公开(公告)号：US06650895B1

公开(公告)日：2003-11-18

申请号：US09447696

申请日：1999-11-23

申请人： Channasandra Ravishankar ,  David Roos ,  Anthony Noerpel ,  Chandra Joshi ,  James Hobza ,  Prabir Datta ,  Yi Chen

发明人： Channasandra Ravishankar ,  David Roos ,  Anthony Noerpel ,  Chandra Joshi ,  James Hobza ,  Prabir Datta ,  Yi Chen

IPC分类号： H04Q720

CPC分类号： H04B7/19 ,  H04M3/2281 ,  H04M3/533 ,  H04Q1/45

摘要： A system and a methodology to improve the end-user quality of service both in terms of response time and reliability for the transport of in-call DTMF signals in wireless systems, particularly in geostationary mobile satellite systems. The methodology encompasses several techniques to provide acceptable end-to-end quality of service for DTMF. A technique is applicable for transport of DTMF in the wireless subscriber to network direction, where DTMF digits are carried in the form of an out-band message. The central part of the technique is to allow multiple key presses in the same message, thereby increasing efficiency and throughput in long-delay environment. Another technique utilizes the vocoder's functionality to carry DTMF in-band, thereby reducing system complexity. The scheme makes the use of an integrated DTMF detector which can classify a given frame of signal into several classes so that the DTMF encoded packet can carry a unique pattern across the air-interface to the voice decoder at AT, which is capable of identifying the pattern. Another technique pertains to the use of a message based DTMF transport between two-ATs on a separate logical channel with a unique Service Access point Identifier (SAPI) providing guaranteed service for DTMF transport in an AT-AT call.

摘要翻译： 在无线系统，特别是对地静止移动卫星系统中，在无线系统中传输呼叫中的DTMF信号的响应时间和可靠性方面，提高最终用户服务质量的系统和方法。 该方法包括几种为DTMF提供可接受的端到端服务质量的技术。 一种技术适用于将无线用户中的DTMF传输到网络方向，其中DTMF数字以带外消息的形式携带。 该技术的核心部分是允许同一消息中的多个按键按压，从而在长时间延迟环境中提高效率和吞吐量。 另一种技术利用声码器的功能来携带DTMF带内，从而降低系统的复杂性。 该方案使用集成的DTMF检测器，其可以将给定的信号帧分类成多个等级，使得DTMF编码的分组可以在AT的语音解码器的空中接口上携带唯一的模式，其能够识别 模式。 另一种技术涉及在独立的逻辑信道上的两个AT之间使用基于消息的DTMF传输与唯一的服务接入点标识符（SAPI），其在AT-AT呼叫中为DTMF传输提供有保证的服务。

公开(公告)号：US06303793B1

公开(公告)日：2001-10-16

申请号：US09566054

申请日：2000-05-05

申请人： Yi Chen ,  Apostolos Dermatakis ,  Jin-Jun Liu ,  Kin-Chun Luk

发明人： Yi Chen ,  Apostolos Dermatakis ,  Jin-Jun Liu ,  Kin-Chun Luk

IPC分类号： C07D20934

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14

摘要： Disclosed are novel 4-alkenyl- and 4-alkynyl oxindoles having the formula and the pharmaceutically acceptable salts thereof, wherein R1, R2, R3, a, b, and X are as defined herein. These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer, more particularly, the treatment or control of breast and colon tumors. Also disclosed are pharmaceutical compositions containing the compounds of formula I and II as well as intermediates useful in the preparation of the compounds of formula I and II.

