公开(公告)号：US08364228B2

公开(公告)日：2013-01-29

申请号：US11721287

申请日：2005-12-09

申请人： John Frederick Currie ,  Makarand Paranjape

发明人： John Frederick Currie ,  Makarand Paranjape

IPC分类号： A61B5/05

CPC分类号： A61B5/14532 ,  A61B5/053 ,  A61B5/0537 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/14865 ,  A61B2562/0209 ,  A61B2562/043 ,  Y02A50/53 ,  Y02A50/58

摘要： A system and method for transdermal sampling wherein at least one pair of sample electrodes is adapted to provide voltage pulses capable of creating capillary openings in a subject's stratum corneum. Methods for using a transdermal sampling system by creating capillary openings in a subject's stratum corneum via the application of a series of voltage pulses to the stratum corneum and contacting at least a portion of at least one of the sample electrodes with interstitial fluid from the capillary openings are also presented.

摘要翻译： 一种用于透皮采样的系统和方法，其中至少一对样本电极适于提供能够在对象的角质层中产生毛细孔的电压脉冲。 一种通过在角质层中施加一系列电压脉冲并使至少一部分样品电极的至少一部分与来自毛细管开口的间质流体接触的方法，通过在对象的角质层中形成毛细管孔来使用透皮采样系统的方法 也被介绍。

公开(公告)号：US20130144142A1

公开(公告)日：2013-06-06

申请号：US13688954

申请日：2012-11-29

申请人： Flexible Medical Systems, LLC

发明人： Joseph J. Vidalis ,  Joseph A. MARCANIO ,  John Frederick CURRIE ,  Sundar Nadarajan ,  Helena Woodvine

IPC分类号： A61B5/145 ,  A61B5/1477

CPC分类号： A61B5/14514 ,  A61B5/14532 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/1491 ,  A61B5/150022 ,  A61B5/150969 ,  A61B5/15134 ,  A61B5/155 ,  A61B5/157

摘要： A system and methods are provided for reducing electrochemical interference in a transdermal sampling and analysis device. A one-step transdermal glucose biosensor may calculate glucose concentrations that are artificially high compared to traditional home blood glucose sensors due to interference, which may be mitigated by forming an anti-interferent barrier layer over a sensing element. The anti-interferent barrier layer may be formed over a sensing layer and may possess a charge type which repels interferent molecules having the same charge type from interacting with the sensing layer disposed below the anti-interferent barrier layer.

摘要翻译： 提供了一种用于减少透皮采样和分析装置中的电化学干扰的系统和方法。 一步式透皮葡萄糖生物传感器可以计算由于干扰而与传统家庭血糖传感器相比人为高的葡萄糖浓度，这可以通过在感测元件上形成抗干扰屏障层来减轻。 抗干扰屏障层可以形成在感测层之上，并且可以具有将与具有相同电荷类型的干扰分子相互作用的电荷类型与设置在抗干扰物屏障层下方的感测层相互作用。

公开(公告)号：US10898116B2

公开(公告)日：2021-01-26

申请号：US14208344

申请日：2014-03-13

申请人： Flexible Medical Systems LLC

发明人： Joseph J Vidalis ,  Joseph A Marcanio ,  John Frederick Currie ,  Helena Woodvine Snyder ,  Vikas Bhatia

IPC分类号： A61B5/15 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/157 ,  A61B5/151

摘要： Methods and systems for manufacturing a transdermal sampling and analysis device for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples are provided. A method of manufacturing the device may improve performance and includes forming channel structures on the lid of the device, thereby making the spacer/channel support structures physically independent and separable from the sensing electrode. Other methods of manufacturing the device may improve performance and include forming at least one of the electrodes on each of the base and the lid, and forming a recessed second spacer layer over the channel support structures, thereby separating the channel support structures and the electrode on the lid to allow a larger area of the electrode to be exposed to the biological sample.

公开(公告)号：US20140275895A1

公开(公告)日：2014-09-18

申请号：US14208344

申请日：2014-03-13

申请人： Flexible Medical Systems LLC

发明人： Joseph J. Vidalis ,  Joseph A. Marcanio ,  John Frederick Currie ,  Helena Woodvine Snyder ,  Vikas Bhatia

IPC分类号： A61B5/15 ,  A61B5/145 ,  A61B5/157 ,  A61B5/1486

CPC分类号： A61B5/150076 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150022 ,  A61B5/150274 ,  A61B5/150862 ,  A61B5/15134 ,  A61B5/157

摘要： Methods and systems for manufacturing a transdermal sampling and analysis device for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples are provided. A method of manufacturing the device may improve performance and includes forming channel structures on the lid of the device, thereby making the spacer/channel support structures physically independent and separable from the sensing electrode. Other methods of manufacturing the device may improve performance and include forming at least one of the electrodes on each of the base and the lid, and forming a recessed second spacer layer over the channel support structures, thereby separating the channel support structures and the electrode on the lid to allow a larger area of the electrode to be exposed to the biological sample.

