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    Mass spectrometric detection of polypeptides
    81.
    发明授权
    Mass spectrometric detection of polypeptides 有权
    多肽的质谱检测

    公开(公告)号：US06387628B1

    公开(公告)日：2002-05-14

    申请号：US09664977

    申请日：2000-09-18

    Applicant: Daniel Little ,  Hubert Köster ,  G. Scott Higgins ,  David Lough

    Inventor： Daniel Little ,  Hubert Köster ,  G. Scott Higgins ,  David Lough

    IPC: C12Q160

    CPC classification number: G01N33/6848 ,  G01N33/6818 ,  G01N33/6842 ,  G01N33/6851 ,  H01J49/00

    Abstract: A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogenic organism; or for determining identity or heredity. Kits for performing the disclosed processes also are provided.

    Abstract translation: 提供了使用质谱法确定靶多肽的身份的方法。 根据待鉴定的靶多肽，可以使用所公开的方法，例如诊断遗传疾病或染色体异常，疾病或病症的倾向或病原生物的感染; 或用于确定身份或遗传。 还提供了用于执行所公开的处理的套件。

    Probe for the measurement of gas tensions
    85.
    发明授权
    Probe for the measurement of gas tensions 有权
    探测气体张力的测量

    公开(公告)号：US6133567A

    公开(公告)日：2000-10-17

    申请号：US167562

    申请日：1998-10-07

    Applicant: James E. Baumgardner ,  Gordon R. Neufeld ,  Bryan E. Marshall

    Inventor： James E. Baumgardner ,  Gordon R. Neufeld ,  Bryan E. Marshall

    IPC: A61B5/00 ,  G01N7/10 ,  H01J49/04 ,  B01D59/44

    CPC classification number: A61B5/1459 ,  G01N7/10 ,  H01J49/00

    Abstract: A gas measurement probe for measuring gas tensions in liquid. The probe comprises a tubing having one end adapted for connection to a gas measurement device, such as a mass spectrometer, a gas chromatograph, an infrared spectrometer or a Raman spectrometer, among others. The second end of the probe is provided with a tip having at least one pore formed in it. The pore is filled with a membrane material which eliminates water from entering, but admits low molecular weight gases. These low molecular weight gases may then be identified by the measurement device.

    Abstract translation: 用于测量液体中气体张力的气体测量探头。 探针包括具有适于连接到诸如质谱仪，气相色谱仪，红外光谱仪或拉曼光谱仪之类的气体测量装置的一端的管道。 探针的第二端设置有在其中形成有至少一个孔的尖端。 孔中填充有一种膜材料，可以避免水分进入，但承认低分子量气体。 然后可以通过测量装置来识别这些低分子量气体。

    Methods and apparatus for sequencing polymers using mass spectrometry
    86.
    发明授权
    Methods and apparatus for sequencing polymers using mass spectrometry 失效
    使用质谱法测定聚合物的方法和设备

    公开(公告)号：US5827659A

    公开(公告)日：1998-10-27

    申请号：US796598

    申请日：1997-02-07

    Applicant: Dale H. Patterson

    Inventor： Dale H. Patterson

    IPC: C07K1/12 ,  C07K14/00 ,  C12P21/06 ,  C12Q1/34 ,  G01N33/68 ,  H01J49/04 ,  C12Q1/68 ,  C07K5/00 ,  C12P19/34 ,  C12Q1/70

    CPC classification number: G01N33/6848 ,  C07K1/128 ,  C07K14/003 ,  C12P21/06 ,  C12Q1/34 ,  H01J49/0418 ,  H01J49/00

    Abstract: The methods and apparatus disclosed herein are useful for sequencing polymers using mass spectrometry. The methods involve differing ratios of hydrolyzing agent to polymer disposed upon a reaction surface adapted for use with a mass spectrometer. The methods further involve integrating data obtained from mass spectrometry analysis of a plurality of series of hydrolyzed polymer fragments, and optionally provide statistical interpretation paradigms and computer software therefor. The apparatus involves a mass spectrometer sample holder, having hydrolyzing agent disposed thereon, which is useful for adapting any mass spectrometer for polymer sequencing.

    Abstract translation: 本文公开的方法和装置可用于使用质谱法测序聚合物。 该方法涉及不同比例的水解剂与聚合物的配置在适合与质谱仪一起使用的反应表面上。 所述方法还涉及整合从多个水解聚合物片段系列的质谱分析获得的数据，并且可选地提供统计解释范例及其计算机软件。 该装置包括质谱仪样品架，其上设置有水解剂，其可用于使任何质谱仪适合聚合物测序。

    Methods for sequencing polymers using mass spectrometry
    87.
    发明授权
    Methods for sequencing polymers using mass spectrometry 失效
    使用质谱法测定聚合物的方法

    公开(公告)号：US5821063A

    公开(公告)日：1998-10-13

    申请号：US844462

    申请日：1997-04-18

    Applicant: Dale H. Patterson ,  George E. Tarr

    Inventor： Dale H. Patterson ,  George E. Tarr

    IPC: C07K1/12 ,  C07K14/00 ,  C12P21/06 ,  C12Q1/34 ,  G01N33/68 ,  H01J49/04 ,  C12Q1/68 ,  C12N9/14 ,  C12N9/24

    CPC classification number: G01N33/6848 ,  C07K1/128 ,  C07K14/003 ,  C12P21/06 ,  C12Q1/34 ,  H01J49/0418 ,  H01J49/00

    Abstract: The methods and apparatus disclosed herein are useful for sequencing polymers using mass spectrometry. The methods involve differing ratios of hydrolyzing agent to polymer disposed upon a reaction surface adapted for use with a mass spectrometer. The methods further involve integrating data obtained from mass spectrometry analysis of a plurality of series of hydrolyzed polymer fragments, and optionally provide statistical interpretation paradigms and computer software therefor. The apparatus involves a mass spectrometer sample holder, having hydrolyzing agent disposed thereon, which is useful for adapting any mass spectrometer for polymer sequencing.

