公开(公告)号：US5384461A

公开(公告)日：1995-01-24

申请号：US140195

申请日：1994-02-03

申请人： Joseph P. R. Jullien ,  Jonathan H. Batey ,  Robert Mellor

发明人： Joseph P. R. Jullien ,  Jonathan H. Batey ,  Robert Mellor

IPC分类号： H01J9/14 ,  H01J3/18 ,  H01J49/42

CPC分类号： H01J49/4215 ,  H01J3/18 ,  H01J49/068 ,  H01J49/4255

摘要： The method includes the steps of assembling one or more blanks (1) in supporting means (2, 3) so that the or each blank occupies at least the space to be occupied by elongate electrodes and, without disturbing the position of the blanks relative to said supporting means, removing material from all said blanks to generate said electrodes in position in said supporting means. Preferably the material is removed by an electrode-discharge machining (EDM) process, e.g. diesinking. The method avoids time-consuming alignment of preformed electrodes in said supporting means.

摘要翻译： PCT No.PCT / GB92 / 00835 Sec。 371日期：1994年2月3日 102（e）日期1994年2月3日PCT提交1992年5月8日PCT公布。 WO92 / 21141 PCT出版物 该方法包括以下步骤：将一个或多个坯件（1）组装在支撑装置（2,3）中，使得所述或每个坯件至少占据由细长电极占据的空间，并且不受干扰 坯件相对于所述支撑装置的位置，从所有所述坯料上去除材料，以在所述支撑装置中产生所述电极就位。 优选地，通过电极放电加工（EDM）工艺，例如， 沉没 该方法避免了所述支撑装置中预成型电极的耗时对准。

公开(公告)号：US5376787A

公开(公告)日：1994-12-27

申请号：US119985

申请日：1993-09-10

申请人： Peter L. Smith

发明人： Peter L. Smith

IPC分类号： H01J49/02 ,  H01J49/06

CPC分类号： H01J49/06 ,  H01J49/025

摘要： In a mass spectrometer, an aperture defining a beam path to a particle detector (4) is defined by a fixed aperture (5) and a cover (6) mounted on respective carriage assemblies (50,49) running along a beam 46. When a shaft (36) drives carriage (50), a rod (22) on carriage (49) is engaged by an end of a slot (21) of carriage (50), so that both carriages can be moved to a desired aperture location. After reaching this position, carriage (50) may be moved in the opposite direction, within a range defined by the length of the slot (22), without causing movement of carriage (49), to vary the amount by which member (6) covers member (5) and to thereby define a desired aperture width. A plurality of carriages can be coupled to one another in this manner to form a chain of apertures whose positions and widths may be varied independently using a single drive shaft (36). The fixed aperture (5) and cover ( 6) may be replaced by a pair of opposed aperture-edge defining members in the same plane.

摘要翻译： 在质谱仪中，限定到颗粒检测器（4）的光束路径的孔由固定孔（5）和安装在沿着梁46运行的相应托架组件（50,49）上的盖（6）限定。当 轴（36）驱动滑架（50），托架（49）上的杆（22）由托架（50）的槽（21）的端部接合，使得两个托架可以移动到期望的孔位置 。 在达到该位置之后，托架（50）可以在由槽（22）的长度限定的范围内沿相反方向移动，而不会导致托架（49）的移动，从而改变构件（6）的数量， 盖构件（5），从而限定所需的孔宽度。 多个托架可以以这种方式彼此联接以形成一连串的孔，其位置和宽度可以使用单个驱动轴（36）独立地改变。 固定孔（5）和盖（6）可以由同一平面内的一对相对的孔边限定构件代替。

公开(公告)号：US5374563A

公开(公告)日：1994-12-20

申请号：US984430

申请日：1993-04-09

申请人： Coin H. Maule

发明人： Coin H. Maule

IPC分类号： G01N21/21 ,  G01N21/27 ,  G01N21/55 ,  G01N21/77 ,  C01N21/55

CPC分类号： G01N21/553 ,  G01N21/21 ,  Y10S435/808 ,  Y10S436/805 ,  Y10S436/807

摘要： A sensor based on the technique of surface plasmon resonance (SPR) comprises an SPR device, a source of electromagnetic radiation from which radiation can be directed onto the device, and a detector to measure the intensity of radiation reflected from the SPR device. The electromagnetic radiation directed onto the SPR device contains both Transverse Electric-polarized and Transverse Electric-polarized components. A polarization analyzer is interposed between the device and the detector such that, at angles away from resonance, little or no light reaches the detector. The sensor is particularly useful in the qualitative and/or quantitative determination of biological, biochemical or chemical analytes.

