公开(公告)号：US11613552B2

公开(公告)日：2023-03-28

申请号：US17238354

申请日：2021-04-23

Applicant: Alltech, Inc.

Inventor： Zi-Jian Lan ,  Ronan Power ,  Alexandros Yiannikouris ,  Thirupathi Reddy Yerramreddy

IPC: A61K31/7076 ,  C07H19/16 ,  A61P3/10 ,  C07H19/167

Abstract: The present disclosure provides compounds of formulas (1)-(3), and compositions and methods of use thereof. The present disclosure also provides methods of preparing a provided compound and composition, and methods of characterizing a provided compound and composition.

公开(公告)号：US10201558B2

公开(公告)日：2019-02-12

申请号：US14855065

申请日：2015-09-15

Applicant: Alltech, Inc.

Inventor： Ronan Power ,  Zi-Jian Lan

IPC: A61K31/28 ,  A61K38/05 ,  A61K38/28 ,  C07D473/34 ,  A61K31/7076 ,  A61K31/7135 ,  A61K31/706 ,  A61K31/7064

Abstract: The present application relates to compositions comprising selenium compounds, such as 5′-Methylselenoadenosine, a compound of Formula (I), and combinations thereof, and methods of using the same for inhibiting β amyloid aggregation, ApoE4 expression, p38 or Tau protein phosphorylation, or increasing Neprilysin and Insulin Degrading Enzyme expression.

公开(公告)号：US20160324188A1

公开(公告)日：2016-11-10

申请号：US15108976

申请日：2014-12-31

Applicant: ALLTECH, INC.

Inventor： James Dennison JOHNSTON ,  Robin Alexander JOHNSTON ,  Tyler Cole BRAMBLE ,  Karl A. DAWSON

IPC: A23K20/10 ,  A23K50/10 ,  G06Q10/06

CPC classification number: A23K20/10 ,  A01K29/005 ,  A23K10/00 ,  A23K50/10 ,  G06Q10/06 ,  G06Q10/063

Abstract: Systems and methods for estimating meat producing animal feed conversion efficiency and carbon footprint, such as to allow adjustments to be made in the animals feed to improve meat production, reduce waste, and/or reduce the carbon footprint. In embodiments of the present application, a system is provided that integrates a digestion model of an animal feed with weight gain efficiency and carbon footprint. Such systems and methods are useful to analyze and compare different animal feed compositions that differ from one another in one or more components and/or to analyze the effect of the addition of a feed supplement on weight gain efficiency and/or carbon footprint. In embodiments, the systems and methods described herein provide a feed parameter-carbon footprint compromise. A feed parameter-carbon footprint compromise is useful to adjust animal feed composition by balancing weight gain efficiency with effects on carbon footprint. Different feed supplements or amounts of feed supplements, and/or different feed compositions are selected based on the desired feed parameter-carbon footprint compromise.

Abstract translation: 用于估计肉类生产动物饲料转化效率和碳足迹的系统和方法，例如允许在动物饲料中进行调整以改善肉类生产，减少浪费和/或减少碳足迹。 在本申请的实施例中，提供了一种将动物饲料的消化模型与增重效率和碳足迹相结合的系统。 这样的系统和方法可用于分析和比较在一种或多种组分中彼此不同的不同动物饲料组合物和/或分析添加饲料补充剂对体重增加效率和/或碳足迹的影响。 在实施例中，本文所述的系统和方法提供进料参数 - 碳足迹损害。 饲料参数 - 碳足迹损害是通过平衡体重增加效率和碳足迹的影响来调整动物饲料组成的。 基于所需的进料参数 - 碳足迹损害来选择不同的饲料添加剂或饲料添加剂的量，和/或不同的饲料组合物。

公开(公告)号：US20140147515A2

公开(公告)日：2014-05-29

申请号：US11571053

申请日：2004-07-21

Applicant: Cepta Duffy ,  Aidan Joseph Connolly

Inventor： Cepta Duffy ,  Aidan Joseph Connolly

IPC: A61K36/064 ,  A61K33/04 ,  A61P33/02 ,  A61K36/53 ,  A61K31/715 ,  A61K33/30

CPC classification number: A61K33/30 ,  A23K10/16 ,  A23K10/30 ,  A23K20/163 ,  A23K50/75 ,  A61K31/715 ,  A61K33/04 ,  A61K36/064 ,  A61K36/53 ,  A61K36/896 ,  A61K2300/00

Abstract: A composition for preventing or reducing harmful effects of protozoal infection is provided, comprising in one embodiment a yeast cell wall and a preparation derived from oregano. The composition may further include a mineral nutrient selected from selenium and/or zinc. The composition may also include a preparation derived from Yucca. Efficacy of the composition is shown against a variety of protozoal organisms.

