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    Protein AMSH and cDNA thereof
    2.
    发明授权
    Protein AMSH and cDNA thereof 失效
    蛋白AMSH及其cDNA

    公开(公告)号：US07423134B1

    公开(公告)日：2008-09-09

    申请号：US09831452

    申请日：1999-11-12

    申请人： Kazuo Sugamura ,  Nobuyuki Tanaka

    发明人： Kazuo Sugamura ,  Nobuyuki Tanaka

    IPC分类号： C07K21/04 ,  C07K14/00 ,  C12N15/00 ,  C12N15/63 ,  C12N15/12

    CPC分类号： C07K14/4702

    摘要： This application provides a human protein AMSH having the amino acid sequence of SEQ ID No. 1 which is a novel signal transduction molecule interacting with the SH3 domain of cytokine based signal transduction molecule STAM; a gene encoding the above AMSH; a cDNA having the nucleotide sequence of SEQ ID No. 2; and antibody against AMSH.

    摘要翻译： 本申请提供了具有SEQ ID No.1的氨基酸序列的人蛋白质AMSH，其是与基于细胞因子的信号转导分子STAM的SH3结构域相互作用的新型信号转导分子; 编码上述AMSH的基因; 具有SEQ ID No.2的核苷酸序列的cDNA; 和针对AMSH的抗体。

    Apparatus and method for filtering a spectrum spread communication
    3.
    发明授权
    Apparatus and method for filtering a spectrum spread communication 失效
    滤波频谱扩展通信的装置和方法

    公开(公告)号：US07411997B2

    公开(公告)日：2008-08-12

    申请号：US10473310

    申请日：2002-03-26

    申请人： Ken Umeno ,  Shenghung Shih ,  Akihiro Yamaguchi

    发明人： Ken Umeno ,  Shenghung Shih ,  Akihiro Yamaguchi

    IPC分类号： H04B1/707

    CPC分类号： H04J13/0018 ,  H03H17/0254 ,  H04B1/7093 ,  H04J13/10

    摘要： A filter (201) accepts spreading code sequences or the like as input sequences of a chip rate 1/D, the accepted spreading code sequences are sequentially delayed and distributed by delay circuits (202) connected in series, delay times of individual signals are an arithmetical progression with a chip length D being a common difference D, the individual signals are amplified with spreading codes by amplifiers (203), amplification factors for the individual signals are a geometrical progression of a common ratio r, the sum of the amplified signals is obtained by addition in an adder (204), and the result is sequentially output as an output sequence.

    摘要翻译： 滤波器（201）接受扩展码序列等作为码片速率1 / D的输入序列，接收到的扩展码序列被顺序延迟并由串联连接的延迟电路（202）分配，各个信号的延迟时间为 具有码片长度D的算术进程是公共差D，各个信号由放大器（203）的扩展码放大，各个信号的放大因子是公共比率r的几何进展，放大信号的和是 通过在加法器（204）中相加获得，并且将结果顺序地输出为输出序列。

    Information searching method, information searching program, and computer-readable recording medium on which information searching program is recorded
    5.
    发明授权
    Information searching method, information searching program, and computer-readable recording medium on which information searching program is recorded 失效
    信息搜索方法，信息搜索程序和记录信息搜索程序的计算机可读记录介质

    公开(公告)号：US07346614B2

    公开(公告)日：2008-03-18

    申请号：US10492760

    申请日：2001-10-17

    申请人： Koiti Hasida

    发明人： Koiti Hasida

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30967 ,  Y10S707/99933 ,  Y10S707/99935 ,  Y10S707/99942

    摘要： This invention relates to the subject matter identified in the title. An effective interaction is conducted by giving the user adequate information during information search so as to improve the search efficiency and accuracy. A CPU initially sets a set G containing deleted solution candidates to null and receives input for a search question Q from the user (S1). The CPU refers to a database storage section and creates a solution candidate set F as the result of the search of the database (D) in response to the search question Q by using the similarity of labels defined by a thesaurus T or a subset R of the thesaurus T (S2). The CPU presents the user the information concerning the solution candidates and search question Q as the help for interaction on a display part (S3). The user can check if there is a solution among the solution candidates.

