公开(公告)号：US12077742B2

公开(公告)日：2024-09-03

申请号：US16853865

申请日：2020-04-21

Applicant: Life Technologies Corporation

Inventor： Nephi D. Jones ,  Christopher D. Brau

IPC: C12M1/06 ,  B01F27/1111 ,  B01F27/191 ,  B01F27/2111 ,  B01F35/41 ,  B01F35/513 ,  B01F101/44 ,  C12M1/00 ,  C12M1/02 ,  C12N1/00

CPC classification number: C12M27/02 ,  B01F27/1111 ,  B01F27/191 ,  B01F27/2111 ,  B01F35/4121 ,  B01F35/513 ,  C12M1/007 ,  C12M1/02 ,  C12M23/14 ,  C12N1/00 ,  B01F2101/44

Abstract: A method for mixing a biological suspension includes disposing a biological suspension within a compartment of a container, the biological suspension comprising cells or microorganisms suspended within a nutrient growth medium; and rotating a first drive line and laterally spaced apart second drive line within the compartment of the container so as to cause the drive lines to twist into a helical configuration and mix the biological suspension.

公开(公告)号：US11865475B2

公开(公告)日：2024-01-09

申请号：US17521445

申请日：2021-11-08

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Scott P. Collins ,  Christopher D. Brau ,  Nephi D. Jones

IPC: B01D11/04 ,  B01F31/00 ,  B01F31/60 ,  B01F33/80 ,  G01N1/34 ,  G01N1/40

CPC classification number: B01D11/0423 ,  B01D11/043 ,  B01D11/0449 ,  B01D11/0457 ,  B01F31/56 ,  B01F31/60 ,  B01F33/80 ,  G01N1/34 ,  G01N2001/4061

Abstract: A sample purification system includes a mixing zone; a settling zone in fluid communication with the mixing zone; a mixer element disposed in the mixing zone, the mixer element being configured to mix immiscible liquids to form a mixture; and a first acoustic wave settler configured to emit an acoustic wave into the mixture.

公开(公告)号：US11833259B2

公开(公告)日：2023-12-05

申请号：US17086723

申请日：2020-11-02

Applicant: Life Technologies Corporation

Inventor： Michael E. Goodwin ,  Nephi D. Jones ,  Bradley H. Buchanan

IPC: A61L2/00 ,  B01D17/06 ,  G01N23/00 ,  A61L2/08 ,  A61L2/26

CPC classification number: A61L2/087 ,  A61L2/007 ,  A61L2/26

Abstract: A method for collecting a sterilized fluid includes passing a fluid through an inlet stem and into a chamber of a storage container so that the fluid collects within the chamber of the storage container; and applying a beam of radiation to the inlet stem so that the beam of radiation passes through the inlet stem and through at least a portion of the fluid passing through the inlet stem, the beam of radiation at least partially sterilizing the fluid passing through the inlet stem and into the chamber of the storage container.

公开(公告)号：US11173417B2

公开(公告)日：2021-11-16

申请号：US16819951

申请日：2020-03-16

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Scott P. Collins ,  Christopher D. Brau ,  Nephi D. Jones

IPC: B01D11/04 ,  B01F11/00 ,  B01F13/10 ,  G01N1/34 ,  G01N1/40

Abstract: A sample purification system includes a container assembly bounding a sample purification compartment and having an upper end and an opposing lower end, the sample purification compartment comprising mixing zones and settling zones. A plurality of shielding elements are positioned within the sample purification compartment so as to at least partially separate adjacent mixing zones and settling zones or separate adjacent mixing zones, the mixing zones being in fluid communication with the settling zones. A mixing element is disposed within each mixing zone. An acoustic wave settler is aligned with a portion of the container assembly, the acoustic wave settler being configured to emit an acoustic wave through the portion of the container assembly and a mixture disposed therein, the acoustic wave coalescing fluid phase droplets disposed in the mixture to increase the buoyancy or density of the fluid phase droplets.

公开(公告)号：US20210046200A1

公开(公告)日：2021-02-18

申请号：US17086723

申请日：2020-11-02

Applicant: Life Technologies Corporation

Inventor： Michael E. Goodwin ,  Nephi D. Jones ,  Bradley H. Buchanan

IPC: A61L2/08 ,  A61L2/00 ,  A61L2/26

Abstract: A method for collecting a sterilized fluid includes passing a fluid through an inlet stem and into a chamber of a storage container so that the fluid collects within the chamber of the storage container; and applying a beam of radiation to the inlet stem so that the beam of radiation passes through the inlet stem and through at least a portion of the fluid passing through the inlet stem, the beam of radiation at least partially sterilizing the fluid passing through the inlet stem and into the chamber of the storage container.

