公开(公告)号：US06620203B2

公开(公告)日：2003-09-16

申请号：US10017921

申请日：2001-12-13

申请人： Anthony Atala

发明人： Anthony Atala

IPC分类号： A61F236

CPC分类号： A61L27/3839 ,  A61F2/0059 ,  A61F2/02 ,  A61F2/022 ,  A61K35/12 ,  A61L27/18 ,  A61L27/3804 ,  A61L27/3817 ,  A61L27/3886 ,  A61L27/58 ,  C12N5/0697 ,  C12N2502/1317 ,  C12N2502/246 ,  C12N2533/40 ,  C08L67/04

摘要： The present invention provides a tissue engineered testicular prosthesis for implanting within a patient having a scaffold with a biodegradable polymer scaffold having a substantially elliptical body in longitudinal cross-section replicating the shape of a testicle and a substantially circular cross-section in transverse cross-section, the biodegradable scaffold defining an interior and an exterior of the prosthesis, and the scaffold being seeded with disassociated chondrocytes or Leydig cells, or both chondrocytes and Leydig cells. The interior of the prosthesis can be at least partially filled with testosterone.

摘要翻译： 本发明提供了一种组织工程睾丸假体，用于植入患有具有可生物降解的聚合物支架的患者的患者，所述支架具有基本上椭圆形的纵向截面，复制睾丸的形状和横截面的基本圆形的横截面 ，所述可生物降解的支架限定假体的内部和外部，并且所述支架用解离的软骨细胞或Leydig细胞，或软骨细胞和Leydig细胞接种。 假体的内部可以至少部分地被睾酮填充。

公开(公告)号：US06502574B2

公开(公告)日：2003-01-07

申请号：US09992277

申请日：2001-11-14

申请人： Walter J. Stevens ,  Anja K. Metzger ,  Larry A. Walter ,  Mark B. Knudson ,  Timothy R. Conrad

发明人： Walter J. Stevens ,  Anja K. Metzger ,  Larry A. Walter ,  Mark B. Knudson ,  Timothy R. Conrad

IPC分类号： A61F556

CPC分类号： A61F5/566 ,  A61F2/00 ,  A61F2/0059 ,  A61F2/20 ,  A61F5/56 ,  Y10S602/902

摘要： A method for treating snoring includes identifying first and second locations disposed on right and left sides, respectively, of a soft palate and separated by an anterior-posterior midline extending centrally positioned on the palate. The first and second locations are linked across the midline by creating a linkage between the first and second locations and through the midline with the linkage having a stiffness greater than a stiffness of untreated tissue naturally residing between the locations.

公开(公告)号：US06494868B2

公开(公告)日：2002-12-17

申请号：US09818464

申请日：2001-03-27

申请人： Roger E. Amar

发明人： Roger E. Amar

IPC分类号： A61M532

CPC分类号： A61M5/32 ,  A61B17/3468 ,  A61F2/0059 ,  A61M2005/341

摘要： A set of cannulae for tissue injections is disclosed. The cannulae are ideally suited for tissue injections in the human body. In particular, the cannulae are well-suited for muscle injections in the human face. Each cannula injecting device includes a hub attached to a tubular needle with a blunt tip or spatula-like tip. The tubular needle is curved and includes a side opening located near the tip.

摘要翻译： 公开了一组用于组织注射的套管。 套管非常适用于人体中的组织注射。 特别地，套管非常适合人脸上的肌肉注射。 每个插管注射装置包括附接到具有钝头或刮刀状末端的管状针的毂。 管状针弯曲并且包括位于尖端附近的侧开口。

公开(公告)号：US20020108618A1

公开(公告)日：2002-08-15

申请号：US10121166

申请日：2002-04-11

申请人： Pi Medical

发明人： Timothy R. Conrad ,  Mark B. Knudson

IPC分类号： A61B019/00

CPC分类号： A61F2/00 ,  A61F2/0059 ,  A61F5/566

摘要： An apparatus for use in treating snoring of a patient suffering from snoring includes an implant of bio-compatible material sized to be embedded within the soft palate. The implant is disposed within a bore of a distal tip of a needle for penetration into the soft palate. The bore is sized to receive a rod from a proximal end of the needle with the rod opposing the implant to eject the implant from the distal tip upon relative sliding movement of said needle and said rod. The needle at the distal tip is perforated for fluid to flow through a wall of the needle into engagement with the implant. The implant is selected to altering a dynamic response of the soft palate to airflow past the soft palate.

