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    Neisserial antigenic peptides
    81.
    发明授权
    Neisserial antigenic peptides 有权
    Neisserial抗原肽

    公开(公告)号：US08734812B1

    公开(公告)日：2014-05-27

    申请号：US10111983

    申请日：2000-10-30

    申请人： Cesira Galeotti ,  Guido Grandi ,  Vega Masignani ,  Mariarosa Mora ,  Mariagrazia Pizza ,  Rino Rappuoli ,  Guilio Ratti ,  Vincenzo Scarlato ,  Maria Scarselli

    发明人： Cesira Galeotti ,  Guido Grandi ,  Vega Masignani ,  Mariarosa Mora ,  Mariagrazia Pizza ,  Rino Rappuoli ,  Guilio Ratti ,  Vincenzo Scarlato ,  Maria Scarselli

    IPC分类号： A61K39/095 ,  A61K39/02 ,  A61K39/00 ,  A61K38/00

    CPC分类号： A61K39/095 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/55505 ,  C07K14/22

    摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto (e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.

    摘要翻译： 本发明尤其提供衍生自脑膜炎奈瑟氏球菌B的细菌的蛋白质，多肽和其片段。还提供了编码这种蛋白质，多肽和/或片段的核酸，以及与其互补的核酸（例如， ，反义核酸）。 另外，本发明提供了结合蛋白质，多肽和/或片段的抗体。 本发明进一步提供了可用于制备蛋白质，多肽和/或片段以及用这些载体转化的宿主细胞的表达载体。 本发明还提供用作疫苗，诊断试剂，免疫原性组合物等的蛋白质，多肽，片段和/或核酸的组合物。 还提供了用组合物制备组合物和处理方法的方法。 本发明还提供了检测蛋白质，多肽，片段和/或核酸的方法。

    IMMUNOGENIC COMPOSITIONS
    84.
    发明申请
    IMMUNOGENIC COMPOSITIONS 审中-公开
    免疫组化

    公开(公告)号：US20130273091A1

    公开(公告)日：2013-10-17

    申请号：US13824041

    申请日：2011-09-16

    申请人： Francesco Berti ,  Mario Contorni ,  Paolo Costantino ,  Oretta Finco ,  Guido Grandi ,  Domenico Maione ,  John Telford

    发明人： Francesco Berti ,  Mario Contorni ,  Paolo Costantino ,  Oretta Finco ,  Guido Grandi ,  Domenico Maione ,  John Telford

    IPC分类号： A61K39/385

    CPC分类号： A61K39/385 ,  A61K39/092 ,  A61K47/6415 ,  A61K47/646 ,  A61K2039/6037 ,  A61K2039/627

    摘要： The invention provides an immunogenic composition comprising: a) a conjugate that is a capsular saccharide from GBS serotype 1a conjugated to a carrier protein; b) a conjugate that is a capsular saccharide from GBS serotype 1b conjugated to a carrier protein; and c) a conjugate that is a capsular saccharide from GBS serotype III conjugated to a carrier protein. The invention also provides a method for immunising a patient against infection by GBS comprising the step of administering to the patient a conjugate that is a capsular saccharide from GBS conjugated to a diphtheria toxoid or derivative thereof, wherein the patient has been pre-immunised with a diphtheria toxoid or derivative thereof.

    摘要翻译： 本发明提供免疫原性组合物，其包含：a）缀合物，其是与载体蛋白缀合的GBS血清型1a的荚膜糖; b）缀合物，其是与载体蛋白质缀合的GBS血清型1b的荚膜糖; 和c）缀合物，其是与载体蛋白质缀合的GBS血清型III的荚膜糖。 本发明还提供了一种用于免疫患者免受GBS感染的方法，包括向患者施用作为与白喉类毒素或其衍生物缀合的GBS的荚膜糖的缀合物的步骤，其中所述患者已经用 白喉类毒素或其衍生物。