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81.发明公开公开(公告)号：US20230204596A1
公开(公告)日：2023-06-29
申请号：US18178288
申请日：2023-03-03
Applicant: Seer, Inc.
Inventor： William Manning , Young Kim , Brandon Kwan-Leong , Hope Liou , Xiaoyan Zhao , Daniel Hornburg , Martin Goldberg
CPC classification number: G01N33/6848 , B01L3/5085 , B01L7/00 , G01N1/34 , G01N1/44 , G01N33/54326 , G01N33/54346 , B01L2400/043 , B82Y5/00
Abstract: Systems and methods for automated sample preparation and processing of protein corona are described herein, as well as its application in the discovery of advanced diagnostic tools as well as therapeutic agents.
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公开(公告)号：US20230204546A1
公开(公告)日：2023-06-29
申请号：US18117634
申请日：2023-03-06
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Qian Zhang
CPC classification number: G01N30/7266 , G01N30/80 , G01N33/6848 , A61K47/6803 , H01J49/165
Abstract: Methods and system for protein characterization using online chromatography and electrospray ionization mass spectrometry are provided.
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公开(公告)号：US20230194543A1
公开(公告)日：2023-06-22
申请号：US18053093
申请日：2022-11-07
Applicant: Waters Technologies Corporation
Inventor： Johannes Vissers , Thomas McDonald , Keith Richardson
CPC classification number: G01N33/6848 , G01N30/88 , G01N2030/8831
Abstract: Provided herein are methods, techniques and processes for selecting one or more peptides for virus detection (e.g., influenza, SARS-CoV-2) in clinical samples using mass spectrometry. Methods for selecting a combination of peptides to identify one or more disease states in a patient can include: (i) selecting the one or more disease states; (ii) collecting information on proteins associated with the one or more disease states being present within the subject; (ii) in silico digesting individual proteins associated with the one or more disease state to obtain possible workflow peptides; (iv) collecting filtering data associated with the possible workflow peptides; (iv) analyzing the possible workflow peptides for coverage of the one or more disease states and for mass spectrometry detection and resolution; and (iv) selecting the combination of peptides from the possible workflow peptides based on the analyzing step.
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公开(公告)号：US20230192779A1
公开(公告)日：2023-06-22
申请号：US17955214
申请日：2022-09-28
Applicant: Lawrence Livermore National Security, LLC
Inventor： Mathew Gerald Lyman , Deon S. Anex , Bonnee Rubinfeld
IPC: C07K14/245 , G01N33/68
CPC classification number: C07K14/245 , G01N33/6848
Abstract: Described are methods, compositions, and devices for a concatemeric protein standard that behaves as a protein but transforms into single peptides upon digestion, which is optimized to function as a non-obtrusive process control for mass spectrometry analysis.
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公开(公告)号：US20190242907A1
公开(公告)日：2019-08-08
申请号：US16329926
申请日：2017-08-31
Applicant: Georgetown University
Inventor： Radoslav GOLDMAN , Miloslav SANDA
CPC classification number: G01N33/6893 , C07K14/47 , G01N33/6827 , G01N33/6848 , G01N2800/085 , G01N2800/52
Abstract: Provided are in vitro serologic methods of assessing the presence of, and assessing the progression of, liver fibrosis in a subject. Also provided are methods of assessing efficacy of an agent for the treatment of liver fibrosis, and methods of treating liver fibrosis. The methods involve quantitatively measuring di-sialylated and mono-sialylated O-glycoforms of a peptide fragment of hemopexin (HPX) in a test serum sample obtained from a test subject, and comparing the measured amounts of di-sialylated and mono-sialylated O-glycoforms of the peptide fragment of hemopexin to a reference amount. In certain embodiments, the measuring is performed using LC-MS/MS-MRM (liquid chromatography/tandem mass spectrometry/multiple reaction monitoring). In certain embodiments, the measuring is performed using LC/MS3 (liquid chromatography with triple-stage mass spectrometric detection).
