申请人： Kyle Harrison ,  David King ,  Robert On

发明人： Kyle Harrison ,  David King ,  Robert On

IPC分类号： G06Q30/00 ,  G06Q10/00 ,  G06Q50/00 ,  H04N7/173

CPC分类号： H04N7/17318 ,  G06Q30/02 ,  G06Q30/0247 ,  G06Q30/0254 ,  G06Q30/0274 ,  H04N21/2541 ,  H04N21/2743

摘要： Hosted content received from media hosts is used to generate a set of fingerprints representing the hosted content. The fingerprints representing the hosted content are compared to a set of fingerprints representing reference content submitted by content owners to generate one or more match metrics. Based on the match metrics, the media host may provide indication that they accept policy terms specified by the content owners, including revenue sharing terms. If the media host accepts the revenue sharing terms, the media host may provide advertising content to viewers in association with the hosted content matching the reference content. Funds received from providing advertising content are distributed to the media host and the content owner according to the revenue sharing terms.

摘要翻译： 从媒体主机接收的主机内容用于生成一组代表托管内容的指纹。 将表示托管内容的指纹与表示由内容所有者提交以生成一个或多个匹配度量的参考内容的一组指纹进行比较。 根据比赛指标，媒体主持人可能会提供他们接受内容所有者指定的政策条款的指示，包括收益分享条款。 如果媒体主机接受收益共享条款，则媒体主机可以向与参考内容匹配的托管内容相关联的观众提供广告内容。 从提供广告内容收到的资金根据收入分配条件分发给媒体主持人和内容所有者。

公开(公告)号：US07789445B2

公开(公告)日：2010-09-07

申请号：US11833711

申请日：2007-08-03

申请人： Patrick Hoffman ,  David King ,  Thomas B. Murphy

发明人： Patrick Hoffman ,  David King ,  Thomas B. Murphy

IPC分类号： B60J7/00

CPC分类号： B60R21/06

摘要： A net pet barrier designed for installation behind the front or rear seat in a vehicle to keep pets off vehicle seats and in the back of the vehicle. Netting formed of micro-mesh material is attached to a pop-up wire frame which keeps the net from sagging and facilitates installation and removal. Adjustable side expansion panels allow installation of the barrier in vehicles of various sizes and configurations, from sedans to full-size SUVs.

摘要翻译： 一个净宠物屏障，设计用于安装在车辆前后座椅后面，以保持宠物离开车辆座椅和车辆后方。 由微网材料形成的网状物连接到弹性线框架上，其使网不会下垂并且便于安装和移除。 可调节的侧面扩展面板允许在各种尺寸和配置的车辆中安装屏障，从轿车到全尺寸SUV。

公开(公告)号：US20100034984A1

公开(公告)日：2010-02-11

申请号：US12456388

申请日：2009-06-16

申请人： Jes Asmussen ,  Timothy Grotjohn ,  Donnie K. Reinhard ,  Thomas Schuelke ,  M. Kagan Yaran ,  Kadek W. Hemawan ,  Michael Becker ,  David King ,  Yajun Gu ,  Jing Lu

发明人： Jes Asmussen ,  Timothy Grotjohn ,  Donnie K. Reinhard ,  Thomas Schuelke ,  M. Kagan Yaran ,  Kadek W. Hemawan ,  Michael Becker ,  David King ,  Yajun Gu ,  Jing Lu

IPC分类号： C23C16/511 ,  C23C16/00

CPC分类号： C23C16/511 ,  C23C16/274 ,  C23C16/279 ,  C30B25/105 ,  C30B25/16 ,  C30B29/04 ,  C30B35/00 ,  H01J37/32256 ,  H05H1/46

摘要： New and improved microwave plasma assisted reactors, for example chemical vapor deposition (MPCVD) reactors, are disclosed. The disclosed microwave plasma assisted reactors operate at pressures ranging from about 10 Torr to about 760 Torr. The disclosed microwave plasma assisted reactors include a movable lower sliding short and/or a reduced diameter conductive stage in a coaxial cavity of a plasma chamber. For a particular application, the lower sliding short position and/or the conductive stage diameter can be variably selected such that, relative to conventional reactors, the reactors can be tuned to operate over larger substrate areas, operate at higher pressures, and discharge absorbed power densities with increased diamond synthesis rates (carats per hour) and increased deposition uniformity.

