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102 条记录 (耗时 0.044 秒)

    Mismatch detection techniques
    2.
    发明授权
    Mismatch detection techniques 失效
    不匹配检测技术

    公开(公告)号：US6110684A

    公开(公告)日：2000-08-29

    申请号：US243558

    申请日：1999-02-02

    申请人： Borries Kemper ,  Karin Birkenkamp-Demtroder ,  Stefan Golz

    发明人： Borries Kemper ,  Karin Birkenkamp-Demtroder ,  Stefan Golz

    IPC分类号： C12N15/09 ,  C12P19/34 ,  C12Q1/34 ,  C12Q1/68 ,  C12Q1/70

    CPC分类号： C12Q1/683

    摘要： Disclosed herein is a method for detecting a mismatch in a duplex nucleic acid, involving: a) contacting the duplex nucleic acid with a reactive agent under conditions which permit the agent to bind but not cleave a mismatch in said duplex nucleic acid; b) detecting binding of the agent to the duplex nucleic acid as an indication of the presence of a mismatch in the duplex nucleic acid; c) contacting the duplex nucleic acid with the reactive agent under conditions which permit the agent to cleave a mismatch in the duplex nucleic acid; and d) detecting a cleavage product as an indication of the presence of a mismatch in the duplex nucleic acid.

    摘要翻译： 本文公开了一种用于检测双链体核酸错配的方法，其涉及：a）在允许所述试剂结合但不裂解所述双链体核酸中的错配的条件下使所述双链体核酸与活性剂接触; b）检测所述试剂与所述双链体核酸的结合作为所述双链体核酸中存在错配的指示; c）使所述双链体核酸与所述反应剂在允许所述试剂裂解所述双链体核酸中的错配的条件下接触; 和d）检测切割产物作为双链体核酸中错配存在的指示。

    G-Protein Coupled Receptor 30 (GPR30) transgenic animals as a model for cardiovascular diseases
    4.
    发明申请
    G-Protein Coupled Receptor 30 (GPR30) transgenic animals as a model for cardiovascular diseases 审中-公开
    G-蛋白偶联受体30（GPR30）转基因动物作为心血管疾病的模型

    公开(公告)号：US20110219462A1

    公开(公告)日：2011-09-08

    申请号：US13054509

    申请日：2009-07-02

    申请人： Martina Delbeck ,  Stefan Golz ,  Stefan Schafer ,  Christiane Otto

    发明人： Martina Delbeck ,  Stefan Golz ,  Stefan Schafer ,  Christiane Otto

    IPC分类号： A01K67/00 ,  A61K9/00 ,  C12N5/07 ,  G01N33/567

    CPC分类号： C12N15/8509 ,  A01K67/0276 ,  A01K2217/077 ,  A01K2227/105 ,  A01K2267/035 ,  A01K2267/0375

    摘要： The present invention relates to use of the GPR30 gene for diagnosis and treatment of cardiovascular disorders, especially cardiomyopathy. The present invention also relates to a GPR30 deficient animal model, more specifically to a mouse in which the GPR30 gene is disrupted and which exhibits a cardiomyopathy, a tissue and a cell of the mouse and a process of producing the same. The present invention further relates to use of said knockout mouse as a model of cardiovascular diseases, especially cardiomyopathy, and a method of screening a compound useful for the prevention and/or treatment of cardiovascular diseases, especially cardiomyopathy, using the knockout mouse.

    摘要翻译： 本发明涉及GPR30基因用于诊断和治疗心血管疾病，特别是心肌病的用途。 本发明还涉及GPR30缺陷动物模型，更具体地说涉及其中GPR30基因被破坏并显示出心肌病，小鼠的组织和细胞的小鼠及​​其制备方法。 本发明还涉及使用所述敲除小鼠作为心血管疾病，特别是心肌病的模型，以及使用敲除小鼠筛选可用于预防和/或治疗心血管疾病，特别是心肌病的化合物的方法。

    Acylglycerol acyltransferase-like protein MGAT-X1 and uses thereof
    5.
    发明授权
    Acylglycerol acyltransferase-like protein MGAT-X1 and uses thereof 失效
    酰基甘油酰基转移酶样蛋白MGAT-X1及其用途

