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90 条记录 (耗时 0.046 秒)

    Family of high affinity, modified antibodies for cancer treatment
    85.
    发明授权
    Family of high affinity, modified antibodies for cancer treatment 失效
    高亲和力家族，用于癌症治疗的修饰抗体

    公开(公告)号：US06207815B1

    公开(公告)日：2001-03-27

    申请号：US08479285

    申请日：1995-06-07

    申请人： Peter S. Mezes ,  Brian B. Gourlie ,  Mark W. Rixon ,  Jeffrey Schlom ,  Donald A. Kaplan ,  W. H. Kerr Anderson

    发明人： Peter S. Mezes ,  Brian B. Gourlie ,  Mark W. Rixon ,  Jeffrey Schlom ,  Donald A. Kaplan ,  W. H. Kerr Anderson

    IPC分类号： C12N1514

    CPC分类号： C07K16/462 ,  A61K38/00 ,  A61K47/6877 ,  A61K51/1087 ,  A61K2123/00 ,  C07K16/30 ,  C07K2317/24 ,  C07K2319/00

    摘要： This invention concerns a family of chimeric antibodies with high affinities to a high molecular weight, tumor-associated sialylated glycoprotein antigen (TAG-72) of human origin. These antibodies have (1) high affinity animal VH and VL sequences which mediate TAG-72 binding and (2) human CH and CL regions. They are thought to produce significantly fewer side-effects when administered to human patients by virtue of their human CH and CL antibody domains. The nucleotide and amino acid sequences of VH&agr;TAG VH, CC46 VH, CC49H, CC83 VH, and CC92 VH, and CC49L, CC83 VL, and CC92 VL idiotype sequences are disclosed, as well as in vivo methods of treatment and diagnostic assay using these chimeric antibodies.

    摘要翻译： 本发明涉及对人类高分子量肿瘤相关唾液酸化糖蛋白抗原（TAG-72）具有高亲和力的嵌合抗体家族。 这些抗体具有（1）介导TAG-72结合的高亲和力动物VH和VL序列，（2）人CH和CL区。 据认为，由于其人类CH和CL抗体结构域，当向人类患者施用时，它们会产生显着较少的副作用。 公开了VHαphaVV，CC46VH，CC49H，CC83VV和CC92VV，CC49L，CC83VL和CC92VV独立型序列的核苷酸和氨基酸序列，以及使用这些嵌合体的体内治疗和诊断测定方法 抗体。

    Monoclonal antibodies reactive with human breast cancer
    90.
    发明授权
    Monoclonal antibodies reactive with human breast cancer 失效
    与人乳腺癌反应的单克隆抗体

    公开(公告)号：US4612282A

    公开(公告)日：1986-09-16

    申请号：US707400

    申请日：1985-03-01

    申请人： Jeffrey Schlom ,  David Colcher ,  Marianna Nuti ,  Patricia H. Hand ,  Faye Austin

    发明人： Jeffrey Schlom ,  David Colcher ,  Marianna Nuti ,  Patricia H. Hand ,  Faye Austin

    IPC分类号： A61K38/00 ,  A61K51/10 ,  C07K16/30 ,  C12P21/00 ,  C12N5/00 ,  C12N15/00

    CPC分类号： C07K16/3015 ,  A61K51/1051 ,  A61K2123/00 ,  A61K38/00 ,  Y10S435/96

    摘要： Monoclonal antibodies demonstrating a reactivity with human breast cancer are produced. The hybridoma cultures secreting immunoglobins are produced by hydridoma technology. Splenic lymphocytes of mice, immunized with membrane-enriched fractions of metastatic human mammary carcinoma tissue are fused with the NS-1 non-immunoglobulin-secreting murine myeloma cell line. Screening of immunoglobulin reactivities and double cloning of cultures yielded 11 monoclonal antibodies that demonstrated activities with the surface of human mammary tumor cells and not with the surface of apparently normal human tissues. These monoclonal antibodies aid in the diagnosis, prognosis and treatment of human breast cancer.

    摘要翻译： 产生显示与人乳腺癌反应性的单克隆抗体。 分泌免疫球蛋白的杂交瘤培养物是通过胶体技术产生的。 用转移性人乳腺癌组织的膜富集部分免疫的小鼠的脾淋巴细胞与NS-1非免疫球蛋白分泌的小鼠骨髓瘤细胞系融合。 免疫球蛋白反应性的筛选和双克隆培养物产生了11种单克隆抗体，其表现出与人乳腺肿瘤细胞表面的活性，而不是表面上正常人组织的表面。 这些单克隆抗体有助于人乳腺癌的诊断，预后和治疗。