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    Fibronectin binding protein B compounds
    82.
    发明授权
    Fibronectin binding protein B compounds 失效

    公开(公告)号：US5858709A

    公开(公告)日：1999-01-12

    申请号：US732791

    申请日：1996-10-15

    Applicant: John Edward Hodgson ,  Martin Karl Russell Burnham

    Inventor： John Edward Hodgson ,  Martin Karl Russell Burnham

    IPC: A61K38/00 ,  A61K39/00 ,  C07K14/31 ,  C12P21/06 ,  C07H21/02 ,  C07H21/04

    CPC classification number: C07K14/31 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00

    Abstract: Novel fibronectin binding protein B polypeptides and DNA (RNA) encoding such novel fibronectin binding protein B and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such novel fibronectin binding protein B for the treatment of infection, particularly bacterial infections. Antagonists against such novel fibronectin binding protein B and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of novel fibronectin binding protein B nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding novel fibronectin binding protein B family and for detecting the polypeptide in a host.

    Heterocyclic compounds as pharmaceutical
    84.
    发明授权
    Heterocyclic compounds as pharmaceutical 失效
    杂环化合物作为药物

    公开(公告)号：US5827865A

    公开(公告)日：1998-10-27

    申请号：US460162

    申请日：1995-06-02

    Applicant: David Haigh ,  John Thomas Sime

    Inventor： David Haigh ,  John Thomas Sime

    IPC: C07D213/74 ,  C07D263/58 ,  A61K31/44

    CPC classification number: C07D213/74 ,  C07D263/58

    Abstract: Compounds of Formula (I) A.sup.1 --X--(CH.sub.2).sub.n --O--A.sup.2 --A.sup.3 --Y.R.sup.2(I) or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof, and/or a pharmaceutically acceptable solvate thereof, wherein A.sup.1, A.sup.2, A.sup.3, R.sup.2, X, Y and n are as defined herein; a pharmaceutical composition comprising such a compound and the use of such a compound or composition in medicine as described.

    Abstract translation: 式（I）化合物A1-X-（CH2）nO-A2-A3-Y.R2（Ⅰ）或其互变异构形式和/或其药学上可接受的盐，和/或其药学上可接受的溶剂合物，其中A1 ，A2，A3，R2，X，Y和n如本文所定义; 包含这种化合物的药物组合物和在所述药物中使用这种化合物或组合物。

    Dispensing device for two fluid materials
    85.
    发明授权
    Dispensing device for two fluid materials 失效
    两种流体材料的分配装置

    公开(公告)号：US5823394A

    公开(公告)日：1998-10-20

    申请号：US757031

    申请日：1996-11-26

    Applicant: Adrian Francis Davis ,  Willy Lorscheidt ,  David Reed Wilkins

    Inventor： Adrian Francis Davis ,  Willy Lorscheidt ,  David Reed Wilkins

    IPC: B05B11/00 ,  B65D47/34 ,  B65D81/32 ,  B65D83/00 ,  B67D5/42

    CPC classification number: B05B11/3085 ,  B05B11/0048 ,  B05B11/3074 ,  B05B11/3001

    Abstract: A dispenser for dispensing together a first fluid material and a second fluid material comprising a first material chamber (1a) and a second material supply chamber (1b) for containing first and second fluid materials, and a headpiece (2) comprising a first pump chamber (24) having a first pump piston (27) and being connectable to a first discharge channel (30) and to the first material supply chamber (1a) and a second pump chamber (19) having a second pump piston (26) and being connectable to a second discharge channel (31) and to the second material supply chamber (1b), and having a coaxial arrangement.

