公开(公告)号：US10004831B2

公开(公告)日：2018-06-26

申请号：US15598544

申请日：2017-05-18

申请人： South Dakota Board of Regents ,  SANFORD HEALTH

发明人： Gopinath Mani ,  Sujan Lamichhane ,  Jordan Anderson ,  Tyler Remund ,  Patrick W. Kelly

IPC分类号： A61L29/08 ,  A61L29/16 ,  A61L31/10 ,  A61M25/10

CPC分类号： A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/608 ,  A61L2420/02 ,  A61L2420/06 ,  A61L2420/08 ,  A61M25/10 ,  A61M2025/105

摘要： The present invention provides formulations comprising polymers and therapeutics and methods for their manufacture. The present invention also provides medical devices coated with such formulations and methods for their manufacture. The drug-loaded polymer formulations, solutions, and films tailor the drug release characteristics for medical devices.

公开(公告)号：US20180140772A1

公开(公告)日：2018-05-24

申请号：US15876865

申请日：2018-01-22

申请人： Sanford Health

发明人： Patrick W. Kelly

IPC分类号： A61M5/172 ,  A61B5/0215 ,  A61M5/142 ,  A61M25/00 ,  A61M25/10 ,  A61M25/04

CPC分类号： A61M25/003 ,  A61B5/0215 ,  A61B5/02158 ,  A61B5/6852 ,  A61M5/142 ,  A61M5/1723 ,  A61M25/0068 ,  A61M25/007 ,  A61M25/0075 ,  A61M25/04 ,  A61M25/10 ,  A61M2005/1726 ,  A61M2025/0002 ,  A61M2025/0004 ,  A61M2025/0037 ,  A61M2025/0039 ,  A61M2025/004 ,  A61M2025/0175 ,  A61M2025/1045 ,  A61M2205/3379 ,  A61M2230/30

摘要： An apparatus and methods for use are provided, where the apparatus includes: (a) a first catheter having a proximal end and a distal end, and wherein a distal portion of the first catheter includes a first one or more outlets, (b) a first tubular housing having a proximal end and a distal end, wherein the first tubular housing is coupled to the first catheter proximal to the at least one first outlet, (c) one or more pressure sensors coupled to the distal end of the first tubular housing, and (d) a second catheter having a proximal end and a distal end, wherein a distal portion of the second catheter includes a second one or more outlets, and wherein the distal end of the second catheter is configured to be positioned substantially within one of (i) the first catheter or (ii) a second tubular housing coupled to one or more of the first catheter and the first tubular housing, when the second catheter is in a first position.

公开(公告)号：US20170014252A1

公开(公告)日：2017-01-19

申请号：US15214199

申请日：2016-07-19

申请人： Sanford Health

发明人： Patrick W. Kelly

IPC分类号： A61F2/95 ,  A61B17/34 ,  A61M25/00

CPC分类号： A61F2/95 ,  A61B17/3417 ,  A61B17/3468 ,  A61B2017/3454 ,  A61F2/07 ,  A61M25/0068 ,  A61M25/0069 ,  A61M25/0074 ,  A61M25/008 ,  A61M2025/0024 ,  A61M2025/0079 ,  A61M2025/1093

摘要： The present disclosure provides a catheter tip comprising a flexible housing comprising a cavity extending between an expandable opening arranged at a first end of the catheter tip and a second end of the catheter tip, wherein the expandable opening is configured to increase in diameter from a first position to a second position in response to application of an external force to the second end of the flexible housing.

摘要翻译： 本公开提供了一种导管末端，其包括柔性壳体，其包括在布置在导管尖端的第一端处的可扩张开口和导管末端的第二端之间延伸的腔，其中可扩张开口构造成从第一 响应于向柔性壳体的第二端施加外力而将其定位到第二位置。

公开(公告)号：US20160256302A1

公开(公告)日：2016-09-08

申请号：US15059124

申请日：2016-03-02

申请人： Sanford Health

发明人： Patrick W. Kelly

IPC分类号： A61F2/95 ,  A61F2/07

CPC分类号： A61F2/95 ,  A61F2/07 ,  A61F2/954 ,  A61F2002/061 ,  A61F2002/065 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/9505 ,  A61F2002/9522 ,  A61M25/09033 ,  A61M2025/09175 ,  A61M2025/09183

摘要： The present disclosure provides an apparatus comprising (a) a guide wire having a first end and a second end, (b) an affixing harness coupled to the guide wire, the affixing harness having at least one projection extending towards the first end of the guide wire, (c) a plurality of alignment strings having a first end and a second end, where the first end of each of the plurality of alignment strings is removably coupled to the at least one projection of the affixing harness, and (d) an affixing shield removably coupled to at least one of the affixing harness and the guide wire, wherein the affixing shield is movably positioned over the at least one projection of the affixing harness.

