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    DUAL BLADE LANCING TEST STRIP
    82.
    发明申请
    DUAL BLADE LANCING TEST STRIP 有权
    双刃测试条纹

    公开(公告)号：US20100042017A1

    公开(公告)日：2010-02-18

    申请号：US12581477

    申请日：2009-10-19

    申请人： Steven N. Roe ,  Jeffrey N. Roe

    发明人： Steven N. Roe ,  Jeffrey N. Roe

    IPC分类号： A61B5/151

    CPC分类号： A61B5/14532 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150442 ,  A61B5/150503 ,  A61B5/15142

    摘要： An integrated lancing test strip includes a pair of blade members that each have a lancing tip that are configured to lance skin. A pair of spacer members connect the blade members together such that the blade members define an internal capillary. A test strip is positioned along the internal capillary, and the test strip is configured to test analyte levels in the bodily fluid. During use, the lancing tips form one or more incisions in the skin. The fluid from the incisions is drawn via capillary action through the internal capillary and onto the test strip.

    摘要翻译： 集成的穿刺测试条包括一对刀片构件，每个刀片构件具有构造成刺穿皮肤的穿刺尖端。 一对间隔件将叶片构件连接在一起，使得叶片构件限定内部毛细管。 测试条沿着内部毛细管定位，并且测试条被配置成测试体液中的分析物水平。 在使用过程中，穿刺尖端在皮肤中形成一个或多个切口。 来自切口的流体通过毛细管作用通过内部毛细管并被拉到测试条上。

    ORGAN OXYGENATION STATE MONITOR AND METHOD
    83.
    发明申请
    ORGAN OXYGENATION STATE MONITOR AND METHOD 审中-公开
    有机氧化态监测和方法

    公开(公告)号：US20090137910A1

    公开(公告)日：2009-05-28

    申请号：US11946055

    申请日：2007-11-28

    申请人： Jason L. Pyle ,  Alexander M. Aravanis ,  Jeffrey N. Roe ,  Myer H. Rosenthal

    发明人： Jason L. Pyle ,  Alexander M. Aravanis ,  Jeffrey N. Roe ,  Myer H. Rosenthal

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14546 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/14556 ,  A61B5/1459 ,  A61B5/412 ,  A61B5/413 ,  A61B5/416 ,  A61B5/42

    摘要： One aspect of the invention provides a patient tissue state monitoring system with a light source; a light detector; a probe adapted to be inserted into a patient to transmit light from the light source to an organ tissue site and to direct light from the organ tissue site to the detector; and a processor programmed to determine tissue state with respect to a tissue site pre-dysoxia point from a fluorescence emission detected by the detector (such as by determining tissue NADH concentration) and to provide an indication of tissue state through an output device (such as by displaying a numerical value corresponding to the fluorescence emission). Another aspect of the invention provides a method of monitoring a patient tissue state including the following steps: monitoring an aerobic energy production level of an organ tissue site (such as tissue within the patient's gastro-intestinal tract, bladder and/or urethra); determining tissue state with respect to a tissue site pre-dysoxia point from the monitored aerobic energy production level; and providing an output of the tissue state (such as by displaying a numerical value corresponding to the fluorescence emission).

    摘要翻译： 本发明的一个方面提供一种具有光源的患者组织状态监测系统; 光检测器 探针，适于插入患者中以将光从所述光源透射到器官组织部位并将来自所述器官组织部位的光引导到所述检测器; 以及处理器，被编程为根据由检测器检测到的荧光发射（例如通过确定组织NADH浓度）来确定组织位置前染色体点的组织状态，并且通过输出装置（例如， 通过显示对应于荧光发射的数值）。 本发明的另一方面提供一种监测患者组织状态的方法，包括以下步骤：监测器官组织部位（例如患者胃肠道，膀胱和/或尿道内的组织）的有氧能量产生水平; 从所监测的有氧能量产生水平确定组织位置前染色体点的组织状态; 并提供组织状态的输出（例如通过显示对应于荧光发射的数值）。

    Method and apparatus for the quantitative analysis of a liquid sample with surface enhanced spectroscopy
    84.
    发明授权
    Method and apparatus for the quantitative analysis of a liquid sample with surface enhanced spectroscopy 失效