摘要翻译： 公开了具有下式的新的4-烯基 - 和4-炔基羟基吲哚及其药学上可接受的盐，其中R1，R2，R3，a，b和X如本文所定义。 这些化合物抑制细胞周期蛋白依赖性激酶（CDK），特别是CDK2。 这些化合物及其药学上可接受的盐和所述化合物的前药是用于治疗或控制细胞增殖性疾病，特别是癌症的抗增殖剂，更具体地，涉及乳腺癌和结肠肿瘤的治疗或控制。 还公开了含有式I和II化合物的药物组合物以及可用于制备式I和II化合物的中间体。

公开(公告)号：US6130239A

公开(公告)日：2000-10-10

申请号：US464502

申请日：1999-12-15

申请人： Yi Chen ,  Wendy Lea Corbett ,  Apostolos Dermatakis ,  Jin-Jun Liu ,  Kin-Chun Luk ,  Paige E. Mahaney ,  Steven Gregory Mischke

发明人： Yi Chen ,  Wendy Lea Corbett ,  Apostolos Dermatakis ,  Jin-Jun Liu ,  Kin-Chun Luk ,  Paige E. Mahaney ,  Steven Gregory Mischke

IPC分类号： A61K31/404 ,  A61K31/4178 ,  A61K31/4409 ,  A61K31/454 ,  A61K31/5377 ,  A61P35/00 ,  A61P43/00 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D209/34

CPC分类号： C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14

摘要： Disclosed are novel 4-alkenyl- and 4-alkynyl oxindoles having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, a, b, and X are as defined herein. These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer, more particularly, the treatment or control of breast and colon tumors. Also disclosed are pharmaceutical compositions containing the compounds of formula I and II as well as intermediates useful in the preparation of the compounds of formula I and II.

摘要翻译： 公开了具有下式的新的4-烯基 - 和4-炔基羟基吲哚及其药学上可接受的盐，其中R1，R2，R3，a，b和X如本文所定义。 这些化合物抑制细胞周期蛋白依赖性激酶（CDK），特别是CDK2。 这些化合物及其药学上可接受的盐和所述化合物的前药是可用于治疗或控制细胞增殖性疾病，特别是癌症的抗增殖剂，更特别是乳腺癌和结肠肿瘤的治疗或控制。 还公开了含有式I和II化合物的药物组合物以及可用于制备式I和II化合物的中间体。

公开(公告)号：US09681798B2

公开(公告)日：2017-06-20

申请号：US14933666

申请日：2015-11-05

申请人： Ian W. Hunter ,  Yi Chen

发明人： Ian W. Hunter ,  Yi Chen

IPC分类号： A61B1/06 ,  G01J3/45 ,  G01J3/28 ,  G01J3/02 ,  G01J3/12 ,  G01J3/453

CPC分类号： A61B1/0638 ,  G01J3/0286 ,  G01J3/0291 ,  G01J3/1256 ,  G01J3/2823 ,  G01J3/45 ,  G01J3/453 ,  G01J3/4535

摘要： Imaging spectrometers can be used to generate hyperspectral images for medical diagnoses, contaminant detection, and food safety inspections, among other applications. An exemplary imaging spectrometer includes an integrated position sensing array that measures the relative positions of the interferometer components based on an interference pattern generated by illuminating the interferometer with a reference beam. Such an imaging spectrometer includes a processor that controls the interferometer component position by actuating a voice coil and several piezo-electric elements to align the components with respect to each other and to provide a desired optical path length mismatch between the interferometer arms. In some cases, the processor may use feedback and feed forward control, possibly based on the actuators' transfer functions, for more precise positioning. The processor may also implement adaptive and recursive spectral sampling to reduce the image acquisition period.

公开(公告)号：US09546197B2

公开(公告)日：2017-01-17

申请号：US13982797

申请日：2012-01-31

申请人： Shidong Liu ,  Zhaoli Zhang ,  Yi Chen ,  Xiusheng Wang ,  Liangliang Zhou ,  Xiaoming Ji

发明人： Shidong Liu ,  Zhaoli Zhang ,  Yi Chen ,  Xiusheng Wang ,  Liangliang Zhou ,  Xiaoming Ji

IPC分类号： C07K7/54 ,  C07K7/56 ,  C12N1/14 ,  C12R1/645 ,  C12P7/64

CPC分类号： C07K7/54 ,  C07K7/56 ,  C12N1/14 ,  C12P7/64 ,  C12R1/645

摘要： Provided is a method for preparing a compound represented by Formula I or a salt thereof, wherein Coleophoma empetri F-11899 (FERM BP2635) and/or a mutant strain thereof is cultured in a medium containing amino acid or a salt thereof, an insoluble organic source, and a sugar alcohol, to produce the compound of Formula I or a salt thereof.

