公开(公告)号：US07979765B2

公开(公告)日：2011-07-12

申请号：US12442996

申请日：2007-09-25

申请人： Xiaoqing Wen ,  Seiji Kajihara ,  Kohei Miyase ,  Yoshihiro Minamoto ,  Hiroshi Date

发明人： Xiaoqing Wen ,  Seiji Kajihara ,  Kohei Miyase ,  Yoshihiro Minamoto ,  Hiroshi Date

IPC分类号： G01R31/28 ,  G06F11/00

CPC分类号： G11C29/10 ,  G01R31/31721 ,  G01R31/31813 ,  G01R31/31917 ,  G11C29/56004

摘要： Provided are a generation device and the like for generating a test vector which can reduce capture power efficiently. The generation device 100 generates a test vector for a logic circuit by assigning logic values to each of a plurality of unspecified bits (X-bits) included in a test cube. The generation device 100 includes a selection unit 101 for selecting, among the plurality of X-bits, a target X-bit, which is a target of assigning a logic value, a capture transition metric calculation unit 103 for calculating capture transition metric caused by a test cube including an X-bit, and a logic value assignment unit 105 for assigning, to the selected target X-bit, a logic value which causes the smaller capture transition metric, by applying the capture transition metric calculation means to a first test cube obtained by assigning a logic value 0 to the selected target X-bit and to a second test cube obtained by assigning a logic value 1 to the selected target X-bit, and by comparing a capture transition metric caused by a first test cube and a capture transition metric caused by a second test cube.

摘要翻译： 提供了用于生成能够有效地降低捕获功率的测试向量的生成装置等。 生成装置100通过向包括在测试立方体中的多个未指定位（X位）中的每一个分配逻辑值来生成用于逻辑电路的测试向量。 生成装置100包括：选择单元101，用于在多个X位中选择作为分配逻辑值的目标的目标X位;捕获转移度量计算单元103，用于计算由 包括X位的测试立方体和用于通过将捕获转移度量计算装置应用于第一测试来向所选择的目标X位分配导致较小捕获转换度量的逻辑值的逻辑值分配单元105 通过将逻辑值0分配给所选择的目标X位获得的立方体以及通过将逻辑值1分配给所选择的目标X位获得的第二测试立方体，并且通过将由第一测试立方体引起的捕获转变度量与 由第二个测试立方体引起的捕获转换度量。

公开(公告)号：US07962822B2

公开(公告)日：2011-06-14

申请号：US12235628

申请日：2008-09-23

申请人： Xiaoqing Wen ,  Seiji Kajihara ,  Kohei Miyase ,  Yoshihiro Minamoto ,  Hiroshi Date

发明人： Xiaoqing Wen ,  Seiji Kajihara ,  Kohei Miyase ,  Yoshihiro Minamoto ,  Hiroshi Date

IPC分类号： G01R31/28

CPC分类号： G01R31/318544 ,  G01R31/318502

摘要： A generation apparatus and the like for generating a test vector set capable of reducing differences in a logic value generated before and after a scan capture for outputs from scan cells included in a full-scan sequential circuit are provided. A generation apparatus 200 generating an initial test vector set 216 for a logic circuit includes a target vector identification unit 204 identifying a test vector satisfying a predetermined criterion and to be selected for the number of bits (the number of bit transitions) whose logic values differ before and after scan capture with respect to outputs from scan cells included in the sequential circuit, from among test vectors in the initial test vector set 216, and a test vector set conversion unit 206 converting the test vector identified by the test vector identification unit 204 and to be selected so as to reduce the number of bit transitions with respect to outputs from the scan cells included in the sequential circuit.

摘要翻译： 提供了一种用于生成能够减少在扫描捕获之前和之后产生的逻辑值中的差异的测试向量集的生成装置等，用于从全扫描时序电路中包括的扫描单元的输出。 生成用于逻辑电路的初始测试向量集合216的生成装置200包括：目标矢量识别单元204，其识别满足预定标准的测试向量，并且对于其逻辑值不同的位数（位数转换的数量）来选择 相对于包括在顺序电路中的扫描单元的输出，从初始测试向量集合216的测试向量中的扫描捕获之前和之后，以及转换由测试向量识别单元204识别的测试向量的测试向量集合转换单元206 并且被选择为减少相对于包括在顺序电路中的扫描单元的输出的位转换的数量。

