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    Use of avocado skin for obtaining an avocado unsaponifiable material enriched with saturated aliphatic hydrocarbons and with sterols
    81.
    发明授权
    Use of avocado skin for obtaining an avocado unsaponifiable material enriched with saturated aliphatic hydrocarbons and with sterols 有权
    使用鳄梨皮肤获得富含饱和脂肪烃和甾醇的鳄梨不皂化物质

    公开(公告)号：US09439938B2

    公开(公告)日：2016-09-13

    申请号：US14370892

    申请日：2013-01-14

    Applicant: LABORATOIRES EXPANSCIENCE

    Inventor： Philippe Msika ,  Jacques Legrand ,  Sebastien Garnier

    IPC: A61K36/54 ,  A23L1/30 ,  A23D9/00 ,  A23D9/02 ,  C11B1/08 ,  A61K31/01 ,  A61K31/575

    CPC classification number: A61K36/54 ,  A23D9/00 ,  A23D9/02 ,  A23L33/105 ,  A23L33/11 ,  A23L33/115 ,  A61K31/01 ,  A61K31/575 ,  C11B1/08

    Abstract: The present invention relates to the use of avocado peels in order to obtain avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, said avocado peels accounting for 5 to 50% by weight relative to the total weight of avocado used. The invention also relates to a method for obtaining avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols from at least avocado peels, said avocado peels accounting for 5 to 50% by weight relative to the total weight of avocado used. The invention also relates to an avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, obtainable by this method. Lastly, the invention relates to an avocado unsaponifiable enriched in saturated aliphatic hydrocarbons and in sterols, for use as a drug, advantageously in the in the prevention and/or treatment of conjunctive tissue disorders such as arthrosis, articular pathologies such as rheumatism, or periodontal diseases such as gingivitis or periodontitis.

    Abstract translation: 本发明涉及鳄梨皮的使用以获得不可皂化的富含饱和脂肪烃的牛油果和甾醇，所述鳄梨皮相对于所用鳄梨的总重量占5至50重量％。 本发明还涉及一种用于从至少鳄梨皮中获得富含饱和脂肪烃和甾醇的鳄梨不可皂化的方法，所述鳄梨皮相对于所用牛油的总重量计算为5至50重量％。 本发明还涉及可通过该方法获得的不可皂化的富含饱和脂肪烃和甾醇的鳄梨。 最后，本发明涉及不可皂化的富含饱和脂族烃和固醇的鳄梨，用作药物，有利地用于预防和/或治疗结缔组织疾病如关节病，关节病变如风湿病或牙周病 疾病如牙龈炎或牙周炎。

    CORNEODESOMOSOMES AND BARRIER FUNCTION MATURATION
    82.
    发明申请
    CORNEODESOMOSOMES AND BARRIER FUNCTION MATURATION 审中-公开
    CORNEODESOMOSOMES和BARRIER功能成熟

    公开(公告)号：US20160195515A1

    公开(公告)日：2016-07-07

    申请号：US14915702

    申请日：2014-09-03

    Applicant: LABORATOIRES EXPANSCIENCE

    Inventor： Philippe Msika ,  Nadege Lachmann ,  Caroline Baudouin

    IPC: G01N33/50 ,  G01N33/68

    CPC classification number: G01N33/5044 ,  G01N33/5023 ,  G01N33/6881 ,  G01N2333/47

    Abstract: The present invention thus relates to a method for determining the degree of maturation of the skin surface of a subject. In particular, the present invention relates to method for determining whether the skin surface of a subject is mature/immature in its organization/function, said method comprising the steps of taking a skin sample of the said subject; and determining the corneodesmosome distribution within the stratum corneum of the sample.

