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289 条记录 (耗时 0.042 秒)

    Method for electrostatic coating of a stent
    81.
    发明授权
    Method for electrostatic coating of a stent 有权
    支架静电涂敷方法

    公开(公告)号：US08821958B2

    公开(公告)日：2014-09-02

    申请号：US13600125

    申请日：2012-08-30

    申请人： Cameron K. Kerrigan ,  Stephen D. Pacetti

    发明人： Cameron K. Kerrigan ,  Stephen D. Pacetti

    IPC分类号： A61L33/00 ,  A61K9/50 ,  B05D1/04 ,  A61F2/06 ,  A61L31/16 ,  A61L31/14

    CPC分类号： A61L31/08 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/606 ,  A61L2420/02 ,  B05D1/007

    摘要： A method for electrostatic coating of medical devices such as stents and balloons is described. The method includes applying a composition to a polymeric component of a medical device which has little or no conductivity. The polymeric component could be a material from which the body or a strut of the stent is made or could be a polymeric coating pre-applied on the stent. The polymeric component could be the balloon wall. A charge can then be applied to the polymeric component or the polymeric component can be grounded. Charged particles of drugs, polymers, biobeneficial agents, or any combination of these can then be electrostatically deposited on the medical device or the coating on the medical device. One example of the composition is iodine, iodine, iodide, iodate, a complex or salt thereof which can also impart imaging capabilities to the medical device.

    摘要翻译： 描述了诸如支架和气囊的医疗装置的静电涂覆方法。 该方法包括将组合物施用于具有很少或不具有导电性的医疗器械的聚合物组分。 聚合物组分可以是制造支架的主体或支柱的材料，或者可以是预先施加在支架上的聚合物涂层。 聚合物组分可以是球囊壁。 然后可以向聚合物组分施加电荷，或者聚合物组分可以接地。 药物，聚合物，生物有益剂或它们的任何组合的带电颗粒然后可以静电沉积在医疗装置或医疗装置上的涂层上。 组合物的一个实例是碘，碘，碘化物，碘酸盐，其复合物或盐，其也可以赋予医疗装置成像能力。

    Direct fluid coating of drug eluting balloon
    84.
    发明授权
    Direct fluid coating of drug eluting balloon 有权
    直接液体涂层药物洗脱球囊

    公开(公告)号：US08632837B2

    公开(公告)日：2014-01-21

    申请号：US13108283

    申请日：2011-05-16

    申请人： Victoria M. Gong ,  Stephen D. Pacetti ,  Anthony S. Andreacchi ,  Shih-hsiung Albert Yuan

    发明人： Victoria M. Gong ,  Stephen D. Pacetti ,  Anthony S. Andreacchi ,  Shih-hsiung Albert Yuan

    IPC分类号： B03D3/02 ,  A61M25/10 ,  B05B7/16

    CPC分类号： A61L29/08 ,  A61M25/1027 ,  B05D1/002 ,  B05D1/26 ,  B05D3/0254

    摘要： A system and method for coating an expandable member of a medical device comprises providing a dispenser in fluid communication with a fluid source with the dispenser having at least one outlet to dispense fluid of the fluid source therefrom. The outlet(s) of the dispenser is positioned proximate a surface of an expandable member, with relative movement between the outlet(s) and the surface of the expandable member established along a coating path, and fluid is dispensed from the dispenser to form a substantially continuous bead of fluid between the at least one outlet and the surface of the expandable member along the coating path, and simultaneously drying the fluid while dispensing the fluid from the dispenser to control flow of fluid on the surface of the expandable member. The fluid source can include a variety of therapeutic agents.

