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公开(公告)号：US07268167B2
公开(公告)日：2007-09-11
申请号：US10468015
申请日：2002-02-13
CPC分类号： B01F13/0062 , B01F3/0807 , B01F3/0811 , B01F5/045 , B01F5/0471 , B01F13/0076 , B01F15/0201 , B01F15/0255 , B01F2003/0834 , B01F2003/0838 , B01F2215/0431 , B01J13/04 , B01J19/0093 , B01J2219/00783 , B01J2219/00853 , B01L3/5027 , Y10S366/04 , Y10S516/924 , Y10S516/927 , Y10T137/0329 , Y10T428/2984
摘要： A process and apparatus for rapidly producing an emulsion and microcapsules in a simple manner. A dispersion phase is ejected from a dispersion phase-feeding port toward a continuous phase flowing in a microchannel such that flows of the dispersion phase and the continuous phase cross each other, thereby obtaining microdroplets, formed by the shear force of the continuous phase, having a size smaller than the width of the channel for feeding the dispersion phase.
摘要翻译： 用于以简单的方式快速生产乳液和微胶囊的方法和装置。 分散相从分散相进料口朝着在微通道中流动的连续相排出，使得分散相和连续相的流动彼此交叉，从而获得通过连续相的剪切力形成的微滴，其具有由连续相的剪切力形成的微滴， 尺寸小于用于供给分散相的通道的宽度。
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2.发明申请PCR and hybridization methods utilizing electrostatic transportation and devices therefor 审中-公开利用静电运输的PCR和杂交方法及其装置公开(公告)号：US20060166262A1
公开(公告)日：2006-07-27
申请号：US11392504
申请日：2006-03-30
CPC分类号： B01L3/50273 , B01J2219/00274 , B01L3/502792 , B01L7/525 , B01L2200/0647 , B01L2300/0645 , B01L2300/089 , B01L2300/1827 , B01L2400/0415 , C12Q1/6813 , C12Q1/686 , G01N2035/00366 , G01N2035/00376 , C12Q2565/607 , C12Q2563/173 , C12Q2531/113 , C12Q2523/307
摘要： To provide a PCR method utilizing electrostatic transportation which allows separate control of individual DNA-containing droplets by accurately transporting the droplets, suitably controlling the temperature thereof and allowing a primer to react therewith; a hybridization method utilizing electrostatic transportation which allows rapid and easy detection of hybridization; and devices therefor. A biological sample (droplets containing DNA and primer) (9) is prepared in a chemically inert liquid layer (8), is electrostatically transported by the action of an electrostatic transportation plate (1) with electrostatic transportation electrodes (2) and is heated at a predetermined position of the electrostatic transportation plate (1), thus carrying out PCR.
摘要翻译： 为了提供利用静电转移的PCR方法，其允许通过精确地输送液滴来单独控制含有DNA的液滴，适当地控制其温度并允许底漆与其反应; 利用静电运输的杂交方法，其允许快速和容易地检测杂交; 及其设备。 在化学惰性液体层（8）中制备生物样品（含有DNA和底漆的液滴）（9），通过静电输送板（1）的作用与静电输送电极（2）静电输送，并在 静电传输板（1）的预定位置，从而进行PCR。
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3.发明申请PCR and hybridization methods utilizing electrostatic transportation and devices therefor 审中-公开利用静电运输的PCR和杂交方法及其装置公开(公告)号：US20060166261A1
公开(公告)日：2006-07-27
申请号：US11392496
申请日：2006-03-30
CPC分类号： B01L3/50273 , B01J2219/00274 , B01L3/502792 , B01L7/525 , B01L2200/0647 , B01L2300/0645 , B01L2300/089 , B01L2300/1827 , B01L2400/0415 , C12Q1/6813 , C12Q1/686 , G01N2035/00366 , G01N2035/00376 , C12Q2565/607 , C12Q2563/173 , C12Q2531/113 , C12Q2523/307
摘要： To provide a PCR method utilizing electrostatic transportation which allows separate control of individual DNA-containing droplets by accurately transporting the droplets, suitably controlling the temperature thereof and allowing a primer to react therewith; a hybridization method utilizing electrostatic transportation which allows rapid and easy detection of hybridization; and devices therefor. A biological sample (droplets containing DNA and primer) (9) is prepared in a chemically inert liquid layer (8), is electrostatically transported by the action of an electrostatic transportation plate. (1) with electrostatic transportation electrodes (2) and is heated at a predetermined position of the electrostatic transportation plate (1), thus carrying out PCR.
