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    METHOD FOR SYNTHESIZING CONFORMATIONALLY CONSTRAINED PEPTIDES, PEPTIDOMIMETICS AND THE USE THEREOF AS SYNTHETIC VACCINES
    81.
    发明申请
    METHOD FOR SYNTHESIZING CONFORMATIONALLY CONSTRAINED PEPTIDES, PEPTIDOMIMETICS AND THE USE THEREOF AS SYNTHETIC VACCINES 审中-公开
    用于合成受约束的肽，肽衍生物及其作为合成疫苗的用途的方法

    公开(公告)号：US20110008414A9

    公开(公告)日：2011-01-13

    申请号：US12499500

    申请日：2009-07-08

    申请人： Gerd Pluschke ,  Ursula Kienzl ,  John Robinson ,  Rinaldo Zurbriggen

    发明人： Gerd Pluschke ,  Ursula Kienzl ,  John Robinson ,  Rinaldo Zurbriggen

    IPC分类号： A61K39/002 ,  A61K9/127 ,  A61P31/00

    CPC分类号： G01N33/56911 ,  A61K38/00 ,  A61K39/00 ,  A61K39/015 ,  C07K7/56 ,  C07K16/205 ,  Y02A50/412 ,  Y02A50/58

    摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S, 4S)4-functionalized proline residue. The invention further relates to the use of (2S, 4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.

    摘要翻译： 本发明涉及通过这些方法获得的构象约束肽和循环肽模拟物的方法，其由于内部交联而被构象约束。 这种交联在氨基酸残基或类似物的侧链与（2S，4S）4-官能化的脯氨酸残基之间形成。 本发明还涉及（2S，4S）-4-官能化的脯氨酸残基作为构建单元在合成这种肽模拟物中的用途，以及其作为抗原的单独使用或与合适的免疫增强递送系统组合的用途，例如免疫增强重建 流感病毒体引起哺乳动物的免疫反应。 此外，本发明还涉及含有该组合物的药物组合物。

    Programmable, multi-spectral, image-capture environment
    84.
    发明授权
    Programmable, multi-spectral, image-capture environment 有权
    可编程，多光谱，图像捕获环境

    公开(公告)号：US07603031B1

    公开(公告)日：2009-10-13

    申请号：US11167540

    申请日：2005-06-27

    申请人： George Viaud ,  Ken Budris ,  Doug Canfield ,  Dennis DaSilva ,  Jim Dornbusch ,  John Robinson

    发明人： George Viaud ,  Ken Budris ,  Doug Canfield ,  Dennis DaSilva ,  Jim Dornbusch ,  John Robinson

    IPC分类号： G03B15/03 ,  H04N5/222 ,  A61B6/00

    CPC分类号： G03B15/03 ,  A61B5/0059 ,  A61B5/441 ,  G03B7/16 ,  G03B2215/0557

    摘要： A multi-flash photography system provides a dynamically-configurable lighting environment for a single exposure that is created and shaped through the sequentially firing of various light sources with different lighting characteristics controlled in accordance with both a programmed template specifying the flash type, position, firing order, and output intensity, as well as optical processing requirements such as filtering, polarizing, etc., and a shared photometric detector located sufficiently close to the subject being photographed to ensure that the light seen by the detector is substantially the same as the light received at the subject.

    摘要翻译： 多闪光摄影系统为单次曝光提供动态可配置的照明环境，通过依次指定闪光灯类型，位置，发射的编程模板控制不同照明特性的各种光源的顺序点火 顺序和输出强度以及诸如滤波，偏振等的光学处理要求，以及与被拍摄的物体充分接近的共享光度检测器，以确保检测器所看到的光基本上与光线相同 收到的主题。

    Method for synthesizing conformationally constrained peptides, peptidomimetics and the use thereof as synthetic vaccines
    85.
    发明授权
    Method for synthesizing conformationally constrained peptides, peptidomimetics and the use thereof as synthetic vaccines 失效
    合成约束肽，肽模拟物及其作为合成疫苗的用途的方法