Abstract translation: 提供了用于预防或减少原生动物感染的有害作用的组合物，其包括在一个实施方案中为酵母细胞壁和源自牛至的制剂。 该组合物还可包含选自硒和/或锌的矿物质营养物质。 组合物还可以包括衍生自丝兰的制剂。 针对各种原生动物生物体显示了组合物的功效。

公开(公告)号：US20110038889A1

公开(公告)日：2011-02-17

申请号：US12895382

申请日：2010-09-30

Applicant: Thomas P. Lyons ,  Ronan Power

Inventor： Thomas P. Lyons ,  Ronan Power

IPC: A61K36/06 ,  A61P25/28

CPC classification number: A61K31/095 ,  A61K31/13 ,  A61K31/136 ,  A61K31/198 ,  A61K31/355 ,  A61K31/385 ,  A61K31/41 ,  A61K31/433 ,  A61K31/445 ,  A61K31/47 ,  A61K31/473 ,  A61K31/55

Abstract: The present invention relates to compositions and methods for altering cell function. In particular, the present invention provides compositions comprising selenium (e.g., SEL-PLEX) and methods of using the same (e.g., as a therapeutic and/or prophylactic treatment for neurodegenerative disease). Additionally, the present invention demonstrates that specific forms of selenium (e.g., SEL-PLEX) possess the ability to alter expression of genes associated with disease and/or aging while other forms of selenium (e.g., selenomethionine) do not.

Abstract translation: 本发明涉及用于改变细胞功能的组合物和方法。 特别地，本发明提供了包含硒（例如SEL-PLEX）的组合物及其使用方法（例如，作为神经变性疾病的治疗和/或预防性治疗）。 另外，本发明证明硒的特定形式（例如，SEL-PLEX）具有改变与疾病和/或衰老相关基因表达的能力，而其他形式的硒（例如硒代甲硫氨酸）不具有这种能力。

公开(公告)号：US20110033576A1

公开(公告)日：2011-02-10

申请号：US12856407

申请日：2010-08-13

Applicant: Alexandros Yiannikouris ,  Ursula Anne Thielen

Inventor： Alexandros Yiannikouris ,  Ursula Anne Thielen

IPC: A23L1/28 ,  C12N1/16 ,  A23K1/18

CPC classification number: A23K1/16 ,  A01K1/0154 ,  A23K10/18 ,  A23K20/00 ,  A23K20/28 ,  A23K50/75 ,  A23L2/52 ,  A23L29/015 ,  A23L33/145 ,  A23L33/16 ,  A61K36/06 ,  C12H1/0408 ,  C12H1/0424 ,  C12N1/16

Abstract: The present invention relates to compositions comprising yeast cells and/or yeast cell components and methods for producing and utilizing the same. In particular, the invention provides novel yeast comprising altered cell wall structure (e.g., clay and/or clay component(s) integrated (e.g., interlaced) into cell wall(s) and/or cell wall(s) comprising altered glucan:mannan ratio), methods of producing the same, compositions comprising and/or derived from the same, and methods of using the same (e.g., to sequester and/or adsorb bacteria and toxins). Compositions and methods of the invention find use in a variety of applications including dietary (e.g., admixing with feedstuffs or otherwise feeding to animals), therapeutic, prophylactic (e.g. admixing with bedding sources and/or other materials that come into contact with animals, usage during food and beverage processing and manufacture, and usage during filtration of liquids) as well as research applications.

Abstract translation: 本发明涉及包含酵母细胞和/或酵母细胞成分的组合物及其生产和利用方法。 特别地，本发明提供了包含改变的细胞壁结构（例如，粘土和/或粘土组分（例如，交织）到细胞壁和/或细胞壁中的新型酵母，其包含改变的葡聚糖：甘露聚糖 比例），其制备方法，包含和/或衍生自其的组合物及其使用方法（例如，螯合和/或吸附细菌和毒素）。 本发明的组合物和方法可用于各种应用，包括饮食（例如，与饲料混合或以其他方式喂养动物），治疗，预防（例如与床上用品和/或与动物接触的其它材料混合，使用 在食品和饮料加工和制造过程中以及在液体过滤期间的使用）以及研究应用。

公开(公告)号：US20100248320A1

公开(公告)日：2010-09-30

申请号：US12726248

申请日：2010-03-17

Applicant: Mark P. Lyons ,  Brian J. Hoskins

Inventor： Mark P. Lyons ,  Brian J. Hoskins

IPC: C12P7/10 ,  A23K1/06

CPC classification number: C12N1/14 ,  A23K10/12 ,  A23K10/38 ,  A23K50/10 ,  A23K50/30 ,  C12N1/20 ,  C12P7/10 ,  Y02E50/16 ,  Y02P60/873

Abstract: The present invention relates to compositions and methods for the conversion of lignocellulosic material to fermentable sugars and to products produced therefrom (e.g., ethanol, foodstuffs, etc.). In particular, the invention provides lignocellulose-degrading compositions (e.g., generated via incubation of microbes with lignocellulosic priming feedstock in solid-state fermentation format) and methods of using the same (e.g., in saccharification and/or hydrolysis steps (e.g., on ethanologenic feedstock) and as food or feed additives).