公开(公告)号：US20100004327A1

公开(公告)日：2010-01-07

申请号：US12504823

申请日：2009-07-17

申请人： Masayoshi Shichiri ,  Yujiro Tanaka

发明人： Masayoshi Shichiri ,  Yujiro Tanaka

IPC分类号： A61K31/395

CPC分类号： A61K31/395 ,  A61K31/496 ,  G01N33/5011

摘要： The present invention provides novel angiogenesis inhibitors effective, safe and highly practical for inhibition of angiogenesis in various diseases, and a method for screening the same. The active ingredients of the angiogenesis inhibitors of the present invention comprise ansamycin antibiotics such as rifampicin, rifamycin SV and 3-formyl rifamycin, which have long been used extensively as antibacterial agents for treating tuberculosis or Gram-positive bacterial infections. The active ingredients of the present invention have excellent angiogenesis-inhibiting activity. The angiogenesis inhibitor of the present invention is effective for inhibition of angiogenesis in malignant tumors, diabetic retinopathy, retinal angiogenesis, inflammatory diseases, and angiogenesis accompanying cardiovascular remodeling, etc., and can be used as therapeutic agents against each disease, etc. Further, the screening method of the present invention makes it possible to perform an effective screening of angiogenesis-inhibiting substances by detecting angiogenesis-inhibiting signals based on gene expression levels.

摘要翻译： 本发明提供了用于抑制各种疾病中的血管发生的有效，安全和高度实用的新型血管生成抑制剂及其筛选方法。 本发明的血管发生抑制剂的活性成分包括长时久以来被广泛用作治疗结核病或革兰氏阳性细菌感染的抗菌剂的安莎霉素抗生素如利福平，利福霉素SV和3-甲酰基利福霉素。 本发明的活性成分具有优异的血管生成抑制活性。 本发明的血管生成抑制剂对于抑制恶性肿瘤，糖尿病性视网膜病变，视网膜血管生成，炎症性疾病以及伴随心血管重塑等的血管发生等，对于抑制血管生成有效，可用作针对各种疾病的治疗剂等。另外， 通过本发明的筛选方法，可以通过基于基因表达水平检测血管生成抑制信号来进行血管新生抑制物质的有效筛选。

公开(公告)号：US07601348B2

公开(公告)日：2009-10-13

申请号：US10568544

申请日：2004-07-09

申请人： Reiji Kannagi ,  Mineko Izawa ,  Takashi Muramatsu ,  Kenji Uchimura ,  Hideaki Hosokawa

发明人： Reiji Kannagi ,  Mineko Izawa ,  Takashi Muramatsu ,  Kenji Uchimura ,  Hideaki Hosokawa

IPC分类号： A61K39/395

CPC分类号： G01N33/57419 ,  G01N2333/91097 ,  G01N2400/02

摘要： The present invention provides a method for examining colorectal cancer and colorectal adenoma, which enables to detect colorectal cancer patients and patients at high risk of colorectal cancer at a high probability and is useful for diagnosis of colorectal cancer and colorectal adenoma, and provides the examination reagents thereof. The present inventors discovered that there are significant differences in the distribution of GlcNAc-6-sulfotransferase isozymes, sulfation enzymes of sugar residues, among non-cancer colorectal tissues, colorectal cancer tissues and colorectal adenoma tissues. Furthermore the inventors applied the discovery to diagnosis and found that colorectal cancers and adenomas are detected specifically by assaying a definite range of GlcNAc-6-sulfated sugar residues in tissues from patients or feces samples. MECA-79 antibody (Pharmingen, catalog No. 09961D, Distributor: Becton Dickinson), reacting with GlcNAc-6-sulfated sugar residues, which are produced specifically by the enzyme present in colorectal cancer and colorectal adenoma tissues could be used for the examination of colorectal cancers and colorectal adenomas.

摘要翻译： 本发明提供一种检查结肠直肠癌和结肠直肠腺瘤的方法，其能够以高概率检测结肠直肠癌患者和结肠直肠癌风险高的患者，并且可用于诊断结肠直肠癌和结肠直肠腺瘤，并提供检查试剂 其中。 本发明人发现，GlcNAc-6-磺基转移酶同工酶，糖残基的硫酸化酶在非癌结肠直肠组织，结肠直肠癌组织和结肠直肠腺瘤组织中的分布存在显着差异。 此外，本发明人将该发现应用于诊断，并发现通过测定来自患者或粪便样品的组织中GlcNAc-6-硫酸化糖残基的确定范围来特异性检测结肠直肠癌和腺瘤。 与存在于结肠直肠癌和结肠直肠腺瘤组织中的酶特异性产生的GlcNAc-6硫酸化糖残基反应的MECA-79抗体（Pharmingen，目录号09961D，经销商：Becton Dickinson）可用于检查 结肠直肠癌和结直肠腺瘤。