摘要翻译： 本公开提供了一种装置，包括（a）具有第一端和第二端的导丝，（b）连接到导丝的固定线束，固定线束具有朝向导向件的第一端延伸的至少一个突起 （c）具有第一端和第二端的多个对准线，其中，所述多个对准线中的每一个的第一端可移除地联接到所述固定线束的所述至少一个突出部，以及（d） 固定屏蔽可移除地联接到固定线束和引导线中的至少一个，其中固定屏蔽件可移动地定位在固定线束的至少一个突起上方。

公开(公告)号：US20160151182A9

公开(公告)日：2016-06-02

申请号：US14244134

申请日：2014-04-03

申请人： Sanford Health

发明人： Patrick W. Kelly

IPC分类号： A61F2/954

CPC分类号： A61F2/954 ,  A61M25/04 ,  A61M25/09 ,  A61M2025/09125

摘要： An anchoring guidewire and methods for use, where the anchoring guidewire comprises: (a) an outer core, (b) an anchoring basket, (c) a steerable tip, and (d) an actuator core. The outer core, the anchoring basket and the steerable tip are axially aligned with one another. Further, the actuator core may be movably disposed within both the outer core and the anchoring basket and may be coupled to the steerable tip.

公开(公告)号：US20150209135A1

公开(公告)日：2015-07-30

申请号：US14636249

申请日：2015-03-03

申请人： Sanford Health

发明人： Patrick W. Kelly

IPC分类号： A61F2/07

CPC分类号： A61F2/07 ,  A61F2/064 ,  A61F2/852 ,  A61F2/88 ,  A61F2002/061 ,  A61F2002/8486 ,  A61F2220/0008 ,  A61F2220/0033 ,  A61F2230/0091 ,  A61F2250/0039 ,  A61F2250/0069

摘要： Example stent grafts and methods for placement thereof are provided. An example stent graft may include (a) a main body stent graft defining a lumen having an inlet defined at a proximal end of the main body stent graft and having an outlet defined at a distal end of the main body stent graft, (b) a visceral-vessel opening defined in a sidewall of the main body stent graft between the proximal end and the distal end of the main body stent graft, (c) a diaphragm disposed within the lumen of the main body stent graft and coupled to the main body stent graft, wherein a first renal inlet, a second renal inlet, an infrarenal inlet and a visceral inlet are defined in the diaphragm and (d) a visceral chamber defined by a sidewall coupled to the visceral inlet and to the visceral-vessel opening.

摘要翻译： 提供示例性支架移植物及其放置方法。 示例性支架移植物可以包括（a）主体支架移植物，其限定具有限定在主体覆膜支架的近端处的入口的内腔，并且具有限定在主体支架移植物的远端处的出口，（b） 限定在主体覆膜支架的侧壁中的内脏血管开口，其位于主体支架移植物的近端和远端之间，（c）隔膜，其设置在主体支架移植物的内腔内并联接到主体 其中在所述隔膜中限定第一肾进入口，第二肾入口，肾下入口和内脏入口，以及（d）由与所述内脏入口和内脏血管开口连接的侧壁限定的内脏室 。

公开(公告)号：US20150157446A1

公开(公告)日：2015-06-11

申请号：US14625506

申请日：2015-02-18

申请人： Sanford Health

发明人： Patrick W. Kelly

IPC分类号： A61F2/07 ,  A61F2/954

CPC分类号： A61F2/07 ,  A61F2/848 ,  A61F2/852 ,  A61F2/856 ,  A61F2/95 ,  A61F2/954 ,  A61F2002/061 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2002/9522 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/001 ,  A61F2230/006 ,  A61F2250/006 ,  A61F2250/0062 ,  A61F2250/0098

摘要： A visceral double-barreled main body stent graft and methods for its use, the stent graft comprises, a main body stent graft having distal and proximal ends, the main body stent graft's length ranges from about 100-120 mm and diameter at the proximal end ranges from about 30-45 mm, first and second lumens defined at the main body stent graft's distal end, the first lumen's diameter ranges from about 18-20 mm, the second lumen's diameter ranges from about 16-18 mm, the first and second lumens have about the same length from about 50-70 mm, the first lumen is secured to the second lumen along a shared length, and the main body stent graft defines a tubular wall that is contiguous with the first and second lumens such that any fluid entering the main body must exit through one of the first or second lumens.

