公开(公告)号：US20240336650A1

公开(公告)日：2024-10-10

申请号：US18563232

申请日：2022-05-26

申请人： CSL Behring AG

发明人： Ibrahim EL MENYAWI

IPC分类号： C07K1/36 ,  B01D21/01 ,  B01D61/14 ,  B01D63/16 ,  B01D65/02 ,  B01D69/06 ,  B01D71/02

CPC分类号： C07K1/36 ,  B01D21/01 ,  B01D61/145 ,  B01D63/16 ,  B01D65/02 ,  B01D69/06 ,  B01D71/02 ,  B01D2313/501 ,  B01D2315/02 ,  B01D2315/10 ,  B01D2315/17

摘要： The invention relates to a method for the purification of immunoglobulin and/or albumin from a sample of plasma, the method comprising mixing a sample of plasma with a medium chain fatty acid, and recovering the soluble immunoglobulin from the mixture.

公开(公告)号：US20240262861A1

公开(公告)日：2024-08-08

申请号：US18567475

申请日：2022-06-07

申请人： PreviPharma Consulting GmbH ,  CSL Behring AG

发明人： Maurice MANDAGO ,  Ricarda WELZ ,  Stephan T KIESSIG ,  Simon GERBER

IPC分类号： C07K1/36 ,  C12N9/68

CPC分类号： C07K1/36 ,  C12N9/6435 ,  C12Y304/21007

摘要： The present invention relates to a method for isolating plasminogen from a blood plasma fraction comprising dispersing a precipitate of a blood plasma fraction containing plasminogen in a basic aqueous buffer, separating solid parts thereof and removing at least parts of other proteins, and extracting the plasminogen with an acidic aqueous buffer.

公开(公告)号：US20230083398A1

公开(公告)日：2023-03-16

申请号：US17864622

申请日：2022-07-14

申请人： CSL Behring AG

发明人： Werner Maeder ,  Reinhard Franz Bolli ,  Peter Lerch ,  Renzo Pedrussio ,  Liane Hoefferer

IPC分类号： A61K39/395 ,  A61K9/00 ,  C07K16/06

摘要： The present invention relates to an immunoglobulin preparation comprising immunoglobulin in a mass-volume percentage of at least 4%, wherein the concentration of oxygen dissolved in the preparation at room temperature is less than 40 μmol/l.

公开(公告)号：US09937229B2

公开(公告)日：2018-04-10

申请号：US15358368

申请日：2016-11-22

申请人： CSL Behring AG

发明人： Nathan Brinkman

IPC分类号： A61K38/17 ,  A61K45/06 ,  A61K47/42 ,  A61P7/00 ,  C07K14/47

CPC分类号： A61K38/1709 ,  A61K45/06 ,  A61K47/42 ,  C07K14/47 ,  C07K14/4717 ,  Y02A50/411

摘要： The present invention relates generally to a method of purifying proteins. More specifically, the present inventions relates to a method of purifying haptoglobin and hemopexin from the same starting material, and uses thereof.

公开(公告)号：US09932392B2

公开(公告)日：2018-04-03

申请号：US14383962

申请日：2013-03-08

申请人： CSL Behring AG ,  BETH ISRAEL DEACONESS MEDICAL CENTER INC

发明人： Ciaran Kelly ,  Xinhua Chen ,  Sylvia Miescher ,  Martin Spycher ,  Sandra Wymann ,  Adrian Zuercher

IPC分类号： C07K16/12 ,  A61K39/40 ,  A61K38/14 ,  A61K39/395 ,  A61K45/06 ,  A61K38/17 ,  A61K39/00

CPC分类号： C07K16/1282 ,  A61K38/14 ,  A61K38/1774 ,  A61K39/395 ,  A61K39/40 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  A61K2300/00

摘要： The invention relates to compositions and methods to prevent enteric infection in a subject at risk of such infection. In particular, the invention relates to the prevention of recurrence of infection by Clostridium difficile.

