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公开(公告)号：US20240115227A1
公开(公告)日：2024-04-11
申请号：US18353306
申请日：2023-07-17
发明人： Yi-Wen Chen , Cheng-Ting Shih , Yu-Fen Chen
摘要： A phantom-free calibration method for a computerized tomography scan has the steps of: scanning a plurality of homogeneous human tissues with a computerized tomography scanner and obtaining homogeneous human tissue scan information; scanning a tissue to be tested with the computerized tomography scanner and obtaining tissue to be tested scan information; calculating a spectral characteristic parameter of the computerized tomography scanner with a computing device using a model, wherein a standard tissue parameter of the homogeneous human tissues and the human tissue scan information are used in the model; and calculating a tissue parameter of the tissue to be tested with the computing device using the model, wherein the spectral characteristic parameter and the tissue to be tested scan information are inputted in the model. The phantom-free calibration method makes the tissue parameters of the tissue to be tested more accurate and the calibration process easier and more convenient.
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公开(公告)号：US20230211009A1
公开(公告)日：2023-07-06
申请号：US18060966
申请日：2022-12-02
发明人： Yi-Wen Chen , Der-Yang Cho , Hsin-Yuan Fang , Ming-You Shie , Chih-Ming Pan , Kai-Wen Kan , Cheng-Yu Chen , Min-Hua Yu , Shao-Chih Chiu
IPC分类号： A61K47/69 , C07K16/28 , C07K14/705 , A61P35/00 , C12N5/071
CPC分类号： A61K47/6901 , C07K16/2833 , C07K14/70596 , A61P35/00 , C12N5/0686 , C07K2319/03 , C07K2317/569 , C12N2527/00
摘要： A method for producing exosomes in a large-scale by using a cyclic tensile bioreactor to stimulate cells to release exosomes. In addition, the exosome having an anti-HLA-G protein specific for cancer is used as a delivery vehicle to deliver therapeutic agents for treating cancer.
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公开(公告)号：US20230011168A1
公开(公告)日：2023-01-12
申请号：US17508140
申请日：2021-10-22
发明人： Yi-Wen Chen , Ming-You Shie , Chien-Chang Chen
IPC分类号： G01N33/50 , C12M1/34 , C12M1/42 , B01L3/00 , C12N5/071 , B33Y80/00 , B33Y10/00 , B33Y40/20 , B29C64/35 , B29C64/10
摘要： The present invention is related to a biochip and production method thereof. The biochip comprises a carrier, a cell or tissue culture area deposited on the carrier, and a sensor area deposited on the carrier adjacent and fluidly communicating with the cell or tissue culture area. A containing space is contained in the cell or tissue culture area comprising a simulated vascular channel, a cell or a tissue and a culture medium. At least one sensor fixation area is contained at the sensor area for placing a sensor element. The present invention can be a model for stimulating cancer of specific patient to realtimely reflecting the cancer formation, transferring status and treatment strategies. The biochip could also carry testing drugs to observe how the drugs functioning to the cells/tissue as to provide a more accurate instruction of the drugs. The present invention can perform multiple test just within on chip which can save cost and also provide a more accurate test model for the patient.
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公开(公告)号：US20230008649A1
公开(公告)日：2023-01-12
申请号：US17508020
申请日：2021-10-22
发明人： Yi-Wen Chen , Ming-You Shie , Der-Yang Cho , Shao-Chih Chiu , Kai-Wen Kan , Chien-Chang Chen
摘要： Present invention is related to a tumor microenvironment on chip or a biochip for cell therapy having a carrier, a first cell or tissue culture area and a second cell or tissue area imbedded within the carrier. The present invention provides a biochip successfully cooperating micro fluidic technology and cell culture achieving the goal for detecting or testing the function of cell therapy for cancer or tumor.
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公开(公告)号：US20240230579A1
公开(公告)日：2024-07-11
申请号：US18311957
申请日：2023-05-04
发明人： Yi-Wen Chen , Yi-An Chen , Ming-You Shie
IPC分类号： G01N27/327 , B82Y15/00 , B82Y30/00
CPC分类号： G01N27/3278 , B82Y15/00 , B82Y30/00
摘要： An electrochemical biosensor has an electrode which is sequentially decorated a molybdenum (VI) oxide (MoO3) nanomaterial, a gold-composite nanomaterial, a carboxyl-sulfhydryl compound, and a carbodiimide/N-hydroxysuccinimide (EDC/NHS, EN) to modify the surface of the electrode. That the sulfhydryl group of the carboxyl-sulfhydryl compound forms a bond with the gold-composite nanomaterial, and the carbodiimide/N-hydroxybutanediimide forms a bond with a carboxyl group of the carboxyl-sulfhydryl compound.