    Abstract translation: 本文公开的方法和装置可用于使用质谱法测序聚合物。 该方法涉及不同比例的水解剂与聚合物的配置在适合与质谱仪一起使用的反应表面上。 所述方法还涉及整合从多个水解聚合物片段系列的质谱分析获得的数据，并且可选地提供统计解释范例及其计算机软件。 该装置包括质谱仪样品架，其上设置有水解剂，其可用于使任何质谱仪适合聚合物测序。

    Method for preparing blend products
    88.
    发明授权
    Method for preparing blend products 失效
    混合产品的制备方法

    公开(公告)号：US5600134A

    公开(公告)日：1997-02-04

    申请号：US494202

    申请日：1995-06-23

    Applicant: Terrence R. Ashe ,  Robert J. Falkiner ,  Tian C. Lau

    Inventor： Terrence R. Ashe ,  Robert J. Falkiner ,  Tian C. Lau

    IPC: G01N30/04 ,  G01N30/72 ,  G01N30/86 ,  G01N33/28 ,  G05D11/13 ,  H01J49/00

    CPC classification number: G01N33/2829 ,  G05D11/139 ,  G01N2030/042 ,  G01N30/7206 ,  G01N30/8644 ,  G01N30/8665 ,  G01N30/8682 ,  H01J49/00

    Abstract: A method for controlling the blending of blend stocks having boiling points less that 350.degree. C. into blend products or controlling refinery or chemical processes with feedstocks and products with boiling points less than 350.degree. C. The method comprises selecting one or more chemical or perceptual or physical property or performance properties of the blend stock or blend product or refinery or chemical feed or product, creating a training set from reference samples which contain characteristic molecular species present in the blend stock or blend product or refinery or chemical process feed or product. The reference samples are subject to GC/MS analysis wherein the often collinear data generated is treated by multivariate correlation methods. The training set produces coefficients which are multiplied by the matrix generated from a GC/MS analysis of an unknown blend stock or blend product or refinery or chemical process feed or product to produce a predicted value for the chemical, performance, perceptual or physical property or groups of properties selected.

    Abstract translation: 控制将沸点低于350℃的共混料料混合到共混产品中或用沸点低于350℃的原料和产品控制炼油或化学过程的方法。该方法包括选择一种或多种化学物质或感知 或混合物料或混合物或炼油厂或化学饲料或产品的物理性能或性能特性，从包含混合原料或混合产物或炼油厂或化学工艺进料或产品中存在的特征分子种类的参考样品创建培训组。 参考样品进行GC / MS分析，其中生成的经常共线数据通过多变量相关方法进行处理。 训练集合产生的系数乘以由未知混合物料或混合产品或炼油厂或化学工艺进料或产品的GC / MS分析产生的基质，以产生化学，性能，感知或物理性质的预测值，或 所选属性组。

    Method for determining water vapor transmission rate or water content
    89.
    发明授权
    Method for determining water vapor transmission rate or water content 失效
    测定水蒸气透过率或含水量的方法

    公开(公告)号：US4050995A

    公开(公告)日：1977-09-27

    申请号：US358576

    申请日：1973-05-09

    Applicant: Roger L. Bredeweg

    Inventor： Roger L. Bredeweg

    IPC: G01N27/42 ,  H01J49/04 ,  G01N27/46

    CPC classification number: G01N27/423 ,  G01N27/42 ,  H01J49/00

    Abstract: A cell for absorbing and electrolyzing the water vapor transmitted from a sample used in an apparatus for rapidly determining the water vapor transmission rate through plastic films or like structures and water content in solid, liquid and gaseous materials wherein electrolysis of the water vapor from a test sample takes place in a cell electrolysis assembly comprising a first electrode support and a first electrode and a second electrode support and a second electrode with a formaminous matrix having an electrically conductive water absorption material therein disposed electrically between the first and second electrodes. The water vapor transmission rate or water content of the sample can be rapidly and accurately determined by quantitative mass spectrometer calculations of the oxygen and hydrogen generated during electrolysis or by calculation of the electrical current needed to electrolyze the water vapor which are related with primary accuracy.

    Abstract translation: 用于吸收和电解从用于快速确定通过塑料膜或类似结构的水蒸汽透过率的设备中所用的样品传输的水蒸气的电池，以及固体，液体和气体材料中的水分含量，其中从测试中电解水蒸汽 样品发生在包括第一电极支撑件和第一电极和第二电极支撑件的电池电解组件中，以及第二电极，其中具有电导率在第一和第二电极之间的导电吸水材料的形式的基体。 可以通过定量质谱仪计算电解过程中产生的氧气和氢气，或通过计算与初级精度相关的水蒸汽电流所需要的电流来快速，准确地测定样品的水汽透过率或含水量。

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