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256 条记录 (耗时 0.033 秒)

    Polypeptide analogs of apolipoprotein E, diagnostic systems and methods using the analogs
    82.
    发明授权
    Polypeptide analogs of apolipoprotein E, diagnostic systems and methods using the analogs 失效
    载脂蛋白E的多肽类似物，诊断系统和使用类似物的方法

    公开(公告)号：US5473039A

    公开(公告)日：1995-12-05

    申请号：US805193

    申请日：1991-12-09

    申请人： Cheryl A. Dyer ,  Linda K. Curtiss ,  Richard Smith

    发明人： Cheryl A. Dyer ,  Linda K. Curtiss ,  Richard Smith

    IPC分类号： A61K38/00 ,  C07K14/775 ,  C07K16/18 ,  C07K7/00 ,  C07K7/06 ,  C07K7/08

    CPC分类号： C07K16/18 ,  C07K14/775 ,  A61K38/00

    摘要： The present invention contemplates a multimeric polypeptide capable of mimicking the ability of apo E to induce differentiated cellular function. The repeating unit of the polypeptide has an amino acid residue sequence corresponding to that represented by the formula LRXLRKRLLX. Also contemplated is a method for treating hypercholesterolemia in a patient, which method comprises administering to the patient an LDL plasma concentration-reducing amount of the polypeptide. Described as well, is the use of the polypeptide in preparing diagnostic antibodies, and their use in diagnostic systems and methods for detecting apo E antigens in vascular body fluids.

    摘要翻译： 本发明考虑了能够模拟载脂蛋白E诱导分化的细胞功能的能力的多聚体多肽。 多肽的重复单元具有与由式LRXLRKRLLX表示的氨基酸残基相对应的氨基酸残基。 还考虑了用于治疗患者的高胆固醇血症的方法，该方法包括向患者施用LDL血浆浓度降低量的多肽。 还描述了多肽在制备诊断抗体中的用途，以及它们在用于检测血管体液中的载脂蛋白E抗原的诊断系统和方法中的用途。

    Surgical anastomosis stapling instrument
    84.
    发明授权
    Surgical anastomosis stapling instrument 失效
    手术吻合吻合器械

    公开(公告)号：US5275322A

    公开(公告)日：1994-01-04

    申请号：US10682

    申请日：1993-01-28

    申请人： Ronald J. Brinkerhoff ,  Rudolph H. Nobis ,  Helmut Wolf ,  Federico Bilotti ,  William Fox ,  Mark S. Zeiner ,  E. David Allen ,  Richard Smith ,  Jerome Reckelhoff ,  Philip Churchill ,  Richard Grant ,  Roger Hildwein ,  J. David Hughett ,  Clifton Coles ,  W. Thompson Lawrence

    发明人： Ronald J. Brinkerhoff ,  Rudolph H. Nobis ,  Helmut Wolf ,  Federico Bilotti ,  William Fox ,  Mark S. Zeiner ,  E. David Allen ,  Richard Smith ,  Jerome Reckelhoff ,  Philip Churchill ,  Richard Grant ,  Roger Hildwein ,  J. David Hughett ,  Clifton Coles ,  W. Thompson Lawrence

    IPC分类号： A61B20060101 ,  A61B17/115 ,  A61B17/28 ,  A61B17/068

    CPC分类号： A61B17/115 ,  A61B17/1155 ,  A61B2017/07257 ,  A61B2017/2905 ,  A61B2017/2919

    摘要： A surgical stapling instrument for performing a circular anastomosis stapling operation is provided. The surgical instrument includes a stapling head assembly mounted by a curved shaft to an actuator handle assembly and incorporates an improved actuator mechanism for transmitting the required operating forces and movements from the actuator handle assembly through the curved shaft to an anvil and staple driver of the stapling head assembly. The stapling head assembly includes a longitudinally movable trocar detachably secured by one or more retainer clips on a hollow shaft of the anvil. When the trocar is retracted, the anvil shaft slides into a central support tube which aligns the anvil axially and circumferentially with a staple holder on the stapling head assembly. The retainer clips are locked against the trocar by the support tube and transmit tension from the trocar to the anvil with no tension load on the anvil shaft. The actuator mechanism permits adjustment of the anvil gap to produce a desired staple height and precludes actuation of the staple head assembly if the anvil gap is set outside of a predetermined range. Also, the actuator mechanism is adapted to both advance and retract the staple driver relative to the staple holder in the stapling head assembly. Further, an improved arrangement for attaching the support shaft to the stapling head assembly and to the actuator handle assembly is provided.

