公开(公告)号：US20250042922A1

公开(公告)日：2025-02-06

申请号：US18756455

申请日：2024-06-27

Applicant: Gilead Sciences, Inc.

Inventor： Chaodi Dai ,  Julie Farand ,  Juan A. Guerrero ,  Tezcan Guney ,  Hongyan Guo ,  Jason R. Hudlicky ,  Darryl Kato ,  Irene N. Kiburu ,  Scott E. Lazerwith ,  Paulo A. Machicao Tello ,  James B.C. Mack ,  Erik P. McAuley ,  Jessica L. McKinley ,  Jonathan William Medley ,  Hyung-Jung Pyun ,  Thomas P. Stratton ,  Maoqun Tian ,  Jeremy R. Tuck ,  William J. Watkins ,  Jie Xu ,  Jennifer R. Zhang

IPC: C07D519/00 ,  A61K31/55 ,  C07D471/22

Abstract: Provided herein are compounds, and pharmaceutically acceptable salts thereof, useful as KRAS inhibitors, methods of making and using the same (singly or in combination with additional agents), and pharmaceutical compositions thereof.

公开(公告)号：US12162844B2

公开(公告)日：2024-12-10

申请号：US18181336

申请日：2023-03-09

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Tae H. Hwang ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  John E. Knox ,  Scott E. Lazerwith ,  Xiaofen Li ,  David W. Lin ,  Jonathan W. Medley ,  Michael L. Mitchell ,  Devan Naduthambi ,  Zachary Newby ,  Neil H. Squires ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang

IPC: C07D513/08 ,  A61K31/553 ,  C07D267/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  C07D513/10 ,  C07D513/20 ,  C07D513/22 ,  A61K45/06

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US12084467B2

公开(公告)日：2024-09-10

申请号：US18061127

申请日：2022-12-02

Applicant: Gilead Sciences, Inc.

Inventor： Zhimin Du ,  Julie Farand ,  Tezcan Guney ,  Darryl Kato ,  John O. Link ,  James B. C. Mack ,  Dong Min Mun ,  William J. Watkins ,  Jennifer R. Zhang

IPC: C07F9/6503 ,  A61K45/06 ,  C07D401/14

CPC classification number: C07F9/65038 ,  A61K45/06 ,  C07D401/14

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.

公开(公告)号：US20240132527A1

公开(公告)日：2024-04-25

申请号：US18236532

申请日：2023-08-22

Applicant: Gilead Sciences, Inc.

Inventor： Julie Farand ,  Michael Graupe ,  Tezcan Guney ,  Darryl Kato ,  Jiayao Li ,  John O. Link ,  James B. C. Mack ,  Dong Min Mun ,  Roland D. Saito ,  William J. Watkins ,  Jennifer R. Zhang

IPC: C07F9/09

CPC classification number: C07F9/095

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.

公开(公告)号：US11897862B2

公开(公告)日：2024-02-13

申请号：US18297316

申请日：2023-04-07

Applicant: Gilead Sciences, Inc.

Inventor： Gayatri Balan ,  Peter A. Blomgren ,  Chen Chen ,  Julian A. Codelli ,  Zhimin Du ,  Musong Kim ,  Dorothée Saddier Axe ,  Gregg M. Schwarzwalder ,  Rhiannon Thomas-Tran ,  Michael T. Tudesco ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Brian M. Weist ,  Suet C. Yeung ,  Helen Yu

IPC: C07D401/04

CPC classification number: C07D401/04 ,  C07B2200/05 ,  C07D401/04 ,  C07B2200/05

Abstract: The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

公开(公告)号：US20230312490A1

公开(公告)日：2023-10-05

申请号：US18181336

申请日：2023-03-09

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Tae H. Hwang ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  John E. Knox ,  Scott E. Lazerwith ,  Xiaofen Li ,  David W. Lin ,  Jonathan W. Medley ,  Michael L. Mitchell ,  Devan Naduthambi ,  Zachary Newby ,  Neil H. Squires ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang

IPC: C07D267/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04

CPC classification number: C07D267/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61K45/06

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US20230203069A1

公开(公告)日：2023-06-29

申请号：US18061375

申请日：2022-12-02

Applicant: Gilead Sciences, Inc.

Inventor： Julie Farand ,  Michael Graupe ,  Tezcan Guney ,  Darryl Kato ,  Jiayao Li ,  John O. Link ,  James B. C. Mack ,  Dong Min Mun ,  Roland D. Saito ,  William J. Watkins ,  Jennifer R. Zhang

IPC: C07F9/09

CPC classification number: C07F9/095

Abstract: The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions provided herein may be used for the treatment or prevention of a Retroviridae infection, including an HIV infection.

公开(公告)号：US11643400B2

公开(公告)日：2023-05-09

申请号：US17171201

申请日：2021-02-09

Applicant: Gilead Sciences, Inc.

Inventor： Hang Chu ,  Juan A. Guerrero ,  Anna E. Hurtley ,  Tae H. Hwang ,  Lan Jiang ,  Darryl Kato ,  Tetsuya Kobayashi ,  John E. Knox ,  Scott E. Lazerwith ,  Xiaofen Li ,  David W. Lin ,  Jonathan W. Medley ,  Michael L. Mitchell ,  Devan Naduthambi ,  Zachary Newby ,  Neil H. Squires ,  Vickie H. Tsui ,  Chandrasekar Venkataramani ,  William J. Watkins ,  Hong Yang

IPC: C07D513/08 ,  A61K31/553 ,  C07D267/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61K45/06

CPC classification number: C07D267/20 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D498/04 ,  A61K45/06

Abstract: The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.

公开(公告)号：US20220204491A1

公开(公告)日：2022-06-30

申请号：US17534951

申请日：2021-11-24

Applicant: Gilead Sciences, Inc.

Inventor： Peter A. Blomgren ,  Kevin S. Currie ,  Morin Mae Frick ,  Elizabeth M. Horstman ,  Joshua A. Kaplan ,  Jeffrey E. Kropf ,  William J. Watkins

IPC: C07D413/14 ,  A61P1/16

Abstract: The present disclosure relates generally to compounds that bind to FXR and act as agonists of FXR. The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds and to a process for the synthesis of said compounds.

公开(公告)号：US11021467B2

公开(公告)日：2021-06-01

申请号：US14735244

申请日：2015-06-10

Applicant: Gilead Sciences, Inc.

Inventor： Shaopei Cai ,  Zhimin Du ,  Musong Kim ,  Jennifer A. Loyer-Drew ,  Devan Naduthambi ,  Leena Patel ,  Barton W. Phillips ,  Gary Phillips ,  Kirk L. Stevens ,  Jennifer Anne Treiberg ,  Joshua Van Veldhuizen ,  William J. Watkins ,  Suet Chung Yeung

IPC: C07D403/12 ,  C07D401/14 ,  C07D403/14 ,  C07D473/34 ,  C07D487/04 ,  C07D513/04 ,  C07D405/14 ,  C07D413/14 ,  C07D471/04

Abstract: The present application provides the compounds of formula (J), or pharmaceutically acceptable salts, isomers, tautomer, or a mixture thereof, wherein n, W, A′, B′, R1, R2, and R3 are described herein. The compounds are inhibitors to the activities of phosphatidylinositol 3-kinase (PI3K) and are useful for treating conditions mediated by one or more PI3K isoforms. The present application further provides pharmaceutical compositions that include a compound of formula (I), or pharmaceutically acceptable salts, isomers, tautomer, or mixture thereof, and methods of using these compounds and compositions for treating conditions mediated by one or more PI3K isoforms.