    公开(公告)号：US07803593B2

    公开(公告)日：2010-09-28

    申请号：US10573500

    申请日：2004-09-16

    申请人： Stefan Golz ,  Ulf Brüggemeier ,  Bernhard Weingärtner ,  Andreas Geerts

    发明人： Stefan Golz ,  Ulf Brüggemeier ,  Bernhard Weingärtner ,  Andreas Geerts

    IPC分类号： C12N9/10 ,  C12N9/00 ,  C12N15/00 ,  C12N1/20 ,  C12N1/00 ,  C12P19/34 ,  C07H21/04 ,  A01N43/04

    CPC分类号： C07K16/40 ,  C12N9/1029

    摘要： The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明涉及新的酰基甘油酰基转移酶样蛋白MGAT-X1的多核苷酸序列。 本发明还提供了与皮肤病，泌尿疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或胃肠疾病有关的人MGAT-X1。 本发明还提供了用于鉴定可用于调节皮肤病，泌尿系统疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经疾病，代谢疾病，心血管疾病或用于治疗这些疾病的胃肠病学疾病的化合物的测定 与MGAT-X1的表达相关。 本发明还涉及结合和/或活化或抑制MGAT-X1的活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and Therapeutics for Diseases Associated with Puromycin Sensitive Aminopeptidase Npepps (Npepps)
    8.
    发明申请
    Diagnostics and Therapeutics for Diseases Associated with Puromycin Sensitive Aminopeptidase Npepps (Npepps) 审中-公开
    与嘌呤霉素敏感性氨肽酶Npepps（Npepps）相关的疾病诊断和治疗

    公开(公告)号：US20070258974A1

    公开(公告)日：2007-11-08

    申请号：US10588104

    申请日：2005-01-22

    申请人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Ralf Thiele

    发明人： Stefan Golz ,  Ulf Bruggemeier ,  Andreas Geerts ,  Ralf Thiele

    IPC分类号： A61K31/7052 ,  A61K31/7105 ,  A61K38/00 ,  A61K39/395 ,  A61P1/00 ,  A61P11/00 ,  A61P19/00 ,  A61P21/00 ,  A61P29/00 ,  A61P3/00 ,  A61P35/00 ,  A61P5/00 ,  A61P9/00 ,  C12Q1/37 ,  C12Q1/68 ,  G01N33/573

    CPC分类号： C12Q1/37 ,  G01N33/573

    摘要： The invention provides a human NPEPPS which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, muscle-skeleton diseases, neurological diseases, respiratory diseases, inflammation and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, gastroenterological diseases, muscle-skeleton diseases, neurological diseases, respiratory diseases, inflammation and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of NPEPPS as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，肌肉骨骼疾病，神经系统疾病，呼吸系统疾病，炎症和泌尿系疾病相关的人NPEPPS。 本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，胃肠疾病，肌肉骨骼疾病，神经系统疾病，呼吸系统疾病，炎症和泌尿疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制NPEPPS的活性的化合物以及包含这些化合物的药物组合物。

    Diagnostics and Therapeutics for Diseases Associated with Kallikrein 2 (KLK2)
    9.
    发明申请
    Diagnostics and Therapeutics for Diseases Associated with Kallikrein 2 (KLK2) 审中-公开
    与激肽释放酶2（KLK2）相关的疾病诊断和治疗

    公开(公告)号：US20070218047A1

    公开(公告)日：2007-09-20

    申请号：US10587452

    申请日：2005-01-15

    申请人： Stefan Golz ,  Ulf Bruggemeter ,  Andreas Geerts ,  Holger Summer

    发明人： Stefan Golz ,  Ulf Bruggemeter ,  Andreas Geerts ,  Holger Summer

    IPC分类号： C12Q1/00

    CPC分类号： G01N33/502 ,  G01N33/5008 ,  G01N33/574 ,  G01N33/68 ,  G01N2333/96455 ,  G01N2500/00

    摘要： The invention provides a human KLK2 which is associated with the hematological disorders, cancer, cardiovascular diseases, inflammatory diseases, neurological disorders, reproduction disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of hematological disorders, cancer, cardiovascular diseases, inflammatory diseases, neurological disorders, reproduction disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KLK2 as well as pharmaceutical compositions comprising such compounds.

    摘要翻译： 本发明提供了与血液学疾病，癌症，心血管疾病，炎性疾病，神经障碍，繁殖障碍和泌尿系统疾病有关的人类KLK2。 本发明还提供了用于鉴定可用于治疗或预防血液学疾病，癌症，心血管疾病，炎症性疾病，神经障碍，繁殖障碍和泌尿系统疾病的化合物的测定。 本发明还涉及结合和/或活化或抑制KLK2活性的化合物以及包含这些化合物的药物组合物。