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公开(公告)号：US20220346412A1
公开(公告)日：2022-11-03
申请号：US17764713
申请日：2021-05-20
申请人： KIKKOMAN CORPORATION
发明人： Gaku OKAMURA , Yasushi INOMOTO , Yuri KUNITAKE
摘要： The purpose of the present invention is to provide a container-packed composition in which a heat deterioration smell, such as a retort smell based on contained ingredients such as soy sauce, meat, and soybean protein, is reduced; a processed food using the composition and a method of producing the processed food; and a composition in which a smell specific to meat is suppressed, and a flavor of the meat is improved so as to impart umami of meat, regardless of the type of meat. The purpose is achieved by: a container-packed composition containing at least one ingredient selected from the group consisting of a seasoning component, vegetables, meat, and seafood and having a phenethyl acetate content of 1.0 ppb or more and less than 1,000 ppb; and a container-packed composition containing animal meat and having a phenethyl acetate content of 1 ppb or more and less than 1,500 ppb.
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公开(公告)号：US20220308074A1
公开(公告)日：2022-09-29
申请号：US17837142
申请日：2022-06-10
申请人： KIKKOMAN CORPORATION
发明人： Kanako HAYASHI , Atsushi ICHIYANAGI
摘要： A quantitation method of vitamin D derivative is provided including adding an oxidoreductase to a sample. The quantitation method of vitamin D derivative may further include reducing a mediator by adding the oxidoreductase, and reacting the reduced mediator with a reagent to determine a concentration of the vitamin D derivative.
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公开(公告)号：US11312523B2
公开(公告)日：2022-04-26
申请号：US16652807
申请日：2018-10-12
摘要： A synthetic resin-made multilayer bottle includes: an outer shell bottle having a shoulder section continuing from an outer opening section, and a body section continuing from the shoulder section; a synthetic resin-made inner container body having a cylindrical inner opening section provided inside the outer opening section of the outer shell bottle, and an inner container main body continuing from the inner opening section, shaped along an inner surface shape of the outer shell bottle, which deforms by an external pressure; and an air passage formed between the outer opening section and the inner opening section and which introduces outside air between the outer shell bottle and the inner container body. The inner circumferential surface of the inner opening section is provided with a small-diameter section having a diameter smaller than the inner diameter of the open end of the inner opening section.
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公开(公告)号：US20210317463A1
公开(公告)日：2021-10-14
申请号：US17319362
申请日：2021-05-13
申请人： KIKKOMAN CORPORATION
发明人： Keiichi ICHIKAWA , Yasutomo SHINOHARA , Seiichi HARA , Keiko KUROSAWA , Yumiko YAMASHITA , Michiaki YAMASHITA
摘要： The purpose of the present invention is to provide a method for producing selenoneine that allows production of selenoneine at higher yields as compared with a conventional technology, and, therefore, enables selenoneine production on an industrial scale. This purpose can be achieved by a method for producing selenoneine, comprising the step of applying histidine and a selenium compound to a transformant that has a gene encoding an enzyme of (1) below introduced therein and that can overexpress the introduced gene, to obtain selenoneine.
(1) An enzyme that catalyzes a reaction in which hercynylselenocysteine is produced from histidine and selenocysteine in the presence of S-adenosylmethionine and iron (II).-
公开(公告)号：US20210301250A1
公开(公告)日：2021-09-30
申请号：US17267028
申请日：2019-08-08
发明人： Yuki ISHIKAWA , Tadaomi KAWASHIMA , Masaki ADACHI , Naoki SHIMOJO
IPC分类号： C12N1/20 , A61K35/744 , A23L33/135 , A23L2/52 , G01N33/68
摘要： The purpose of the present invention is to provide a composition containing, as an active ingredient, a substance having rich history of use in foods or an ingestion experience in human and having an effect of inhibiting FcεRI expression on a pDC. This purpose can be achieved by a composition for activating plasmacytoid dendritic cell comprising: at least one active ingredient selected from the group consisting of a bacterial cell, a bacterial component, and a culture of Pediococcus lactic acid bacteria, and a product obtained by treating any one of them, and having an effect of inhibiting FcεRI expression on a plasmacytoid dendritic cell.
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公开(公告)号：US11066690B2
公开(公告)日：2021-07-20
申请号：US16099779
申请日：2017-05-09
申请人： KIKKOMAN CORPORATION
发明人： Yousuke Masakari , Chiaki Hara
摘要： The present invention relates to FAD-GDH consisting of the amino acid sequence of SEQ ID NO: 1 or 3, an amino acid sequence having an identity of 70% or more with the amino acid sequence of SEQ ID NO: 1 or 3, or an amino acid sequence having a deletion, substitution or addition of one or several amino acids in the amino acid sequence (the amino acid sequence of SEQ ID NO: 1 or the amino acid sequence having an identity of 70% or more with the amino acid sequence of SEQ ID NO: 1); having an amino acid substitution at the position(s) corresponding to the following amino acid(s): the amino acid at the 175th position in the amino acid sequence of SEQ ID NO: 1, the amino acid at the 214th position in the amino acid sequence of SEQ ID NO: 1, the amino acid at the 192nd position in the amino acid sequence of SEQ ID NO: 1, the amino acid at the 212th position in the amino acid sequence of SEQ ID NO: 1, the amino acid at the 218th position in the amino acid sequence of SEQ ID NO: 1, and/or the amino acid at the 226th position in the amino acid sequence of SEQ ID NO: 1; and having an improved thermal stability compared to that before the substitution, provided that an FAD-GDH consisting of the amino acid sequence of SEQ ID NO: 28, 30 or 32 is excluded.
