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公开(公告)号:US5834239A
公开(公告)日:1998-11-10
申请号:US825782
申请日:1997-04-08
申请人: Jennifer L. Hillman , Surya K. Goli
发明人: Jennifer L. Hillman , Surya K. Goli
CPC分类号: C07K14/4702 , A61K38/00
摘要: The present invention provides a human cofactor A-like protein (COAPR) and polynucleotides which identify and encode COAPR. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of COAPR.
摘要翻译: 本发明提供鉴定和编码COAPR的人辅因子A样蛋白(COAPR)和多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供了治疗与COAPR表达相关的疾病的方法。
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公开(公告)号:US5831018A
公开(公告)日:1998-11-03
申请号:US801972
申请日:1997-02-18
摘要: The present invention provides a human cytochrome b5 (HCB5) and polynucleotides which encode HCB5. The invention also provides genetically engineered expression vectors and host cells and a method for producing HCB5. The invention also provides for agonists, antisense molecules, antibodies, or antagonists of HCB5, and their use in the prevention and treatment of diseases associated with expression of HCB5. The invention also provides a method for detecting polynucleotides which encode HCB5.
摘要翻译: 本发明提供人细胞色素b5(HCB5)和编码HCB5的多核苷酸。 本发明还提供基因工程表达载体和宿主细胞以及生产HCB5的方法。 本发明还提供HCB5的激动剂,反义分子,抗体或拮抗剂及其在预防和治疗与HCB5表达有关的疾病中的用途。 本发明还提供了一种检测编码HCB5的多核苷酸的方法。
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公开(公告)号:US06531575B1
公开(公告)日:2003-03-11
申请号:US09546306
申请日:2000-04-10
申请人: Olga Bandman , Jennifer L. Hillman , Surya K. Goli
发明人: Olga Bandman , Jennifer L. Hillman , Surya K. Goli
IPC分类号: C07K100
摘要: The present invention provides two ATP synthase subunits (designated individually as Asy-1 and Asy-2, and collectively as Asy) and polynucleotides which identify and encode Asy. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Asy and a method for producing Asy. The invention also provides for use of Asy and agonists, antibodies, or antagonists specifically binding Asy, in the prevention and treatment of diseases associated with expression of Asy. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Asy for the treatment of diseases associated with the expression of Asy. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Asy.
摘要翻译: 本发明提供两个ATP合成酶亚单位(分别命名为Asy-1和Asy-2,统称为Asy)和识别和编码Asy的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞,其包含编码Asy的核酸序列和产生Asy的方法。 本发明还提供了用于预防和治疗与Asy表达相关的疾病的Asy和特异性结合Asy的激动剂,抗体或拮抗剂。 另外,本发明提供反义分子用于编码Asy的多核苷酸用于治疗与Asy表达相关的疾病。 本发明还提供利用多核苷酸或其片段或其互补体和特异性结合Asy的抗体的诊断测定法。
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公开(公告)号:US06207148B1
公开(公告)日:2001-03-27
申请号:US09272796
申请日:1999-03-19
申请人: Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
发明人: Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
IPC分类号: A61K3843
CPC分类号: C12N9/1205 , A61K38/00
摘要: The invention provides human disease associated protein kinases and polynucleotides (collectively designated DAPK) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing and treating disorders associated with expression of human disease associated protein kinases.
摘要翻译: 本发明提供了识别和编码它们的人类疾病相关蛋白激酶和多核苷酸(统称为DAPK)。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供用于诊断和治疗与人类疾病相关蛋白激酶的表达相关的疾病的方法。
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公开(公告)号:US6156523A
公开(公告)日:2000-12-05
申请号:US153939
申请日:1998-09-16
申请人: Olga Bandman , Y. Tom Tang , Surya K. Goli , Neil C. Corley , Karl J. Guegler , Gina A. Gorgone , Jennifer L. Hillman
发明人: Olga Bandman , Y. Tom Tang , Surya K. Goli , Neil C. Corley , Karl J. Guegler , Gina A. Gorgone , Jennifer L. Hillman
IPC分类号: C12N15/09 , A61K38/00 , A61K38/45 , A61K45/00 , A61P1/00 , A61P1/18 , A61P3/00 , A61P3/10 , A61P5/14 , A61P5/38 , A61P7/06 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P25/00 , A61P25/08 , A61P27/02 , A61P27/06 , A61P27/12 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P37/08 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/12 , C12N15/54 , C12Q1/68 , A61K38/43 , C07K14/00 , C12N9/00 , C12N15/52 , G01N23/53
CPC分类号: C12N9/1205 , C12Y207/01037 , A61K38/00
摘要: The invention provides human serine/threonine protein kinases (HSTK) and polynucleotides which identify and encode HSTK. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating or preventing disorders associated with expression of HSTK.