    Abstract translation: 一种用于将第一流体材料和第二流体材料分配在一起的分配器，所述第二流体材料包括用于容纳第一和第二流体材料的第一材料室（1a）和第二材料供应室（1b），以及包括第一泵室 （24）具有第一泵活塞（27）并且可连接到第一排放通道（30）和第一供料室（1a）和具有第二泵活塞（26）的第二泵室（19） 可连接到第二排放通道（31）和第二材料供应室（1b），并且具有同轴布置。

    Process for the preparation of azabicycloc derivatives
    87.
    发明授权
    Process for the preparation of azabicycloc derivatives 失效
    制备氮杂双环衍生物的方法

    公开(公告)号：US5773619A

    公开(公告)日：1998-06-30

    申请号：US439616

    申请日：1995-05-12

    Applicant: Steven Mark Bromidge ,  Martyn Voyle ,  Erol Ali Faruk ,  Mark Jason Hughes ,  John Kitteringham ,  Gary Thomas Borrett

    Inventor： Steven Mark Bromidge ,  Martyn Voyle ,  Erol Ali Faruk ,  Mark Jason Hughes ,  John Kitteringham ,  Gary Thomas Borrett

    IPC: C07D487/18 ,  C07D453/02

    CPC classification number: C07D453/02

    Abstract: A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt thereof: ##STR1## wherein R.sub.1 represents ##STR2## in which r represents an integer of 2 to 4, s represents 1 or 2 and t represents 0 or 1; R.sub.2 is a group OR.sub.4, where R.sub.4 is C.sub.1-4 alkyl, C.sub.2-4 alkenyl or C.sub.2-4 alkynyl or a group OCOR.sub.5 where R.sub.5 is hydrogen or R.sub.4 ; and R.sub.3 is CN; said process comprising reacting a compound of formula (II): ##STR3## wherein R.sub.1 ' is R.sub.1 or a group convertible thereto, and R.sub.3 ' is an electron withdrawing group, with a source of nitrous acid, and thereafter converting the resulting .dbd.NOH group to .dbd.NR.sub.2 wherein R.sub.2 is as defined in formula (I), converting R.sub.1 ' and R.sub.3 ' when other than R.sub.1 and R.sub.3 to R.sub.1 and R.sub.3, and thereafter optionally forming a pharmaceutically acceptable salt.

    Abstract translation: 制备式（I）化合物或其药学上可接受的盐的方法：其中R 1表示，其中r表示2至4的整数，s表示1或2，t表示 表示0或1; R2是OR4，其中R4是C1-4烷基，C2-4烯基或C2-4炔基或OCOR5，其中R5是氢或R4; R3为CN; 所述方法包括使式（II）化合物：其中R 1'为R 1或可转换的基团，并且R 3'为吸电子基团，并与亚硝酸源反应，然后将所得 = NOH基团= NR 2，其中R 2如式（I）中所定义，当R 1和R 3不同于R 1和R 3时，将R 1'和R 3'转化，然后任选形成药学上可接受的盐。

    Glycyl tRNA synthetase polynucleotides of streptococcus
    90.
    发明授权
    Glycyl tRNA synthetase polynucleotides of streptococcus 失效
    链球菌的糖基tRNA合成酶多核苷酸

    公开(公告)号：US5756330A

    公开(公告)日：1998-05-26

    申请号：US844085

    申请日：1997-04-18

    Applicant: Elizabeth Jane Lawlor

    Inventor： Elizabeth Jane Lawlor

    IPC: A61K38/00 ,  A61K39/00 ,  C12N9/00 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00

    CPC classification number: C12N9/93 ,  A61K38/00 ,  A61K39/00

    Abstract: The invention provides glyS (beta) and glyS (alpha) polypeptides and DNA (RNA) encoding glyS (beta) and glyS (alpha) polypetides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing glyS (beta) and glyS (alpha) polypeptides to screen for antibacterial compounds.

    Abstract translation: 本发明提供了glyS（β）和glyS（α）多肽和编码glyS（β）和glyS（α）多肽的DNA（RNA）和通过重组技术产生此类多肽的方法。 还提供了利用glyS（β）和glyS（α）多肽筛选抗菌化合物的方法。

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