摘要翻译： PCT No.PCT / GB91 / 01466 Sec。 371日期：1993年4月9日 102（e）日期1993年4月9日PCT 1991年8月30日PCT PCT。 公开号WO92 / 04617 日本1991年3月19日。基于表面等离子体共振（SPR）技术的传感器包括SPR装置，可以将辐射从该辐射源引导到装置上的电磁辐射源，以及用于测量反射的辐射强度的检测器 从SPR设备。 引导到SPR装置上的电磁辐射包含横向电极化和横向电极化分量。 偏振分析器被插入在装置和检测器之间，使得在远离谐振的角度处，很少或没有光到达检测器。 该传感器在定性和/或定量测定生物，生物化学或化学分析物方面特别有用。

公开(公告)号：US5369035A

公开(公告)日：1994-11-29

申请号：US969228

申请日：1993-04-02

申请人： Alan R. Eastgate ,  Wilfried Vogel

发明人： Alan R. Eastgate ,  Wilfried Vogel

IPC分类号： B01D1/00 ,  B01D1/16 ,  G01N1/00 ,  G01N1/44 ,  G01N21/01 ,  G01N21/31 ,  G01N21/73 ,  G01N21/62

CPC分类号： B01D1/16 ,  B01D1/0017 ,  G01N1/44 ,  Y10T436/24 ,  Y10T436/25125 ,  Y10T436/25875

摘要： In the elemental analysis of an analyte present in a sample by optical or mass spectrometry, a nebulizer sprays the liquid sample into a chamber which has a wall transparent to infra-red radiation. Infra-red radiation from a heater external to the chamber is focused on to the droplets of sample as they emerge from the nebulizer, disrupting the droplets into smaller ones and evaporating solvent from them as they pass through the chamber. The thus desolvated sample stream is delivered into a plasma and the reaction accuracy within the plasma is qualified by the spectrometer.

摘要翻译： PCT No.PCT / GB91 / 01345 Sec。 371日期：1993年4月2日 102（e）日期1993年4月2日PCT 1991年8月7日PCT PCT。 出版物WO92 / 02282 日期1992年2月20日。通过光学或质谱法对样品中存在的分析物进行元素分析，喷雾器将液体样品喷射到具有对红外辐射透明的壁的室中。 来自室外的加热器的红外辐射聚焦在样品的液滴上，当它们从喷雾器出现时，将液滴分解成更小的液滴，并在它们通过室时从其中蒸发溶剂。 将这样脱溶的样品流输送到等离子体中，等离子体内的反应精度由光谱仪进行鉴定。

公开(公告)号：US5349944A

公开(公告)日：1994-09-27

申请号：US958449

申请日：1992-10-07

申请人： Kevan E. Chippendale ,  John S. Corbett ,  John L. Hart ,  Geraldine Walkley

发明人： Kevan E. Chippendale ,  John S. Corbett ,  John L. Hart ,  Geraldine Walkley

IPC分类号： A61M11/00 ,  A61M15/00 ,  B65D83/14

CPC分类号： B65D83/75 ,  A61M15/009

摘要： An aerosol inhalation device, having a mouthpiece (12) and a canister (15) of pressurized hygroscopic medicament, the canister (15) being fitted at one end with a dispensing metering valve; wherein a protective barrier (19) is provided between the dispensing metering valve and the mouthpiece (12) so as to eliminate or substantially reduce blockage of the device.

