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    INTEGRATED SAMPLE PROCESSING SYSTEM
    6.
    发明申请
    INTEGRATED SAMPLE PROCESSING SYSTEM 有权

    公开(公告)号：US20210230668A1

    公开(公告)日：2021-07-29

    申请号：US17137807

    申请日：2020-12-30

    申请人： AKONNI BIOSYSTEMS, INC.

    发明人： Christopher G. COONEY ,  Rebecca HOLMBERG ,  Phillip BELGRADER ,  Peter Qiang QU

    IPC分类号： C12Q1/6806 ,  G01N35/10 ,  B01L3/00 ,  B01L9/06 ,  G01N35/00 ,  C12N1/06 ,  C12N13/00 ,  C12Q1/689

    摘要： An integrated sample purification system includes a housing, a sample container rack, a filter holder, and a cylindrical magnet. The sample container rack and the filter device holder are disposed in the housing. The sample container rack is configured to hold one or more sample containers, the filter device holder is configured to hold one or more filter devices. The cylindrical magnet is adjacent to and external to the sample container rack, and is rotated about a central, longitudinal axis of the magnet by an electric motor disposed in the housing to lyse cells. Molecules of interest in the lysed cells are purified using filters that bind specifically to the molecules of interest. The system is readily amenable to automation and rapid purification and analysis of molecules of interest, such as nucleic acids and proteins.

    Molecular analysis system and use thereof
    7.
    发明授权
    Molecular analysis system and use thereof 有权

    公开(公告)号：US10882046B2

    公开(公告)日：2021-01-05

    申请号：US16107468

    申请日：2018-08-21

    申请人： AKONNI BIOSYSTEMS, INC.

    发明人： Christopher G. Cooney ,  Peter Qiang Qu ,  Arial Bueno

    IPC分类号： B01L7/00

    摘要： A molecular testing device comprises a heating and cooling module having a thin-film thermoelectric heating and cooling device, and a removable test module having a combined amplification and hybridization reaction chamber. The reaction chamber comprises a thermo-conductive exterior surface and a microarray on an interior surface. The thin-film thermoelectric heating and cooling device has a heat transfer surface that is adapted to make contact with the thermo-conductive exterior surface of the reaction chamber. The molecular testing device may be used to perform a PCR in the reaction chamber.

    Method and kit for purifying nucleic acids
    9.
    发明授权
    Method and kit for purifying nucleic acids 有权
    用于纯化核酸的方法和试剂盒

    公开(公告)号：US09428746B2

    公开(公告)日：2016-08-30

    申请号：US14011267

    申请日：2013-08-27

    申请人： AKONNI BIOSYSTEMS, INC.

    发明人： Rebecca Holmberg ,  Alissa Erin Gindlesperger ,  Tinsley Janna Stokes ,  Phillip Belgrader

    IPC分类号： C12N15/10 ,  B01L3/00 ,  G01N1/40 ,  G01N33/53

    CPC分类号： C12N15/1017 ,  B01L3/0275 ,  B01L3/5025 ,  B01L2200/0631 ,  B01L2300/0681 ,  B01L2300/0832 ,  B01L2300/12 ,  G01N1/405 ,  G01N33/5308

    摘要： Methods for automated extraction of nucleic acids are disclosed. Also disclosed are method and kits for isolating fetal nucleic acids from a plasma sample of a pregnant woman. The method includes flowing the plasma sample through a first filter under conditions that allow binding of the fetal and maternal nucleic acids to the first filter; eluting the fetal and maternal nucleic acids bound to the first filter to produce a concentrated nucleic acid sample; flowing the concentrated nucleic acid sample through a second filter under conditions that allow preferential binding of the maternal nucleic acids to the second filter; and recovering the fetal nucleic acid from the concentrated nucleic acid sample that flow through the second filter.

    摘要翻译： 公开了自动提取核酸的方法。 还公开了用于从孕妇血浆样品中分离胎儿核酸的方法和试剂盒。 该方法包括在允许胎儿和母体核酸与第一过滤器结合的条件下使血浆样品流过第一过滤器; 洗脱与第一过滤器结合的胎儿和母体核酸以产生浓缩的核酸样品; 在允许母体核酸优先结合到第二过滤器的条件下使浓缩的核酸样品流过第二过滤器; 以及从流过第二过滤器的浓缩的核酸样品回收胎儿核酸。