    公开(公告)号：US07569541B2

    公开(公告)日：2009-08-04

    申请号：US10559010

    申请日：2004-06-02

    申请人： Gerd Pluschke ,  Ursula Kienzl ,  John Robinson ,  Rinaldo Zurbriggen

    发明人： Gerd Pluschke ,  Ursula Kienzl ,  John Robinson ,  Rinaldo Zurbriggen

    IPC分类号： A61K38/12

    CPC分类号： G01N33/56911 ,  A61K38/00 ,  A61K39/00 ,  A61K39/015 ,  C07K7/56 ,  C07K16/205 ,  Y02A50/412 ,  Y02A50/58

    摘要： The present invention relates to methods for synthesizing conformationally constrained peptides and cyclic peptidomimetics obtainable by these methods which are conformationally constrained due an internal cross-link. This cross-link is formed between the side chain of an amino acid residue or analog and a (2S, 4S)4-functionalized proline residue. The invention further relates to the use of (2S, 4S)-4-functionalized proline residues as building units in the synthesis of such peptidomimetics and to the use thereof as antigens, alone or in combination with suitable immunopotentiating delivery systems, for example immunopotentiating reconstituted influenza virosomes to elicit an immune response in a mammal. Moreover, the invention also relates to pharmaceutical compositions containing the same.

    摘要翻译： 本发明涉及通过这些方法获得的构象约束肽和循环肽模拟物的方法，其由于内部交联而被构象约束。 这种交联在氨基酸残基或类似物的侧链与（2S，4S）4-官能化的脯氨酸残基之间形成。 本发明还涉及（2S，4S）-4-官能化的脯氨酸残基作为构建单元在合成这种肽模拟物中的用途，以及其作为抗原的单独使用或与合适的免疫增强递送系统组合的用途，例如免疫增强重建 流感病毒体引起哺乳动物的免疫反应。 此外，本发明还涉及含有该组合物的药物组合物。

    POLYMERIC MATERIALS
    86.
    发明申请
    POLYMERIC MATERIALS 审中-公开
    聚合材料

    公开(公告)号：US20090092827A1

    公开(公告)日：2009-04-09

    申请号：US12299022

    申请日：2007-05-01

    申请人： John Robinson

    发明人： John Robinson

    IPC分类号： B32B27/32 ,  B32B27/00 ,  C09D171/10 ,  C09D127/12

    CPC分类号： C08G65/4012 ,  C08G2650/40 ,  C08L27/12 ,  C08L27/18 ,  C08L71/00 ,  C09D171/10 ,  Y10T428/273 ,  Y10T428/3154 ,  C08L2666/04

    摘要： An assembly comprises a part for example a part of an item of cookware, bakeware, domestic appliance or the like which is subjected to a wear means in use such that the wear means may abrade the outer surface of the part. The part is provided with an outer surface which comprises a polyaryletherketone polymer, especially polyetheretherketone, and a fluoropolymer. Such a combination is found to exhibit superior wear properties over other known materials.

    摘要翻译： 组件包括例如炊具，烤盘，家用电器等的一部分的部件，其经受使用中的磨损装置，使得磨损装置可能磨损部件的外表面。 该部件设置有包含聚芳醚酮聚合物，特别是聚醚醚酮和含氟聚合物的外表面。 发现这种组合与其它已知材料相比表现出优异的耐磨性。

    METHOD AND SYSTEM FOR OPTIMIZING ALIGNMENT PERFORMANCE IN A FLEET OF EXPOSURE TOOLS
    87.
    发明申请
    METHOD AND SYSTEM FOR OPTIMIZING ALIGNMENT PERFORMANCE IN A FLEET OF EXPOSURE TOOLS 有权
    在接触工具中优化对准性能的方法和系统

    公开(公告)号：US20080073589A1

    公开(公告)日：2008-03-27

    申请号：US11686871

    申请日：2007-03-15

    申请人： Michael Adel ,  John Robinson ,  Pavel Izikson ,  Brad Eichelberger ,  Amir Widmann ,  Atsuhiko Kato

    发明人： Michael Adel ,  John Robinson ,  Pavel Izikson ,  Brad Eichelberger ,  Amir Widmann ,  Atsuhiko Kato

    IPC分类号： G21K5/10

    CPC分类号： G03F7/70458 ,  G03F7/70525 ,  G03F7/706 ,  G03F9/7046

    摘要： A method for optimizing alignment performance in a fleet of exposure systems involves characterizing each exposure system in a fleet of exposure systems to generate a set of distinctive distortion profiles associated with each exposure system. The set of distinctive distortion profiles are stored in a database. A wafer having reference pattern formed thereon is provided for further pattern fabrication and an exposure system is selected from the fleet to fabricate a next layer on the wafer. Linear and higher order parameters of the selected exposure system are adjusted using the distinctive distortion profiles to model the distortion of the reference pattern. Once the exposure system is adjusted, it is used to form a lithographic pattern on the wafer.