摘要翻译： 一种具有吸嘴（12）和加压吸湿药剂的罐（15）的气溶胶吸入装置，所述罐（15）在一端装配有分配计量阀; 其中在所述分配计量阀和所述接口管（12）之间设置有保护屏障（19），以便消除或基本上减少所述设备的阻塞。

公开(公告)号：US5347125A

公开(公告)日：1994-09-13

申请号：US068743

申请日：1993-05-28

申请人： John L. Holmes ,  Alexander A. Mommers

发明人： John L. Holmes ,  Alexander A. Mommers

IPC分类号： G01N23/225 ,  H01J49/32 ,  B01D59/44 ,  H01J49/00

CPC分类号： H01J49/32 ,  G01N23/2255 ,  G01N2223/071 ,  G01N2223/081

摘要： A collision cell for observing the emission spectrum of ions. The substantially enclosed collision cell (8) is bounded by a wall (46), the wall having an entrance aperture (47) and an exit aperture (29) through which an ion beam (5) may be passed to traverse the collision cell, and has an observation region (15) therein adjacent to the entrance aperture and a first window (22) in the wall through which radiation generated in the observation region may pass, and, disposed adjacent to the exit aperture and in communication with the observation region, an exit region (16) comprising radiation-trapping means for minimizing the transmission to the first window of radiation generated in the exit region. The collision cell may be incorporated in a conventional mass spectrometer.

摘要翻译： 用于观察离子发射光谱的碰撞池。 基本上封闭的碰撞池（8）由壁（46）限定，壁具有入口孔（47）和出口孔（29），离子束（5）可以通过该孔径穿过碰撞池， 并且在其中与入口孔相邻的观察区域（15）和在观察区域中产生的辐射通过的壁中的第一窗口（22），并且邻近出口孔设置并与观察区域连通 ，出射区域（16），其包括用于最小化在出射区域中产生的辐射到第一窗口的辐射捕获装置。 碰撞单元可以结合在传统的质谱仪中。

公开(公告)号：US5296816A

公开(公告)日：1994-03-22

申请号：US820862

申请日：1992-01-16

申请人： Keith Birkinshaw

发明人： Keith Birkinshaw

IPC分类号： G01N27/62 ,  G01T1/24 ,  G01T1/28 ,  H01J43/24 ,  H01J49/02 ,  H01J49/06 ,  H01L27/14 ,  G01R29/12 ,  G01R5/28

CPC分类号： G01T1/28 ,  H01J49/025

摘要： A sensor for electrical charge fabricated as an integrated circuit and including an electrode (1) for receiving charge, a potential-sensitive switching device (2) for generating a pulse whenever the charge received on the electrode (1) is sufficiently great, a counting device (4) for counting the number of times the switching device operates, and a member (3) for restoring the potential on the electrode (1) to its initial potential each time the switching device (3) operates and/or continuously towards its initial potential. An integrated circuit having an array of such sensors and digital logic for controlling their operation is included. The array may be used as a multiple-channel detector for charged particles, particularly as a detector for electrons emerging from a channel plate electron multiplier. Dispersive particle and photon spectrometers, especially mass spectrometers, using such a detector are also provided.

摘要翻译： PCT No.PCT / GB90 / 01003 Sec。 371日期：1992年1月16日 102（e）日期1992年1月16日PCT Filed 1990年6月29日PCT公布。 出版物WO91 / 00612 日本1991年1月10日。作为集成电路制造并包括用于接收电荷的电极（1）的电荷传感器，每当电极（1）上接收到的电荷（1）产生脉冲的电位敏感开关装置 ）足够大，用于对切换装置工作的次数进行计数的计数装置（4）和每次切换装置（3）将电极（1）上的电位恢复到其初始电位的部件（3） 操作和/或不断地朝着其初始潜力。 包括具有用于控制其操作的这种传感器阵列和数字逻辑的集成电路。 该阵列可以用作带电粒子的多通道检测器，特别是作为从通道板电子倍增器出现的电子的检测器。 还提供了使用这种检测器的分散粒子和光子光谱仪，特别是质谱仪。