摘要翻译： 本发明提供了制备式I化合物或其盐的方法，其中，在含有氨基酸或其盐的培养基中培养含有绒毛母细胞F-11899（FERM BP2635）和/或其突变株的不溶性有机物 来源和糖醇，以制备式I化合物或其盐。

公开(公告)号：US09376395B2

公开(公告)日：2016-06-28

申请号：US14345562

申请日：2012-09-14

申请人： Yu Chen ,  Lan Yang ,  Feiyu Feng ,  Qiufu Ge ,  Dianwu Guo ,  Yi Chen

发明人： Yu Chen ,  Lan Yang ,  Feiyu Feng ,  Qiufu Ge ,  Dianwu Guo ,  Yi Chen

IPC分类号： C07D235/16 ,  A61K47/40 ,  A61K31/16 ,  A61K31/4184 ,  A61K9/00 ,  A61K9/19 ,  A61K47/48

CPC分类号： C07D235/16 ,  A61K9/0019 ,  A61K9/19 ,  A61K31/16 ,  A61K31/4184 ,  A61K47/40 ,  A61K47/6951 ,  Y02A50/414

摘要： The present invention is directed to pharmaceutical compositions comprising: (a) a cyclopolysaccharide and (b) a compound of Formula (I) or its pharmaceutical acceptable salt: wherein X1, X2, Q, Z, and m are defined herein. Also disclosed is a method for treating a neoplastic disease or an immune disease with these compositions.

摘要翻译： 本发明涉及药物组合物，其包含：（a）环多糖和（b）式（I）化合物或其药学上可接受的盐：其中X 1，X 2，Q，Z和m如本文所定义。 还公开了用这些组合物治疗肿瘤疾病或免疫疾病的方法。

公开(公告)号：US09265461B2

公开(公告)日：2016-02-23

申请号：US12872643

申请日：2010-08-31

申请人： Ian W. Hunter ,  Yi Chen ,  Lynette A. Jones ,  N. Catherine Hogan

发明人： Ian W. Hunter ,  Yi Chen ,  Lynette A. Jones ,  N. Catherine Hogan

IPC分类号： A61B5/103 ,  A61B9/00 ,  A61B5/00

CPC分类号： A61B5/442 ,  A61B5/0048 ,  A61B5/0051 ,  A61B5/0053 ,  A61B5/0055 ,  A61B5/0057 ,  A61B5/441 ,  A61B5/6824 ,  A61B9/00

摘要： A method for testing the effect of a skin care product includes measuring a mechanical property of skin tissue using nonlinear stochastic system identification, applying the product to the skin, repeating the measurement of the mechanical property after the application of the product, and comparing the before and after measurements to quantify the effect of the product.Measuring the mechanical property of the skin can include placing a probe against a surface of the skin, perturbing the skin with the probe using a stochastic sequence, and measuring the response of the skin to the perturbation. Perturbing the skin can include indenting the skin with the probe, extending the skin with the probe, and sliding the probe across the skin surface. The mechanical property may be indicative of skin compliance, skin elasticity, skin stiffness, or skin damping. The mechanical property can be dependent on perturbation depth and may be measured at a plurality of anatomical locations.