    摘要翻译： 用于优化曝光系统队列中的对准性能的方法涉及表征曝光系统中的每个曝光系统，以产生与每个曝光系统相关联的一组独特的失真曲线。 一组有特色的失真简档存储在数据库中。 提供具有形成在其上的参考图案的晶片用于进一步的图案制造，并且从车队中选择曝光系统以在晶片上制造下一层。 使用不同的失真曲线来调整所选曝光系统的线性和高阶参数以对参考图案的失真进行建模。 一旦调整曝光系统，就用于在晶片上形成平版印刷图案。

    Tri-state control for an electronic faucet
    89.
    发明申请
    Tri-state control for an electronic faucet 审中-公开
    电子龙头的三态控制

    公开(公告)号：US20070138421A1

    公开(公告)日：2007-06-21

    申请号：US11312136

    申请日：2005-12-20

    申请人： Jeffrey Gibson ,  John Robinson ,  Jeffrey Iott ,  Jeffrey Belz

    发明人： Jeffrey Gibson ,  John Robinson ,  Jeffrey Iott ,  Jeffrey Belz

    IPC分类号： F16K31/02

    CPC分类号： E03C1/057

    摘要： An electronic faucet includes a control that has at least three different modes of operation. The control has an auto or normal mode of operation where fluid flows for a predetermined amount of time when a sensor detects an object adjacent to the electronic faucet. The control has an “off” mode where system electronics are disabled such that fluid cannot flow, and the control has an “on” mode where fluid is constantly flowing. A mechanical or electronic selector is selectively actuated to place the control in one of the auto, off, or on modes.

    摘要翻译： 电子水龙头包括具有至少三种不同操作模式的控制。 当传感器检测到与电子水龙头相邻的物体时，控制器具有自动或正常操作模式，其中流体流动预定时间量。 控制器具有“关闭”模式，其中禁用系统电子设备，使得流体不能流动，并且控制器具有流体不断流动的“开”模式。 选择性地致动机械或电子选择器以将控制置于自动，关闭或打开模式之一中。

    Tandem gate release mechanism for a vending machine
    90.
    发明申请
    Tandem gate release mechanism for a vending machine 有权
    用于自动售货机的串联门释放机构

    公开(公告)号：US20070084877A1

    公开(公告)日：2007-04-19

    申请号：US11249376

    申请日：2005-10-14

    申请人： Richard Albert ,  Dan Bowen ,  Bryan Collins ,  Aron Lewis ,  Paul Miller ,  Charles Percy ,  John Robinson ,  William Roe ,  Russell Watts

    发明人： Richard Albert ,  Dan Bowen ,  Bryan Collins ,  Aron Lewis ,  Paul Miller ,  Charles Percy ,  John Robinson ,  William Roe ,  Russell Watts

    IPC分类号： G07F11/16

    CPC分类号： G07F11/16

    摘要： A vending machine includes first and second integrated dispensing systems mounted at front portions of adjacent product shelf dividers establishing at least first, second and third product queues. Each of the first and second dispensing systems includes first and second release mechanisms having a plurality of hinged plates supported by a frame. The plurality of hinged plates are selectively shifted into and out of corresponding ones of the first, second and third product queues, such that each product queue has associated therewith two opposing release mechanisms. Preferably, at least one of the first and second release mechanisms for each dispensing system includes a queue spacing member which is mounted to one of the hinged plates and projects into the product queue to establish a desired spacing between the release mechanisms.

    摘要翻译： 自动售货机包括安装在相邻产品货架隔板的前部的第一和第二集成分配系统，其建立至少第一，第二和第三产品排队。 第一和第二分配系统中的每一个包括具有由框架支撑的多个铰接板的第一和第二释放机构。 多个铰接板选择性地移入和移出第一，第二和第三产品队列中的相应的一个，使得每个产品队列具有与其相对的两个相对的释放机构。 优选地，用于每个分配系统的第一和第二释放机构中的至少一个包括队列间隔构件，其被安装到铰链板中的一个并且突出到产品队列中以在释放机构之间建立期望的间隔。