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102 条记录 (耗时 0.037 秒)

    ACYLGLYCEROL ACETYLTRANSFERASE-LIKE PROTEIN MGAT-X1 AND USES THEREOF
    81.
    发明申请
    ACYLGLYCEROL ACETYLTRANSFERASE-LIKE PROTEIN MGAT-X1 AND USES THEREOF 失效
    ACYLGLYCEROL乙酰胆碱酯酶蛋白MGAT-X1及其用途

    公开(公告)号：US20110086013A1

    公开(公告)日：2011-04-14

    申请号：US12854524

    申请日：2010-08-31

    申请人： Stefan Golz ,  Ulf Brüggemeier ,  Bernhard Weingärtner ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Brüggemeier ,  Bernhard Weingärtner ,  Andreas Geerts

    IPC分类号： A61K38/45 ,  C12N9/10 ,  C12N9/96

    CPC分类号： C07K16/40 ,  C12N9/1029

    摘要： The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明涉及新的酰基甘油酰基转移酶样蛋白MGAT-X1的多核苷酸序列。 本发明还提供了与皮肤病，泌尿疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或胃肠疾病有关的人MGAT-X1。 本发明还提供了用于鉴定可用于调节皮肤病，泌尿系统疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或用于治疗这些疾病的胃肠病学疾病的化合物的测定 与MGAT-X1的表达相关。 本发明还涉及结合和/或活化或抑制MGAT-X1的活性的化合物以及包含这些化合物的药物组合物。

    Methods of screening for potential therapeutics for diseases associated with G-protein coupled receptor HM74a
    83.
    发明授权
    Methods of screening for potential therapeutics for diseases associated with G-protein coupled receptor HM74a 失效
    筛选与G蛋白偶联受体HM74a相关疾病的潜在治疗方法

    公开(公告)号：US07465548B2

    公开(公告)日：2008-12-16

    申请号：US10544615

    申请日：2004-02-05

    申请人： Stefan Golz ,  Ulf Brüggemeier ,  Holger Summer

    发明人： Stefan Golz ,  Ulf Brüggemeier ,  Holger Summer

    IPC分类号： G01N33/53 ,  G01N33/567 ,  A61K49/00

    CPC分类号： G01N33/566 ,  A61K38/177 ,  G01N33/74 ,  G01N2333/726 ,  G01N2500/00

    摘要： The invention provides a human HM74a which is associated with the disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, cancer, inflammation, urological diseases, respiratory diseases and gastroenterological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of disorders of the peripheral and central nervous system, cardiovascular diseases, hematological diseases, cancer, inflammation, urological diseases, respiratory diseases and gastroenterological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of HM74a as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与周围和中枢神经系统疾病，心血管疾病，血液疾病，癌症，炎症，泌尿科疾病，呼吸系统疾病和胃肠疾病相关的人类HM74a。 本发明还提供了用于鉴定可用于治疗或预防外周和中枢神经系统疾病，心血管疾病，血液疾病，癌症，炎症，泌尿科疾病，呼吸系统疾病和胃肠疾病的化合物的化合物。 本发明还涉及结合和/或活化或抑制HM74a的活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics And Therapeutics For Diseases Associated With Dipeptidyl-Peptidase 1 (Dpp1)
    84.
    发明申请
    Diagnostics And Therapeutics For Diseases Associated With Dipeptidyl-Peptidase 1 (Dpp1) 审中-公开
    与二肽基肽酶1（Dpp1）相关的疾病的诊断和治疗

    公开(公告)号：US20070286854A1

    公开(公告)日：2007-12-13

    申请号：US11578798

    申请日：2005-04-15

    申请人： Stefan Golz ,  Bruggemeiere Ulf ,  Andeas Geerts

    发明人： Stefan Golz ,  Bruggemeiere Ulf ,  Andeas Geerts

    IPC分类号： G01N33/53 ,  A61K38/17 ,  A61P1/00 ,  A61P11/00 ,  A61P13/00 ,  A61P17/00 ,  A61P19/00 ,  G01N33/567 ,  A61P25/00 ,  A61P3/00 ,  A61P35/00 ,  A61P7/00 ,  A61P9/00 ,  C12Q1/68