公开(公告)号：US20020091448A1

公开(公告)日：2002-07-11

申请号：US10017921

申请日：2001-12-13

发明人： Anthony Atala

IPC分类号： A61F002/04

CPC分类号： A61L27/3839 ,  A61F2/0059 ,  A61F2/02 ,  A61F2/022 ,  A61K35/12 ,  A61L27/18 ,  A61L27/3804 ,  A61L27/3817 ,  A61L27/3886 ,  A61L27/58 ,  C12N5/0697 ,  C12N2502/1317 ,  C12N2502/246 ,  C12N2533/40 ,  C08L67/04

摘要： The present invention provides a tissue engineered testicular prosthesis for implanting within a patient comprises a scaffold comprising a biodegradable polymer scaffold having a substantially elliptical body in longitudinal cross-section replicating the shape of a testicle and a substantially circular cross-section in transverse cross-section the biodegradable scaffold defining an interior and an exterior of the prosthesis and the scaffold being seeded with disassociated chondrocytes or Leydig cells, or both chondrocytes and Leydig cells. The interior of the prosthesis can be at least partially filled with testosterone.

摘要翻译： 本发明提供了一种用于植入在患者体内的组织工程睾丸假体，包括一种支架，其包括具有基本椭圆体的可生物降解的聚合物支架，纵向截面复制睾丸的形状，横截面为大致圆形横截面 所述可生物降解的支架限定假体的内部和外部以及支架被分离的软骨细胞或Leydig细胞或软骨细胞和Leydig细胞接种。 假体的内部可以至少部分地被睾酮填充。

公开(公告)号：US06390096B1

公开(公告)日：2002-05-21

申请号：US09602141

申请日：2000-06-23

申请人： Timothy R. Conrad ,  Mark B. Knudson

发明人： Timothy R. Conrad ,  Mark B. Knudson

IPC分类号： A61B1900

CPC分类号： A61F2/00 ,  A61F2/0059 ,  A61F5/566

摘要： An apparatus for use in treating snoring of a patient suffering from snoring includes an implant of bio-compatible material sized to be embedded within the soft palate. The implant is disposed within a bore of a distal tip of a needle for penetration into the soft palate. The bore is sized to receive a rod from a proximal end of the needle with the rod opposing the implant to eject the implant from the distal tip upon relative sliding movement of said needle and said rod. The needle at the distal tip is perforated for fluid to flow through a wall of the needle into engagement with the implant. The implant is selected to altering a dynamic response of the soft palate to airflow past the soft palate.

摘要翻译： 用于治疗打鼾患者的打鼾的装置包括尺寸适于嵌入软腭的生物相容性材料的植入物。 植入物设置在针的远侧末端的孔内，用于穿透软腭。 孔的尺寸被设计成从针的近端接收杆，杆与植入物相对，以在所述针和所述杆的相对滑动运动时从远侧尖端喷射植入物。 在远侧末端处的针被穿孔以使流体流过针的壁与植入物接合。 选择植入物以改变软腭对通过软腭的气流的动态响应。

公开(公告)号：US20020022883A1

公开(公告)日：2002-02-21

申请号：US09879360

申请日：2001-06-12

发明人： Karen J.L. Burg

IPC分类号： A61F002/08 ,  A61F002/12 ,  A61F002/10

CPC分类号： A61L27/50 ,  A61F2/0059 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/3099 ,  A61F2/442 ,  A61F2002/2817 ,  A61F2002/30062 ,  A61F2210/0004 ,  A61F2310/00365 ,  A61F2310/00982 ,  A61L27/48 ,  A61L27/52 ,  A61L27/56

摘要： The invention provides a biocompatible composite for use in a living subject for purposes of repairing damaged tissues and reconstructing a new tissue. The composite includes a biodegradable or absorbable three-dimensional support construct, a liquid or viscous fluid forming a gel matrix or viscous fluid when delivered to an area of interest in a living subject. The biodegradable construct provides an ideal surface for cell or cell extract attachment, while the gel matrix or viscous fluid acts as both a carrier material and a separator for maintaining the space between the constructs as well as the structural integrity of the developing issue.

