公开(公告)号：US20240209454A1

公开(公告)日：2024-06-27

申请号：US18556049

申请日：2022-04-19

申请人： Deirdre Hill ,  Eric R. Prossnitz ,  Yan Guo

发明人： Deirdre Hill ,  Eric R. Prossnitz ,  Yan Guo

IPC分类号： C12Q1/6886 ,  G16B20/20

CPC分类号： C12Q1/6886 ,  G16B20/20 ,  C12Q2600/106 ,  C12Q2600/156

摘要： A method to determine disease-specific survival, disease-free interval, progression-free interval, progression-free survival or overall survival in a cancer patient based on specific mutational signatures is provided.

公开(公告)号：US20240209452A1

公开(公告)日：2024-06-27

申请号：US18542277

申请日：2023-12-15

申请人： Arizona Board of Regents on Behalf of the University of Arizona

发明人： Lukas Vrba ,  Bernard W. Futscher

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/154

摘要： Cancer specific DNA methylation regions have been studied to find cancer specific DNA methylation markers for most common cancers. Differentially methylated regions for individual cancer types were identified and those were further filtered against data from normal tissues to obtain marker regions with cancer specific methylation, resulting in total of 1,250 hypermethylated and 584 hypomethylated marker CpGs. Optimal sets of six markers for each TCGA cancer type that could identify most tumors with high specificity and sensitivity (AUC 0.969-1.00) were chosen from hypermethylated markers and a universal 12 marker set that can detect tumors of all 33 TCGA cancer types (AUC>0.84) was also chosen from hypermethylated markers.

公开(公告)号：US12018331B2

公开(公告)日：2024-06-25

申请号：US16304150

申请日：2017-05-23

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.

发明人： Yoav Smith

IPC分类号： C12Q1/6886 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  G01N33/57423 ,  G01N33/5743 ,  G01N33/57434 ,  G01N33/57438 ,  G01N33/57449 ,  G01N33/57488 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N2800/52 ,  G01N2800/56

摘要： Methods and kits for the diagnosis of cancer based on specific expression profiles of Cancer Testis Antigens (CTA) are provided.

公开(公告)号：US12018314B2

公开(公告)日：2024-06-25

申请号：US15738871

申请日：2016-07-04

申请人： Arima Genomics, Inc.

发明人： Siddarth Selvaraj ,  Nathaniel Heintzman ,  Christian Edgar Laing

IPC分类号： C12Q1/6806 ,  C12Q1/6883 ,  C12Q1/6886 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B20/40 ,  G16B40/00

CPC分类号： C12Q1/6806 ,  C12Q1/6883 ,  C12Q1/6886 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B20/40 ,  G16B40/00 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The present disclosure relates to methods to deconvolute a mixture sample of genetic material from different origins or sources. The disclosed methods can be used in various applications, including, the non-invasive determination of a fetal genome, a fetal -ome (e.g. exome). or other targeted fetal locus from cell-free nucleic acids in maternal plasma or other body fluids; the determination of cancer-associated mutations from cell-free nucleic acids in a body fluid sample that contains a mixture of nucleic acids from normal cells and tumor cells; and quantification of donor cell contamination using a body fluid from a transplantation recipient to monitor and/or predict the outcome of a transplantation procedure.

公开(公告)号：US20240200150A1

公开(公告)日：2024-06-20

申请号：US18594336

申请日：2024-03-04

申请人： GUARDANT HEALTH, INC.

发明人： AmirAli TALASAZ

IPC分类号： C12Q1/6886 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q1/6874 ,  G16B30/00 ,  G16B30/10

CPC分类号： C12Q1/6886 ,  C12N15/1065 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q1/6874 ,  G16B30/00 ,  G16B30/10 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16

摘要： The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides. Generally, the systems and methods comprise sample preparation, or the extraction and isolation of cell free polynucleotide sequences from a bodily fluid; subsequent sequencing of cell free polynucleotides by techniques known in the art; and application of bioinformatics tools to detect rare mutations and copy number variations as compared to a reference. The systems and methods also may contain a database or collection of different rare mutations or copy number variation profiles of different diseases, to be used as additional references in aiding detection of rare mutations, copy number variation profiling or general genetic profiling of a disease.

公开(公告)号：US20240200144A1

公开(公告)日：2024-06-20

申请号：US18431820

申请日：2024-02-02

申请人： CERTARA USA, INC.

