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公开(公告)号：US09017973B2
公开(公告)日：2015-04-28
申请号：US13305415
申请日：2011-11-28
申请人： Steven Gordon , Jerzy Olejnik
发明人： Steven Gordon , Jerzy Olejnik
CPC分类号： C07H19/00 , C12Q1/6869 , C12Q1/6874 , C12Q2535/101 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N2021/0346 , G01N2021/058 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6471 , G01N2201/062 , G01N2201/0627 , G01N2201/12
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
摘要翻译： 本发明提供了方法和组合物，包括但不限于使用例如通过合成方法的测序获得的数据来确定核苷酸序列中核酸的身份的算法，计算机可读介质，计算机程序，装置和系统。 本发明的方法包括校正核苷酸测序期间遇到的一种或多种现象，例如通过合成方法进行测序。 这些现象包括但不限于序列引导，序列滞后，光谱串扰以及由照明和/或滤波器响应变化引起的噪声。
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公开(公告)号：US08940481B2
公开(公告)日：2015-01-27
申请号：US12704842
申请日：2010-02-12
申请人： Steven Gordon , Steven Auger , Alan Schinazi
发明人： Steven Gordon , Steven Auger , Alan Schinazi
CPC分类号： C12Q1/6874 , G01N21/05 , G01N21/6428 , G01N21/6452 , G01N21/6486 , G01N2021/0325 , G01N2021/6421 , G01N2021/6441 , G01N2021/6471
摘要： An imaging system for exciting and measuring fluorescence on or in samples comprising fluorescent materials (e.g. fluorescent labels, dyes or pigments). In one embodiment, a device is used to detect fluorescent labels on nucleic acid. In a preferred embodiment, the device is configured such that fluorescent labels in a plurality of different DNA templates are simultaneously detected.
摘要翻译： 用于激发和测量包含荧光材料（例如荧光标记，染料或颜料）的样品中或其中的荧光的成像系统。 在一个实施方案中，使用装置来检测核酸上的荧光标记。 在优选实施例中，该装置被配置为使得同时检测多个不同DNA模板中的荧光标记。
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公开(公告)号：US20140234832A1
公开(公告)日：2014-08-21
申请号：US14012622
申请日：2013-08-28
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , C12Q1/6806 , C12Q1/6825 , G06F19/20 , C12Q2527/137 , C12Q2525/186 , C12Q2525/117 , C12Q2565/601 , C12Q2563/107 , C12Q2537/165
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable Media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
摘要翻译： 本发明提供了方法和组合物，包括但不限于使用例如通过合成方法的测序获得的数据来确定核苷酸序列中的核酸的身份的算法，计算机可读介质，计算机程序，装置和系统。 本发明的方法包括校正核苷酸测序期间遇到的一种或多种现象，例如通过合成方法进行测序。 这些现象包括但不限于序列引导，序列滞后，光谱串扰以及由照明和/或滤波器响应变化引起的噪声。
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公开(公告)号：US20130217596A1
公开(公告)日：2013-08-22
申请号：US13398462
申请日：2012-02-16
申请人： Steven Gordon , Steven Auger , Alan Schinazi
发明人： Steven Gordon , Steven Auger , Alan Schinazi
IPC分类号： C40B30/10
CPC分类号： G01N21/6452 , G01N21/6428 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6482
摘要： An imaging system for exciting and measuring fluorescence on or in samples comprising fluorescent materials (e.g. fluorescent labels, dyes or pigments). In one embodiment, a device is used to detect fluorescent labels on nucleic acid. In a preferred embodiment, the device is configured such that fluorescent labels in a plurality of different DNA templates are simultaneously detected.
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公开(公告)号：US20090298131A1
公开(公告)日：2009-12-03
申请号：US12370125
申请日：2009-02-12
申请人： Steven Gordon , Daniel Stetson
发明人： Steven Gordon , Daniel Stetson
CPC分类号： C12Q1/6806 , C12N15/10 , C40B50/14 , G01N33/54353
摘要： The present invention relates to methods and devices for amplifying nucleic acid, and, in particular, amplifying so as to generate products on a surface without the use of emulsions. In a preferred embodiment, a plurality of groups of amplified product are generated on the surface, each group positioned in different (typically predetermined) locations on said surface so as to create an array.