    公开(公告)号：US06646738B2

    公开(公告)日：2003-11-11

    申请号：US09985649

    申请日：2001-11-05

    申请人： Jeffrey N. Roe

    发明人： Jeffrey N. Roe

    IPC分类号： G01J344

    CPC分类号： G01N21/658 ,  G01N21/35 ,  G01N33/49 ,  G01N33/54366

    摘要： Surface-enhanced spectroscopy for quantitative analysis of analytes in biological liquid samples. A device for testing a biological liquid sample for the presence or concentration of an analyte includes: (a) a substrate defining a surface which has electrically conductive particles disposed thereon, wherein the surface is adapted to accommodate the liquid sample; (b) means for generating radiation and directing the radiation to be incident on said surface of the substrate so that radiation is emitted from the electrically conductive particles; and (c) means for detecting the emitted radiation. In another embodiment a matrix having electrically conductive particles that are incorporated in the matrix or that are disposed on a surface thereof, wherein the matrix is permeable to the liquid biological sample is used in place of the substrate. The device is particularly suited for determining glucose in human whole blood.

    Cleaning system for infrared ATR glucose measurement system (II)
    85.
    发明授权
    Cleaning system for infrared ATR glucose measurement system (II) 失效
    红外ATR葡萄糖测定系统清洗系统（二）

    公开(公告)号：US06362144B1

    公开(公告)日：2002-03-26

    申请号：US09665391

    申请日：2000-09-20

    申请人： Herbert L. Berman ,  Jeffrey N. Roe

    发明人： Herbert L. Berman ,  Jeffrey N. Roe

    IPC分类号： C11D344

    CPC分类号： A61B5/1455 ,  A61B5/14532 ,  A61B2562/245 ,  G01N21/552

    摘要： This involves a non-invasive glucose measurement device and a process for determining blood glucose level in the human body using the device. In typical operation, the glucose measurement device is self-normalizing in that it does not employ an independent reference sample in its operation. The device uses attenuated total reflection (ATR) infrared spectroscopy. Preferably, the device is used on a fingertip and compares two specific regions of a measured infrared spectrum to determine the blood glucose level of the user. Clearly, this device is especially suitable for monitoring glucose levels in the human body, and is especially beneficial to users having diabetes mellitus. The device and procedure may be used for other analyte materials which exhibit unique mid-IR signatures of the type described herein and that are found in appropriate regions of the outer skin.

    摘要翻译： 这涉及非侵入性葡萄糖测量装置和使用该装置来测定人体血糖水平的方法。 在典型的操作中，葡萄糖测量装置是自标准化的，因为其操作中不使用独立的参考样品。 该装置使用衰减全反射（ATR）红外光谱。 优选地，将该装置用于指尖，并比较测量的红外光谱的两个特定区域以确定用户的血糖水平。 显然，该装置特别适用于监测人体内的葡萄糖水平，对于患有糖尿病的使用者尤其有益。 该装置和程序可用于展示本文所述类型的独特的中红外特征并且存在于外皮的合适区域中的其它分析物质。

    Dual blade lancing test strip
    88.
    发明授权
    Dual blade lancing test strip 有权
    双刀片测试条

    公开(公告)号：US07244264B2

    公开(公告)日：2007-07-17

    申请号：US10308463

    申请日：2002-12-03

    申请人： Steven N. Roe ,  Jeffrey N. Roe

    发明人： Steven N. Roe ,  Jeffrey N. Roe

    IPC分类号： A61B17/32

    CPC分类号： A61B5/14532 ,  A61B5/150022 ,  A61B5/150213 ,  A61B5/150358 ,  A61B5/150442 ,  A61B5/150503 ,  A61B5/15142

    摘要： An integrated lancing test strip includes a pair of blade members that each have a lancing tip that are configured to lance skin. A pair of spacer members connect the blade members together such that the blade members define an internal capillary. A test strip is positioned along the internal capillary, and the test strip is configured to test analyte levels in the bodily fluid. During use, the lancing tips form one or more incisions in the skin. The fluid from the incisions is drawn via capillary action through the internal capillary and onto the test strip.

    摘要翻译： 集成的穿刺测试条包括一对刀片构件，每个刀片构件具有构造成刺穿皮肤的穿刺尖端。 一对间隔件将叶片构件连接在一起，使得叶片构件限定内部毛细管。 测试条沿着内部毛细管定位，并且测试条被配置成测试体液中的分析物水平。 在使用过程中，穿刺尖端在皮肤中形成一个或多个切口。 来自切口的流体通过毛细管作用通过内部毛细管并被拉到测试条上。