公开(公告)号：US09828418B2

公开(公告)日：2017-11-28

申请号：US14377535

申请日：2013-03-08

申请人： CSL BEHRING AG

发明人： Ibrahim El Menyawi ,  Marius Loetscher ,  Doreen Siegemund

IPC分类号： B01D15/36 ,  C07K16/06 ,  C07K16/00 ,  C07K16/18

CPC分类号： C07K16/065 ,  B01D15/363 ,  C07K16/00 ,  C07K16/18

摘要： The invention relates to a process for enriching IgA (and IgM) from IgA-comprising material. In particular, it relates to a sequential elution process of an anion exchanger that leads to an advantageous enrichment and separation of monomeric and dimeric IgA.

公开(公告)号：US20170166640A1

公开(公告)日：2017-06-15

申请号：US15384140

申请日：2016-12-19

申请人： CSL BEHRING AG ,  UNIVERSITÄT BERN

发明人： Stephan VON GUNTEN ,  Marc WEHRLI ,  Adrian ZÜRCHER ,  Sylvia MIESCHER

IPC分类号： C07K16/28

CPC分类号： C07K16/283 ,  A61K39/3955 ,  C07K2317/73 ,  C07K2317/75

摘要： The invention relates to the use of CD89 activating molecules, in particular Fc alpha comprising molecules, and more particularly, IgA, for inducing apoptosis in neutrophils. Anti-CD89 antibodies can alternatively be used. The CD89 activation is beneficial in the treatment of various disorders associated with increases in neutrophils, such as autoimmune disorders, inflammatory disorders, NETosis, or cystic fibrosis.

公开(公告)号：US20160368970A1

公开(公告)日：2016-12-22

申请号：US14900499

申请日：2014-07-01

申请人： CSL BEHRING AG

发明人： Ibrahim EL MENYAWI ,  Doreen SIEGEMUND

IPC分类号： C07K16/06 ,  B01D15/36

CPC分类号： C07K16/065 ,  B01D15/363 ,  C07K1/30 ,  C07K2317/14

摘要： The invention relates to a modified process for the purification of IgG, improving the yield of IgG per liter of starting material without compromising the quality of the product.

摘要翻译： 本发明涉及纯化IgG的改进方法，提高每升原料的IgG产量，而不损害产品的质量。

公开(公告)号：US20240101640A1

公开(公告)日：2024-03-28

申请号：US18042179

申请日：2021-08-20

申请人： CSL Behring AG

发明人： Catherine OWCZAREK ,  Lisa LINDQVIST ,  Kirstee MARTIN ,  Thomas GENTINETTA

IPC分类号： C07K14/705 ,  G01N33/68 ,  G01N33/72

CPC分类号： C07K14/70596 ,  G01N33/6872 ,  G01N33/721

摘要： The present invention relates to the use of a CD91 polypeptide for detection and quantification of a hemopexin:heme complex in a biological sample, to the use of a CD91 polypeptide for separation of a hemopexin:heme complex from a biological sample and to the monitoring of a hemolysis treatment using a CD91 polypeptide.

公开(公告)号：US11471617B2

公开(公告)日：2022-10-18

申请号：US15300820

申请日：2015-04-02

申请人： CSL BEHRING AG ,  PARI PHARMA GMBH ,  MEDIZINISCHE HOCHSCHULE HANNOVER

发明人： Cédric Pierre Vonarburg ,  Karin Steinfuehrer ,  Ulrich Baumann

IPC分类号： A61M11/00 ,  A61K9/00 ,  A61K39/395 ,  C07K16/10 ,  C07K16/12 ,  B05B17/00 ,  A61M15/00 ,  C07K16/00 ,  A61K39/00

摘要： The invention relates to methods for generating an aerosol by nebulization of a composition comprising polyclonal immunoglobulin (Ig). The selection of an efficient membrane nebulizer and a composition optimized for nebulization with such membrane nebulizer results in a particularly efficient method of generating an aerosol for administration of Ig to the respiratory tract.