摘要翻译： 本发明提供了一种用于活体受试者的生物相容性复合物，用于修复受损组织和重建新组织。 该复合材料包括可生物降解的或可吸收的三维支撑构造物，当递送到活体中感兴趣区域时形成凝胶基质或粘性流体的液体或粘性流体。 可生物降解的构造提供了细胞或细胞提取物附着的理想表面，而凝胶基质或粘性流体既用作载体材料又用作隔离物，以保持构建体之间的空间以及发展中的问题的结构完整性。

公开(公告)号：US20010053353A1

公开(公告)日：2001-12-20

申请号：US09008945

申请日：1998-01-20

发明人： LINDA G GRIFFITH ,  ANTHONY ATALA ,  CHARLES A. VACANTI ,  KEITH T. PAIGE

IPC分类号： A01N063/00 ,  A01N065/00 ,  A61F013/00

CPC分类号： A61L27/383 ,  A61F2/0036 ,  A61F2/0059 ,  A61F2/02 ,  A61F2310/00365 ,  A61F2310/00383 ,  A61K35/34 ,  A61L27/20 ,  A61L27/222 ,  A61L27/24 ,  A61L27/38 ,  A61L27/3826 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/3882 ,  A61L27/50 ,  A61L27/52 ,  A61L2400/06 ,  C12N5/0068 ,  C08L5/08 ,  C08L5/04

摘要： Slowly polymerizing polysaccharide hydrogels have been demonstrated to be useful as a means of delivering large numbers of isolated cells via injection. The gels promote engraftment and provide three dimensional templates for new cell growth. The resulting tissue is similar in composition and histology to naturally occurring tissue. This method can be used for a variety of reconstructive procedures, including custom molding of cell implants to reconstruct three dimensional tissue defects, as well as implantation of tissues generally.

摘要翻译： 已经证明慢聚合多糖水凝胶可用作通过注射递送大量分离的细胞的手段。 凝胶促进植入，并为新细胞生长提供三维模板。 所得到的组织在组成和组织学上与天然存在的组织相似。 该方法可用于各种重建程序，包括定制模制细胞植入物以重建三维组织缺陷，以及一般植入组织。

公开(公告)号：US20010050084A1

公开(公告)日：2001-12-13

申请号：US09814456

申请日：2001-03-21

发明人： Mark B. Knudson ,  Timothy R. Conrad

IPC分类号： A61B019/00

CPC分类号： A61F2/00 ,  A61F2/0059 ,  A61F5/566

摘要： A method and apparatus for treating snoring include selecting an implant formed of a bio-compatible material having a longitudinal length between a proximal end and a distal end. The material is compliant in response to tensile forces along the length. The material is sized to be inserted into the soft palate with the longitudinal length extending aligned with an anterior-posterior axis of the palate and with the thickness contained within a thickness of the soft palate.

摘要翻译： 用于治疗打鼾的方法和装置包括选择由近端和远端之间具有纵向长度的生物相容性材料形成的植入物。 该材料响应于沿着长度的拉伸力而是柔顺的。 该材料的尺寸被设计成插入软腭中，其纵向长度与腭的前后轴线对准，并且厚度包含在软腭的厚度内。

公开(公告)号：US06284284B1

公开(公告)日：2001-09-04

申请号：US09182822

申请日：1998-10-29

申请人： Gail K. Naughton

发明人： Gail K. Naughton

IPC分类号： A61K3512

CPC分类号： A61L27/3633 ,  A61F2/0059 ,  A61F2/105 ,  A61K8/99 ,  A61L27/3683 ,  A61L27/3804 ,  A61L27/3839 ,  A61Q19/08 ,  Y10S514/801 ,  Y10T442/2525

摘要： The present invention discloses compositions containing natural human extracellular matrices and methods for the use thereof. More particularly, the present invention provides compositions and methods for the repair of skin defects using natural human extracellular matrix by injection.

摘要翻译： 本发明公开了含天然人细胞外基质的组合物及其使用方法。 更具体地，本发明提供了通过注射使用天然人细胞外基质修复皮肤缺陷的组合物和方法。