发明人： Brahim ACHOUR ,  Amin ROSTAMI-HODJEGAN

IPC分类号： C12Q1/6886 ,  A61K45/06 ,  C12Q1/6806

CPC分类号： C12Q1/6886 ,  A61K45/06 ,  C12Q1/6806 ,  C12Q2600/106 ,  C12Q2600/158

摘要： Methods and systems for generating a personalised pharmacodynamic profiles for an individual subject are provided. The method comprises the steps of: isolating total cell free RNA (cfRNATOTAL) from a liquid biopsy obtained from the individual subject and identifying an amount of at least a first cell free RNA (cfRNA) present in the liquid biopsy, wherein the first cfRNA encodes a first protein that has a pharmacodynamic activity. From the amount of cfRNA in the liquid biopsy an amount of the first protein in the individual subject can be determined, thereby allowing a personalised pharmacodynamic profile for the individual subject to be generated. The methods and systems find utility in precision dosing and personalised medicine.

公开(公告)号：US12012635B2

公开(公告)日：2024-06-18

申请号：US17592818

申请日：2022-02-04

申请人： EWINGER INC.

发明人： Edward E. Winger ,  Jane Reed

IPC分类号： C12N15/11 ,  C12Q1/6883 ,  C12Q1/6886

CPC分类号： C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The invention is directed to methods and compositions for collecting a non-placental biological samples of cells and quantifying and comparing levels of expression of microRNAs to characterize a preeclampsia-related condition. The samples may be collected before or after an intervention or may be collected over a period of time. One of the samples may be a control sample. Patients may then be treated according to their response.

公开(公告)号：US12012599B2

公开(公告)日：2024-06-18

申请号：US17046276

申请日：2019-04-15

申请人： CZ Biohub SF LLC ,  The Board of Trustees of the Leland Stanford Junior University

发明人： Michael F. Clarke ,  Neethan A. Lobo ,  Maider Zabala Ugalde ,  Jane Antony

IPC分类号： A61P35/00 ,  A61K38/18 ,  C07K16/22 ,  C12N15/113 ,  C12Q1/6886 ,  G01N33/574 ,  G01N33/74 ,  A61K39/00

CPC分类号： C12N15/1136 ,  A61K38/1808 ,  A61K38/1841 ,  A61K38/1875 ,  A61P35/00 ,  C07K16/22 ,  C12Q1/6886 ,  G01N33/57484 ,  G01N33/74 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C12N2310/122 ,  C12N2310/14 ,  C12Q2600/158 ,  G01N2333/495 ,  G01N2333/51 ,  G01N2500/02

摘要： This disclosure provides data showing that LEFTY inhibits differentiation-promoting pathways such as BMP7/pSMAD5 in breast cancer cell lines, over and above its known role of inhibiting Nodal/pSMAD2. LEFTY competes with BMP7 to bind to its cell surface receptor BMPR2, leading to inhibition of pSMAD5. The LEFTY-BMPR2 interaction is dominant over BMP-BMPR2 in tumorigenic cells, resulting in diminished pSMAD status, whereas in non-tumorigenic cells, there is minimal LEFTY-BMPR2 interaction, increased BMP7-BMPR2 association, and elevated pSMAD. Compositions and methods for inducing or inhibiting expression and/or the activity of LEFTY and BMP proteins are described, which can be used in diagnosis and therapy of cancer and other conditions, and to promote proliferation of stem cells.

公开(公告)号：US20240191308A1

公开(公告)日：2024-06-13

申请号：US18508945

申请日：2023-11-14

申请人： Mayo Foundation for Medical Education and Research ,  Exact Sciences Corporation

发明人： David A. Ahlquist ,  William R. Taylor ,  John B. Kisiel ,  Tracy C. Yab ,  Douglas W. Mahoney ,  Hatim T. Allawi

IPC分类号： C12Q1/6886

CPC分类号： C12Q1/6886 ,  C12Q2600/154 ,  C12Q2600/16

摘要： Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as gastric cancer.

公开(公告)号：US20240191306A1

公开(公告)日：2024-06-13

申请号：US18430156

申请日：2024-02-01

申请人： Case Western Reserve University

发明人： Sanford D. Markowitz ,  Helen Moinova ,  Amitabh Chak ,  Joseph Willis ,  Thomas LaFramboise

IPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6853 ,  G01N33/574

CPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6853 ,  G01N33/574 ,  C12Q2600/154 ,  C12Q2600/156

摘要： The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.