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公开(公告)号：US11969727B2
公开(公告)日：2024-04-30
申请号：US17508020
申请日：2021-10-22
发明人： Yi-Wen Chen , Ming-You Shie , Der-Yang Cho , Shao-Chih Chiu , Kai-Wen Kan , Chien-Chang Chen
CPC分类号： B01L3/502707 , C12N5/0634 , C12N5/0693 , B01L2200/12 , B01L2300/0636 , B01L2300/069 , B01L2300/0819 , G01N33/5008
摘要： Present invention is related to a tumor microenvironment on chip or a biochip for cell therapy having a carrier, a first cell or tissue culture area and a second cell or tissue area imbedded within the carrier. The present invention provides a biochip successfully cooperating micro fluidic technology and cell culture achieving the goal for detecting or testing the function of cell therapy for cancer or tumor.
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公开(公告)号：US20220061819A1
公开(公告)日：2022-03-03
申请号：US17367757
申请日：2021-07-06
发明人： Jui Fang , Yi-Wen Chen , Hsin-Yuan Fang
IPC分类号： A61B8/08
摘要： An ultrasound image reading method has steps as follows: (1) reading an ultrasound image; (2) labeling artifacts in the ultrasound image; (3) identifying features of the artifacts and transforming the features into parameters, and using the parameters to determine an artifacts combination; and (4) using the artifacts combination to look up a corresponding score of disease.
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公开(公告)号：US10932859B2
公开(公告)日：2021-03-02
申请号：US16455850
申请日：2019-06-28
发明人： Yi-Wen Chen , Cheng-Ting Shih
摘要： An implant surface mapping and unwrapping method provided by the present invention selects or defines a mesh implant geometry, and places and rotates it in a specific spatial position according to a mesh. Vertex space coordinates, which are interpolated in medical images such as computed tomography, magnetic resonance imaging, or ultrasound to calculate the gray scale values of these spatial coordinate points, and map them on the surface of the implant. In addition, the implant is irregular. The surface can be further unwrapped through the planar image to help understand its contact with the anatomy. If the medical image is pre-converted to other anatomical, physiological, pathological, and functional parameters, the mapping and unwrapping results will also be displayed with these parameters. Learn more about the relationship between implants and these parameters.
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9.发明公开公开(公告)号：US20240341611A1
公开(公告)日：2024-10-17
申请号：US18636654
申请日：2024-04-16
发明人： Kai-Sheng Hsieh , Chun-Yen Lin , Bo-Yen Chang , Yen-Chieh Wang
CPC分类号： A61B5/0261 , A61B5/0077 , A61B5/1032 , A61B5/6898 , A61B5/742 , G16H50/70
摘要： A capillary refill time determining system is configured to judge a color variation of an image, and the capillary refill time determining system includes an electronic device including an image capturing unit, a storage unit and a processor. The storage unit is configured to access a refill start time and a default value. The processor is electronically connected to the image capturing unit and the storage unit, and the processor is configured to analyze an average color value of the image at an initial period, wherein at least one refill color value is obtained by analyzing the image according to the refill start time, the difference between the average color value and the refill color value is confirmed whether less than or equal to the default value, and a refill period is calculated between the refill start time and the refill end time.
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公开(公告)号：US12105097B2
公开(公告)日：2024-10-01
申请号：US17269257
申请日：2020-01-20
发明人： Gregory Tsay , Hsin-Yi Peng
IPC分类号： G01N33/68 , C07K7/08 , G01N33/543
CPC分类号： G01N33/6893 , C07K7/08 , G01N33/54393 , G01N2800/102
摘要： The present invention relates to a peptide capable of binding to rheumatoid arthritis autoantibodies, which is a consecutive 10-25 amino acid sequence of any one fragment of the group consisting of SEQ ID NO: 3-4, 7-13 or 16-19, wherein the peptide fragment has an epitope that binds to the rheumatoid arthritis autoantibodies. Furthermore, the peptide fragment bound to the rheumatoid arthritis autoantibodies is used for testing rheumatoid arthritis, and according to this use, the present invention provides a method for testing rheumatoid arthritis disease and a test reagent kit used for determining whether a subject to be tested suffers from rheumatoid arthritis disease.
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