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公开(公告)号：US20230240838A1
公开(公告)日：2023-08-03
申请号：US18102320
申请日：2023-01-27
发明人： Alycia Berman , Alex Brethauer , Christopher A. Carruthers , Michelle Chutka , Alex de Poix , Shaun Davis Gittard , Katie Herget , Michael Hiles , George Malinee , Elena Monroe , Bhavin B. Shah , Brayden Smith
IPC分类号： A61F2/18
CPC分类号： A61F2/18 , A61F2002/183
摘要： Medical devices for repairing defects in tissue, such as perforations in the tympanic membrane of an animal, methods of manufacturing medical devices, methods of implanting a medical device in a defect in a tissue; and methods of repairing a defect in a tissue are described. In one form, a medical device includes an overlay member having multiple arms and defining an overlay member passageway, an underlay member having multiple flaps and defining an underlay member passageway, and a securement member extending through the overlay member passageway and the underlay member passageway. In methods, the multiple flaps of the underlay member can be sequentially advanced into a defect in a tissue, such as a perforation in a tympanic membrane of an animal.
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公开(公告)号：US11583276B2
公开(公告)日：2023-02-21
申请号：US16718396
申请日：2019-12-18
IPC分类号： A61B17/072 , A61B17/064 , A61B17/00 , A61B90/00 , A61B50/20
摘要： Described are medical devices useful for applying a bolster material to a surgical fastening device such as a stapler, and related methods of manufacture and use. The devices include an applicator element for receipt between arms of the stapler, and a bolster material, desirably a remodelable extracellular matrix material, coupled to the applicator element. In certain embodiments, the bolster material is held by the applicator element, for example having at least a portion looped around or received through or over a portion of the applicator element. Also described are unique implantable materials including coatings of dried, reversible adhesive.
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公开(公告)号：US20220296351A1
公开(公告)日：2022-09-22
申请号：US17833193
申请日：2022-06-06
摘要： Described are embodiments of a multilaminate or multiple layer implantable surgical graft with an illustrative graft comprising a remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.
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公开(公告)号：US20220280696A1
公开(公告)日：2022-09-08
申请号：US17527679
申请日：2021-11-16
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
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5.发明申请公开(公告)号：US20190117825A1
公开(公告)日：2019-04-25
申请号：US16156340
申请日：2018-10-10
摘要： Various compositions of matter, methods of making compositions of matter, and methods of using compositions of matter, e.g. for inducing hemostasis, are disclosed. In some embodiments, a starting fibrin material is subjected to controlled hydrolysis, desirably base-catalyzed, to prepare a fibrin hydrolysate material with increased water sorption capacity. Such fibrin hydrolysate materials, alone or combined with one or more additional substances, can be used in the preparation of hemostasis promoting foams, powders or gels. In some embodiments, a starting dialdehyde starch material is subjected to controlled hydrolysis to prepare a dialdehyde starch hydrolysate material. Such dialdehyde starch hydrolysate materials, alone or combined with one or more additional substances, in some cases combined with a fibrin hydrolysate material, can be used in the preparation of hemostasis promoting foams, powders or gels.
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公开(公告)号：US20190046211A1
公开(公告)日：2019-02-14
申请号：US16077284
申请日：2016-12-02
摘要： A filamentous graft has an elongate filament body including one or more intact segments of a decellularized collagenous tissue membrane. The graft can have a length of at least about 20 cm. The graft can be cut from a laminate of two or more decellularized collagenous tissue membranes. The graft can have a generally rectangular cross-section and can have substantially uniform dimensions and tensile strength along at least a substantial portion of its length. Methods for preparing and using filamentous grafts are also described.
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公开(公告)号：US10123900B2
公开(公告)日：2018-11-13
申请号：US14211704
申请日：2014-03-14
摘要： Devices, kits, and methods useful in the treatment of Obstructive Sleep Apnea (OSA) are described. Example devices include a jig, a first needle, a second needle, and a third needle. An example jig comprises a drill guide and a tongue depressor. A first needle comprises an elongate shaft that defines a bend and a curve. A second needle comprises an elongate shaft that defines a curve. A third needle comprises an elongate shaft that defines a curve.
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8.发明申请公开(公告)号：US20180168442A1
公开(公告)日：2018-06-21
申请号：US15898320
申请日：2018-02-16
发明人： Darin Schaeffer , Charlie Agnew , Arun Mohan , Thomas Cherry , Pamela Ridgley , Kathryn Evert , Ken Kennedy , Daniel Dalenberg
CPC分类号： A61B1/267 , A61B1/005 , A61B1/0051 , A61B1/0057 , A61B1/233 , A61B1/2673 , A61B1/2676 , A61B5/4806 , A61B5/4818
摘要： Medical devices are described herein. More particularly, the disclosure relates to medical devices, systems, and methods for the visualization and treatment of bodily passages, such as an airway, sinus cavity, or sinus passages. An exemplary medical device comprises an elongate member, an actuator moveable between an actuator first position and an actuator second position, and a wire member. The elongate member has a first straight, or substantially straight configuration, when the actuator is in the actuator first position and a second curved configuration when the actuator is in the actuator second position.
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公开(公告)号：US09931439B2
公开(公告)日：2018-04-03
申请号：US14088606
申请日：2013-11-25
发明人： Neal E. Fearnot , Michael C. Hiles , Jeremy Metz , F. Joseph Obermiller , Andrew J. Kaucher , Steven Charlebois
CPC分类号： A61L27/60 , A61F2/0063 , A61F2/02 , A61F2002/0072 , A61F2210/0076 , A61F2250/0003 , A61F2250/0068 , A61L27/3633 , A61L27/38
摘要： Described are medical graft materials and devices which can be usefully modified with liquid additives such as cell suspensions, bioactive agents, or combinations of these. The medical graft materials and devices can have a first outer surface and a second outer surface and can define an internal chamber between the first outer surface and the second outer surface. The medical graft materials and devices can also have at least one region of the graft material interrupting the chamber and surrounded by the chamber. Also described are methods for making and using these medical graft materials and devices.
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10.发明授权公开(公告)号：US09572556B2
公开(公告)日：2017-02-21
申请号：US11415403
申请日：2006-05-01
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00641 , A61B2017/00654 , A61M27/00
摘要： Described are devices, methods, and systems useful in the treatment of fistulae, and in certain embodiments those having openings extending into the alimentary canal, such as anorectal fistulae. Illustratively, an anorectal fistula can be treated by placing a volumetric construct within the primary opening of the fistula. In certain embodiments, the volumetric construct can include a rolled remodelable material processed to form a substantially unitary body. Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa.
摘要翻译： 描述了可用于治疗瘘的装置，方法和系统，并且在某些实施例中，具有延伸进入消化道的开口的那些，诸如肛门直肠瘘。 说明性地，可以通过在瘘的初级开口内放置体积结构来治疗肛门直肠瘘。 在某些实施方案中，体积构造可以包括经加工以形成基本上单体的卷状可重塑材料。 有益的这种可重塑材料可以包括胶原细胞外基质材料，如小肠粘膜下层。
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