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Patent Agency Ranking
公开(公告)号：US20190234960A1
公开(公告)日：2019-08-01
申请号：US16260471
申请日：2019-01-29
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Shunhai Wang
IPC: G01N33/68 , G01N30/72 , B01J20/281 , G01N30/46
CPC classification number: G01N33/6848 , B01D15/1871 , C07K1/16 , C07K1/20 , G01N30/462 , G01N30/463 , G01N30/465 , G01N30/468 , G01N30/482 , G01N30/7233 , G01N33/6821 , G01N2030/8831
Abstract: Methods for achieving complete sequence coverage of monoclonal antibodies by trypsin digestion and dual-column LC-MS system are provided. The disclosed method improves upon current techniques for standard peptide mapping.
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公开(公告)号：US20190212338A1
公开(公告)日：2019-07-11
申请号：US16328233
申请日：2017-08-24
Applicant: THERMO FISHER SCIENTIFIC OY
Inventor： Mikko KOSKINEN , Leena VALMU , Joni RANNISTO , Kelly FLOOK , Roger GRIST , Anssi RANTAKARI
IPC: G01N33/569 , G01N33/68
CPC classification number: G01N33/56944 , G01N33/569 , G01N33/56911 , G01N33/56916 , G01N33/56938 , G01N33/56961 , G01N33/6848
Abstract: The present invention includes a novel method and system for identification of microorganisms in samples that proteins and other biological material from non-microorganism sources (e.g., proteins of mammalian origin) that can interfere with identification of the microorganisms. The methods and systems described herein include use of a single-use chromatography medium to purify intact proteins prior to mass spectrometry analysis. The chromatography medium and the methods described herein can rapidly and efficiently remove of a substantial portion of interfering biological material (e.g., mammalian proteins) from a crude cell lysate while preserving high signal strength and removing enough of the interfering protein(s) to allow for identification of the microorganism(s) by mass spectrometry analysis.
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公开(公告)号：US20190212337A1
公开(公告)日：2019-07-11
申请号：US16358533
申请日：2019-03-19
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Subhasish Purkayastha , Subhakar Dey
CPC classification number: G01N33/569 , C12Q1/02 , C12Q1/04 , C12Q1/68 , C12Q1/686 , G01N30/72 , G01N30/7233 , G01N30/88 , G01N33/6848 , G01N2030/8831
Abstract: Systems and methods are provided for microbial identification using cleavable tags. Control information is sent to a mass spectrometer to fragment one or more nucleic acid primers labeled with a first tag and monitor for an intensity of the first tag in a mass spectrometry (MS) method. An ion source provides a beam of ions from a polymerase chain reaction amplified sample that includes one or more nucleic acid primers labeled with the first tag. The first tag binds to one or more nucleic acid primers of a known microbe and is cleaved from the nucleic acid primers during the MS method. The mass spectrometer receives the beam of ions and is adapted to perform the MS method on the beam of ions. If the intensity of the first tag received from the mass spectrometer exceeds a threshold value, the known microbe is identified in the sample.
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公开(公告)号：US20190112632A1
公开(公告)日：2019-04-18
申请号：US16223615
申请日：2018-12-18
Inventor： Marie-Hélène CHARLES , Jean-Philippe CHARRIER , Myriam-Laure CUBIZOLLES , Agnès DUPONT-FILLIARD , Véronique LANET , Florence RIVERA , Laurent VERON , Lucie BAUJARD-LAMOTTE , Christine PEPONNET
CPC classification number: C12Q1/37 , C07K1/1077 , C07K1/12 , C07K1/36 , C12N13/00 , G01N33/6848
Abstract: The present invention relates to a method of obtaining peptides from procaryotic and/or eucaryotic cells.
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公开(公告)号：US20180321253A1
公开(公告)日：2018-11-08
申请号：US15773187
申请日：2016-11-04
Applicant: Promise Advanced Proteomics
Inventor： Dorothée Lebert , Guillaume Picard
IPC: G01N33/68 , C07K16/24 , G01N33/573
CPC classification number: G01N33/6848 , C07K16/241 , G01N33/573 , G01N2800/52 , G01N2800/56
Abstract: The present invention relates to a method for quantifying an anti-TNF antibody in a sample of a human individual comprising a step of adding to a test sample which may contain therapeutic anti-TNF antibodies a known amount of two or more labeled forms of said anti-TNF antibodies.
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