摘要翻译： 为了提供利用静电转移的PCR方法，其允许通过精确地输送液滴来单独控制含有DNA的液滴，适当地控制其温度并允许底漆与其反应; 利用静电运输的杂交方法，其允许快速和容易地检测杂交; 及其设备。 在化学惰性液体层（8）中制备生物样品（含有DNA和底漆的液滴）（9），通过静电输送板的作用静电输送。 （1）用静电输送电极（2）进行加热，并在静电输送板（1）的规定位置加热，进行PCR。
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公开(公告)号：US08741192B2
公开(公告)日：2014-06-03
申请号：US10593783
申请日：2005-03-15
CPC分类号： B01F13/0071 , B01F3/0807 , B01F5/0471 , B01F13/0062 , B01F15/00253 , B01J13/04 , Y10T137/0391 , Y10T428/2982
摘要： A method and an apparatus for producing various types of microdroplets. The apparatus has a cross intersection portion at which a first continuous phase, a first dispersion phase, and a second dispersion phase intersect with each other. A first liquid feed device controls the first dispersion phase and a second liquid feed device controls the second dispersion phase. A control device is connected to the first liquid feed device and the second liquid feed device. The first liquid feed device and the second liquid feed device are controlled by a signal from the control device so that microdroplets formed of the first dispersion phase and microdroplets formed of the second dispersion phase are sequentially produced.
摘要翻译： 一种用于生产各种微滴的方法和装置。 该装置具有交叉相交部分，第一连续相位，第一分散相位和第二分散相位彼此相交。 第一液体进料装置控制第一分散相，第二液体进料装置控制第二分散相。 控制装置连接到第一液体供给装置和第二液体供给装置。 第一液体供给装置和第二液体供给装置由来自控制装置的信号控制，从而顺序地产生由第一分散相形成的微滴和由第二分散相形成的微滴。
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5.发明申请Process for microchannel production of colorred spherical grain and microchannel production apparatus for use therein 有权用于其中使用的彩色球形颗粒和微通道生产装置的微通道生产方法公开(公告)号：US20060014894A1
公开(公告)日：2006-01-19
申请号：US10537602
申请日：2003-12-05
IPC分类号： C08F2/32
CPC分类号： C08F2/44 , Y10T137/0329
摘要： Monodisperse colored spherical particles each having two separated color regions of two hues, that is, two-colored spherical particles, useful, for example, for displays of characters, graphics, images and the like, the two hues being for reverse display in terms of electricity and magnetism from the viewpoint of good suitability for display are provided. In the production process and the apparatus for producing the colored spherical polymer particles, microchannels are utilized including a first microchannel through which a colored continuous phase comprising a color dye/pigment dispersed in a fluid dispersing medium containing a polymerizable resin component and having colored phases of different hues is transferred, and a second microchannel through which a spheroidizing disperse phase flows. The process and apparatus spheroidizes the discharged colored continuous phase having two hues and cures the polymerizable resin component in the colored continuous phase, whereby colored spherical polymer particles are formed.