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公开(公告)号：US11028400B2
公开(公告)日：2021-06-08
申请号：US15750792
申请日：2016-06-17
申请人： KIKKOMAN CORPORATION
发明人： Keiichi Ichikawa , Yasutomo Shinohara , Seiichi Hara , Keiko Kurosawa , Yumiko Yamashita , Michiaki Yamashita
IPC分类号： C12P17/10 , C12N9/88 , C12N9/02 , C12N1/14 , C12N15/63 , C12R1/665 , C12R1/685 , C12R1/69 , C12N15/09 , C12R1/66
摘要： The purpose of the present invention is to provide a method for producing selenoneine that allows production of selenoneine at higher yields as compared with a conventional technology, and, therefore, enables selenoneine production on an industrial scale. This purpose can be achieved by a method for producing selenoneine, comprising the step of applying histidine and a selenium compound to a transformant that has a gene encoding an enzyme of (1) below introduced therein and that can overexpress the introduced gene, to obtain selenoneine. (1) An enzyme that catalyzes a reaction in which hercynylselenocysteine is produced from histidine and selenocysteine in the presence of S-adenosylmethionine and iron (II).
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公开(公告)号：US20200281240A1
公开(公告)日：2020-09-10
申请号：US16759369
申请日：2018-10-26
申请人： KIKKOMAN CORPORATION
发明人： Hiroshi KATAYAMA , Yuri KUNITAKE , Yoichi HANADA , Ryo FUJIMORI , Kazuma OOKUBO , Katsuhiro MOTOJIMA
IPC分类号： A23L27/50
摘要： A first object of the present invention is to provide a raw liquid for a seasoning which can be utilized for obtaining a seasoning with a mellow aroma and high palatability by simply performing yeast fermentation so as to enable the yeast fermentation even at home, an index of fermentation control, a set of members including the raw liquid and the index, and a method for manufacturing a seasoning. A second object of the present invention is to provide a seasoning that has a fruity aroma hardly noticeable in a conventional soy sauce while having a flavor inherent in a soy sauce. The first object is achieved by a raw liquid for a seasoning having a reducing sugar content of 4.5 wt % or more and an ethanol content of 1.5 wt % or less, a wood piece characterized by having been subjected to compression processing, and having a volume less than 20 cm3, a kit for manufacturing a seasoning including the raw liquid, the wood piece, a yeast-containing liquid, and a container for yeast fermentation, and a method for manufacturing a seasoning utilizing the kit. The second object is achieved by a soy sauce or a soy sauce-like seasoning containing ethyl octanoate and/or ethyl decanoate, or the like.
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公开(公告)号：US10767211B2
公开(公告)日：2020-09-08
申请号：US14396855
申请日：2013-04-26
申请人： KIKKOMAN CORPORATION
摘要： This invention provides an amadoriase having high reactivity with α-fructosyl hexapeptide (αF6P) derived from the β-chain amino terminus of glycated hemoglobin (HbAlc), which enables satisfactory quantification of αF6P cleaved from HbAlc. A novel amadoriase is derived from the amadoriase of the genus Coniochaeta by substitution of one or more amino acids at positions selected from the group consisting of positions 62, 63, 102, 106, 110, 113, 355, and 419. Such amadoriase enables rapid, simple, accurate, and satisfactory quantification of αF6P cleaved from HbAlc. With the use of such amadoriase, a method for measurement of HbAlc by an enzymatic method and a kit for measurement of HbAlc that are based on the same principle as used in the conventional standard method and excellent in terms of the relevance with the standard method.
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公开(公告)号：US20200263228A1
公开(公告)日：2020-08-20
申请号：US16832712
申请日：2020-03-27
申请人： Kikkoman Corporation
摘要： Provided is a composition by which glycated hemoglobin can be measured even in the presence of a stronger surfactant than a conventional case. Also provided is a buffer and/or stabilizer which maintains the residual activity of an amadoriase or lowers a reduction of residual activity. The present invention provides a composition for use in measuring glycated hemoglobin containing an amadoriase having substitution of one or more amino acid residues at a position(s) corresponding to an amino acid(s) selected from the group consisting of position 262, position 257, position 249, position 253, position 337, position 340, position 232, position 129, position 132, position 133, position 44, position 256, position 231 and position 81 of an amadoriase derived from the genus Coniochaeta and represented by SEQ ID No: 1 or 3, and having residual activity even in the presence of a surfactant. The present invention also provides a composition and kit for use in measuring glycated hemoglobin, comprising a specific stabilizer and/or a buffer. The present invention can provide an enzyme and a composition for use in measuring glycated hemoglobin, excellent in storage stability even if they are exposed to a surfactant.
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