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公开(公告)号：US20190240260A1
公开(公告)日：2019-08-08
申请号：US16327817
申请日：2017-08-23
发明人： Tokunori Yamamoto , Satoshi Suzuki , Yasuhito Funahashi , Yoshihisa Matsukawa , Momokazu Gotoh , Tomohiro Kitayama , Yoichiro Hoshino , Tetsuma Murase
CPC分类号： A61K35/50 , A61K35/28 , A61K35/32 , A61K35/35 , A61K35/51 , A61K35/52 , A61K35/54 , A61P15/08 , C12N5/061 , C12N5/0664 , C12N5/0665 , C12N5/0667
摘要： It is an object to provide a technique useful for embryo transfer and development of reproductive medical care. Provided are a sperm activator containing a disrupted product of one or more cells selected from the group consisting of adipose tissue-derived stem cells, dental pulp-derived stem cells, bone marrow-derived stem cells, and umbilical cord blood-derived stem cells as an active ingredient, and an artificial insemination method utilizing the same.
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公开(公告)号：US10322186B2
公开(公告)日：2019-06-18
申请号：US16235964
申请日：2018-12-28
发明人： Dov Tamarkin , Elana Gazal , Irakliy Papiashvili , Yohan Hazot , David Schuz , Rita Keynan
IPC分类号： A61K8/18 , A61K35/50 , A61K31/65 , C07C50/36 , C07C237/26 , A61K47/44 , A61Q17/04 , A61K9/00 , A61K9/12 , A61K47/24 , A61K45/06 , A61K47/10 , A61K8/36 , A61K8/34 , A61Q19/10 , A61Q19/00 , A61K8/31 , A61K47/02 , A61K31/192 , A61K31/137 , A61K47/12 , A61K31/593 , A61K31/573 , A61K31/57 , A61K31/4164 , A61K47/06
摘要： A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity or the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents. The tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracycline has not broken down. The composition is packaged as a breakable foam that breaks easily upon application of shear force.
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公开(公告)号：US10300091B2
公开(公告)日：2019-05-28
申请号：US15309306
申请日：2015-05-07
发明人： Peter S. McFetridge , Marc C. Moore
IPC分类号： A61K35/50 , A61K9/16 , A61L27/36 , C12N5/071 , A61K38/18 , A61K38/19 , A61L27/38 , A61L27/54
摘要： The present disclosure provides compositions including a human placental extract and biodegradable microparticles, sustained release angiogenesis-modulating compositions, compositions and methods for releasing a placental extract to a target over a period of time, and methods for inducing and/or modulating angiogenesis and identifying modulators of angiogenesis. The present disclosure also provides methods of making a composition, including a placental extract that can induce and/or modulate angiogenesis.
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公开(公告)号：US20190134099A1
公开(公告)日：2019-05-09
申请号：US16229823
申请日：2018-12-21
发明人： STEVEN MICHAEL SINCLAIR , ALLA DANILKOVITCH , MALATHI SATHYAMOORTHY , JIN-QIANG KUANG , SANDEEP DHALL , YISHAN LIU , ANTHONY JOHN MELCHIORRI , MATTHEW ROBERT MOORMAN , MENA SCHIANO LO MORIELLO , ANNE ALLGOOD LERCH
IPC分类号： A61K35/50 , A61P19/02 , A61P19/10 , A61L26/00 , A61K35/51 , A61K9/00 , A61K9/06 , A61K9/19 , A61K35/33 , A61P19/00 , A61P19/04 , A61P17/02 , A61P29/00 , A61L27/36 , A61L27/38
摘要： Disclosed are compositions comprising a non-homogenized chorionic matrix, a homogenized amniotic matrix and a homogenized UC (UC) matrix, wherein the non-homogenized chorionic matrix comprises viable cells. Disclosed are methods of making the compositions disclosed herein comprising preparing a non-homogenized chorionic matrix, preparing a homogenized amniotic matrix, preparing a homogenized UC matrix, and combining the non-homogenized chorionic matrix, the non-homogenized chorionic matrix, and the homogenized UC matrix. Disclosed are methods of treating a tissue injury or chronic pain comprising administering any of the disclosed compositions to an area of a subject comprising a tissue injury.