    Abstract translation: 因此，本发明涉及一种用于确定受试者的皮肤表面的成熟程度的方法。 特别地，本发明涉及用于确定受试者的皮肤表面在其组织/功能中是否成熟/不成熟的方法，所述方法包括以下步骤：摄取所述受试者的皮肤样品; 并测定样品角质层内的角质层分布。

    Extract of the above-ground portions of gynandropsis gynandra or cleome gynandra, and cosmetic, dermatological or pharmaceutical compositions including same
    83.
    发明授权
    Extract of the above-ground portions of gynandropsis gynandra or cleome gynandra, and cosmetic, dermatological or pharmaceutical compositions including same 有权
    金莲花（Gynandropsis gynandra）或清骨霉（gynandra）的地上部分的提取物，以及包含其的化妆品，皮肤病学或药物组合物

    公开(公告)号：US09370541B2

    公开(公告)日：2016-06-21

    申请号：US13824187

    申请日：2011-12-22

    Applicant: Philippe Msika ,  Alex Saunois ,  Caroline Baudouin ,  Sophie Leclere-Bienfait ,  Sebastien Debrock

    Inventor： Philippe Msika ,  Alex Saunois ,  Caroline Baudouin ,  Sophie Leclere-Bienfait ,  Sebastien Debrock

    IPC: A61K36/185 ,  A61K8/97 ,  A61K8/60 ,  A61Q19/06 ,  A61Q19/08 ,  A61K45/00

    CPC classification number: A61K36/185 ,  A61K8/602 ,  A61K8/97 ,  A61K45/00 ,  A61K2800/805 ,  A61Q19/06 ,  A61Q19/08

    Abstract: The invention relates to a composition, such as a cosmetic, dermatological, or pharmaceutical composition, including an extract of the above-ground portions of Gynandropsis gynandra, advantageously the leaves and, optionally, a suitable carrier. The invention also relates to such a composition or such an extract to be used in the prevention or treatment of disorders or diseases of the skin, mucous membranes, or nails and hair, to be used in the prevention or treatment of vascular disorders and/or problems linked to hyperseborrhea, or further to be used as an anti-ageing, healing, moisturizing, slimming and/or anti-cellulite, anti-allergy and pro-pigmenting product. Finally, the invention relates to a cosmetic care method for the skin, nails and hair, or mucous membranes, with a view to improving the condition or appearance thereof, consisting of administering such a composition or such an extract.

    Abstract translation: 本发明涉及一种组合物，例如化妆品，皮肤病学或药物组合物，包括Gynandropsis gynandra的地上部分的提取物，有利地是叶和任选的合适的载体。 本发明还涉及这种用于预防或治疗皮肤，粘膜或指甲和毛发的疾病或疾病的组合物或提取物，其用于预防或治疗血管疾病和/或 与高脂血症相关的问题，或进一步用作抗衰老，愈合，保湿，减肥和/或抗脂肪团，抗过敏和促色素产品。 最后，本发明涉及一种用于皮肤，指甲和头发或粘膜的美容护理方法，以改善其状况或外观，包括施用这种组合物或这种提取物。

    Cosmetic composition for the treatment of acne comprising a peptide extract of Schisandra
    85.
    发明授权
    Cosmetic composition for the treatment of acne comprising a peptide extract of Schisandra 有权
    用于治疗痤疮的化妆品组合物，其包含五味子肽提取物

    公开(公告)号：US08758833B2

    公开(公告)日：2014-06-24

    申请号：US13387518

    申请日：2010-07-27

    Applicant: Sebastien Garnier ,  Dalale Naaimi ,  Caroline Baudouin

    Inventor： Sebastien Garnier ,  Dalale Naaimi ,  Caroline Baudouin

    IPC: A61K36/79 ,  A61K38/00

    CPC classification number: A61K8/602 ,  A61K8/645 ,  A61K8/97 ,  A61K36/79 ,  A61Q19/00

    Abstract: The present invention relates to a cosmetic, nutraceutical or dermatological composition for treating or preventing acne, comprising a peptide and oside extract of Schizandra fruit and a suitable excipient. Preferably, the extract is obtained from Schizandra sphenanthera. The composition may also comprise at least one anti-acne agent selected from a sebum-regulating agent, an antibacterial and/or antifungal agent, a keratolytic agent and/or a keratoregulating agent, an astringent, an anti-inflammatory and/or anti-irritant, an antioxidant and/or a free-radical scavenger, a cicatrizing agent, an anti-ageing agent and a moisturizing agent. The invention also relates to a method for cosmetic treatment of acne, characterized in that a cosmetic composition according to the invention is applied to the affected areas of the skin, or in that the affected individual takes a nutraceutical composition according to the invention orally.

