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    Peptides, devices, and methods for the detection of Ehrlichia antibodies
    4.
    发明授权
    Peptides, devices, and methods for the detection of Ehrlichia antibodies 有权
    用于检测埃里希抗体的肽，装置和方法

    公开(公告)号：US09470682B2

    公开(公告)日：2016-10-18

    申请号：US14450154

    申请日：2014-08-01

    申请人： Abaxis, Inc.

    发明人： Rajesh K. Mehra ,  Kenneth P. Aron ,  Dennis M. Bleile

    IPC分类号： G01N33/543 ,  C07K14/195 ,  G01N33/569

    CPC分类号： G01N33/54306 ,  C07K14/195 ,  G01N33/54353 ,  G01N33/54366 ,  G01N33/56911 ,  G01N2333/29

    摘要： The invention provides compositions (e.g., peptide compositions) useful for the detection of antibodies that bind to Ehrlichia antigens. The peptide compositions comprise polypeptide sequences based on an immunogenic fragment of the Ehrlichia Outer Membrane Protein 1 (OMP-1) protein. The invention also provides devices, methods, and kits comprising such peptide compositions and useful for the detection of antibodies that bind to Ehrlichia antigens and the diagnosis of monocytic ehrlichiosis.

    摘要翻译： 本发明提供可用于检测结合埃氏杆菌抗原的抗体的组合物（例如肽组合物）。 肽组合物包含基于埃氏杆菌外膜蛋白1（OMP-1）蛋白的免疫原性片段的多肽序列。 本发明还提供了包含这样的肽组合物的装置，方法和试剂盒，并且可用于检测结合埃氏杆菌抗原的抗体和单核细胞性鹰毒病的诊断。

    PEPTIDES, DEVICES, AND METHODS FOR THE DETECTION OF EHRLICHIA ANTIBODIES
    6.
    发明申请
    PEPTIDES, DEVICES, AND METHODS FOR THE DETECTION OF EHRLICHIA ANTIBODIES 有权
    用于检测EHRLICHIA抗体的肽，装置和方法

    公开(公告)号：US20140121125A1

    公开(公告)日：2014-05-01

    申请号：US14052296

    申请日：2013-10-11

    申请人： ABAXIS, INC.

    发明人： Rajesh K. MEHRA ,  Kenneth P. Aron ,  Dennis M. Bleile ,  Timothy P. Forsyth ,  Jeremy D. Walker ,  Cristina R. Cuesico

    IPC分类号： G01N33/569

    CPC分类号： G01N33/54306 ,  C07K14/29 ,  C07K17/14 ,  G01N33/56911 ,  G01N33/6854 ,  G01N2333/29 ,  G01N2469/20

    摘要： The invention provides peptide compositions and mixtures useful for the detection of antibodies that bind to Ehrlichia antigens. The peptide compositions and mixtures comprise polypeptide sequences based on an immunogenic fragment of the Ehrlichia Outer Membrane Protein 1 (OMP-1) protein. The invention also provides devices, methods, and kits comprising such peptide compositions and mixtures useful for the detection of antibodies that bind to Ehrlichia antigens and the diagnosis of monocytic and/or granulocytic ehrlichiosis.

    摘要翻译： 本发明提供了用于检测结合埃氏杆菌抗原的抗体的肽组合物和混合物。 肽组合物和混合物包含基于埃氏杆菌外膜蛋白1（OMP-1）蛋白的免疫原性片段的多肽序列。 本发明还提供了包含这样的肽组合物和可用于检测结合埃氏杆菌抗原的抗体和用于诊断单核细胞和/或粒细胞性肝病的混合物的装置，方法和试剂盒。

    VALIDATION OF POINT-OF-CARE TEST RESULTS BY ASSESSMENT OF EXPECTED ANALYTE RELATIONSHIPS
    7.
    发明申请
    VALIDATION OF POINT-OF-CARE TEST RESULTS BY ASSESSMENT OF EXPECTED ANALYTE RELATIONSHIPS 审中-公开
    通过评估预期的分析关系来验证点保护测试结果