摘要翻译： 公开了新的和改进的微波等离子体辅助反应器，例如化学气相沉积（MPCVD）反应器。 所公开的微波等离子体辅助反应器在约10托至约760托的压力下工作。 所公开的微波等离子体辅助反应器包括在等离子体室的同轴空腔中的可移动的下滑动短路径和/或直径减小的导电平台。 对于特定应用，可以可变地选择较低的滑动短位置和/或导电平台直径，使得相对于常规的反应器，可以将反应器调整为在更大的衬底区域上操作，在更高的压力下操作，并且放电吸收的功率 具有增加的金刚石合成速率（克拉每小时）和增加的沉积均匀性的密度。

公开(公告)号：US20080109369A1

公开(公告)日：2008-05-08

申请号：US11935386

申请日：2007-11-05

申请人： Yi-Ling Su ,  Frey Waid ,  Rui Chen ,  Matthew Good ,  Franck Chastagnol ,  Jianliang Zhao ,  Zheng Liu ,  David King

发明人： Yi-Ling Su ,  Frey Waid ,  Rui Chen ,  Matthew Good ,  Franck Chastagnol ,  Jianliang Zhao ,  Zheng Liu ,  David King

IPC分类号： G06Q10/00 ,  G06F17/00 ,  G06Q30/00 ,  H04L9/28

CPC分类号： G06Q30/06 ,  G06Q10/06 ,  G06Q30/0273

摘要： Content rights holders provide digital content to a hosting site to be used as reference content. The content owner specifies a policy for each digital content item, indicating how that content may be used on the site when uploaded by someone other than the content owner. An identification module compares the uploaded content against reference content. If the content matches reference content, the specified policy for that reference content is applied to the uploaded content. Policy options provided by the content owner include tracking the content to see how it is viewed, preventing the content from being distributed on the site, and allowing the content to be displayed in a revenue-sharing environment. In one embodiment, if the identification module matches the uploaded content to a reference item but the match does not have a sufficiently high level of confidence, the suggested match is queued for review by the content owner.

摘要翻译： 内容权利持有者将数字内容提供给托管站点以用作参考内容。 内容所有者为每个数字内容项目指定一个策略，指示当由内容所有者以外的人上传时，该内容可以在该网站上使用。 识别模块将上传的内容与参考内容进行比较。 如果内容与参考内容相匹配，则该引用内容的指定策略将应用于上传的内容。 内容所有者提供的策略选项包括跟踪内容以查看其内容，以防止在网站上分发内容，并允许内容在收益分享环境中显示。 在一个实施例中，如果识别模块将上传的内容与参考项匹配，但匹配没有足够高的置信度，则建议的匹配排队等待内容所有者审查。

公开(公告)号：US20070059760A1

公开(公告)日：2007-03-15

申请号：US11599523

申请日：2006-11-13

申请人： Andreas Dorsel ,  David King ,  Nicholas Sampas

发明人： Andreas Dorsel ,  David King ,  Nicholas Sampas

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： G01N21/6452 ,  G01N21/6428

摘要： A method and apparatus of interrogating an addressable array unit, which includes a substrate, a light reflecting layer on a front side of the substrate, and a plurality of features on a front side of the array. The method may include, for each of multiple features, illuminating the feature simultaneously with reflected and non-reflected interrogating light. A light emitted from respective features is detected. Either or both, constructive interference of interrogating light at the features, or constructive interference of light emitted from the features, can be obtained to allow lowering of light power from the source, enhanced signal, or reduced noise, or combinations of the foregoing. High depth discrimination may also be obtained without the need for a confocal detection system with conventional pinhole.

摘要翻译： 一种询问可寻址阵列单元的方法和装置，其包括基板，在基板的前侧上的光反射层，以及阵列的前侧上的多个特征。 对于多个特征中的每一个，该方法可以包括与反射和未反射的询问光同时照亮特征。 检测从各个特征发射的光。 可以获得在特征中询问光的建构性干扰或从特征发射的光的建构性干扰，以允许降低源的光功率，增强的信号或降低的噪声或前述的组合。 也可以获得高深度鉴别，而不需要具有常规针孔的共焦检测系统。

公开(公告)号：US07112111B1

公开(公告)日：2006-09-26

申请号：US11318002

申请日：2005-12-22

申请人： David King

发明人： David King

IPC分类号： B63B22/20

CPC分类号： B63G8/001 ,  B63B1/00 ,  B63B7/00

摘要： A closed loop buoyancy system wherein a device housing the system is submerged in a liquid filled container, the device dives to the bottom of the container, remains for a regulated amount of time, and then floats back to the surface of the liquid.

摘要翻译： 闭环浮力系统，其中容纳系统的装置浸没在液体填充的容器中，该装置潜入容器的底部，保持一段规定的时间量，然后漂浮回液体的表面。