    Abstract translation: 本发明涉及用于治疗或预防痤疮的化妆品，保健品或皮肤病学组合物，其包含五味子果实的肽和盎司提取物以及合适的赋形剂。 优选地，提取物是从五味子（Schisandra sphenanthera）获得的。 组合物还可以包含至少一种选自皮脂调节剂，抗菌剂和/或抗真菌剂，角质分解剂和/或角质调节剂，收敛剂，抗炎剂和/或抗真菌剂的抗痤疮剂。 刺激物，抗氧化剂和/或自由基清除剂，c zing剂，抗老化剂和保湿剂。 本发明还涉及一种美容治疗痤疮的方法，其特征在于将根据本发明的化妆品组合物应用于皮肤的受影响区域，或者受影响的个体口服本发明的营养组合物。

    Depigmenting or brigthening cosmetic composition comprising at least one oxazolin as an active ingredient
    86.
    发明授权
    Depigmenting or brigthening cosmetic composition comprising at least one oxazolin as an active ingredient 有权
    包含至少一种恶唑啉作为活性成分的脱色或增韧化妆品组合物

    公开(公告)号：US08722023B2

    公开(公告)日：2014-05-13

    申请号：US11919253

    申请日：2006-04-27

    Applicant: Philippe Msika ,  Nathalie Piccardi

    Inventor： Philippe Msika ,  Nathalie Piccardi

    IPC: A61Q19/00

    CPC classification number: A61K8/49 ,  A61Q19/02

    Abstract: The invention relates to the cosmetic use of at least one oxazolin as a depigmenting active ingredient in a depigmenting composition, and to the associated cosmetic treatment method. The invention also relates to the use of at least one oxazolin for preparing an active medicament as a depigmenting agent, and to a depigmenting cosmetic composition comprising at least one oxazolin as a depigmenting active ingredient.

    Abstract translation: 本发明涉及至少一种恶唑啉在脱色组合物中作为脱色素活性成分的美容应用，以及相关的美容治疗方法。 本发明还涉及至少一种恶唑啉用于制备活性药物作为脱色剂的用途，以及涉及包含至少一种恶唑啉作为脱色素活性成分的脱色处理化妆品组合物的用途。

    Cosmetic method for preventing and/or treating skin stretchmarks, and use in dermatology
    88.
    发明授权
    Cosmetic method for preventing and/or treating skin stretchmarks, and use in dermatology 有权
    用于预防和/或治疗皮肤妊娠纹的化妆方法，并用于皮肤病学

    公开(公告)号：US08466109B2

    公开(公告)日：2013-06-18

    申请号：US10808701

    申请日：2004-03-25

    Applicant: Philippe Msika

    Inventor： Philippe Msika

    IPC: A61K38/00 ,  A61K33/34 ,  A61K38/48

    CPC classification number: A61Q19/00 ,  A61K8/365 ,  A61K8/41 ,  A61K8/60 ,  A61K8/64 ,  A61K8/645 ,  A61K8/97 ,  A61K38/011 ,  A61Q19/08

    Abstract: A method for reducing the formation of and/or treating skin stretchmarks is described. The method is characterized in that a composition is applied to the areas of skin liable to form or comprising stretchmarks, including skin of the thighs, abdomen, and/or breast. The applied composition includes a soya peptide, a tripeptide consisting of the amino acids glycine, histidine, and lysine, and/or mixtures of the soya peptide and tripeptide in a suitable application vehicle. The composition displays good skin tolerance.