    摘要翻译： 用于涂覆医疗装置的可扩张构件的系统和方法包括提供与流体源流体连通的分配器，分配器具有至少一个出口，用于从其中分配流体源的流体。 分配器的出口定位在可扩张构件的表面附近，其中出口与沿着涂覆路径建立的可膨胀构件的表面之间的相对运动，并且流体从分配器分配以形成 在所述至少一个出口和所述可扩张构件的所述表面之间沿着所述涂覆路径的基本上连续的流体珠，并且同时干燥所述流体，同时从所述分配器分配所述流体以控制所述可膨胀构件的表面上的流体的流动。 流体源可以包括各种治疗剂。

    System for coating a stent
    85.
    发明授权
    System for coating a stent 有权
    支架涂层系统

    公开(公告)号：US08573148B2

    公开(公告)日：2013-11-05

    申请号：US12554671

    申请日：2009-09-04

    申请人： Stephen D. Pacetti ,  Laura Melton Kalvass

    发明人： Stephen D. Pacetti ,  Laura Melton Kalvass

    IPC分类号： B05C13/00 ,  B05D3/00

    CPC分类号： B05C11/00 ,  A61F2/82 ,  A61L2420/02 ,  B05B13/0442 ,  B05D1/002

    摘要： A systems and method for reducing coating defects on a stent may involve a support apparatus comprising wire cage for carrying a stent. The support apparatus may have no structure that extends inside the stent. A support apparatus may include a plurality of wires that pass through the stent but do not pass through the midplane of the stent. A support apparatus may contact only the proximal ends of the stent. The method may involve keeping the stent in motion during a spray coating process to prevent the stent from having a point remain in continuous contact with a support apparatus.

    摘要翻译： 用于减少支架上的涂层缺陷的系统和方法可以涉及包括用于承载支架的线架的支撑装置。 支撑装置可以没有在支架内部延伸的结构。 支撑装置可以包括穿过支架但不穿过支架的中平面的多根线。 支撑装置可以仅接触支架的近端。 该方法可以包括在喷雾涂覆过程期间保持支架运动，以防止支架保持与支撑装置的连续接触。

    Polymeric coating for reducing the rate of release of a therapeutic substance from a stent
    89.
    发明授权
    Polymeric coating for reducing the rate of release of a therapeutic substance from a stent 有权
    用于降低治疗物质从支架释放速率的聚合物涂层

    公开(公告)号：US08303651B1

    公开(公告)日：2012-11-06

    申请号：US09948513

    申请日：2001-09-07

    申请人： Stephen D. Pacetti

    发明人： Stephen D. Pacetti

    IPC分类号： A61F2/06

    CPC分类号： A61L31/16 ,  A61L31/10 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2420/08

    摘要： A stent for delivery of a therapeutic agent is disclosed. The stent includes a polymer coating for reducing the rate of release of the therapeutic agent. The polymer has a crystalline structure wherein the polymer is capable of significantly maintaining the crystalline lattice structure while the therapeutic agent is released from the stent such that the aqueous environment to which the stent is exposed subsequent to the implantation of the stent does not significantly convert the crystalline lattice structure of the polymer to an amorphous structure.

    摘要翻译： 公开了用于递送治疗剂的支架。 支架包括用于降低治疗剂释放速率的聚合物涂层。 聚合物具有结晶结构，其中聚合物能够显着地保持结晶晶格结构，同时治疗剂从支架中释放，使得在支架植入之后支架暴露的水性环境不会显着地转化为 聚合物的晶格结构为非晶结构。

    Suction Pump And Apparatus For Loading Material Into A Stent Strut
    90.
    发明申请
    Suction Pump And Apparatus For Loading Material Into A Stent Strut 有权
    吸入泵和用于将材料装载到支架中的装置

    公开(公告)号：US20120216914A1

    公开(公告)日：2012-08-30

    申请号：US13035819

    申请日：2011-02-25

    申请人： Stephen D. Pacetti

    发明人： Stephen D. Pacetti

    IPC分类号： B65B31/04

    CPC分类号： A61F2/91 ,  A61F2240/001 ,  A61F2250/0068 ,  B65B31/044

    摘要： An apparatus for loading material into a stent strut can comprise a suction pump connected to an opening to a lumen within the stent strut. The stent strut is immersed in the material. As the suction pump draws gas out of the lumen, the material is drawn into side openings to the lumen.

    摘要翻译： 用于将材料装载到支架支柱中的装置可以包括连接到支架支架内的内腔的开口的抽吸泵。 将支架支柱浸入材料中。 当抽吸泵将气体从管腔中抽出时，材料被吸入管腔的侧面开口。