摘要翻译： 每个具有两个分离的两个色调的颜色区域的单分散着色球形颗粒，即双色球形颗粒，例如可用于显示字符，图形，图像等，这两个色调用于反向显示 提供了从显示适用性的观点出发的电力和磁性。 在制造方法和着色球形聚合物颗粒的制造装置中，使用微通道，其包括第一微通道，通过该第一微通道，包含分散在含有可聚合树脂组分的流体分散介质中并具有着色相的着色染料/颜料的着色连续相 不同的色调被转移，并且第二微通道通过球状分散相流过。 该方法和装置对具有两个色调的排出的有色连续相进行球化并固化着色连续相中的可聚合树脂组分，从而形成着色的球形聚合物颗粒。
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6.发明申请Pcr method by electrostatic transportation, hybridization method for electrostatic transportation and devices therefor 审中-公开静电运输的Pcr方法，静电运输的杂交方法及其装置公开(公告)号：US20050064423A1
公开(公告)日：2005-03-24
申请号：US10499827
申请日：2003-01-08
CPC分类号： B01L3/50273 , B01J2219/00274 , B01L3/502792 , B01L7/525 , B01L2200/0647 , B01L2300/0645 , B01L2300/089 , B01L2300/1827 , B01L2400/0415 , C12Q1/6813 , C12Q1/686 , G01N2035/00366 , G01N2035/00376 , C12Q2565/607 , C12Q2563/173 , C12Q2531/113 , C12Q2523/307
摘要： To provide a PCR method utilizing electrostatic transportation which allows separate control of individual DNA-containing droplets by accurately transporting the droplets, suitably controlling the temperature thereof and allowing a primer to react therewith; a hybridization method utilizing electrostatic transportation which allows rapid and easy detection of hybridization; and devices therefor. A biological sample (droplets containing DNA and primer) (9) is prepared in a chemically inert liquid layer (8), is electrostatically transported by the action of an electrostatic transportation plate (1) with electrostatic transportation electrodes (2) and is heated at a predetermined position of the electrostatic transportation plate (1), thus carrying out PCR.
摘要翻译： 为了提供利用静电转移的PCR方法，其允许通过精确地输送液滴来单独控制含有DNA的液滴，适当地控制其温度并允许底漆与其反应; 利用静电运输的杂交方法，其允许快速和容易地检测杂交; 及其设备。 在化学惰性液体层（8）中制备生物样品（含有DNA和底漆的液滴）（9），通过静电输送板（1）的作用与静电输送电极（2）静电输送，并在 静电传输板（1）的预定位置，从而进行PCR。
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公开(公告)号：US20100327471A1
公开(公告)日：2010-12-30
申请号：US12826845
申请日：2010-06-30
CPC分类号： B01F13/0062 , B01F3/0807 , B01F3/0811 , B01F5/045 , B01F5/0471 , B01F13/0076 , B01F15/0201 , B01F15/0255 , B01F2003/0834 , B01F2003/0838 , B01F2215/0431 , B01J13/04 , B01J19/0093 , B01J2219/00783 , B01J2219/00853 , B01L3/5027 , Y10S366/04 , Y10S516/924 , Y10S516/927 , Y10T137/0329 , Y10T428/2984
摘要： A process and apparatus for rapidly producing an emulsion and microcapsules in a simple manner is provided wherein a dispersion phase is ejected from a dispersion phase-feeding port toward a continuous phase flowing in a microchannel in such a manner that flows of the dispersion phase and the continuous phase cross each other, thereby obtaining microdroplets, formed by the shear force of the continuous phase, having a size smaller than the width of the channel for feeding the dispersion phase.