摘要翻译： 用于测试皮肤护理产品的效果的方法包括使用非线性随机系统识别来测量皮肤组织的机械性质，将产品施用于皮肤，重复产品施用后的机械性能的测量，并比较之前 并经过测量以量化产品的影响。 测量皮肤的机械性能可以包括将探针放置在皮肤表面上，使用随机序列用探针扰动皮肤，以及测量皮肤对扰动的反应。 刺激皮肤可以包括使用探针压伤皮肤，用探头延伸皮肤，并将探头滑过皮肤表面。 机械性能可以指示皮肤顺应性，皮肤弹性，皮肤刚度或皮肤阻滞。 机械性能可以取决于扰动深度，并且可以在多个解剖位置处测量。

公开(公告)号：US20150011830A1

公开(公告)日：2015-01-08

申请号：US14355490

申请日：2011-08-25

申请人： Ian W. Hunter ,  Yi Chen ,  Jillian M. Oliveira

发明人： Ian W. Hunter ,  Yi Chen ,  Jillian M. Oliveira

IPC分类号： A61B1/00 ,  A61B1/005

CPC分类号： A61B1/0016 ,  A61B1/0052 ,  A61B1/0055

摘要： The present invention relates to an endoscope having a motorized assembly to control the distal end of an endoscope. Preferred embodiments can include disposable and reusable components. The system reduces the force need to control the tip of the endoscope and thereby reduce the risk of perforation′.

摘要翻译： 本发明涉及一种具有控制内窥镜前端的机动组件的内窥镜。 优选实施例可以包括一次性和可重复使用的部件。 该系统减少了控制内窥镜尖端的力量，从而降低了穿孔的风险。

公开(公告)号：US20140067246A1

公开(公告)日：2014-03-06

申请号：US13600398

申请日：2012-08-31

申请人： David A. Eldredge ,  Yi Chen ,  Jerob Svidunovich ,  Timothy Robert Brown ,  John W. Mcelroy

发明人： David A. Eldredge ,  Yi Chen ,  Jerob Svidunovich ,  Timothy Robert Brown ,  John W. Mcelroy

IPC分类号： G06F7/00

CPC分类号： B61L3/006 ,  B60L2200/26 ,  B61L15/0027 ,  B61L27/0022 ,  B61L27/0027

摘要： A system includes a vehicle control module, an operating information module, and a fuel analysis module. The vehicle control module is configured to obtain a trip plan for the vehicle. The operating information module is configured to be disposed on-board the vehicle and to autonomously obtain operating information describing one or more of tractive events or braking events performed during the trip. The fuel analysis module is configured to be disposed on-board the vehicle, to receive the operating information from the operating information module, and to autonomously determine a fuel consumption for at least a portion of the trip using the operating information received from the operating information module.

摘要翻译： 一种系统包括车辆控制模块，操作信息模块和燃料分析模块。 车辆控制模块被配置为获得车辆的行程计划。 操作信息模块被配置为布置在车辆上并且自主地获得描述在行程期间执行的牵引事件或制动事件中的一个或多个的操作信息。 燃料分析模块被配置为布置在车辆上，以从操作信息模块接收操作信息，并且使用从操作信息接收的操作信息自主地确定行程的至少一部分的燃料消耗 模块。

公开(公告)号：US08515939B2

公开(公告)日：2013-08-20

申请号：US12296490

申请日：2007-04-10

申请人： Yi Chen ,  Yuliang He

发明人： Yi Chen ,  Yuliang He

IPC分类号： G06F17/30

CPC分类号： G06F17/2785 ,  G06F17/2247

摘要： A system for facilitating rule-based content mining to extract content from structured or unstructured data receives a file that contains structured or unstructured data, or a mixture of both. The system then generates a processable extensible markup language (pXML) file based on the received file. The system further extracts content from the pXML file based on one or more rules and generates a semantic XML file based on a specified format.

摘要翻译： 用于促进基于规则的内容挖掘以从结构化或非结构化数据提取内容的系统接收包含结构化或非结构化数据的文件，或两者的混合。 然后，系统基于接收到的文件生成可执行的可扩展标记语言（pXML）文件。 该系统基于一个或多个规则进一步从pXML文件中提取内容，并基于指定的格式生成语义XML文件。