摘要翻译： 本发明涉及用于扩增核酸的方法和装置，特别是扩增以在不使用乳剂的情况下在表面上产生产物。 在优选实施例中，在表面上产生多组放大产物，每组放置在所述表面上的不同（通常是预定的）位置，以便产生阵列。
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公开(公告)号：US09765384B2
公开(公告)日：2017-09-19
申请号：US14012622
申请日：2013-08-28
CPC分类号： C12Q1/6869 , C12Q1/6806 , C12Q1/6825 , G06F19/20 , C12Q2527/137 , C12Q2525/186 , C12Q2525/117 , C12Q2565/601 , C12Q2563/107 , C12Q2537/165
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
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公开(公告)号：US09399799B2
公开(公告)日：2016-07-26
申请号：US14518114
申请日：2014-10-20
发明人： Steven Gordon , Jerzy Olejnik
CPC分类号： C07H19/00 , C12Q1/6869 , C12Q1/6874 , C12Q2535/101 , G01N21/05 , G01N21/6428 , G01N21/645 , G01N2021/0346 , G01N2021/058 , G01N2021/6417 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6471 , G01N2201/062 , G01N2201/0627 , G01N2201/12
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. The methods of the invention include correcting one or more phenomena that are encountered during nucleotide sequencing, such as using sequencing by synthesis methods. These phenomena include, without limitation, sequence lead, sequence lag, spectral crosstalk, and noise resulting from variations in illumination and/or filter responses.
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公开(公告)号：US20150038339A1
公开(公告)日：2015-02-05
申请号：US14463211
申请日：2014-08-19
发明人： Steven Gordon , Thomas Hagerott , Edmund Golaski , Jerzy Olejnik
IPC分类号： C12Q1/68
CPC分类号： G01N27/44791 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2300/0877 , B01L2400/0487 , C12Q1/6869 , G01N27/44726
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. A plurality of smaller flow cells is employed, each with a relatively small area to be imaged, in order to provide greater flexibility and efficiency.
摘要翻译： 本发明提供了方法和组合物，包括但不限于使用例如通过合成方法的测序获得的数据来确定核苷酸序列中核酸的身份的算法，计算机可读介质，计算机程序，装置和系统。 为了提供更大的灵活性和效率，采用多个较小的流动池，每个具有相对小的要被成像的面积。
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公开(公告)号：US09791409B2
公开(公告)日：2017-10-17
申请号：US14708675
申请日：2015-05-11
发明人： Steven Gordon , Thomas Hagerott , Edmund Golaski , Jerzy Olejnik
IPC分类号： G01N27/447 , C12Q1/68 , B01L3/00
CPC分类号： G01N27/44791 , B01L3/502715 , B01L3/502761 , B01L2200/0668 , B01L2300/0877 , B01L2400/0487 , C12Q1/6869 , G01N27/44726
摘要： The invention provides methods and compositions, including, without limitation, algorithms, computer readable media, computer programs, apparatus, and systems for determining the identity of nucleic acids in nucleotide sequences using, for example, data obtained from sequencing by synthesis methods. A plurality of smaller flow cells is employed, each with a relatively small area to be imaged, in order to provide greater flexibility and efficiency.
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公开(公告)号：US09790548B2
公开(公告)日：2017-10-17
申请号：US14182975
申请日：2014-02-18
发明人： Steven Gordon , Daniel Stetson
CPC分类号： C12Q1/6874 , B01L3/50851 , B01L3/50853 , B01L7/52 , B01L2200/0689 , B01L2300/0819 , C12Q1/6837 , C12Q1/686 , C12Q1/6869 , C12Q2565/537 , C40B50/06
摘要： The present invention relates to methods and devices for amplifying nucleic acid, and, in particular, amplifying so as to generate products on a surface without the use of emulsions. In a preferred embodiment, a plurality of groups of amplified product are generated on the surface, each group positioned in different (typically predetermined) locations on said surface so as to create an array.
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