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![SOLID FORMS OF 4-(3,3-DIFLUORO-2,2-DIMETHYL-PROPANOYL)-3,5-DIHYDRO-2H-PYRIDO[3,4-F][1,4]OXAZEPINE-9-CARBONITRILE](/abs-image/US/2024/09/26/US20240317776A1/abs.jpg.150x150.jpg)
1.发明公开公开(公告)号：US20240317776A1
公开(公告)日：2024-09-26
申请号：US18582522
申请日：2024-02-20
IPC分类号： C07D498/04
CPC分类号： C07D498/04 , C07B2200/13
摘要： Described herein are solid forms of 4-(3,3-difluoro-2,2-dimethyl-propanoyl)-3,5-dihydro-2H-pyrido[3,4-f][1,4]oxazepine-9-carbonitrile, the process of preparing the forms, pharmaceutical compositions comprising same, and methods of use thereof.
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公开(公告)号：US20240271326A1
公开(公告)日：2024-08-15
申请号：US18435766
申请日：2024-02-07
发明人： Xiaocheng Chen , Mark S. Dennis , Mihalis Kariolis , Adam P. Silverman , Ankita Srivastava , Robert C. Wells , Joy Yu Zuchero , Ryan J. Watts
CPC分类号： C07K16/2881 , C07K16/005 , C12N15/1058 , C40B20/00 , C40B30/04 , C40B50/00 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C12N2320/10
摘要： Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
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公开(公告)号：US20240150376A1
公开(公告)日：2024-05-09
申请号：US18232435
申请日：2023-08-10
发明人： Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Colin Phillip Leslie , Joseph P. Lyssikatos , Alfonso Pozzan , Zachary K. Sweeney , Javier de Vicente Fidalgo
IPC分类号： C07D513/04 , C07D261/18 , C07D267/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D498/14
CPC分类号： C07D513/04 , C07D261/18 , C07D267/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D498/14
摘要： The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.
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公开(公告)号：US20230406898A1
公开(公告)日：2023-12-21
申请号：US18299458
申请日：2023-04-12
发明人： Gilbert Di Paolo , Todd P. Logan , Kathryn M. Monroe , Ankita Srivastava , Bettina Van Lengerich
IPC分类号： C07K14/475
CPC分类号： C07K14/475 , A61K38/00
摘要： Provided herein are fusion proteins that comprise progranulin and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
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公开(公告)号：US11834439B2
公开(公告)日：2023-12-05
申请号：US18099082
申请日：2023-01-19
发明人： Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Joseph P. Lyssikatos , Zachary K. Sweeney
IPC分类号： C07D403/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D491/20 , C07D498/04 , C07B59/00 , C07D403/14 , C07D405/14 , C07D409/14 , C07D487/04
CPC分类号： C07D403/12 , C07B59/002 , C07D401/14 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/20 , C07D498/04 , C07B2200/05
摘要： The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or mixture of stereoisomers thereof, and methods of making and using thereof.
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公开(公告)号：US20230265137A1
公开(公告)日：2023-08-24
申请号：US18189413
申请日：2023-03-24
发明人： Gerald Maxwell Cherf , Gunasekaran Kannan , Katrina W. Lexa , Ray L. Y. Low , Rachel Prorok , Ankita Srivastava
IPC分类号： C07K14/47 , A61P25/28 , C07K14/475
CPC分类号： C07K14/47 , A61P25/28 , C07K14/475 , C07K2319/30 , A61K38/00
摘要： Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
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公开(公告)号：US20230092681A1
公开(公告)日：2023-03-23
申请号：US17797644
申请日：2021-02-05
摘要： Certain embodiments provide a method of treating Hunter syndrome in a subject in need thereof, comprising administering to the subject a therapeutically effective dose of a pharmaceutical composition comprising an ETV:IDS protein.
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公开(公告)号：US20220411485A1
公开(公告)日：2022-12-29
申请号：US17410686
申请日：2021-08-24
发明人： David Holtzman , Hong Jiang , Fan Liao , Thu Nga Bien-Ly , Mark S. Dennis , Jing Guo , Adam P. Silverman , Ryan J. Watts , Yin Zhang
IPC分类号： C07K16/18 , A61P25/28 , A61K9/00 , A61K9/127 , A61K31/192
摘要： The present disclosure encompasses compositions and methods for effectively treating at least one symptom or sign of Aß plaque or cerebral amyloid angiopathy (CAA) associated symptoms, or for decreasing amyloid plaque load or CAA load. The method comprises administering an effective amount of an anti-ApoE antibody to a mammalian subject, such as to a human.
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公开(公告)号：US20220213155A1
公开(公告)日：2022-07-07
申请号：US17697771
申请日：2022-03-17
发明人： Gerald Maxwell Cherf , Gunasekaran Kannan , Katrina W. Lexa , Ray L.Y. Low , Rachel Prorok , Ankita Srivastava
IPC分类号： C07K14/475 , A61P25/28
摘要： Provided herein are progranulin variants and fusion proteins that comprise a progranulin variant and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
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公开(公告)号：US20220119371A1
公开(公告)日：2022-04-21
申请号：US17564850
申请日：2021-12-29
发明人： Anthony A. Estrada , Jianwen A. Feng , Joseph P. Lyssikatos , Zachary K. Sweeney , Javier de Vicente Fidalgo
IPC分类号： C07D403/12 , C07D403/14 , C07D487/04 , C07D417/14 , C07D471/04 , C07D413/14
摘要： Compounds having activity as LRRK2 inhibitors are disclosed. The compounds are of formula (I) including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
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