公开(公告)号：US5166518A

公开(公告)日：1992-11-24

申请号：US804361

申请日：1991-12-09

申请人： Philip A. Freedman

发明人： Philip A. Freedman

IPC分类号： H01J49/32

CPC分类号： H01J49/32

摘要： A mass spectrometer comprising ion source means (1) for producing ions characteristic of a sample to be analysed; ion detector means (14) for receiving at least some of said ions; magnetic sector analyzing means (18) and electrostatic analyzing means (8) disposed in any order between said ion source means (1) and said ion detector means (14); wherein said magnetic sector analyzing means (18) comprises means for dispersing ions according to their mass-to-charge ratios and for transmitting ions whose mass-to-charge ratios lie within a predetermined range and have a first kinetic energy; said electrostatic analyzing means (8) comprises means for generating an electrostatic field for deflecting ions having different kinetic energies around different curved trajectories such that ions having a second kinetic energy, lower than said first kinetic energy, are deflected around a central curved trajectory (15) and transmitted through said electrostatic analyzing means (8), and the strength of said electrostatic field is substantially equal to the strength of a similar reference field multiplied by the ratio of said second and said first kinetic energies when the strength of said reference field is that necessary to deflect ions having said first kinetic energy around said central curved trajectory (15); and means (11) are provided prior to said magnetic sector analyzing means for changing the kinetic energy of ions to said first kinetic energy and (4) prior to said electrostatic analyzing means for changing the kinetic energy of ions to said second kinetic energy.

公开(公告)号：US4803216A

公开(公告)日：1989-02-07

申请号：US46656

申请日：1987-05-05

申请人： Richard A. Appleton ,  John Dixon ,  Sidney C. Burford

发明人： Richard A. Appleton ,  John Dixon ,  Sidney C. Burford

IPC分类号： A61K31/415 ,  C07D231/38

CPC分类号： C07D231/38

摘要： There are described compounds of formula I, ##STR1## in which R.sub.1 represents hydrogen, alkyl, alkanoyl or alkyl substituted by Ar.sub.1,R.sub.3, R.sub.4 and R.sub.5, which may be the same or different, each independently represent hydrogen, alkyl or Ar.sub.3,Ar.sub.1, Ar.sub.2 and Ar.sub.3, which may be the same or different, independently represent phenyl or phenyl substituted by one or more of alkyl, hydroxy, alkoxy, NR.sub.6 R.sub.7 or halogen,R.sub.6 and R.sub.7, which may be the same or different, independently represent hydrogen or alkyl,and pharmaceutically acceptable acid addition salts thereof.Compositions containing the compounds and methods for their preparation are also described.The compounds are indicated for use as pharmaceutical, e.g. anti-inflammatory, agents.

公开(公告)号：US4791216A

公开(公告)日：1988-12-13

申请号：US938249

申请日：1986-12-05

申请人： Francis Ince ,  Alan C. Tinker

发明人： Francis Ince ,  Alan C. Tinker

IPC分类号： A61K31/135 ,  A61K31/165 ,  C07C43/174 ,  C07C43/23 ,  C07C45/51 ,  C07C65/24 ,  C07C275/28 ,  C07C311/02 ,  C07C317/22 ,  C07C323/25 ,  C07D215/22 ,  C07D215/227 ,  C07D215/26 ,  C07D263/14 ,  C07D319/08 ,  C07C147/06 ,  C07C87/28 ,  C07C103/85

CPC分类号： C07D215/227 ,  C07C255/00 ,  C07C275/28 ,  C07C323/00 ,  C07C323/25 ,  C07C43/174 ,  C07C43/23 ,  C07C45/515 ,  C07C65/24 ,  C07D215/26 ,  C07D263/14 ,  C07D319/08 ,  C07C2101/14 ,  Y10S514/821

摘要： There are provided paraethylamine phenol compounds of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. There are also described the use of the compounds of formula I as pharmaceuticals, methods for making the compounds and pharmaceutical, e.g. cardiac, compositions containing the compounds.

摘要翻译： 提供式I的对甲基苯酚酚化合物及其药学上可接受的衍生物。 还描述了式I化合物作为药物的用途，制备化合物的方法和药物，例如， 心脏，含有化合物的组合物。