    CPC分类号： C12Q1/37 ,  G01N33/573 ,  G01N33/574 ,  G01N2333/96438 ,  G01N2500/04

    摘要： The invention provides a human DPP1 which is associated with the infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of infections, cardiovascular diseases, respiratory diseases, cancer, endocrinological diseases, metabolic diseases, gastroenterological diseases, inflammation, hematological diseases, muscle skeleton diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of DPP1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与感染，心血管疾病，呼吸系统疾病，癌症，内分泌疾病，代谢疾病，胃肠疾病，炎症，血液疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病有关的人类DPP1。 本发明还提供了用于鉴定可用于治疗或预防感染，心血管疾病，呼吸系统疾病，癌症，内分泌疾病，代谢疾病，胃肠疾病，炎症，血液疾病，肌肉骨骼疾病，神经系统疾病和泌尿系疾病的化合物的测定 。 本发明还涉及结合和/或活化或抑制DPP1的活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and therapeutics for diseases associated with G-protein coupled receptor AdipoR1(AdipoR1)
    86.
    发明授权
    Diagnostics and therapeutics for diseases associated with G-protein coupled receptor AdipoR1(AdipoR1) 有权
    与G蛋白偶联受体AdipoR1（AdipoR1）相关疾病的诊断和治疗

    公开(公告)号：US08252525B2

    公开(公告)日：2012-08-28

    申请号：US10572883

    申请日：2004-09-16

    申请人： Stefan Golz ,  Ulf Brüggemeier ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Brüggemeier ,  Andreas Geerts

    IPC分类号： C12Q1/68

    CPC分类号： G01N33/6893 ,  G01N33/74 ,  G01N2800/32

    摘要： The invention provides a human AdipoR1 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of AdipoR1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，炎症，呼吸系统疾病，神经系统疾病和泌尿系疾病相关的人AdipoR1。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，炎症，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。 本发明还具有结合和/或活化或抑制AdipoR1活性的化合物以及包含这些化合物的药物组合物。

    USE OF LYSOSOMAL CARBOXYPEPTIDASE C (PRCP) AS A THERAPEUTIC OR DIAGNOSTIC TARGET
    87.
    发明申请
    USE OF LYSOSOMAL CARBOXYPEPTIDASE C (PRCP) AS A THERAPEUTIC OR DIAGNOSTIC TARGET 审中-公开
    作为治疗或诊断性目标的骨质疏松性羧肽酶C（PRCP）的使用

    公开(公告)号：US20110033844A1

    公开(公告)日：2011-02-10

    申请号：US12303718

    申请日：2007-05-25

    申请人： Stefan Golz ,  Ulf Brüggemeier ,  Adreas Geerts

    发明人： Stefan Golz ,  Ulf Brüggemeier ,  Adreas Geerts

    IPC分类号： C12Q1/68 ,  G01N33/566

    CPC分类号： G01N33/57438 ,  G01N2333/948

    摘要： The invention provides a human PRCP which is associated with the cardiovascular diseases, hematological diseases, neurological diseases and cancer. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, hematological diseases, neurological diseases and cancer. The invention also features compounds which bind to and/or activate or inhibit the activity of PRCP as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，血液疾病，神经疾病和癌症有关的人类PRCP。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，血液疾病，神经疾病和癌症的化合物的测定。 本发明还涉及结合和/或活化或抑制PRCP的活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and therapeutics for diseases associated with g-protein coupled receptor adipor1(adipor1)
    89.
    发明申请
    Diagnostics and therapeutics for diseases associated with g-protein coupled receptor adipor1(adipor1) 有权
    与g-蛋白偶联受体adipor1（adipor1）相关疾病的诊断和治疗

    公开(公告)号：US20070037226A1

    公开(公告)日：2007-02-15

    申请号：US10572883

    申请日：2004-09-16

    申请人： Stefan Golz ,  Ulf Bruggermeier ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Bruggermeier ,  Andreas Geerts

    IPC分类号： G01N33/574

    CPC分类号： G01N33/6893 ,  G01N33/74 ,  G01N2800/32

    摘要： The invention provides a human AdipoR1 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of AdipoR1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，炎症，呼吸系统疾病，神经系统疾病和泌尿系疾病相关的人AdipoR1。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，炎症，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。 本发明还具有结合和/或活化或抑制AdipoR1活性的化合物以及包含这些化合物的药物组合物。