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85.发明申请公开(公告)号：US20190127702A1
公开(公告)日：2019-05-02
申请号：US15503709
申请日：2015-08-14
发明人： Irina KERKIS , Sabina GLOZMAN
IPC分类号： C12N5/0775 , C12N5/073 , A61K35/50 , A61K35/51 , A61K35/12
摘要： The present method relates to methods of expanding or increasing stem cell production obtained from donor samples. The methods preferably including the steps of harvesting cells from minimally manipulated tissue using multiply harvesting cycles to increase the number of obtained stem cells.
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公开(公告)号：US10265344B2
公开(公告)日：2019-04-23
申请号：US14291256
申请日：2014-05-30
发明人： Samson Tom , Alla Danilkovitch , Dana Yoo , Timothy Jansen , Jin-Qiang Kuang , Jennifer Michelle Marconi
摘要： Provided herein is a placental product comprising an immunocompatible chorionic membrane. Such placental products can be cryopreserved and contain viable therapeutic cells after thawing. The placental product of the present invention is useful in treating a patient with a tissue injury (e.g. wound or burn) by applying the placental product to the injury. Similar application is useful with ligament and tendon repair and for engraftment procedures such as bone engraftment.
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公开(公告)号：US10258652B2
公开(公告)日：2019-04-16
申请号：US15521537
申请日：2015-12-18
申请人： PLURISTEM LTD.
摘要： Described herein are methods of treating and preventing muscle wasting and muscle loss, using adherent stromal cells and conditioned medium produced thereby.
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公开(公告)号：US10251917B1
公开(公告)日：2019-04-09
申请号：US15708413
申请日：2017-09-19
申请人： Gary M. Petrucci
发明人： Gary M. Petrucci
摘要： This document provides methods and materials for treating a mammal (e.g., a human) having one or more tumors. For example, embolic agents including an amnion tissue preparation (e.g., amnion coated embolic agents) that can be used in arterial embolization to reduce or eliminate blood flow in a blood vessel that supplies a tumor are provided.
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89.发明授权公开(公告)号：US10232000B2
公开(公告)日：2019-03-19
申请号：US15110668
申请日：2015-01-08
发明人： Chul Won Ha , Jin A. Kim
摘要： The present disclosure relates to stem cells derived from the basal portion of the chorionic trophoblast layer (bCT), which is a part of the issues of the placenta, and cell therapy comprising same. Stem cells derived from the basal portion of the chorionic trophoblast layer according to the present invention exhibit uniform growth characteristic, and superb proliferation and differentiation characteristic as compared with the conventional stem cells derived from the full placenta or other tissues, and exhibit excellent tissue regeneration effect in an animal model, thus can be effectively used in cell therapy.
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90.发明申请公开(公告)号：US20190070223A1
公开(公告)日：2019-03-07
申请号：US16086781
申请日：2017-03-30
发明人： Yun Sil CHANG , Won Soon PARK , So Yoon AHN , Dong Kyung SUNG
IPC分类号： A61K35/28 , C12N5/0775 , A61P9/10 , G01N33/50 , A61K38/48 , A61K38/18 , C12N5/077 , C12N5/0735 , C12N5/073 , A61K35/50
摘要： The present invention relates to a selection method of a highly active stem cell for treatment of cerebrovascular diseases, comprising a step of measuring a level of a neurotrophic factor, and a highly active stem cell selected thereby. According to the present invention, BDNF secreted by mesenchymal stem cells mediate inhibitory effects on cell death, inflammation, astrogliosis, and posthemorrhagic hydrocephalus and plays a very important role in improving myelination after intraventricular hemorrhage. Hence, the method according to the present invention can be usefully applied to the treatment of various cerebrovascular diseases including intraventricular hemorrhage in preterm infants.
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