    公开(公告)号：US20110276342A1

    公开(公告)日：2011-11-10

    申请号：US13102394

    申请日：2011-05-06

    申请人： Steven C. KAZMIERCZAK

    发明人： Steven C. KAZMIERCZAK

    IPC分类号： G06Q50/00

    CPC分类号： G06Q50/22 ,  G16H10/40 ,  G16H50/70

    摘要： Methods for determining the validity or accuracy of a clinical test result are provided. The methods entail obtaining patient analyte concentration data for two or more analytes with a concentration relationship; calculating a likelihood distribution for the concentration relationship between the two or more analytes; obtaining a clinical test result comprising measured concentration values for the two or more analytes; and determining the validity or accuracy of the clinical test result based on whether the clinical test result falls within the boundaries of the likelihood distribution. Analyte pairs that can be analyzed by the methods of the invention include albumin/calcium, sodium/chloride, BUN/creatinine, AST/ALT, total protein/albumin, potassium/total CO2, calcium/phosphorus, calcium/magnesium, potassium/creatinine, magnesium/potassium, Anion gap/potassium, sodium/potassium, chloride/potassium, magnesium/phosphate, ALT/GGT, ALT/ALP, CK/LDH and chloride/total CO2.

    摘要翻译： 提供了确定临床测试结果的有效性或准确性的方法。 该方法需要获得具有浓度关系的两种或更多种分析物的患者分析物浓度数据; 计算两种或更多种分析物之间的浓度关系的似然分布; 获得包含两种或多种分析物的测量浓度值的临床测试结果; 并根据临床试验结果是否属于可能性分布的边界，确定临床试验结果的有效性或准确性。 可通过本发明方法分析的分析物对包括白蛋白/钙，钠/氯，BUN /肌酐，AST / ALT，总蛋白/白蛋白，钾/总二氧化碳，钙/磷，钙/镁，钾/肌酸酐 ，镁/钾，阴离子间隙/钾，钠/钾，氯化物/钾，镁/磷酸盐，ALT / GGT，ALT / ALP，CK / LDH和氯化物/总二氧化碳。

    Error checking in blood analyzer
    8.
    发明授权
    Error checking in blood analyzer 失效
    血液分析仪检查错误

    公开(公告)号：US5590052A

    公开(公告)日：1996-12-31

    申请号：US227554

    申请日：1994-04-14

    申请人： Anne R. Kopf-Sill ,  Steven N. Buhl ,  Glenda L. Choate ,  Lloyd A. Schick ,  Robert E. Nagle ,  Jenq C. Chang ,  Daniel Bernstein ,  Wayne A. Britt

    发明人： Anne R. Kopf-Sill ,  Steven N. Buhl ,  Glenda L. Choate ,  Lloyd A. Schick ,  Robert E. Nagle ,  Jenq C. Chang ,  Daniel Bernstein ,  Wayne A. Britt

    IPC分类号： G01N21/25 ,  G01N35/00 ,  G01N35/02 ,  G01N21/17

    CPC分类号： G01N35/00594 ,  G01N21/253 ,  G01N35/025 ,  Y10T436/11 ,  Y10T436/113332 ,  Y10T436/114165

    摘要： The present invention provides various methods for detecting errors in a blood analysis system. The system includes a blood analyzer and a molded plastic rotor with a series of chambers and capillary channels through which blood is processed and distributed to cuvettes which contain lyophilized reagents. The rotor is placed in the analyzer which spins the rotor, and an optical system reads the cuvettes as light is flashed through the cuvettes. The invention provides checks for: confirming the presence of a reagent in the cuvettes before a sample is applied to the cuvettes; determining whether a fluid sample has been properly distributed to the cuvettes of the rotor; determining whether an adequate amount of fluid sample was applied to the analytical rotor; determining whether a fluid sample has been properly distributed to a cuvette of an analytical rotor; determining whether a reaction chemistry in a cuvette has reached an end point; checking the noise level and non-linearity of a reaction rate in a cuvette; determining whether an adequate amount of diluent was delivered to the cuvettes of an analytical rotor; determining dilution systematic failure when measuring different reaction chemistries in the cuvettes of the rotor; determining whether a blood sample in a cuvette is hemolyzed, lipemic, or icteric; determining the degradation of a reagent in a cuvette; determining proper light source and light detector operation; and determining proper motor function and cuvette mark detection.

