Polynucleotides encoding a cofactor A-like protein
    81.
    发明授权
    Polynucleotides encoding a cofactor A-like protein 失效
    编码辅因子A样蛋白的多核苷酸

    公开(公告)号:US5834239A

    公开(公告)日:1998-11-10

    申请号:US825782

    申请日:1997-04-08

    CPC分类号: C07K14/4702 A61K38/00

    摘要: The present invention provides a human cofactor A-like protein (COAPR) and polynucleotides which identify and encode COAPR. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of COAPR.

    摘要翻译: 本发明提供鉴定和编码COAPR的人辅因子A样蛋白(COAPR)和多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 本发明还提供了治疗与COAPR表达相关的疾病的方法。

    Human cytochrome B5
    82.
    发明授权
    Human cytochrome B5 失效
    人细胞色素B5

    公开(公告)号:US5831018A

    公开(公告)日:1998-11-03

    申请号:US801972

    申请日:1997-02-18

    CPC分类号: C07K14/80 A61K38/00

    摘要: The present invention provides a human cytochrome b5 (HCB5) and polynucleotides which encode HCB5. The invention also provides genetically engineered expression vectors and host cells and a method for producing HCB5. The invention also provides for agonists, antisense molecules, antibodies, or antagonists of HCB5, and their use in the prevention and treatment of diseases associated with expression of HCB5. The invention also provides a method for detecting polynucleotides which encode HCB5.

    摘要翻译: 本发明提供人细胞色素b5(HCB5)和编码HCB5的多核苷酸。 本发明还提供基因工程表达载体和宿主细胞以及生产HCB5的方法。 本发明还提供HCB5的激动剂,反义分子,抗体或拮抗剂及其在预防和治疗与HCB5表达有关的疾病中的用途。 本发明还提供了一种检测编码HCB5的多核苷酸的方法。

    ATP synthase subunits
    83.
    发明授权
    ATP synthase subunits 失效
    ATP合酶亚基

    公开(公告)号:US06531575B1

    公开(公告)日:2003-03-11

    申请号:US09546306

    申请日:2000-04-10

    IPC分类号: C07K100

    CPC分类号: C12N9/14 A61K38/00

    摘要: The present invention provides two ATP synthase subunits (designated individually as Asy-1 and Asy-2, and collectively as Asy) and polynucleotides which identify and encode Asy. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Asy and a method for producing Asy. The invention also provides for use of Asy and agonists, antibodies, or antagonists specifically binding Asy, in the prevention and treatment of diseases associated with expression of Asy. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Asy for the treatment of diseases associated with the expression of Asy. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Asy.

    摘要翻译: 本发明提供两个ATP合成酶亚单位(分别命名为Asy-1和Asy-2,统称为Asy)和识别和编码Asy的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞,其包含编码Asy的核酸序列和产生Asy的方法。 本发明还提供了用于预防和治疗与Asy表达相关的疾病的Asy和特异性结合Asy的激动剂,抗体或拮抗剂。 另外,本发明提供反义分子用于编码Asy的多核苷酸用于治疗与Asy表达相关的疾病。 本发明还提供利用多核苷酸或其片段或其互补体和特异性结合Asy的抗体的诊断测定法。

    F.sub.0 ATP synthase subunit
    86.
    发明授权
    F.sub.0 ATP synthase subunit 失效
    F0 ATP合酶亚基

    公开(公告)号:US6110722A

    公开(公告)日:2000-08-29

    申请号:US66049

    申请日:1998-04-24

    CPC分类号: C12N9/14

    摘要: The present invention provides a human ATP synthase subunit (ASYS) and polynucleotides which encode ASYS. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for producing ASYS and for treating disorders associated with expression of ASYS.

    摘要翻译: 本发明提供了人ATP合酶亚基(ASYS)和编码ASYS的多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,反义分子,抗体或拮抗剂。 本发明还提供了用于产生ASYS和用于治疗与ASYS表达相关的疾病的方法。

    Human KDEL receptor
    87.
    发明授权
    Human KDEL receptor 失效
    人类KDEL受体

    公开(公告)号:US6103874A

    公开(公告)日:2000-08-15

    申请号:US133735

    申请日:1998-08-13

    CPC分类号: C07K14/705 A61K38/00

    摘要: The present invention provides a novel human KDEL receptor (NHKR) and polynucleotides which identify and encode NHKR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHKR and a method for producing NHKR. The invention also provides for agonists, antibodies, or antagonists specifically binding NHKR, and their use, in the prevention and treatment of diseases associated with expression of NHKR. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHKR for the treatment of diseases associated with the expression of NHKR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHKR.

    摘要翻译: 本发明提供了一种新的人KDEL受体(NHKR)和识别并编码NHKR的多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞,其包含编码NHKR的核酸序列和生产NHKR的方法。 本发明还提供了特异性结合NHKR的激动剂,抗体或拮抗剂及其在预防和治疗与NHKR表达相关的疾病中的用途。 另外,本发明提供了反义分子用于编码NHKR的多核苷酸用于治疗与NHKR表达有关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHKR的抗体的诊断测定法。

    Rho protein
    88.
    发明授权
    Rho protein 失效
    Rho蛋白

    公开(公告)号:US06060297A

    公开(公告)日:2000-05-09

    申请号:US842976

    申请日:1997-04-17

    CPC分类号: C07K14/4722 A61K38/00

    摘要: The present invention provides a human Rho protein (HRHO) and polynucleotides which identify and encode HRHO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing HRHO and for treating or preventing disorders associated with expression of HRHO.

    摘要翻译: 本发明提供了人类Rho蛋白(HRHO)和识别和编码HRHO的多核苷酸。 本发明还提供表达载体,宿主细胞,激动剂,抗体和拮抗剂。 此外,本发明提供了用于产生HRHO和用于治疗或预防与HRHO表达相关的病症的方法。