公开(公告)号：US07553624B2

公开(公告)日：2009-06-30

申请号：US10557906

申请日：2004-05-20

申请人： Takeharu Nagai ,  Atsushi Miyawaki

发明人： Takeharu Nagai ,  Atsushi Miyawaki

IPC分类号： C12Q1/68 ,  C12Q1/70 ,  G01N33/53 ,  C07H19/04 ,  C07H21/02

CPC分类号： G01N33/533

摘要： The present invention provides a method of analyzing the physiological function of a target substance by inactivating the physiological function of the target substance, comprising the steps of: (a) binding to the target substance a photoactive compound represented by formula (I): (in the formula, Q is a group for binding this compound with the target substance) to form a composite comprising the target substance and the photoactive compound; and (b) irradiating the obtained composite with light to inactivate the function of the target substance to which the photoactive compound has been bound, or to inactivate the function of the target substance at the site where the photoactive compound has been bound.

摘要翻译： 本发明提供了通过使目标物质的生理功能失活来分析目标物质的生理功能的方法，包括以下步骤：（a）与目标物质结合由式（I）表示的光活性化合物：（在 式中，Q为与化合物与目标物质结合的基团），形成包含目标物质和光活性化合物的复合体; 和（b）用光照射得到的复合物，使光活性化合物结合的目标物质的功能失活，或者使光活性化合物结合的位置失活目标物质的功能。

公开(公告)号：US07304315B2

公开(公告)日：2007-12-04

申请号：US11404248

申请日：2006-04-13

申请人： Yoshinori Iketaki ,  Masaaki Fujii ,  Takeshi Watanabe ,  Takashige Omatsu ,  Kimihisa Yamamoto ,  Toshio Suzuki

发明人： Yoshinori Iketaki ,  Masaaki Fujii ,  Takeshi Watanabe ,  Takashige Omatsu ,  Kimihisa Yamamoto ,  Toshio Suzuki

IPC分类号： G01N21/64 ,  G01J3/00

CPC分类号： G01N21/6458 ,  G01N21/645 ,  G01N2021/6419

摘要： A three-dimensional analyzing device includes a first beam source for generating a first beam, a second beam source for generating a second beam, an optical system for spatially overlapping the first and second beams at least partly and irradiating the beams onto a specimen to three-dimensionally confine a photoactive region in a specimen, and a photo acceptance element for accepting a response light emitted from the photoactive region. Preferably, the device further includes an operation unit for calculating a correlation function of a response light in the time domain based on the output of the photo acceptance element to analyze a desired physical value of the specimen.

摘要翻译： 三维分析装置包括用于产生第一光束的第一光束源，用于产生第二光束的第二光束源，至少部分地将第一和第二光束空间重叠的光学系统，并将光束照射到样品上至三 视觉上将光活性区域限制在样本中，以及用于接受从光活性区域发射的响应光的光接收元件。 优选地，所述装置还包括操作单元，用于基于所述光接收元件的输出来计算所述时域中的响应光的相关函数，以分析所述样本的期望物理值。

公开(公告)号：US07220986B2

公开(公告)日：2007-05-22

申请号：US10490476

申请日：2002-07-31

申请人： Masahiro Hiramoto ,  Masaaki Yokoyama

发明人： Masahiro Hiramoto ,  Masaaki Yokoyama

IPC分类号： H01L29/08

CPC分类号： H01L51/4206 ,  H01L27/305 ,  H01L51/0053 ,  H01L51/0064 ,  H01L51/0077 ,  H01L51/0078 ,  H01L51/0081 ,  H01L2251/308 ,  Y02E10/549 ,  Y02P70/521

摘要： A NTCDA single crystal is used as a photoelectric current multiplier layer, and Au thin films are formed as electrodes on the opposite surfaces of the multiplier layer by a vapor deposition method to form a sandwich type cell. When a voltage is applied to the NTCDA single crystal by the electrodes from a dc power source and a monochromatic light is applied, a multiplied photoelectric current flows between the electrodes. A rise of this element at light-on is considerably faster than when a vapor-deposited layer is used as a photoelectric current multiplier layer to permit a faster response.

公开(公告)号：US08237114B2

公开(公告)日：2012-08-07

申请号：US11988166

申请日：2006-04-28

申请人： Shoji Okuno ,  Yoshinao Wada ,  Takashi Yanagishita ,  Hideki Masuda

发明人： Shoji Okuno ,  Yoshinao Wada ,  Takashi Yanagishita ,  Hideki Masuda

IPC分类号： H01J49/26

CPC分类号： H01J49/0418

摘要： In one embodiment of the present invention, a sample target that allows ionization of a substance whose molecular weight is so high as to exceed 10000 in mass spectrometry that ionizes a sample without using matrix, a method for producing the same and a mass spectrometer using the sample target. The sample target includes a sample support surface including a large number of fine pores on its face receiving irradiated laser light. Each of the fine pores has a diameter of 30 nm or more and 5 μm or less. The number indicative of pore depth/(pore cycle−pore diameter) of each of the fine pores is 2 or more and 50 or less. The face of the sample support surface is coated with metal or semiconductor.