摘要翻译： 提供一种用于以简单的方式快速生产乳液和微胶囊的方法和装置，其中将分散相从分散相进料口朝向在微通道中流动的连续相喷射，使得分散相和 连续相交叉，从而获得由连续相的剪切力形成的微滴，其尺寸小于用于进料分散相的通道的宽度。
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公开(公告)号：US07772287B2
公开(公告)日：2010-08-10
申请号：US11287252
申请日：2005-11-28
CPC分类号： B01F13/0062 , B01F3/0807 , B01F3/0811 , B01F5/045 , B01F5/0471 , B01F13/0076 , B01F15/0201 , B01F15/0255 , B01F2003/0834 , B01F2003/0838 , B01F2215/0431 , B01J13/04 , B01J19/0093 , B01J2219/00783 , B01J2219/00853 , B01L3/5027 , Y10S366/04 , Y10S516/924 , Y10S516/927 , Y10T137/0329 , Y10T428/2984
摘要： A process and apparatus for rapidly producing an emulsion and microcapsules in a simple manner is provided wherein a dispersion phase is ejected from a dispersion phase-feeding port toward a continuous phase flowing in a microchannel in such a manner that flows of the dispersion phase and the continuous phase cross each other, thereby obtaining microdroplets, formed by the shear force of the continuous phase, having a size smaller than the width of the channel for feeding the dispersion phase.
摘要翻译： 提供一种用于以简单的方式快速生产乳液和微胶囊的方法和装置，其中将分散相从分散相进料口朝向在微通道中流动的连续相喷射，使得分散相和 连续相交叉，从而获得由连续相的剪切力形成的微滴，其尺寸小于用于进料分散相的通道的宽度。
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公开(公告)号：US07375140B2
公开(公告)日：2008-05-20
申请号：US11287251
申请日：2005-11-28
CPC分类号： B01F13/0062 , B01F3/0807 , B01F3/0811 , B01F5/045 , B01F5/0471 , B01F13/0076 , B01F15/0201 , B01F15/0255 , B01F2003/0834 , B01F2003/0838 , B01F2215/0431 , B01J13/04 , B01J19/0093 , B01J2219/00783 , B01J2219/00853 , B01L3/5027 , Y10S366/04 , Y10S516/924 , Y10S516/927 , Y10T137/0329 , Y10T428/2984
摘要： A process and apparatus for rapidly producing an emulsion and microcapsules in a simple manner is provided wherein a dispersion phase is ejected from a dispersion phase-feeding port toward a continuous phase flowing in a microchannel in such a manner that flows of the dispersion phase and the continuous phase cross each other, thereby obtaining microdroplets, formed by the shear force of the continuous phase, having a size smaller than the width of the channel for feeding the dispersion phase.
摘要翻译： 提供一种用于以简单的方式快速生产乳液和微胶囊的方法和装置，其中将分散相从分散相进料口朝向在微通道中流动的连续相喷射，使得分散相和 连续相交叉，从而获得由连续相的剪切力形成的微滴，其尺寸小于用于进料分散相的通道的宽度。
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公开(公告)号：US20070196397A1
公开(公告)日：2007-08-23
申请号：US10593783
申请日：2005-03-15
CPC分类号： B01F13/0071 , B01F3/0807 , B01F5/0471 , B01F13/0062 , B01F15/00253 , B01J13/04 , Y10T137/0391 , Y10T428/2982
摘要： A method and an apparatus for producing various types of microdroplets. The apparatus has a cross intersection portion at which a first continuous phase, a first dispersion phase, and a second dispersion phase intersect with each other. A first liquid feed device controls the first dispersion phase and a second liquid feed device controls the second dispersion phase. A control device is connected to the first liquid feed device and the second liquid feed device. The first liquid feed device and the second liquid feed device are controlled by a signal from the control device so that microdroplets formed of the first dispersion phase and microdroplets formed of the second dispersion phase are sequentially produced.
摘要翻译： 一种用于生产各种微滴的方法和装置。 该装置具有交叉相交部分，第一连续相位，第一分散相位和第二分散相位彼此相交。 第一液体进料装置控制第一分散相，第二液体进料装置控制第二分散相。 控制装置连接到第一液体供给装置和第二液体供给装置。 第一液体供给装置和第二液体供给装置由来自控制装置的信号控制，从而顺序地产生由第一分散相形成的微滴和由第二分散相形成的微滴。
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