    摘要翻译： 本发明提供了用于检测血液分析系统中的错误的各种方法。 该系统包括血液分析仪和具有一系列腔室和毛细通道的模制塑料转子，通过血液分析器和毛细管通道将血液加工并分配到含有冻干试剂的比色皿。 将转子放置在旋转转子的分析仪中，当光通过反应杯闪烁时，光学系统读取比色皿。 本发明提供了以下检查：在将样品施加到比色杯之前，确认试剂在试管中的存在; 确定流体样品是否已经被适当地分配到转子的比色杯中; 确定足够量的流体样品是否被施加到分析转子; 确定流体样品是否已经被适当地分配到分析转子的比色杯中; 确定比色皿中的反应化学物质是否达到终点; 检查反应杯中的反应速率的噪声水平和非线性; 确定足够量的稀释剂是否被输送到分析转子的比色杯中; 测量转子的比色杯中的不同反应化学物质时的稀释系统失效; 确定比色皿中的血液样品是否溶血，脂肪或黄疸; 确定试剂在试管中的降解; 确定适当的光源和光检测器的操作; 并确定适当的运动功能和比色皿标记检测。

    Simultaneous cuvette filling with means to isolate cuvettes
    9.
    发明授权
    Simultaneous cuvette filling with means to isolate cuvettes 失效
    同时进行比色杯充填，以分离比色皿

    公开(公告)号：US5409665A

    公开(公告)日：1995-04-25

    申请号：US115163

    申请日：1993-09-01

    申请人： Tammy L. Burd

    发明人： Tammy L. Burd

    IPC分类号： G01N21/07 ,  G01N33/483 ,  G01N33/49 ,  G01N21/00

    CPC分类号： G01N33/491 ,  G01N21/07 ,  Y10T436/111666 ,  Y10T436/25375

    摘要： The present invention provides centrifugal rotors for delivering a liquid, typically a biological sample such as diluted plasma, to a plurality of cuvettes in the rotor. The cuvettes are positioned radially inward of an annulate manifold and are connected to the manifold through a plurality of inlet channels. The liquid is introduced in one end of the manifold and, as the rotor spins, the liquid fills the manifold from the radially outward edge inward. After, the manifold fills, the liquid flows radially inward through the inlet channels into the chambers. The design allows the simultaneous filling of the cuvettes. The inlet channels may also be sized such that as liquid enters the cuvettes, gas escapes through the inlet channel.

    摘要翻译： 本发明提供了用于将液体（通常为诸如稀释等离子体的生物样品）输送到转子中的多个比色皿的离心转子。 该比色皿位于一个十字形歧管的径向内侧，并通过多个入口通道与歧管连接。 液体被引入歧管的一端，并且当转子旋转时，液体从径向向外的边缘向内填充歧管。 之后，歧管充满，液体径向向内流过入口通道进入腔室。 该设计允许同时填充比色皿。 入口通道的尺寸也可以使得当液体进入比色杯时，气体通过入口通道逸出。

    Lateral flow strip assay with immobilized conjugate
    10.
    发明授权
    Lateral flow strip assay with immobilized conjugate 有权
    具有固定化缀合物的侧流条测定

    公开(公告)号：US08846319B2

    公开(公告)日：2014-09-30

    申请号：US12630777

    申请日：2009-12-03

    申请人： Rajesh K. Mehra ,  Kenneth P. Aron

    发明人： Rajesh K. Mehra ,  Kenneth P. Aron

    IPC分类号： G01N33/53 ,  C12Q1/68 ,  C12M1/34 ,  G01N31/22 ,  G01N21/77 ,  G01N33/566 ,  G01N33/543

    CPC分类号： G01N33/54313 ,  G01N33/54393

    摘要： The present invention discloses analyte detection devices for detecting one or more analytes present in test samples, especially biological samples. In particular, the devices of the invention are lateral flow assay devices comprising immobilized metal nanoparticle conjugates as the detection means. Methods of using the devices and kits comprising the devices are also described.

    摘要翻译： 本发明公开了用于检测测试样品中特别是生物样品中存在的一种或多种分析物的分析物检测装置。 特别地，本发明的装置是包含固定金属纳米颗粒共轭物作为检测装置的侧流测定装置。 还描述了使用包括这些装置的装置和试剂盒的方法。