公开(公告)号：US20200024289A1

公开(公告)日：2020-01-23

申请号：US16489824

申请日：2018-03-01

申请人： Anacor Pharmaceuticals, Inc. ,  The Government of the United States, as represented by the Secretary of the Army

发明人： Robert Toms Jacobs ,  Yang Liu ,  Richard J. Sciotti ,  Jason D. Speake ,  Gavin Alistair Whitlock ,  Paul Alan Glossop ,  Charles Eric Mowbray ,  Delphine Françoise Monique Launay ,  Stephen John Robinson

IPC分类号： C07F5/02 ,  A61P33/02

摘要： This application describes compounds, compositions, and methods which are useful in treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite.

公开(公告)号：US20240271181A1

公开(公告)日：2024-08-15

申请号：US18266692

申请日：2021-12-10

申请人： THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY

发明人： Jeffrey R. KUGELMAN ,  Peter A. LARSON ,  Raina KUMAR ,  Mariano SANCHEZ-LOCKHART

IPC分类号： C12Q1/6806 ,  C12Q1/6876 ,  C40B50/08

CPC分类号： C12Q1/6806 ,  C12Q1/6876 ,  C40B50/08

摘要： Provided herein are methods for next generation sequencing a target using universal adapter technologies and identifying and reducing error by distinguishing the signals from sequencing the target based on the location on the flow cell of the signals from sequencing the sample identifying region(s) of the adapters.

公开(公告)号：US20240253717A1

公开(公告)日：2024-08-01

申请号：US18631313

申请日：2024-04-10

申请人： Government of the United States, as represented by the Secretary of the Army

发明人： Victor Wilhelm Burguess ,  Frederick Carl Rickert, II

IPC分类号： B62D65/02 ,  B62D21/15 ,  B62D25/20 ,  B66F3/35 ,  B66F3/36

CPC分类号： B62D65/024 ,  B66F3/35 ,  B66F3/36 ,  B62D21/155 ,  B62D25/2072

摘要： A method of installing an underbody kit to a vehicle comprising providing a rapid underbody kit deployment crate comprising a pallet, at least one inflatable bladder, and at least one cover; removing the at least one cover from the pallet; placing the underbody kit onto the pallet and the at least one inflatable bladder; securing the at least one cover back onto the pallet; transporting the rapid underbody kit deployment crate to an assembly location; removing the at least one cover from the pallet; driving the vehicle over the rapid underbody kit deployment crate; inflating the at least one inflatable bladder to vertically lift the underbody kit into installation position; installing the underbody kit to an underbody of the vehicle; deflating the at least one inflatable bladder by releasing the fluid from the at least one inflatable bladder; and driving the vehicle away from the rapid underbody kit deployment crate.

公开(公告)号：US20240165215A1

公开(公告)日：2024-05-23

申请号：US18344780

申请日：2023-06-29

申请人： Dynavax Technologies Corporation ,  The Government of the United States, as Represented by the Secretary of the Army

发明人： Robert S. JANSSEN ,  David Novack ,  Wai Kwan Chung ,  Andrew M. Glenn ,  Lucy A. Ward

IPC分类号： A61K39/02 ,  A61K39/00 ,  A61K39/39 ,  A61P31/04

CPC分类号： A61K39/0291 ,  A61K39/39 ,  A61P31/04 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/55561

摘要： The present disclosure relates to immunogenic compositions comprising at least one Yersinia pestis (Y. pestis) antigen, an aluminum salt adjuvant, and an oligonucleotide comprising an unmethylated cytidine-phospho-guanosine (CpG) motif. The immunogenic compositions are suitable for stimulating an immune response against Y. pestis in a subject in need thereof. The present disclosure also relates to kits and methods using the immunogenic compositions, or two separate compositions which together comprise the antigen, the aluminum salt adjuvant, and the oligonucleotide.

公开(公告)号：US11982297B2

公开(公告)日：2024-05-14

申请号：US15814442

申请日：2017-11-16

申请人： The Government of the United States, as represented by the Secretary of the Army

发明人： Kevin Curran ,  Mikael Mead ,  Raymond Kerby

IPC分类号： F15B19/00 ,  G01M3/00 ,  G01M3/04 ,  G01M3/26

CPC分类号： F15B19/005 ,  F15B19/007 ,  G01M3/007 ,  G01M3/045 ,  G01M3/26 ,  F15B2211/855

摘要： A tester that can be quickly and easily connected and/or disconnected to a device is described. The tester can check for leaks in the device. The tester can provide a conduit for fluid to flow to the device and a flow meter reading can demonstrate that the device has leakage or no leakage.