公开(公告)号：US10898870B2

公开(公告)日：2021-01-26

申请号：US15799580

申请日：2017-10-31

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jeffery C. Hurd ,  Nephi D. Jones ,  Jacob D. Lee

IPC: B01F7/00 ,  B01F15/00 ,  B01F3/04 ,  C12M1/06 ,  C12M1/00 ,  C12M1/34

Abstract: A liquid mixing system includes a support housing at least partially bounding a compartment. A mount is secured to the support housing. A drive motor assembly is configured to engage a drive shaft for moving the drive shaft within the compartment of the support housing. A four bar linkage system extends between the mount and the drive motor assembly, the four bar linkage system being movable between a first position wherein the drive motor assembly is disposed at a first elevation and a second position wherein the drive motor assembly is disposed at a second elevation that is different from the first elevation.

公开(公告)号：US10821197B2

公开(公告)日：2020-11-03

申请号：US16233403

申请日：2018-12-27

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Michael E. Goodwin ,  Nephi D. Jones ,  Bradley H. Buchanan

IPC: A61L2/26 ,  A61L2/08 ,  A61L2/00

Abstract: A container includes a first wall and an opposing second wall that extend between a first end and an opposing second end, a first fluid flow path being bounded between the first wall and the second wall. An inlet is formed at the first end and communicates with the first fluid flow path. An outlet is formed at the second end and communicates with the first fluid flow path. The first wall includes a primary wall portion having a first opening extending therethrough in alignment with the first fluid flow path. A secondary wall portion extends over the first opening and is secured to the primary wall portion so as to seal the first opening closed, the secondary wall portion being comprised of a film having a thickness that is less than a thickness of the primary wall portion.

公开(公告)号：US10688429B2

公开(公告)日：2020-06-23

申请号：US14587976

申请日：2014-12-31

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Jason D. Brown ,  Clinton C. Staheli ,  Nephi D. Jones

IPC: B01D46/00 ,  C12M1/00 ,  B01F3/04 ,  C12M1/12 ,  B01F7/16 ,  B01F7/18 ,  B01F7/00 ,  B01F15/00 ,  C12M1/06

Abstract: A filter assembly includes a casing having of a polymeric film and bounding a compartment, the casing having an inlet opening communicating with the compartment and a first outlet opening communicating with the compartment. A first filter includes a porous filter body through which gas can pass and has a pore size smaller than 1 μm, the first filter being coupled with the casing so that the filter body is at least partially disposed within compartment of the casing and so that gas passing through the compartment of the casing from the inlet opening to the first outlet opening must pass through the filter body.

公开(公告)号：US10669515B2

公开(公告)日：2020-06-02

申请号：US15392906

申请日：2016-12-28

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Nephi D. Jones ,  Christopher D. Brau

IPC: B01F7/00 ,  C12M1/06 ,  B01F15/00 ,  C12M1/00

Abstract: A fluid mixing system includes a container bounding a compartment and extending between a first end and an opposing second end. An elongated first drive line and second drive line are disposed within the compartment of the container and are rotatable therein. At least one tie extends between the first drive line and the second drive line so as to maintain at least a portion of the first drive line and the second drive line at lateral spaced apart positions within the compartment. An impeller or other mixing element can be coupled to the drive lines.

公开(公告)号：US10328404B2

公开(公告)日：2019-06-25

申请号：US15596952

申请日：2017-05-16

Applicant: Life Technologies Corporation

Inventor： Michael E. Goodwin ,  Nephi D. Jones ,  Jeremy K. Larsen

IPC: B01F15/00 ,  B01F3/04 ,  C12M1/00 ,  B01F5/04 ,  B01F13/02 ,  B01F7/00 ,  B01F7/22 ,  C12M1/04 ,  C12M1/12 ,  B01F11/00

Abstract: A container system includes a collapsible bag having an interior surface at least partially bounding a chamber, the chamber being adapted to hold a fluid. A sparger is disposed within the chamber of the bag, the sparger bounding a compartment and having an inside edge that encircles an opening passing through the sparger. At least a portion of the sparger is gas permeable. A tubular member is coupled to the sparger and is in communication with the compartment. A shaft passes into the chamber of the bag and through the opening of the sparger. A mixing element is secured to the shaft and is disposed within the chamber of the bag.