    摘要翻译： 本发明涉及标题中标识的主题。 通过在信息搜索期间给予用户足够的信息来进行有效的交互，以便提高搜索效率和准确性。 CPU首先将包含删除的解决方案候选的集合G设置为空，并从用户接收用于搜索问题Q的输入（S1）。 作为数据库（D）的搜索结果，CPU参照数据库存储部分，并通过使用由词库T或子集R的子集R定义的标签的相似度来响应于搜索问题Q而创建解答候选集合F. 词典T（S 2）。 CPU向用户呈现关于解答候选者和搜索问题Q的信息作为在显示部分上的交互的帮助（S 3）。 用户可以检查解决方案中是否存在解决方案。

    Method using neutral amino acid transporter expressing cell
    6.
    发明授权
    Method using neutral amino acid transporter expressing cell 有权
    使用中性氨基酸转运蛋白表达细胞的方法

    公开(公告)号：US07335482B2

    公开(公告)日：2008-02-26

    申请号：US10913263

    申请日：2004-08-05

    申请人： Hitoshi Endou ,  Yoshikatsu Kanai

    发明人： Hitoshi Endou ,  Yoshikatsu Kanai

    IPC分类号： G01N33/53

    CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00

    摘要： A novel amino acid transporter molecule mediating transportation of amino acids, which are nutrients essentially required in the survival and proliferation of various normal cells constituting a living body and various pathology-associated abnormal cells such as tumor cells, into cells and being expressed specifically in tumor cells compared with normal cells; and drugs for treating various pathogenic conditions such as tumor (cancer) which are obtained by identifying and isolating the above amino acid transporter molecule and identifying a substance capable of inhibiting the biological activity and/or expression of this molecule. Intensive studies were made to identify a tumor cell membrane surface molecule associating or interacting with a cell membrane surface 4F2hc molecule seemingly playing an important role in the activation of an unknown amino acid transporter. As a result, a gene encoding the novel amino acid transporter molecule, which mediates the incorporation of various neutral amino acids, various drugs or physiological substances into cells, has been found out and a substance capable of inhibiting the incorporation of amino acids via this molecule and thus inhibiting the proliferation of tumor cells has been also found out.

    摘要翻译： 介导氨基酸运输的新型氨基酸转运蛋白分子，其是构成活体的各种正常细胞的存活和增殖以及各种病理学相关异常细胞如肿瘤细胞基本上需要的营养素，并且在肿瘤中特异性表达 细胞与正常细胞相比; 以及用于治疗通过鉴定和分离上述氨基酸转运蛋白分子并鉴定能够抑制该分子的生物活性和/或表达的物质而获得的各种病原性病症如肿瘤（癌症）的药物。 进行了深入研究，以确定与细胞膜表面缔合或相互作用的肿瘤细胞膜表面分子4F2hc分子在未知氨基酸转运蛋白的活化中似乎起着重要作用。 结果，已经发现了编码新的氨基酸转运蛋白分子的基因，其介导各种中性氨基酸，各种药物或生理物质掺入细胞中，并且能够通过该分子抑制氨基酸的掺入的物质 从而也发现抑制肿瘤细胞的增殖。

    Clock gene BMAL2
    8.
    发明授权
    Clock gene BMAL2 失效
    时钟基因BMAL2

    公开(公告)号：US07270999B2

    公开(公告)日：2007-09-18

    申请号：US11374725

    申请日：2006-03-13

    申请人： Yoshitaka Fukada ,  Toshiyuki Okano

    发明人： Yoshitaka Fukada ,  Toshiyuki Okano

    IPC分类号： C12N5/10 ,  C07H21/04

    CPC分类号： C07K14/4702 ,  A01K2217/05

    摘要： The present invention provides novel clock proteins BMAL2 (Brain-Muscle-Arnt-Like protein2), which is crucial for the clock oscillation mechanism including photic-input pathway and output pathway, novel clock genes encoding the proteins, a screening method using the proteins to screen a promoter or a suppressor of the promoter transactivation, and the like.Genes for cCLOCK, cPER2, cBMAL1 were isolated from the chicken pineal gland which is a material suitable for studying circadian clock, then cDNA encoding the novel clock protein cBMAL2 having homology with cBMAL1 was isolated and sequenced. Further, BMAL2 cDNAs in human, mouse and rat were isolated respectively from the human embryonic kidney cell line, the mouse mid brain and the rat early fibroblast, and sequences of these cDNAs were determined. BMAL2 forms a heterodimer with CLOCK or BMAL1, etc. and it also forms a homodimer.