    摘要翻译： 提供了一种用于执行圆形吻合缝合操作的外科缝合器械。 手术器械包括一个装订头组件，该装订头组件通过弯曲的轴安装到致动器手柄组件上并且包括改进的致动器机构，用于将所需的操作力和从致动器手柄组件通过弯曲轴的运动传递到钉子的砧座和缝钉驱动器 头组件。 缝合头组件包括可由一个或多个保持夹固定在砧座的空心轴上的可纵向移动的套管针。 当套管针缩回时，砧座轴滑入中心支撑管，该中心支撑管使砧座轴向和周向与钉在钉头组件上的缝钉保持架对准。 保持夹通过支撑管锁定在套针针上，并将张力从套管针传递到砧座，在砧座轴上没有张力负载。 致动器机构允许调整砧座间隙以产生期望的钉高度，并且如果砧座间隙设定在预定范围之外，则阻止钉头组件的致动。 此外，致动器机构适于相对于缝合头组件中的缝钉保持器使订书钉驱动器前进和缩回。 此外，提供了一种用于将支撑轴附接到装订头组件和致动器手柄组件的改进的布置。

    Breathing apparatus
    85.
    发明授权
    Breathing apparatus 失效
    呼吸设备

    公开(公告)号：US5241955A

    公开(公告)日：1993-09-07

    申请号：US784393

    申请日：1991-12-31

    申请人： Peter T. Dearman ,  Richard Smith

    发明人： Peter T. Dearman ,  Richard Smith

    IPC分类号： A61M16/00

    CPC分类号： A61M16/00

    摘要： A breathing apparatus is described for supplying pulses of a breathable gas to a patient; the apparatus comprises a gas inlet (10) connectable to a source of breathable gas, an outlet (37) connectable to provide gas to the patient, a gas flow passage (14,15,34,36) extending between the inlet and the outlet, a main valve (16) located in the gas flow passage for interrupting the flow of gas to the outlet, a throttle (38) in the flow passage downstream of the main valve, a gas reservoir (42) and a valved duct (40,44) connected to supply gas to the reservoir from the part of the flow passage between the main valve and the throttle; the main valve includes a piston (24) that is slidable within a cylinder (22) to open and close the gas flow passage, which piston is biassed in one direction by a resilient member (28) and biassed in the other direction by the gas pressure within the reservoir. When the main valve is open and gas flows from the source to the patient, gas leaks into the reservoir along valved duct (40,44), thereby increasing the pressure in the reservoir (42); this continues until the pressure in the reservoir is sufficient to overcome the spring (28) when the piston moves to close off the gas flow passage. Gas can leak via the valved duct (40, 44) into the flow passage until the pressure in the reservoir falls to a level that allows the spring to move the piston to re-open the flow passage.

    摘要翻译： PCT No.PCT / GB91 / 00019 Sec。 371日期1991年12月31日 102（e）1991年12月31日PCT PCT 1991年1月7日PCT公布。 出版物WO91 / 10463 日期为1991年7月25日。描述了一种呼吸器，用于向患者提供可呼吸气体的脉冲; 该设备包括可连接到可呼吸气体源的气体入口（10），可连接以向患者提供气体的出口（37），在入口和出口之间延伸的气体流动通道（14,15,34,36） ，位于气体流路中的主阀（16），用于中断到出口的气体流动，主阀下游的流动通道中的节流阀（38），气体储存器（42）和阀管道（40） ，44），其连接到从所述主阀和所述节流阀之间的所述流动通道的所述部分向所述储存器供应气体; 主阀包括可在气缸（22）内滑动以打开和关闭气体流动通道的活塞（24），所述活塞通过弹性构件（28）在一个方向上被偏压，并且通过气体在另一方向上被偏压 水库内的压力。 当主阀打开并且气体从源流向患者时，气体沿着阀门管道（40,44）泄漏到储存器中，从而增加储存器（42）中的压力; 这继续直到当活塞移动以关闭气体流动通道时，储存器中的压力足以克服弹簧（28）。 气体可以通过阀门管道（40,44）泄漏到流动通道中，直到储存器中的压力下降到允许弹簧移动活塞以重新打开流动通道的水平。