Abstract translation: 本发明涉及用于将木质纤维素材料转化为可发酵糖和由其制备的产品（例如乙醇，食品等）的组合物和方法。 特别地，本发明提供了降解木素纤维素的组合物（例如，通过微生物与固体发酵形式的木质纤维素起始原料的温育产生）和使用它们的方法（例如，在糖化和/或水解步骤中（例如，在酿酒酵母 原料）和作为食品或饲料添加剂）。

公开(公告)号：US07334409B2

公开(公告)日：2008-02-26

申请号：US10848986

申请日：2004-05-19

Applicant: Donal S. Dunbar, Jr.

Inventor： Donal S. Dunbar, Jr.

IPC: F02K3/10

CPC classification number: F02K3/10

Abstract: The present invention is a retractable afterburner shroud for use upon a jet engine. The retractable shroud conforms to an outer surface of a jet engine. The afterburner shroud is affixed by a plurality of moveable support arms. The afterburner shroud is retractable. During operation of the afterburner shroud, the afterburner shroud is extended rearward toward the exhaust of the jet engine. A storage tank provides liquid oxygen through the support arms to a mixing ring located within the afterburner shroud. The mixing ring mixes the liquid oxygen and fuel to form a combustible mixture. The combustible mixture is injected into the exhaust wherein the mixture is ignited. The ignited mixture provides additional thrust for the jet engine.

Abstract translation: 本发明是一种用于喷气发动机的可伸缩后加热器护罩。 可伸缩护罩符合喷气发动机的外表面。 加力罩通过多个可移动支撑臂固定。 后燃室护罩可伸缩。 在后燃室护罩的操作期间，后燃器护罩向后延伸到喷气发动机的排气口。 储罐通过支撑臂将液氧提供到位于加力器罩内的混合环。 混合环混合液氧和燃料以形成可燃混合物。 将可燃混合物注入排气中，其中混合物被点燃。 点燃的混合物为喷气发动机提供额外的推力。

公开(公告)号：US20180163011A1

公开(公告)日：2018-06-14

申请号：US15869152

申请日：2018-01-12

Applicant: Alltech, Inc.

Inventor： Alexandros Yiannikouris ,  Thirupathi R. Yerramreddy ,  Joshua J. Martinez ,  Jeffrey R. Withers

IPC: C08J9/26 ,  B01J20/26 ,  C07D311/16 ,  C07D311/78

CPC classification number: C08J9/26 ,  B01J20/268 ,  C07D311/16 ,  C07D311/78 ,  C08F222/1006 ,  C08F2222/1013 ,  C08J2201/0422 ,  C08J2335/02 ,  C08F220/06

Abstract: Molecularly imprinted polymers (MIPs) are materials exhibiting molecular recognition of a target molecule. MIPs are synthesized in the presence of an aflatoxin template, a mimic to the targeted molecule, used as an imprint that is further washed away with suitable solvent after completion of the polymerization process, leaving a cavity in the polymer of the same stereochemistry, functionality and morphology to the template. When the MIP encounters an aflatoxin, the molecule is bound in the cavity with a receptor-like affinity.

公开(公告)号：US20160361338A1

公开(公告)日：2016-12-15

申请号：US15121412

申请日：2014-03-14

Applicant: Alltech, Inc.

Inventor： Ronan Power ,  Zi-Jian Lan ,  Alexandros Yiannikouris

IPC: A61K31/7076

CPC classification number: A61K31/7135 ,  A61K31/28 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7076 ,  A61K38/05 ,  A61K38/28 ,  C07D473/34

Abstract: The present application relates to compositions comprising selenium compounds, such as 5′-Methylselenoadenosine, Se-Adenosyl-L-homocysteine, Gamma-glutamyl-methylseleno-cysteine, a compound of formula (I), formula (II), a compound of formula (III) and combinations thereof, and methods of using the same in enhancing mitochondrial function, or treating mitochondrial dysfunction.

Abstract translation: 本申请涉及包含硒化合物如5'-甲基硒腺苷，Se-腺苷-L-高半胱氨酸，γ-谷氨酰 - 甲基硒代半胱氨酸，式（I），式（II）的化合物，式 （III）及其组合，以及使用其提高线粒体功能或治疗线粒体功能障碍的方法。