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    Cobalt-porphyrin complexes and use thereof as an anti-obesity agent
    5.
    发明申请
    Cobalt-porphyrin complexes and use thereof as an anti-obesity agent 审中-公开
    钴 - 卟啉络合物及其作为抗肥胖剂的用途

    公开(公告)号：US20050148768A1

    公开(公告)日：2005-07-07

    申请号：US10984557

    申请日：2004-11-08

    申请人： Tomas Szabo ,  Soumitra Ghosh ,  Robert Davis

    发明人： Tomas Szabo ,  Soumitra Ghosh ,  Robert Davis

    IPC分类号： A61K31/409 ,  A61K33/24 ,  A61P3/04 ,  C07D487/22 ,  C07F15/06

    CPC分类号： C07D487/22

    摘要： Cobalt-porphyrin (Co-P) complexes for use as anti-obesity agents, and compositions and methods related thereto. The Co-P complexes exhibit reduced redox activity compared to cobalt mesoporphyrin (Co-MP) and cobalt protoporphyrin (Co-PP), which alleviates the deleterious effects associated with administration of Co-P associated with oxidative stress, particularly in the context of injection site toxicity.

    摘要翻译： 用作抗肥胖剂的钴卟啉（Co-P）络合物，以及与其相关的组合物和方法。 Co-P配合物与钴中卟啉（Co-MP）和钴原卟啉（Co-PP）相比显示出降低的氧化还原活性，其减轻了与施用与氧化应激相关的Co-P相关的有害作用，特别是在注射的情况下 现场毒性。

    ARYL N-CYANOGUANIDINES AND METHODS RELATED THERETO
    6.
    发明申请
    ARYL N-CYANOGUANIDINES AND METHODS RELATED THERETO 审中-公开
    ARYL N-烷基甘氨酸及其相关方法

    公开(公告)号：US20080032981A1

    公开(公告)日：2008-02-07

    申请号：US11744532

    申请日：2007-05-04

    申请人： Soumitra Ghosh ,  Tomas Szabo

    发明人： Soumitra Ghosh ,  Tomas Szabo

    IPC分类号： A61K31/155 ,  A61K31/16 ,  A61K31/44 ,  A61K31/535 ,  A61K31/537 ,  A61P19/02 ,  C07C279/28 ,  C07D207/46 ,  C07D213/57 ,  C07D265/30 ,  C07D279/00

    CPC分类号： A61K31/5375 ,  A61K31/155 ,  C07C279/28

    摘要： Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.

    摘要翻译： 治疗关节炎疾病如骨关节炎或类风湿性关节炎的化合物，组合物和方法，以及用于治疗与线粒体功能改变相关的其它疾病，例如癌症，牛皮癣，中风，阿尔茨海默氏病和糖尿病。 本发明的化合物具有以下结构（I）：包括其立体异构体，前药和药学上可接受的盐，其中R 1-5如本文所定义。 本发明的方法涉及向有需要的温血动物施用有效量的结构式（I）的化合物，通常为药物组合物的形式。

    Aryl N-cyanoguanidines and methods related thereto
    7.
    发明授权
    Aryl N-cyanoguanidines and methods related thereto 失效
    芳基N-氰基胍及其相关方法

    公开(公告)号：US07230132B2

    公开(公告)日：2007-06-12

    申请号：US11040196

    申请日：2005-01-21

    申请人： Soumitra S Ghosh ,  Tomas R Szabo

    发明人： Soumitra S Ghosh ,  Tomas R Szabo

    IPC分类号： C07C279/28 ,  C07C279/18

    CPC分类号： A61K31/5375 ,  A61K31/155 ,  C07C279/28

    摘要： Compounds, compositions and methods treating arthritic disorders such as osteoarthritis or rheumatoid arthritis, and for treating other diseases associated with altered mitochondrial function, such as cancer, psoriasis, stroke, Alzheimer's Disease and diabetes. The compounds of this invention have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein R1-5 are as defined herein. The methods of this invention are directed to administering to a warm-blooded animal in need thereof an effective amount of a compound of structure (I), typically in the form of a pharmaceutical composition.

    摘要翻译： 治疗关节炎疾病如骨关节炎或类风湿性关节炎的化合物，组合物和方法，以及用于治疗与线粒体功能改变相关的其它疾病，例如癌症，牛皮癣，中风，阿尔茨海默氏病和糖尿病。 本发明的化合物具有以下结构（I）：包括其立体异构体，前药和药学上可接受的盐，其中R 1-5如本文所定义。 本发明的方法涉及向有需要的温血动物施用有效量的结构式（I）的化合物，通常为药物组合物的形式。

    Screening assays using intramitochondrial calcium
    9.
    发明申请
    Screening assays using intramitochondrial calcium 审中-公开
    使用线粒体钙的筛选试验

    公开(公告)号：US20050170329A1

    公开(公告)日：2005-08-04

    申请号：US10974484

    申请日：2004-10-26

    申请人： Anne Murphy ,  Amy Stout

    发明人： Anne Murphy ,  Amy Stout

    IPC分类号： G01N33/50 ,  C12Q1/00 ,  C12Q1/68

    CPC分类号： G01N33/5079

    摘要： The invention provides methods for screening for agents that modulate mitochondrial function and in particular mitochondrial regulation of intracellular calcium. The methods may be used to detect agents that bind to a mitochondrial calcium uniporter and may also detect inhibitors or uncouplers of mitochondrial respiration. Agents identified using the screens provided herein have application in the prevention and treatment of a variety of diseases associated with abnormal mitochondrial function.

    摘要翻译： 本发明提供筛选调节线粒体功能，特别是细胞内钙线粒体调节剂的方法。 该方法可用于检测结合线粒体钙单转运体的试剂，并且还可以检测线粒体呼吸的抑制剂或解偶联剂。 使用本文提供的筛选鉴定的药剂可用于预防和治疗与异常线粒体功能相关的各种疾病。