摘要翻译: 本发明提供人丝氨酸/苏氨酸蛋白激酶(HSTK)和识别和编码HSTK的多核苷酸。 本发明还提供表达载体,宿主细胞,抗体,激动剂和拮抗剂。 本发明还提供用于诊断,治疗或预防与HSTK表达相关的病症的方法。
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公开(公告)号:US6110722A
公开(公告)日:2000-08-29
申请号:US66049
申请日:1998-04-24
申请人: Jennifer L. Hillman , Surya K. Goli
发明人: Jennifer L. Hillman , Surya K. Goli
CPC分类号: C12N9/14
摘要: The present invention provides a human ATP synthase subunit (ASYS) and polynucleotides which encode ASYS. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing ASYS and for treating disorders associated with expression of ASYS.
摘要翻译: 本发明提供了人ATP合酶亚基(ASYS)和编码ASYS的多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,反义分子,抗体或拮抗剂。 本发明还提供了用于产生ASYS和用于治疗与ASYS表达相关的疾病的方法。
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公开(公告)号:US6103874A
公开(公告)日:2000-08-15
申请号:US133735
申请日:1998-08-13
申请人: Olga Bandman , Jennifer L. Hillman , Surya K. Goli
发明人: Olga Bandman , Jennifer L. Hillman , Surya K. Goli
IPC分类号: G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/06 , A61P5/14 , A61P43/00 , C07K14/705 , C07K16/28 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/566 , C07K14/00 , A61K38/16 , C07H21/04
CPC分类号: C07K14/705 , A61K38/00
摘要: The present invention provides a novel human KDEL receptor (NHKR) and polynucleotides which identify and encode NHKR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHKR and a method for producing NHKR. The invention also provides for agonists, antibodies, or antagonists specifically binding NHKR, and their use, in the prevention and treatment of diseases associated with expression of NHKR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHKR for the treatment of diseases associated with the expression of NHKR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHKR.
摘要翻译: 本发明提供了一种新的人KDEL受体(NHKR)和识别并编码NHKR的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞,其包含编码NHKR的核酸序列和生产NHKR的方法。 本发明还提供了特异性结合NHKR的激动剂,抗体或拮抗剂及其在预防和治疗与NHKR表达相关的疾病中的用途。 另外,本发明提供了反义分子用于编码NHKR的多核苷酸用于治疗与NHKR表达有关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHKR的抗体的诊断测定法。
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公开(公告)号:US06060297A
公开(公告)日:2000-05-09
申请号:US842976
申请日:1997-04-17
申请人: Jennifer L. Hillman , Surya K. Goli
发明人: Jennifer L. Hillman , Surya K. Goli
CPC分类号: C07K14/4722 , A61K38/00
摘要: The present invention provides a human Rho protein (HRHO) and polynucleotides which identify and encode HRHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing HRHO and for treating or preventing disorders associated with expression of HRHO.
摘要翻译: 本发明提供了人类Rho蛋白(HRHO)和识别和编码HRHO的多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 此外,本发明提供了用于产生HRHO和用于治疗或预防与HRHO表达相关的病症的方法。
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公开(公告)号:US6034063A
公开(公告)日:2000-03-07
申请号:US231258
申请日:1999-01-15
申请人: Jennifer L. Hillman , Surya K. Goli
发明人: Jennifer L. Hillman , Surya K. Goli
IPC分类号: C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68
摘要: The invention provides a new human phosphatidylinositol transfer protein gamma (PITP.gamma.) and polynucleotides which identify and encode PITP.gamma.. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of PITP.gamma..
摘要翻译: 本发明提供了新的人磷脂酰肌醇转移蛋白γ(PITPγ)和识别和编码PITPγ的多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供了治疗与PITPγ的表达相关的疾病的方法。
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公开(公告)号:US6020478A
公开(公告)日:2000-02-01
申请号:US808148
申请日:1997-02-28
申请人: Jennifer L. Hillman , Surya K. Goli , Hong Zhang
发明人: Jennifer L. Hillman , Surya K. Goli , Hong Zhang
IPC分类号: G01N33/53 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/705 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12Q1/68 , G01N33/566 , G01N33/574 , C07H21/04
CPC分类号: G01N33/57492 , C07K14/4748 , A61K38/00 , A61K48/00 , G01N2333/705
摘要: The present invention provides a human tumor-associated antigen (PRAT) and polynucleotides which identify and encode PRAT. In addition, the invention provides expression vectors and host cells, agonists, antibodies, and antagonists. The invention also provides methods for treating disorders associated with the expression of PRAT.
摘要翻译: 本发明提供了人肿瘤相关抗原(PRAT)和识别和编码PRAT的多核苷酸。 此外,本发明提供表达载体和宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供了治疗与PRAT表达相关的疾病的方法。
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