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公开(公告)号：US10049865B2
公开(公告)日：2018-08-14
申请号：US14703868
申请日：2015-05-04
申请人： Mark A Osgood , Ching Wu
发明人： Mark A Osgood , Ching Wu
摘要： The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.
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公开(公告)号：US20180067078A1
公开(公告)日：2018-03-08
申请号：US15713684
申请日：2017-09-24
IPC分类号： G01N27/62
CPC分类号： G01N27/622
摘要： The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method.
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公开(公告)号：US09859105B2
公开(公告)日：2018-01-02
申请号：US14742653
申请日：2015-06-17
CPC分类号： H01J49/0031 , G01N27/622 , G01N30/7233 , H01J49/004
摘要： A second gate in an Ion Mobility Spectrometer is used to select or block different time windows of the ion mobility spectrum. A second gate in the Ion Mobility Mass Spectrometer is used to modulate peak intensities in the IMS spectrum, allowing each peak in the IMS spectrum to be unambiguously matched with its set of fragment ions in a subsequent MS-MS mass spectrum.
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公开(公告)号：US09719963B2
公开(公告)日：2017-08-01
申请号：US14537863
申请日：2014-11-10
IPC分类号： G01N27/62
CPC分类号： G01N27/622
摘要： An ion mobility spectrometry method wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. Ion mobility spectrometer operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation.
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公开(公告)号：US09177770B2
公开(公告)日：2015-11-03
申请号：US12763092
申请日：2010-04-19
申请人： Mark A. Osgood , Ching Wu
发明人： Mark A. Osgood , Ching Wu
CPC分类号： H01J49/061 , C07B63/00 , G01N27/622 , Y10T29/49227
摘要： The present invention generally relates to systems and methods for transmitting beams of charged particles, and in particular to such systems and methods that employ defecting at least one set of grid elements into the same plane to form an ion gate. In addition, an operation method of closing a gate involving alternating voltages on the adjacent gate wires is described.
摘要翻译： 本发明一般涉及用于传送带电粒子束的系统和方法，特别涉及这样的系统和方法，该系统和方法使用将至少一组栅格元件缺陷到同一平面中以形成离子门。 此外，描述了在相邻栅极线上闭合涉及交流电压的栅极的操作方法。
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公开(公告)号：US09024255B2
公开(公告)日：2015-05-05
申请号：US12764808
申请日：2010-04-21
申请人： Mark A. Osgood , Ching Wu
发明人： Mark A. Osgood , Ching Wu
CPC分类号： H01J49/004 , C07B63/00 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0495 , H01J49/067
摘要： The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching machenism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.
摘要翻译： 本发明涉及提高连字的仪器分析从具有第一仪器对相同样品的分析而受益的样品的能力。 快速切换宏观主义可以用作离子迁移谱仪（IMS）和质谱仪（MS）之间的界面，使得所获得的IMS光谱被转换成时序图，其在中性分析期间动态地控制真空入口的尺寸， /或带电的化学和/或生物物质，使得可以使用较小的泵送系统。
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公开(公告)号：US20140346339A1
公开(公告)日：2014-11-27
申请号：US14214590
申请日：2014-03-14
申请人： Ching Wu , Christopher Hilton
发明人： Ching Wu , Christopher Hilton
CPC分类号： G01N27/624 , C07B63/00
摘要： One aspect of the present invention is to extract multiple ionic species in a FAIMS into one or more IMS drift tubes simultaneously. By adjusting FAIMS operational parameters, ions in FAIMS are detected on IMS detectors through separation in FAIMS and/or separation and collection in the IMS. This method provides a continuous separation of specific ions from an ion swarm by employing a high-field differential mobility analyzer (FAIMS) with a plurality of orthogonal transitions paths spaced incrementally along the electrodes which allow additional separation by a conventional IMS drift tube. The components of the sample can be collected or detected.
摘要翻译： 本发明的一个方面是将FAIMS中的多个离子物质同时提取到一个或多个IMS漂移管中。 通过调整FAIMS操作参数，通过FAIMS中的分离和/或IMS中的分离和收集，在IMS检测器上检测FAIMS中的离子。 该方法通过采用具有多个正交跃迁路径的高场差分迁移率分析器（FAIMS）提供特定离子与离子群的连续分离，所述多个正交跃迁路径沿电极逐渐间隔开，这允许通过常规IMS漂移管进行额外分离。 可以收集或检测样品的组分。
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公开(公告)号：US20130187037A1
公开(公告)日：2013-07-25
申请号：US13792043
申请日：2013-03-09
IPC分类号： H01J49/00
CPC分类号： H01J49/009 , G01N27/622 , G01N30/7206 , G01N30/7233 , H01J49/0027 , H01J49/0031 , H01J49/004
摘要： The present invention relates to a parallel IMS and MS measurement method where a sample flow is split and delivered to an IMS and a MS in parallel. A parallel acquisition MS/IMS method is used to supplement LC-MS and or MS data by using a synchronized MS/IMS acquisition.
摘要翻译： 本发明涉及一种并行的IMS和MS测量方法，其中采样流被并行地分离并传送到IMS和MS。 并行采集MS / IMS方法用于通过使用同步的MS / IMS采集来补充LC-MS和/或MS数据。
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公开(公告)号：US20120126109A1
公开(公告)日：2012-05-24
申请号：US13360760
申请日：2012-01-29
申请人： Ching Wu
发明人： Ching Wu
IPC分类号： H01J49/26
CPC分类号： G01N27/622
摘要： Various embodiments of a multi-dimensional ion mobility analyzer are disclosed that have more than one drift chamber and can acquire multi-dimensional ion mobility profiles of substances. The drift chambers of this device can, for example, be operated under independent operational conditions to separate charged particles based on their distinguishable chemical/physical properties. The first dimension drift chamber of this device can be used either as a storage device, a reaction chamber, and/or a drift chamber according to the operational mode of the analyzer. Also presented are various methods of operating an ion mobility spectrometer including, but not limited to, a continuous first dimension ionization methods that can enable ionization of all chemical components in the sample regardless their charge affinity.
摘要翻译： 公开了具有多于一个漂移室的多维离子迁移率分析仪的各种实施方案，并且可以获得物质的多维离子迁移谱。 该装置的漂移室可以例如在独立操作条件下操作，以根据其可区分的化学/物理性质分离带电粒子。 该装置的第一尺寸漂移室可以根据分析仪的操作模式用作存储装置，反应室和/或漂移室。 还提出了操作离子迁移谱仪的各种方法，包括但不限于连续的第一维电离方法，其能够使得样品中的所有化学组分电离，而不管其电荷亲和力如何。
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10.发明授权Practical ion mobility spectrometer apparatus and methods for chemical and/or biological detection 有权实际的离子迁移光谱仪装置和化学和/或生物检测方法公开(公告)号：US07943901B2
公开(公告)日：2011-05-17
申请号：US11946679
申请日：2007-11-28
申请人： Ching Wu
发明人： Ching Wu
CPC分类号： G01N27/622 , H01J49/004
摘要： This invention describes an ion mobility spectrometer system for chemical detection in the field. The system allows: a high throughput operation, an interface to new ionization methods, and an interface to a mass spectrometer.
摘要翻译： 本发明描述了一种用于现场化学检测的离子迁移谱仪系统。 该系统允许：高通量操作，与新离子化方法的接口以及与质谱仪的接口。
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