公开(公告)号：US11979791B2

公开(公告)日：2024-05-07

申请号：US17504775

申请日：2021-10-19

申请人： The Government of the United States, as represented by the Secretary of the Army

发明人： Michael Adams ,  William Toth ,  Matthew Lazzaro ,  Todd Lutton ,  Michael Neuman ,  Diana Neuman ,  Stanley Fong

IPC分类号： H04W4/02 ,  H04L1/00 ,  H04W8/22 ,  H04W72/0453

CPC分类号： H04W4/025 ,  H04L1/0003 ,  H04W8/22 ,  H04W72/0453

摘要： Various embodiments that relate to local communication are discussed. A radio from one geographical area can enter a communication environment of a different geographical area. However, if the radio still functions consistent with the previous geographical area, then the radio will not blend into the new geographical area. Therefore, the radio can alter operational characteristics when entering the new geographical area such that the radio blends into the new geographical area from a radio frequency perspective.

公开(公告)号：US11961009B2

公开(公告)日：2024-04-16

申请号：US17086853

申请日：2020-11-02

申请人： The Government of the United States, as represented by the Secretary of the Army

发明人： Radhika Roy

IPC分类号： G06F21/62 ,  G06F8/36 ,  G06N3/02 ,  G06N5/022

CPC分类号： G06N5/022 ,  G06F8/36 ,  G06F21/6218 ,  G06N3/02 ,  G06F2221/2113

摘要： Various embodiments that pertain to artificial intelligence algorithms. A repository can retain a reusable common set of artificial intelligence algorithms. Different users can access this common set of artificial intelligence algorithms and employ individual artificial intelligence algorithms in programs as appropriately as they are developing different applications and/or products. Employment of these individual artificial intelligence algorithms can include, for example, tailoring parameters based on the desires of the individual user's desires using the same common set of algorithms or individually or as a group as appropriate.

公开(公告)号：US20240066037A1

公开(公告)日：2024-02-29

申请号：US17913870

申请日：2021-03-26

申请人： GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED ,  THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY ,  THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.

发明人： Sina BAVARI ,  Christopher D. KANE ,  Andrew James PEAT ,  Veronica SOLOVEVA

IPC分类号： A61K31/55 ,  A61K45/06 ,  A61P31/14

CPC分类号： A61K31/55 ,  A61K45/06 ,  A61P31/14

摘要： Provided are cathepsin inhibitor compounds and pharmaceutically acceptable salts thereof, and combinations thereof, for use in the treatment or prophylaxis of viral disease in an animal.

公开(公告)号：US20240017214A1

公开(公告)日：2024-01-18

申请号：US18477581

申请日：2023-09-29

申请人： Government of the United States, as represented by the Secretary of the Army

发明人： Michael Jeffrey Anderson ,  Jeremy Stephen Walker ,  James Saye Dusenbury, IV

IPC分类号： B01D61/02 ,  B01D61/12 ,  B01D65/02 ,  C02F1/00 ,  C02F1/44 ,  B01D61/10

CPC分类号： B01D61/025 ,  B01D61/12 ,  B01D65/02 ,  C02F1/008 ,  C02F1/441 ,  B01D61/10 ,  C02F2303/10 ,  B01D2311/04 ,  B01D2311/06 ,  B01D2311/246 ,  B01D2311/2649 ,  B01D2313/18 ,  B01D2321/02 ,  C02F2209/003 ,  C02F2209/03 ,  C02F2209/10 ,  C02F2301/043

摘要： A portable filtration system is described. The system may comprise: a mixing portion, comprising: a pump adaptor and a contaminant regulator. The pump adaptor may comprise: an upper plate, a lower plate, and a screen. The screen may axially extend between the upper and lower plates, wherein the upper plate, the lower plate, and the screen define a channel of a mixing chamber. The contaminant regulator may comprise a through-passage coupled to the upper plate, wherein the through-passage is in fluid communication with the mixing chamber.

公开(公告)号：US11859214B1

公开(公告)日：2024-01-02

申请号：US16541469

申请日：2019-08-15

申请人： U.S. Government as Represented by the Secretary of the Army

发明人： Laurel A Doherty ,  Jason W Soares ,  Steven Arcidiacono ,  Sarah Pearce

IPC分类号： C12M1/00 ,  C12M3/06 ,  C12N5/071 ,  C12M3/00 ,  C12M1/40 ,  C12M1/36 ,  C12M1/34 ,  G01N33/50 ,  C12M1/02

CPC分类号： C12N5/0697 ,  C12M21/08 ,  C12M21/18 ,  C12M23/58 ,  C12M29/00 ,  C12M41/18 ,  C12M41/26 ,  C12M41/48 ,  G01N33/5088

摘要： An in vitro model of an in vivo gastrointestinal tract including an in vitro model of an in vivo small intestine including a plurality of fermentation vessels and an in vitro model of an in vivo large intestine including a plurality of fermentation vessels is provided. A method of simulating a biotransformation of food product through the human digestive tract using an in vitro model of an in vivo gastrointestinal tract is provided.