摘要翻译： 提供了用于非侵入地和经皮获得来自受试者的生物样品的透皮取样和分析装置的制造方法和系统，并确定所获得的生物样品的分析物的水平。 制造该装置的方法可以提高性能，并且包括在装置的盖上形成通道结构，从而使间隔物/通道支撑结构在物理上是独立的并且与感测电极分离。 制造该器件的其它方法可改善性能，并且包括在基底和盖子的每一个上形成电极中的至少一个，以及在通道支撑结构上方形成凹陷的第二间隔层，从而将通道支撑结构和电极分开 盖子允许电极的较大面积暴露于生物样品。

公开(公告)号：US20130123595A1

公开(公告)日：2013-05-16

申请号：US13609838

申请日：2012-09-11

申请人： John F. Currie ,  Joseph A. Marcanio ,  Joseph J. Vidalis

发明人： John F. Currie ,  Joseph A. Marcanio ,  Joseph J. Vidalis

IPC分类号： A61B5/157 ,  A61B5/1491 ,  A61B5/1477

CPC分类号： A61B5/150022 ,  A61B5/0022 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150076 ,  A61B5/150122 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150854 ,  A61B5/150862 ,  A61B5/15087 ,  A61B5/150946 ,  A61B5/150984 ,  A61B5/15134 ,  A61B5/157 ,  A61B2562/0295

摘要： Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir and transport the biological samples to a sensing chamber. The sensing chamber may contain at least two sensing electrodes coated with a biologically reactive element which reacts with the transported biological sample. The sensing chamber may be configured to mitigate the formation of air bubbles which may impede the transport and distribution of the biological sample across the entirety of the sensing chamber.

摘要翻译： 提供透皮取样和分析装置，方法和系统非侵入性地和经皮地获得来自受试者的生物样品，并确定获得的生物样品的分析物水平。 透皮取样和分析装置，方法和系统可能导致皮肤细胞的破坏，从而产生毛细管样通道，生物样品可以从该细胞流动到经皮采样和分析装置。 透皮采样和分析装置，方法和系统可以将储存器中的生物样品收集并将生物样品运送到感测室。 感测室可以包含至少两个感测电极，其被涂覆有与被输送的生物样品反应的生物反应性元件。 感测室可以被配置为减轻气泡的形成，这可能阻碍生物样品在整个感测室上的输送和分布。

公开(公告)号：US08333874B2

公开(公告)日：2012-12-18

申请号：US12096769

申请日：2006-06-14

申请人： John Frederick Currie

发明人： John Frederick Currie

IPC分类号： G01N27/26

CPC分类号： A61B5/1486 ,  A61B5/0537 ,  A61B5/145 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/4547 ,  Y02A50/53 ,  Y02A50/58

摘要： The present invention generally relates to a system and method that co-locates in a small flexible, configurable system and multi-level substrate sampling, rapid analysis, bio-sample storage and delivery functions to be performed on living tissues or matter obtained from living organisms. The types of the sampling may include chemical, biochemical, biological, thermal, mechanical, electrical, magnetic and optical sampling. In general, the analysis performed at the point of sampling measures the sample taken and records its value. The bio-sample storage function encapsulates a small sample of analyte and preserves it for subsequent examination or analysis, either on the organism by the system or at a remote location by an independent analysis system. Once stored, the sample can provide a record of a biological state at the precise time of sampling. The delivery at the point of sampling can include chemical, biochemical, biological, thermal, mechanical, electrical, magnetic and optical stimuli.

摘要翻译： 本发明一般涉及一种系统和方法，其共同定位在活体组织或从活生物获得的物质上进行的小的灵活，可配置的系统和多层底物取样，快速分析，生物样品储存和递送功能 。 采样的类型可能包括化学，生化，生物，热，机械，电，磁和光取样。 一般来说，在采样点进行的分析测量取样并记录其值。 生物样品储存功能封装了一小部分分析物，并保留在随后的检查或分析中，无论是在系统的生物体上还是在独立分析系统的远程位置。 一旦存储，样品可以在精确的采样时间提供生物状态的记录。 采样点的输送可以包括化学，生化，生物，热，机械，电，磁和光学的刺激。

公开(公告)号：US20120150004A1

公开(公告)日：2012-06-14

申请号：US13294368

申请日：2011-11-11

申请人： John F. Currie ,  Joseph A. Marcanio ,  Joseph J. Vidalis ,  Sundar B. Nadarajan

发明人： John F. Currie ,  Joseph A. Marcanio ,  Joseph J. Vidalis ,  Sundar B. Nadarajan

IPC分类号： A61B5/157

CPC分类号： A61B5/150022 ,  A61B5/0022 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/150076 ,  A61B5/150122 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150854 ,  A61B5/150862 ,  A61B5/15087 ,  A61B5/150946 ,  A61B5/150984 ,  A61B5/15134 ,  A61B5/157 ,  A61B2562/0295

摘要： Transdermal sampling and analysis device, method and system are provided for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples. The transdermal sampling and analysis device, method and system may cause disruption to the skin cells to create capillary-like channels from which biological samples may flow to the transdermal sampling and analysis device. The transdermal sampling and analysis device, method and system may collect the biological samples in a reservoir where the biological sample may chemically react with a biologically reactive element. A sensor may convert the produced electrons (ions) into measured electrical signals. The converted signals may be measured and the levels of an analyte may be determined based on the measured signals.

摘要翻译： 提供透皮取样和分析装置，方法和系统非侵入性地和经皮地获得来自受试者的生物样品，并确定获得的生物样品的分析物水平。 透皮取样和分析装置，方法和系统可能导致皮肤细胞的破坏，从而产生毛细管样通道，生物样品可以从该细胞流动到透皮取样和分析装置。 透皮采样和分析装置，方法和系统可以将生物样品收集在储存器中，其中生物样品可以与生物反应性元件发生化学反应。 传感器可以将产生的电子（离子）转换成测量的电信号。 可以测量转换的信号，并且可以基于测量的信号来确定分析物的水平。