摘要翻译： 在本发明的一个实施方式中，能够使分子量高达10000以上的物质离子化的样品靶，该质谱在不使用基质的情况下离子化样品，其制造方法和质谱仪 样本目标 样品靶包括在其表面上接收照射的激光的大量细孔的样品支撑表面。 每个细孔的直径为30nm以上且5μm以下。 每个细孔的孔深度（孔隙孔径）的数量为2以上且50以下。 样品支撑表面的表面涂有金属或半导体。

公开(公告)号：US08037387B2

公开(公告)日：2011-10-11

申请号：US12345310

申请日：2008-12-29

申请人： Seiji Kajihara ,  Kohei Miyase ,  Xiaqing Wen ,  Yoshihiro Minamoto ,  Hiroshi Date

发明人： Seiji Kajihara ,  Kohei Miyase ,  Xiaqing Wen ,  Yoshihiro Minamoto ,  Hiroshi Date

IPC分类号： G06F11/00

CPC分类号： G01R31/318328 ,  G01R31/318335

摘要： Provided are a conversion device and the like for converting a initial test pattern given in advance into a test pattern of a bit constitution of different logic values, without losing the fault coverage of transition delay fault which can be detected by the constitution element of the initial test pattern. The conversion device converts an initial test pattern 100a given in advance for a logic circuit into an intermediate test pattern 100b of a bit constitution of different logic values, where the constitution elements of the initial test pattern 100a are at least two test vectors applied in succession. The conversion device includes a decision means for deciding a combination of logic values in the initial test pattern 100a which meet a detection condition of faults of the logic circuit which can be detected by applying the constitution elements.

摘要翻译： 提供了一种用于将预先给出的初始测试图案转换成不同逻辑值的比特构造的测试图案的转换装置等，而不会丢失可由初始化的构成元素检测到的过渡延迟故障的故障覆盖 测试模式。 转换装置将用于逻辑电路的预先给出的初始测试图案100a转换成不同逻辑值的比特结构的中间测试图案100b，其中初始测试图案100a的构成元素是连续应用的至少两个测试矢量 。 转换装置包括判定装置，用于决定初始测试图案100a中的逻辑值的组合，其满足通过应用构成要素可以检测的逻辑电路的故障的检测条件。

公开(公告)号：US07971118B2

公开(公告)日：2011-06-28

申请号：US12129746

申请日：2008-05-30

申请人： Xiaoqing Wen ,  Seiji Kajihara ,  Kohei Miyase ,  Yoshihiro Minamoto ,  Hiroshi Date

发明人： Xiaoqing Wen ,  Seiji Kajihara ,  Kohei Miyase ,  Yoshihiro Minamoto ,  Hiroshi Date

IPC分类号： G01R31/28 ,  G06F11/00

CPC分类号： G01R31/318547 ,  G01R31/318335 ,  G01R31/318502

摘要： Provided are a conversion device and others for converting a test vector set so as to reduce a logic value difference generated before and after scan capture in outputs of scan cells included in a full scan sequential circuit. A conversion device converts a test vector set corresponding to the full scan sequential circuit. The conversion device comprises a setting unit for setting a candidate bit which can be a don't care bit and a fixed bit which cannot be the don't care bit according to predetermined constraint conditions based on an input-output relationship in the logic circuit in order to identify the don't care bit identifiable as don't care from each test vector of the test vector set, and a logic value deciding unit for deciding a logic value for the don't care bit in view of a relationship in a plurality of bit pairs in relation to a test cube including the don't care bit identified by the setting unit.

摘要翻译： 提供了一种转换装置和其他用于转换测试矢量集，以便减少在全扫描时序电路中包括的扫描单元的输出中扫描捕获之前和之后产生的逻辑值差。 转换装置转换对应于全扫描时序电路的测试矢量集。 转换装置包括：设置单元，用于根据预定的约束条件，基于逻辑电路中的输入 - 输出关系设置可以是无关位的候选比特和不能不关心比特的固定比特 为了识别不关心的位，可以从测试向量集合的每个测试向量不关心，以及逻辑值决定单元，用于根据关系中的关系来确定无关位的逻辑值 相对于包括由设置单元标识的无关位的测试立方体的多个位对。