    摘要翻译： 本发明提供了新颖的时钟蛋白BMAL2（Brain-Muscle-Arnt-Like蛋白2），其对于包括光输入通路和输出通路的时钟振荡机制至关重要，编码蛋白质的新型时钟基因，使用蛋白质的筛选方法 筛选启动子启动子的启动子或抑制子等。 从鸡松果体中分离出cCLOCK，cPER2，cBMAL1基因，这是适合于研究昼夜节律时钟的材料，然后分离编码与cBMAL1具有同源性的新型时钟蛋白cBMAL2的cDNA并进行测序。 此外，分别从人胚胎肾细胞系，小鼠中脑和大鼠早期成纤维细胞分离人，小鼠和大鼠中的BMAL2 cDNA，并测定这些cDNA的序列。 BMAL2与CLOCK或BMAL1等形成异二聚体，并形成同二聚体。

    Organic photocurrent multiplication device
    9.
    发明授权
    Organic photocurrent multiplication device 失效
    有机光电倍增装置

    公开(公告)号：US07262430B2

    公开(公告)日：2007-08-28

    申请号：US10380764

    申请日：2001-03-23

    申请人： Masahiro Hiramoto ,  Masaaki Yokoyama

    发明人： Masahiro Hiramoto ,  Masaaki Yokoyama

    IPC分类号： H01L35/24 ,  H01L51/00

    CPC分类号： H01L31/08 ,  H01L51/0053 ,  H01L51/0064 ,  H01L51/0077 ,  H01L51/0078 ,  H01L51/0081 ,  H01L51/4206 ,  Y02E10/549

    摘要： Organic semiconductor layers (2, 4) are laminated sandwiching an insulator thin layer (3), and translucent electrodes (1, 5) are formed on the surfaces of the organic semiconductor layers (2, 4), respectively. While a voltage is applied so that the electrode (1) is positive with respect to the electrode (5) and the opposite surfaces of the device are irradiated with two lights (6, 7) simultaneously, photocurrent multiplication is occurred to allow a photocurrent to flow in the device. However, no photocurrent multiplication occurs to allow no flow of photocurrent when the device is irradiated with one of the lights (6, 7).

    摘要翻译： 层叠有绝缘体薄层（3）的有机半导体层（2,4），在有机半导体层（2,4）的表面分别形成有透光性的电极（5,5）。 当施加电压使得电极（1）相对于电极（5）为正时，并且器件的相对表面同时用两个光（6,7）照射时，发生光电流倍增以允许光电流 流入设备。 然而，当器件被照射到其中一个灯（6,7）时，不会发生光电流倍增以不允许光电流流动。

    Nicotianamine synthase and gene encoding the same
    10.
    发明申请
    Nicotianamine synthase and gene encoding the same 失效
    烟碱合成酶和基因编码相同

    公开(公告)号：US20070150981A1

    公开(公告)日：2007-06-28

    申请号：US11702796

    申请日：2007-02-05

    申请人： Satoshi Mori ,  Kyoko Higuchi ,  Kazuya Suzuki ,  Naoko Nishizawa ,  Hiromi Nakanishi

    发明人： Satoshi Mori ,  Kyoko Higuchi ,  Kazuya Suzuki ,  Naoko Nishizawa ,  Hiromi Nakanishi

    IPC分类号： A01H1/00 ,  C07H21/04 ,  C12N9/10 ,  C12N15/82 ,  C12N5/04

    CPC分类号： C12N9/1085 ,  C12N15/8243 ,  C12N15/8271

    摘要： A nicotianamine synthase is isolated and purified. Then the gene of this enzyme is cloned and the base sequence and amino acid sequence thereof are determined. This gene is employed in constructing plants, in particular, grass plants highly tolerant to iron-deficiency. A nicotianamine synthase involved in the mugineic acid biosynthesis pathway; the amino acid sequence thereof; a gene encoding the same; a vector containing this gene; cells transformed by the vector; a process for producing nicotianamine by using the same; plants transformed by the gene encoding the nicotianamine synthase; and an antibody against the nicotianamine syntase.

    摘要翻译： 分离和纯化烟碱胺合酶。 然后克隆该酶的基因，确定其碱基序列和氨基酸序列。 该基因用于构建植物，特别是高度耐铁缺乏的草本植物。 涉及木瓜酸生物合成途径的烟碱胺合酶; 其氨基酸序列; 编码该基因的基因; 含有该基因的载体; 由载体转化的细胞; 通过使用它来生产烟碱胺的方法; 由编码烟碱胺合成酶的基因转化的植物; 和针对烟碱胺合成酶的抗体。