摘要翻译： 内脏双管主体支架移植物及其使用方法，支架移植物包括：具有远端和近端的主体支架移植物，主体支架移植物的长度范围为约100-120mm，近端直径 在主体支架移植物的远端限定的约30-45mm的第一和第二腔，第一腔的直径范围为约18-20mm，第二腔的直径范围为约16-18mm，第一和第二 内腔具有约50-70mm的大约相同的长度，第一内腔沿着共同的长度固定到第二腔，并且主体支架移植物限定与第一和第二腔相邻的管状壁，使得任何流体 进入主体必须通过第一或第二流明之一排出。

公开(公告)号：US20140172064A1

公开(公告)日：2014-06-19

申请号：US14104849

申请日：2013-12-12

申请人： Sanford Health

发明人： Patrick W. Kelly

IPC分类号： A61F2/07 ,  A61F2/95

CPC分类号： A61F2/07 ,  A61F2/95 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2250/0037 ,  A61F2250/0039

摘要： A combination double-barreled and debranching stent graft and methods for its use, where the stent graft comprises, a main body stent graft defining a single lumen with distal and proximal ends, a first bifurcation in the main body defining first and second lumens, the main body stent graft defines a tubular wall that is contiguous with the first and second lumens such that any fluid entering the main body stent graft must exit by entering one of the first or second lumens, (c) a second bifurcation within the first lumen defining a first leg and a second leg, (d) a third bifurcation within the first leg defining a third leg and a fourth leg, and (e) a fourth bifurcation within the second leg between about 10 mm and about 20 mm distal from the second bifurcation defining a fifth leg and a sixth leg.

摘要翻译： 一种组合双筒和脱支的支架移植物及其使用的方法，其中支架移植物包括：主体支架移植物，其限定具有远端和近端的单个腔，主体中的第一分叉限定第一和第二腔， 主体支架移植物限定与第一和第二内腔邻接的管状壁，使得进入主体支架移植物的任何流体必须通过进入第一或第二内腔之一而退出，（c）第一管腔内的第二分叉， （d）在所述第一腿部内限定第三腿部和第四腿部的第三分叉，以及（e）所述第二腿部中的距离所述第二腿部的距离的距离在约10mm和约20mm之间的第四分叉 分叉定义第五条腿和第六条腿。

公开(公告)号：US20130274850A1

公开(公告)日：2013-10-17

申请号：US13706086

申请日：2012-12-05

申请人： SANFORD HEALTH

发明人： Patrick W. Kelly

IPC分类号： A61F2/07 ,  A61F2/95

CPC分类号： A61F2/07 ,  A61F2/848 ,  A61F2/852 ,  A61F2/856 ,  A61F2/95 ,  A61F2/954 ,  A61F2002/061 ,  A61F2002/065 ,  A61F2002/067 ,  A61F2002/072 ,  A61F2002/075 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2002/9522 ,  A61F2220/0025 ,  A61F2220/005 ,  A61F2220/0058 ,  A61F2220/0075 ,  A61F2230/001 ,  A61F2230/006 ,  A61F2250/006 ,  A61F2250/0062 ,  A61F2250/0098

摘要： A visceral double-barreled main body stent graft and methods for its use, the stent graft comprises, a main body stent graft having distal and proximal ends, the main body stent graft's length ranges from about 100-120 mm and diameter at the proximal end ranges from about 30-45 mm, first and second lumens defined at the main body stent graft's distal end, the first lumen's diameter ranges from about 18-20 mm, the second lumen's diameter ranges from about 16-18 mm, the first and second lumens have about the same length from about 50-70 mm, the first lumen is secured to the second lumen along a shared length, and the main body stent graft defines a tubular wall that is contiguous with the first and second lumens such that any fluid entering the main body must exit through one of the first or second lumens.

摘要翻译： 内脏双管主体支架移植物及其使用方法，支架移植物包括：具有远端和近端的主体支架移植物，主体支架移植物的长度范围为约100-120mm，近端直径 在主体支架移植物的远端限定的约30-45mm的第一和第二腔，第一腔的直径范围为约18-20mm，第二腔的直径范围为约16-18mm，第一和第二 内腔具有约50-70mm的大约相同的长度，第一内腔沿着共同的长度固定到第二腔，并且主体支架移植物限定与第一和第二腔相邻的管状壁，使得任何流体 进入主体必须通过第一或第二流明之一排出。