    Abstract translation: 描述了一种减少皮肤妊娠纹形成和/或治疗的方法。 该方法的特征在于，将组合物施用于易于形成或包括包括大腿，腹部和/或乳房的皮肤的妊娠纹的皮肤区域。 应用的组合物包括大豆肽，由氨基酸甘氨酸，组氨酸和赖氨酸组成的三肽，和/或大豆肽和三肽的混合物在合适的应用载体中。 组合物显示出良好的皮肤耐受性。

    LIQUID/LIQUID EXTRACTION
    89.
    发明申请
    LIQUID/LIQUID EXTRACTION 有权
    液体/液体萃取

    公开(公告)号：US20130035383A1

    公开(公告)日：2013-02-07

    申请号：US13575402

    申请日：2011-01-31

    Applicant: Alex Saunois ,  Jacques Legrand ,  Eglantine Mercier

    Inventor： Alex Saunois ,  Jacques Legrand ,  Eglantine Mercier

    IPC: A61K31/341 ,  A61P1/02 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61K8/49 ,  A61Q19/08

    CPC classification number: B01D11/0492 ,  A23L33/10 ,  A23L33/105 ,  A23L33/115 ,  C11B1/10 ,  C11C1/025 ,  C11C3/003

    Abstract: The invention relates to a method for the extraction of all unsaponifiable fraction contained in a vegetable oil, an oil originating from a micro-organism or a vegetable butter or in a co-product from the vegetable oil refining industry, such as deodorisation discharge. The method includes at least: A) a step comprising the transformation of the aforementioned oils, butter or co-product from the vegetable oil refining industry or oils originating from micro-organisms into a hydro-alcoholic solution by means of, in particular, a step selected from saponification and esterification steps; B) a step comprising the extraction of the hydro-alcoholic solution in which the fatty fraction is separated from the unsaponitiable fraction by means of liquid/liquid extraction; and C) an optional step comprising the purification of the unsaponiable fraction, selected from the group containing crystallisation and liquid/liquid extraction steps. According to the invention, at least one step from the liquid/liquid extraction steps in step B, the crystallisation steps in step C and the liquid/liquid extraction steps in step C is performed using a first solvent system containing a concentration of solvent selected from among: fluorinated aromatic solvents, particularly trifluorotoluene (BTF) and hexalluorobenzene (BHF); tert-butyl ethers, particularly 2-ethoxy-2-methylpropane, also known as ethyl-tert-butyl-ether (ETU); solvents comprising at least one silicon atom, particularly hexamethyldisiloxane (HMDS) and tertramethylsilane (TMS); methyl-tetrahydrofuran (MeTHF); and mixtures thereof, representing at least 50 vol.-% in relation to the total volume of the solvent system. The invention also relates to the fractions obtained using this method and to compositions containing said fractions.

    Abstract translation: 本发明涉及一种用于提取植物油，来自微生物或植物黄油的油或来自植物油精炼工业的共同产品（例如除臭排放物）中所含的所有不皂化成分的方法。 该方法至少包括：A）包括将来自植物油精炼工业的前述油，黄油或副产物或由微生物产生的油转化成水醇溶液的步骤，特别是通过 从皂化和酯化步骤中选择的步骤; B）包括通过液/液萃取提取其中脂肪部分与不可撒色部分分离的水醇溶液的步骤; 和C）任选的步骤，其包括纯化不可溶性馏分，其选自包含结晶和液/液萃取步骤的组。 根据本发明，从步骤B中的液/液萃取步骤至少一步，步骤C中的结晶步骤和步骤C中的液/液萃取步骤是使用含有浓度为 其中：氟化芳族溶剂，特别是三氟甲苯（BTF）和六氟苯（BHF）; 叔丁基醚，特别是2-乙氧基-2-甲基丙烷，也称为乙基叔丁基醚（ETU）; 包含至少一个硅原子，特别是六甲基二硅氧烷（HMDS）和三甲基硅烷（TMS）的溶剂; 甲基 - 四氢呋喃（MeTHF）; 和其混合物，相对于溶剂系统的总体积代表至少50vol。％。 本发明还涉及使用该方法获得的级分和含有所述级分的组合物。

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